Lodz University of Technology POLAND

Transcription

1 Synthesis, modification and sterilization of polymeric biomaterials expertise Radoslaw Wach BIOMATERIALS group Division of Applied Radiation Chemistry Main directions of investigations 1. radiation chemistry of polymers, sonochemistry 2. manufacuring of polymeric biomaterials, evaluation of biomaterials, sterilization of biomaterials / relative units 0,4 0,2 0, Time / ms

2 Recent & Current Projects 6FP: Custom IMD SME Supply Chain Integration for Enhanced Fully Customisable Medical Implants, using New Biomaterials and Rapid Manufacturing Technologies, to Enhance the Quality of Life for EU Citizens 6FP: Artemis In-vitro neural tissue system for replacement of transgenic animals with memory / learning deficiencs;,

3 Recent & Current Projects 7FP: NerveRegeneration Nerve guidance channels based on synthetic polymer polysaccharide biomaterials MSHE(POL): Dermostim/Polycel Grafted Thermoresponsive Polymers as Cell Culture Substrates for Burn Wound Healing CH 2 CH C NH O H 3 C CH CH 3 PNIPAAm,

4 Recent & Current Projects 7FP: BIP-UPy Bioactive Implantable Polymers based on UreidoPyrimidinone - pelvic floor repair - intracranial aneurysm treatment Synthesis of new generation of hydrogels with biologically active peptide for treatment of complicated and hard to heal wounds (POL); 6FP: Supercritical carbon dioxide processing technology for biodegradable polymers targeting medical applications; Nanoscale radiation engineering of advanced materials for potential biomed applications; Sonolysis of chitosan and starch (POL); Sonochemical crosslinking of polymers &synthesis of permanent hydrogels (POL); Chemical basis of sonodynamic anticancer therapy (POL); Action of ultrasound in the Hz range on DNA (POL);,

5 Hydrogels hydrogel dressings micro & nano-gels hydrogel dosimeters hydrogel-based dietary products containing fat binding agent 192 Ir - MRI,

6 Implant design Sterilization validation Biomaterials Synthesis Processing Sterilization Implant functionality studies Physical-chemical testing Biocompatibility In vitro In vivo Small animals Technical File Certification Validation Large animals,

7 Subjects of cooperation Evaluation of sterilization influence on new polymeric biomaterials and biomedical devices gamma irradiation, EB irradiation, moist heat, dry heat, ethylene oxide, plasma Evaluation of in vitro biocompatibility of new biomaterials and biomedical devices; Design and supervision of biocompatibility evaluation in vivo Manufacturing of tailored hydrogels for particular biomedical and industrial applications; micro- & nanogels Ultrasound-induced reactions and processes in liquid systems - mainly polymer solutions Application of synthetic biodegradable polymers as biomaterials for manufacturing of advanced medical devices,

8 Influence of sterilisation on biomaterials Biocompatibility evaluation Hydrogels macro-, micro-, nano- Biodegradable synthetic polymers Sonochemistry Radoslaw Wach

9 Routine Service Sterilization by means of EB irradiation and gamma irradiation:, biological materialas and fluids, medical equipment and devices, bones for tissue banking, spices & herbs Influence of sterilisation on materials: EB, gamma, steam, plasma; Manufacturing and biological in-vitro evaluation of new polymeric biomaterials & medical devices - cytotoxicity (MTT, LDH, live-dead), haemocompatibility, pyrogenicity (LAL test) Biodegradation of synthetic polymers, composites, stability of biomaterials Validation of radiation sterilization process (microbiological method based on initial device s bioburden),

10 DERMOSTIM - Development Fund No. POIG /08-01 ARTEMIS, FP LIFESCIHEALTH-7 LSH CUSTOM-IMD, FP6 - NMP3-CT NerveRegeneration, FP7 - MIGR-CT & P843/7 PR UE/2008/7 (MSHE, Poland) BIP-UPy, FP7 - FP NMP-LARGE Hydrogel Dressings, European Regional Development Fund - N R /2009 customised implants in 48h,