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1 TechNavio Infiniti Research Research Limited v2680/ Publisher Sample Phone: (US) or or (Int'l) Hours: Monday - Thursday: 5:30am - 6:30pm EST Fridays: 5:30am - 5:30pm EST customerservice@marketresearch.com MarketResearch.com

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3 01. Market Research Methodology Market Research Process TechNavio identifies the key opportunities in leading markets and develops various methodologies for data collection and analysis. The micro, meso, and macroeconomic indicators of the market are studied to ascertain the dynamics of the market. Research Design TechNavio s reports are based on in-depth qualitative and quantitative analyses of various markets. Qualitative analysis involves the application of various projection and sampling techniques, whereas quantitative analysis involves primary interviews, surveys, and vendor briefings. The data thus gathered is validated through experts' opinions. Based on research results and technical insights, TechNavio analysts refine the existing methodologies to analyze the various aspects of the market. Exhibit 1: Market Research Methodology Global Cell Culture Protein Surface Source: TechNavio Analysis Global Cell Culture Protein Surface

4 TechNavio analysts gather inputs from various vendors and industry experts and verify the information collected with databases, financial reports, industry papers, and various other secondary sources. The impact of global economic conditions and other macroeconomic indicators are also considered while assessing the market. Research Methodology TechNavio analysts have adopted primary as well as secondary research techniques to ascertain the size and vendor landscape of the Global Cell Culture Protein Surface Coating Market. The information is obtained using a combination of the bottom-up and top-down approaches, besides using in-house market modeling tools. The data is then corroborated with data obtained from various market participants and stakeholders across the value chain, including vendors, service providers, distributors, re-sellers, and end-users. Global Cell Culture Protein Surface

5 02. Executive Summary Market Size Market Growth Rate 2014: US$XXX 2019: US$XXX 2014: XXX percent 2019: XXX percent CAGR XXX percent Key Geographies Key Leading Country/Region Americas: XXX percent EMEA: XXX percent APAC: XXX percent US: XXX percent Europe: XXX percent Key Customer Segments Biopharmaceutical and Biotechnology Companies Research Laboratories Academic Institutions Key Market Drivers Key Market Challenges Key Market Trends Growing Focus on Stem Cell Research Driver 2 Driver 3 Driver 4 Disadvantages of Animal-derived Protein Surface Coatings Challenge 2 Challenge 3 Animal-free Synthetic Protein Surface Coating Trend 2 Trend 3 Key Buying Criteria Key Vendors Brand Image Cost Ease of Availability Safety Becton, Dickinson and Co. (BD) Corning Inc. EMD Millipore Corp. Sigma-Aldrich Corp. Thermo Fisher Scientific Inc. Global Cell Culture Protein Surface

6 03. Scope of the Report 03.1 Market Overview This report covers the present scenario and the growth prospects of the Global Cell Culture Protein Surface Coating market for the period. To calculate the market size, the report considers revenue generated from the sales of cell culture protein surface coating products, including consumables and instruments. The Global Cell Culture Protein Surface Coating market is categorized on the basis of source type into four segments: Animal-derived Protein Human-derived Protein Synthetic Protein Plant-derived Protein The report also presents the vendor landscape and a corresponding detailed analysis of the top five vendors in the market. In addition, it discusses the major drivers that influence the growth of the market. It also outlines the challenges faced by vendors and the market at large, as well as the key trends that are emerging in the market Product Offerings Some of the products offered by the major vendors in the Global Cell Culture Protein Surface Coating market are listed below: Company Products Offered BD BD BioCoat Angiogenesis Systems BD BioCoat Collagen I Cultureware BD BioCoat Collagen IV Cultureware BD BioCoat Fibronectin Cultureware BD BioCoat Gelatin Cultureware BD BioCoat Intestinal Epithelium Differentiation Kit BD BioCoat Laminin Cultureware BD BioCoat Matrigel Matrix Cultureware BD BioCoat Poly-D-Lysine Cultureware BD BioCoat Poly-D-Lysine/Laminin, Poly-L-Orinthine/Laminin Global Cell Culture Protein Surface

