LETI-HEALTH. Adrienne Pervès Deputy Director LETI Technologies for Biology and healthcare Department

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1 Adrienne Pervès Deputy Director LETI Technologies for Biology and healthcare Department LETI-HEALTH Micro- NanoTechnologies for Healthcare and Biology

2 MISSION AND EXPERTISE Focused on applications in biology, healthcare, environment and security With a wide spectrum of competencies from component development to system integration Biology Micro fluidic Detection Electronic Packaging Optic Photonic Micro technology Chemistry Instrumentation Electrochemistry Modelling Information processing Multidisciplinary teams - One stop shop for completely integrated systems Micro- NanoTechnologies for Healthcare and Biology 2

3 LETI HEALTH ONE STOP SHOP OFFER ON MEDICAL DEVICES Converting concepts into manufacturable prototypes up to clinical tests with high compliance to safety and security rules: our MedTech platform CONCEPTION & MANUFACTURING CHARACTERIZATION & VALIDATION Micro- NanoTechnologies for Healthcare and Biology 3

4 COLLABORATION WITH MEDICAL TEAMS Legend: past current in discussion More than 80 medical doctors in the world in more than 40 different domains Micro- NanoTechnologies for Healthcare and Biology 4

5 KEY PARTNERS Micro- NanoTechnologies for Healthcare and Biology 5

6 SENSORS AND DIAGNOSTIC INPUTS FROM MICROFLUDICS IMI-ECSEL Workshop

7 THE 3 FUNCTIONAL PILLARS OF SENSING AND DIAGNOSTICS Cancer Metabolic pathologies (Diabetes, obesity, cholesterol, cardiac diseases, sleep disorders, etc. ) Heartbeat Blood pressure Skin conductivity / bioimpedence Physical Activity / movement elements Brain activity (EEG- ECoG) Muscle activity Eye activity (electrical, movement) Genomics (DNA, Biochemical RNA, SiRNA) elements Proteomics in gaz (breath) (proteins) or in fluids Metabolomics (sweat, urine, (biomarkers, blood, saliva, glucose, swabs, etc.) cholesterol, hormones, enzymes, ions, etc.) Sampling and sample preparation Analysis Data processing, algorythms Integration Miniaturization Multi-modal systems Multi-parameter analysis Point of Care In vitro On vivo Point of Care In vitro Point of Care On vivo On vivo In vitro In vitro Point of Care On vivo Point of Care On vivo In vitro Data processing on large patient populations Comprehensive picture of a single patient condition Increased capacity to launch large epidemiologic studies Increased capacity for personalised medicine 7

8 PILOT LINES IN ECSEL The ambition of Makefluidics is to accelerate the maturation and take-off of the MF industry building on the work accomplished in MFManufacturing Overall objective of MakeFluidics : From FCB to multi-module heterogeneous integration (Parallel with the evolution of the electronic industry) 8

9 PILOT LINES IN ECSEL Successful demonstrators in MFManufacturing MicroFactory for radiotracer synthesis Alcen PMB Demonstrators envisaged Fully assembled demonstrator Generic test bench FCB on which every FBB can be connected In-vitro diagnostics for health 3D model of the characterization platform (FLUIGENT). On-site drug preparation platform - EVEON Organ on chip Particle metrology Fully assembled demonstrator in MFM Eveon Intuity Mix 9