Tsai, Wei-Bor ( 蔡偉博 ) Professor. B.S. in Chemical Engineering National Taiwan University, Research and Professional Interests

Transcription

1 Tsai, Wei-Bor ( 蔡偉博 ) Professor B.S. in Chemical Engineering National Taiwan University, 1989 M.S. in Biochemical Sciences National Taiwan University, 1991 Ph.D. in Bioengineering University of Washington, 1998 Research and Professional Interests Biomaterials Tissue engineering Drug delivery Projects ( stared from 2013 ) 1. 發展結合綠光雷射與奈米藥物傳輸的癌症治療技術 NT$ 3,550,000, 國科會, E MY3, 2012/08/01~2015/07/31 Journal Papers 1. Jian-Hua Zhao, Hsuan-Liang Liu, Yi-Fan Liu, Hsin-Yi Lin, Hsu-Wei Fang, Yih Ho, Wei-Bor Tsai, Molecular Dynamics Simulations to Investigate the Aggregation Behaviors of the Aβ(17-42) Oligomers, Journal of Biomolecular Structure & Dynamics, 26(4): , (SCI) 2. Peng-Yuan Wang, Hsiang-Hong Chow, Hsu-Wei Fang, Wei-Bor Tsai*, Modulation of gene expression of rabbit chondrocytes by dynamic compression in polyurethane scaffolds with collagen gel encapsulation, Journal of Biomaterials Applications, 23: , (SCI,EI) 3. Hsiu-Wen Chien, Tsung-Yao Chang, Wei-Bor Tsai*, Spatial control of cellular adhesion using photo-crosslinked micropatterned polyelectrolyte multilayer films, Biomaterials, 30: , (SCI,EI) 4. Wei-Bor Tsai* Jia-Hua Lin, Modulation of morphology and functions of human hepatoblastoma cells by nano-grooved substrata, Acta Biomaterialia, 5(5): , (SCI) 5. Wei-Bor Tsai*, Yen-Chung Ting, Jung-Yen Yang, Juin-Yih Lai, Hsuan-Liang Liu, Fibronectin modulates the morphology of osteoblast-like cells (MG-63) on nano-grooved substrates, Journal of Materials Science: Materials in Medicine, 20: , (SCI,EI) 6. Liang-Kai Chang, Jian-Hua Zhao, Hsuan-Liang Liu, Kung-Tien Liu, Jenn-Tzong Chen, Wei-Bor Tsai, Yih Ho, Molecular Dynamics Simulations to Investigate the Structural Stability and Aggregation Behavior of the GGVVIA Oligomers Derived from Amyloid beta Peptide, Journal of Biomolecular Structure & Dynamics, 26(6): , 2009.(SCI) 7. Jung-Yen Yang, Yen-Chung Ting, Juin-Yih Lai, Hsuan-Liang Liu, Hsu-Wei Fang, Wei-Bor Tsai*, Quantitative analysis of osteoblast-like cells (MG63) morphology on nanogrooved substrata with various groove and ridge dimensions, Journal of Biomedical Materials Research: Part A, 90A: , (SCI,EI)