7 and Laminin/Fibronectin Cultureware BD BioCoat Poly-L-Lysine Cultureware BD BioCoat Tumor Invasion Systems BD Falcon Non-treated Polystyrene BD Falcon Tissue Culture-treated BD Gentest PAMPA Plate System BD Primaria BD PureCoat Amine Cultureware BD PureCoat Carboxyl Cultureware Caco-2 Assay System Cell Culture Inserts Corning Corning BioCoat Cultureware Corning CellBIND Surface Corning Collagens Corning Fibronectin Corning Laminins Corning Matrigel Matrix Corning Osteo Assay Surface Corning Osteopontin Corning Primaria Surface Corning Puramatrix - Synthetic Scaffolds Corning PuraMatrix Peptide Hydrogel Corning PureCoat Surface Corning PureCoat Amine/Carboxyl Surfaces Corning Recombinant Laminin Corning Synthemax Surface Corning Ultra-low Attachment Surface Corning Vitronectin Ultra-low Attachment Surface EMD Millipore Cell Culture Receiver Plate Chemicon ECM Proteins Millicell Inserts and Plates Millicoat ECM-coated Strips Millicoat Extracellular Matrix-coated Plasticware Optimization Array Sigma-Aldrich E-Cadherin Human MAPTRIX-C-TAGSCLRKFSTM MAPTRIX-E-LRAHAVDING MAPTRIX-F-GRGDSP MAPTRIX-F-PHSRN-RGDSP Global Cell Culture Protein Surface

8 MAPTRIX-F-RGD MAPTRIX-L-IKVAV Fibronectin from Bovine Plasma Fibronectin from Human Foreskin Fibroblasts Fibronectin from Human Plasma Fibronectin from Rat Plasma Fibronectin Proteolytic Fragment from Human Plasma MAPTRIX-L-KNSFMALYLSKG Poly-D-Lysine Hydrobromide Poly-L-Lysine Hydrobromide Poly-L-Lysine Solution Poly-L-Ornithine Solution Thermo Fisher Scientific BioLite Cell Culture-treated Dishes BioLite Multidishes and Microwell Plates Nunc Cell Culture/Petri Dishes Nunc Dishes with HydroCell Surface Nunc Dishes with UpCell Surface Nunc Glass Bottom Dishes Nunc Low Cell Binding Surface Dishes and Multidishes Nunc MicroWell MiniTrays Nunc MiniTrays with Nunclon Delta Surface Nunc Non-treated Multidishes Nunc Nunclon Vita 6-Well Multidish Nunc OmniTray Nunc Poly-D-Lysine or Collagen I Coated Multidishes Nunc Rectangular Dishes Nunc Square BioAssay Dishes Global Cell Culture Protein Surface

9 04. Introduction Cell culture protein surface coating is performed to enhance the adhesion and proliferation of cells during in vitro isolation and cultivation. For surface coating, the inner surface of the Petri dish is coated with ECM components or proteins such as fibronectin, laminin, collagen, vitronectin, and osteopontin. These proteins can be human-derived, animal-derived, plantderived, or synthetic. Protein surface coating facilitates the growth of various types of cell such as endothelial, epithelial, fibroblasts, leukocytes, myoblasts and muscle cells, neurons, and CHO cell lines. The Global Cell Culture Protein Surface Coating market is expected to post a CAGR of XXX percent during the period The Americas generated the highest revenue in the market in Increased demand for cell culture and analysis products from pharmaceutical and biotechnology companies, research institutes, and clinical laboratories propelled the growth of the market in the Americas. The US and Europe were the largest revenue contributors to the overall market in However, vendors have huge opportunities to expand their business in the APAC and MEA regions. Countries in these regions are fast emerging as clinical hubs because of the availability of R&D expertise, skilled technicians, and significant cost advantages. The Global Cell Culture Protein Surface Coating market is driven by several factors. Growing focus on stem cell research is one of the major drivers of the market. The use of stem cells in the treatment of several medical disorders, such as bone marrow transplants, has resulted in increased interest among researchers in stem cell research. Stem cells are also employed in the study of human development, drug discovery, and tissue engineering among others. Increased demand for biopharmaceuticals is another major driver of this market. However, the Global Cell Culture Protein Surface Coating market is curtailed by certain challenges. The disadvantages of animal-derived protein surface coating pose a major challenge to the market. The use of animal-derived protein surface coatings has some serious complications, such as risk of contamination and ethical issues associated with its use in human therapeutic production. The control of cell interaction with the surrounding environment is another major challenge facing the market. Note: Information included in this sample are extracts of the full report. Global Cell Culture Protein Surface

10 Key Questions Answered in this Report What will the market size be in 2019 and what will be the growth rate? What are key market trends? What is driving this market? What are the challenges to market growth? Who are the key vendors in this market space? What are the market opportunities and threats faced by key vendors? What are the strengths and weaknesses of each of these key vendors? Global Cell Culture Protein Surface

11 05. Market Landscape 05.1 Market Size and Forecast The Global Cell Culture Protein Surface Coating market was valued at US$XXX in 2014 and is expected to reach US$XXX by 2019, growing at a CAGR of XXX percent. Exhibit 2: Global Cell Culture Protein Surface (US$ XXX) Actual exhibits are available in full report only Source: TechNavio Analysis Note: Information included in this sample are extracts of the full report. Global Cell Culture Protein Surface

12 06. Market Growth Drivers Some of the key drivers of the Global Cell Culture Protein Surface Coating market are discussed below: Growing Focus on Stem Cell Research Trend 2 Trend 3 Trend 4 Growing Focus on Stem Cell Research Cell culture protein surface coating products help researchers to improve the adhesion, proliferation, and growth of cells being cultured. They facilitate various research activities such as the study of receptor-ligand binding, the cell matrix, signal transduction, morphogenesis, and individual cell type differentiation. Advanced protein surface coating products provide enhanced cell growth and attachment. Stem cell therapy plays a vital role in the treatment of several serious diseases including neurodegenerative diseases, cardiac diseases, and diabetes. Stem cell therapy is most commonly used for bone marrow transplants. The high potential of stem cells in the treatment of severe diseases has resulted in demand for advanced cell culture products for stem cell production and study. In addition, stem cell research is important in drug discovery, human development studies, and tissue engineering among others. Note: Information included in this sample are extracts of the full report. Global Cell Culture Protein Surface

13 07. Market Challenges Some of the challenges faced by the vendors in the Global Cell Culture Protein Surface Coating market are discussed below. Disadvantages of Animal-derived Protein Surface Coatings Challenge 2 Challenge 3 Disadvantages of Animal-derived Protein Surface Coatings Though human-derived protein surface coating can be used for surface coating, it is expensive. Collagen, an animal-based protein, is widely used by researchers for surfaces coating in cell culture to promote cell attachment. However, animal-derived protein surface coatings are not suitable in some cell culture applications such as human therapeutic production. In addition, the use of complex and animal-derived protein coating cannot ensure that the produced cells have the required purity and quality and there is also a risk of contamination of the culture. Note: Information included in this sample are extracts of the full report. Global Cell Culture Protein Surface

14 08. Market Trends Some of the key trends in the Global Cell Culture Protein Surface Coating market are discussed below. Animal-free Synthetic Protein Surface Coating Trend 2 Trend 3 Animal-free Synthetic Protein Surface Coating Animal-free synthetic protein surface coatings have a broad range of applications in several areas including biopharmaceutical production and other research. The Animal-free Synthetic Protein segment is growing at a rapid pace because of increased demand from the Pharmaceutical and Biotechnology industries. The Biopharmaceutical industry faces the risk of production failure because of product contamination. Hence, animal-free synthetic protein surface coating is extremely helpful as it reduces the risk of contamination. Vendors are focusing particularly on the development of animal-free synthetic protein surface coating products to meet increased demand from the industry. For instance, BD offers PureCoat ECM Mimetic Cultureware, which is coated with synthetic animal-free peptides that provide optimal cell binding and signaling in a wide range of xeno-free, serum-free, and animal-free media formulations. Note: Information included in this sample are extracts of the full report. Global Cell Culture Protein Surface