2 8. Wei-Bor Tsai*, Ying-Hao Chen, Hsiu-Wen Chien, Collaborative cell-resistant properties of polyelectrolyte multilayer films and surface PEGylation on reducing cell adhesion to cytophilic surfaces, Journal of Biomaterials Science: Polymer Edition, 20: , (SCI,EI) 9. Po-Sheng Fang, Jian-Hua Zhao, Hsuan-Liang Liu, Kung-Tien Liu, Jenn-Tzong Chen, Wei-Bor Tsai, Hsin-Yi Lin, Hsu-Wei Fang, and Yih Ho, Molecular Dynamics Simulations to Investigate the Relationship between the Structural Stability and Amyloidogenesis of the Wild-type and N-terminal Hexapeptide Deletion DN6 b2-microglobulin, Molecular Simulations, 35(9): , (SCI,EI) 10. Chi-An Dai, Chih-Chun Hsiao, An-Cheng Kao, Chien-Pan Liu, Wei-Bor Tsai, Wen-Shiang Chen, Wei-Ming Liu,Wen-Pin Shih and Chien-Ching Ma, A membrane actuator based on an ionic polymer network and carbon nanotubes: the synergy of ionic transport and mechanical properties, Smart Materials and Structures, 18(8): , (EI) 11. Hsu-Wei Fang*, Yu-Chih Su, Huei-Ting Huang, Wei-Bor Tsai, Hsuan-Liang Liu, Investigation of the friction induced conformational change of protein and wear of UHMWPE by a wear process with microfabricated surfaces, Materials Science and Engineering: C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 29(4): , (EI) 12. Peng-Yuan Wang, Hsiang-Hong Chow, Juin-Yih Lai, Hsuan-Liang Liu, Wei-Bor Tsai*, Dynamic compression modulates chondrocyte proliferation and matrix biosynthesis in chitosan/gelatin scaffolds, Journal of Biomedical Materials Research: Part B, 91B(1): , (SCI,EI) 13. Chi-An Dai,* An-Cheng Kao, Wei-Bor Tsai, Wen-Shiang Chen, Wen-Pin Shih, and Chien-Ching Ma, Polymer Actuator Based on PVA/PAMPS Ionic Membrane: Optimization of Ionic Transport Properties, Sensors and Actuators A-Physical. 155: , (SCI,EI) 14. Wei-Bor Tsai*, Rita Pei-Yeh Chen, Kuang-Ling Wei, Yi-Ru Chen, Tai-Yan Liao, Hsuan-Liang Liu, Juin-Yih Lai, Polyelectrolyte multilayer films functionalized with peptides for promoting osteoblast functions, Acta Biomaterialia, 5: , 2009.(SCI) 15. Wei-Bor Tsai*, Rita Pei-Yeh Chen, Kuang-Ling Wei, Su-Fang Tan, Juin-Yih Lai, Modulation of RGD-functionalized polyelectrolyte multilayer membranes for promoting osteoblast function, Journal of Biomaterials Science: Polymer Edition, 21: , (SCI,EI) 16. Veronica Glattauer, Jacinta F. White, Wei-Bor Tsai, Chen-Chi Tsai, Tracy A. Tebb, Stephen J. Danon, Jerome A. Werkmeister and John A.M. Ramshaw, Preparation of resorbable collagen-based beads for direct use in tissue engineering and cell therapy applications, Journal of Biomedical Materials Research: Part A, 92A(4): , (SCI,EI) 17. Lin, Y. F., Zhao, J. H., Liu, H. L., Liu, K. T., Chen, J. T., Tsai, W. B., Ho, Y., Structural stability and aggregation behavior of the VEALYL peptide derived from human insulin: A molecular dynamics simulation study, Biopolymers, 94(3):269-78, (SCI,EI) 18. Hsiu-Wen Chien, Su-Ping Wu, Wei-Hsuan Kuo, Meng-Jiy Wang, Chiapyng Lee, Wei-Bor Tsai*, Modulation of hemocompatibility of polysulfone by polyelectrolyte