15 09. Vendor Landscape 09.1 Competitive Scenario BD, Corning, EMD Millipore, Sigma-Aldrich, and Thermo Fisher Scientific are the leading vendors in the Global Cell Culture Protein Surface Coating market. The market is witnessing significant growth because of the growing focus on cell biology and stem cell research and increase in R&D funding. However, the market is highly competitive with the presence of many global and local players that are developing a broad range of advanced and innovative cell culture products Other Prominent Vendors Company Description Abcam BioMedTech Laboratories Bio-Techne Leading provider of protein research tools for life science research Provides tissue culture ware and coated microplates for HTS and HCS, cell culture, and assay applications Provides high-quality proteins and immunoassays, stem cell products, antibodies, arrays, cell selection and detection products, and other cell biology tools Cedarlane Laboratories Offers polyclonal and monoclonal antibodies, complement for tissue typing, cell separation media, and immunocolumns Note: Information included in this sample are extracts of the full report. Global Cell Culture Protein Surface

16 10. Key Vendor Analysis 10.1 BD Key Facts Actual exhibits are available in full report only Company Details Description Stock Listings New York Stock Exchange Ticker Symbol BDX Business Overview BD is a medical technology company that manufactures and sells a broad range of medical supplies, laboratory equipment, devices, and diagnostic products Key Information Type Details Key Highlights February 2014: Collaborates with the US Agency for International Development to support the National Tuberculosis Program's capacity building and development goals Note: Information included in this sample are extracts of the full report. Global Cell Culture Protein Surface

17 SWOT Analysis Note: Information included in this sample are extracts of the full report. Global Cell Culture Protein Surface

18 TABLE OF CONTENT 01. Executive Summary List of Abbreviations Scope of the Report Market Overview Product Offerings Market Research Methodology Market Research Process Research Methodology Introduction Overview Types of Protein Used for Cell Culture Surface Coating Applications of Cell Culture Protein Surface Coating Market Landscape Market Overview Market Size and Forecast Cell Culture Protein Surface in US Market Size and Forecast Cell Culture Protein Surface in Europe Market Size and Forecast Five Forces Analysis Market Segmentation by Source Type Global Animal-derived Protein Market Market Size and Forecast Global Cell Culture Protein Surface

19 08.2 Global Human-derived Protein Market Market Size and Forecast Global Synthetic Protein Market Market Size and Forecast Global Plant-derived Protein Market Market Size and Forecast Geographical Segmentation Cell Culture Protein Surface in Americas Market Size and Forecast Cell Culture Protein Surface in EMEA Region Market Size and Forecast Cell Culture Protein Surface in APAC Region Market Size and Forecast Buying Criteria Market Growth Drivers Drivers and their Impact Market Challenges Impact of Drivers and Challenges Market Trends Trends and their Impact Vendor Landscape Competitive Scenario Key News Mergers and Acquisitions Vendor Analysis Other Prominent Vendors Key Vendor Analysis Global Cell Culture Protein Surface

20 18.1 BD Key Facts Business Overview Business Segmentation Business Segmentation by Revenue Business Segmentation by Revenue 2013 and Geographical Segmentation by Revenue Business Strategy Key Information SWOT Analysis Corning Key Facts Business Overview Business Segmentation by Revenue Business Segmentation by Revenue 2012 and Geographical Segmentation by Revenue Business Strategy Recent Developments SWOT Analysis EMD Millipore Key Facts Business Overview Business Segmentation Sales by Geography Business Strategy Key Information SWOT Analysis Sigma-Aldrich Global Cell Culture Protein Surface

21 Key Facts Business Overview Sigma-Aldrich: Business Segmentation Business Strategy Business Segmentation by Revenue Sales by Geography Key Developments SWOT Analysis Thermo Fisher Scientific Key Facts Business Overview Business Segmentation Revenue by Product Segmentation Sales Segmentation Business Strategy Key Information SWOT Analysis Other Reports in this Series Global Cell Culture Protein Surface

22 EXHIBITS Exhibit 1: Market Research Methodology... 6 Exhibit 2: Types of Protein Exhibit 3: Applications of Cell Culture Protein Surface Coating Exhibit 4: Global Cell Culture Protein Surface (US$ million) Exhibit 5: Cell Culture Protein Surface in US (US$ million) Exhibit 6: Cell Culture Protein Surface in Europe (US$ million) Exhibit 7: Segmentation of Global Cell Culture Protein Surface by Source Type Exhibit 8: Segmentation of Global Cell Culture Protein Surface by Source Type 2014 and Exhibit 9: Segmentation of Global Cell Culture Protein Surface by Source Type in terms of Revenue (US$ million) and CAGR 2014 and Exhibit 10: Global Animal-derived Protein Market (US$ million) Exhibit 11: Global Human-derived Protein Market (US$ million) Exhibit 12: Global Synthetic Protein Market (US$ million) Exhibit 13: Global Plant-derived Protein Market (US$ million) Exhibit 14: Segmentation of Global Cell Culture Protein Surface by Source Type (US$ million) Exhibit 15: Segmentation of Global Cell Culture Protein Surface by Source Type Global Cell Culture Protein Surface

23 Exhibit 16: Segmentation of Global Cell Culture Protein Surface by Geography 2014 and Exhibit 17: Segmentation of Global Cell Culture Protein Surface by Geography by Revenue (US$ million) and CAGR 2014 and Exhibit 18:Cell Culture Protein Surface in Americas (US$ million) Exhibit 19: Cell Culture Protein Surface in EMEA Region (US$ million) Exhibit 20: Cell Culture Protein Surface in APAC Region (US$ million) Exhibit 21: Segmentation of Global Cell Culture Protein Surface by Geography (US$ million) Exhibit 22: Segmentation of Global Cell Culture Protein Surface by Geography Exhibit 23: BD: Business Segmentation Exhibit 24: BD: Business Segmentation by Revenue Exhibit 25: BD: Business Segmentation by Revenue 2013 and 2012 (US$ million) Exhibit 26: BD: Geographical Segmentation by Revenue Exhibit 27: Corning: Business Segmentation by Revenue Exhibit 28: Corning: Business Segmentation by Revenue 2012 and 2013 (US$ billion) Exhibit 29: Corning: Geographical Segmentation by Revenue Exhibit 30: EMD Millipore: Business Segmentation Exhibit 31: EMD Millipore: Sales by Geography Exhibit 32: Sigma-Aldrich: Business Segmentation Exhibit 33: Business Segmentation by Revenue Global Cell Culture Protein Surface

24 Exhibit 34: Sigma-Aldrich: Geographical Segmentation by Revenue Exhibit 35:Thermo Fisher Scientific: Business Segmentation by Revenue Exhibit 36:Thermo Fisher Scientific: Product Segmentation by Revenue Exhibit 37: Thermo Fisher Scientific: Sales by Geography Global Cell Culture Protein Surface

25 11. Other Reports in this Series Global Flow Cytometry Market Global Biotechnology Reagents Market Global Advanced Wound Care Market Global 3D Bioprinting Market Genomics Market in the US Global High Throughput Screening (HTS) Market Global Affinity Chromatography Reagents Market Global Laboratory Centrifuges Market Global Molecular Spectroscopy Market Global Organ Preservation Solutions Market Global Protein Crystallization & Crystallography Market Global Electrophoresis Equipment Market Global Polymerase Chain Reaction (PCR) Market Global Atomic Spectroscopy Market Global Antisense and RNAi Therapeutics Market Global Dialysis Services Market Global Medical Simulation Market Global mirna Market Global Cell Culture Protein Surface

26 DISCLAIMER This report has been prepared from sources and data that we believe to be reliable, but we make no representation as to its accuracy or completeness. Any decision or action taken by the recipient based on this report shall be solely and entirely at the risk of the recipient. Opinions and information provided are made as at the date of the report issue and are subject to change without notice. All trademarks and copyrights remain the sole ownership of their rightful owners/licensees. In no event shall Infiniti Research have any liability to any party for special, incidental, tort, or consequential damages arising out of or in connection with this report, even if Infiniti Research has been advised of the possibility of such damages. Copyright 2015 Infiniti Research Limited. All Rights Reserved. Reproduction without written permission is completely forbidden. ABOUT TECHNAVIO INSIGHTS TechNavio Insights is a customized set of reports based on the TechNavio platform. It builds on the intelligence available within TechNavio and leverages the custom research experience of our researchers. TechNavio is built on years of experience of Infiniti Research in deep dive custom research and consulting for over 30 Fortune 500 companies and numerous large and medium-sized companies in the technology space. For more information about TechNavio, please visit Global Cell Culture Protein Surface