3 multilayer films, Colloids and Surfaces B: Biointerfaces, 77(2): , (SCI,EI) 19. Peng-Yuan Wang, Hung-Te Yu, Wei-Bor Tsai*, Modulation of alignment and differentiation of skeletal myoblasts by submicron ridges/grooves surface structure, Biotechnology and Bioengineering, 106(2):285-94, (SCI,EI) 20. Shiao-Wen Tsai, Yu-Hui Cheng, Yung Chang, Hsuan-Liang Liu, Wei-Bor Tsai*, Type I collagen structure modulates the behavior of osteoblast-like cells, Journal of the Taiwan Institute of Chemical Engineers, 41: , (SCI,EI) 21. Liang-Kai Chang, Jian-Hua Zhao, Hsuan-Liang Liu*, Josephine W. Wu, Chih-Kuang Chuang, Kung-Tien Liu, Jenn-Tzong Chen, Wei-Bor Tsai, and Yih Ho, The importance of steric zipper on the aggregation of the MVGGVV peptide derived from the amyloid b peptide, Journal of Biomolecular Structure & Dynamics, 28(1):35-50, 2010.(SCI) 22. Fu-Yin Hsu, Ya-Yun Cheng, Shiao-Wen Tsai, Wei-Bor Tsai, Fabrication and evaluation of a biodegradable cohesive plug based on reconstituted collagen/gamma-polyglutamic acid, Journal of Biomedical Materials Research, Part B-Applied Biomaterials, 95B(1):29-35, (SCI,EI) 23. Jian-Hua Zhao, Hsuan-Liang Liu*, Chih-Kuang Chuang, Kung-Tien Liu, Wei-Bor Tsai, and Yih Ho, Molecular dynamics simulations to investigate the stability and aggregation behavior of the amyloid-forming peptide VQIVYK from Tau protein, Molecular Simulation, 36(13): , (SCI,EI) 24. Shin-Hua Lu, Josephine W. Wu, Hsuan-Liang Liu, Jian-Hua Zhao, Kung-Tien Liu, Chih-Kuang Chuang, Hsin-Yi Lin, Wei-Bor Tsai, Yih Ho, The discovery of potential acetylcholinesterase inhibitors: A combination of pharmacophore modeling, virtual screening, and molecular docking studies, Journal of Biomedical Science, 18:8, (SCI) 25. Ying-Ling Liu*, Yen-Hsing Wu, Wei-Bor Tsai, Chih-Chi Tsai, Wen-Shiang Chen, Chuan-Shao Wu, Core-shell silica@chitosan nanoparticles and hollow chitosan nanospheres using silica, Carbohydrate Polymers, 84(2): , (SCI,EI) 26. Zheng-Li Zhou, Jian-Hua Zhao, Hsuan-Liang Liu, Josephine W. Wu, Kung-Tien Liu, Chih-Kuang Chuang, Wei-Bor Tsai, Yih Ho, The possible structural models for polyglutamine aggregation: a molecular dynamics simulations study, Journal of Biomolecular Structure & Dynamics, 28(5): , (SCI) 27. Lauren R. Clements, Peng-Yuan Wang, Frances Harding, Wei-Bor Tsai, Helmut Thissen, Nicolas H. Voelcker, Mesenchymal stem cell attachment to peptide density gradients on porous silicon generated by electrografting, Physica Status Solidi A, 208(6): , (SCI,EI) 28. Wei-Bor Tsai*, Yi-Ru Chen, Hsuan-Liang Liu, Juin-Yih Lai, Fabrication of UV-crosslinked chitosan scaffolds with conjugation of RGD peptides for bone tissue engineering, Carbohydrate Polymers, 85(1): (SCI,EI) 29. Yeh-Fon Lin, Jian-Hua Zhao, Hsuan-Liang Liu*, Josephine W. Wu, Chih-Kuang Chuang, Kung-Tien Liu, Hsin-Yi Lin, Wei-Bor Tsai, and Yih Ho, Insights into the structural stability and possible aggregation pathways of the LYQLEN peptides derived from human insulin, Journal of the Taiwan Institute of Chemical Engineers, 42(3),

4 , (SCI,EI) 30. Wei-Bor Tsai*, Chih-Yuan Chien, Helmut Thissen, Juin-Yih Lai, Dopamine-assisted immobilization of poly(ethylene imine) based polymers for control of cell-surface interactions, Acta Biomaterialia, 7(6): , 2011.(SCI) 31. Peng-Yuan Wang, Jiashing Yu, Jia-Hua Lin, Wei-Bor Tsai*, Modulation of alignment, elongation and contraction of cardiomyocytes through a combination of nanotopography and rigidity of substrates, Acta Biomaterialia, 7(9): , (SCI) ( 合著 ) 32. Hsiu-Wen Chien, Shu-Fang Tan, Kuang-Ling Wei, Wei-Bor Tsai*, Modulation of the functions of osteoblast-like cells on poly(allylamine hydrochloride) and poly(acrylic acid) multilayer films, Colloids and Surfaces B: Biointerfaces, 88(1): , (SCI,EI) 33. Wei-Bor Tsai*, Wen-Tung Chen, Hsiu-Wen Chien, Wei-Hsuan Kuo, Meng-Jiy Wang, Poly(dopamine) coating to scaffolds for articular cartilage tissue engineering, Acta Biomaterialia, 7(12): , (SCI) 34. Wei-Hsuan Kuo, Meng-Jiy Wang, Hsiu-Wen Chien, Ta-Chin Wei, Chiapyng Lee*, Wei-Bor Tsai*, Surface modification with poly(sulfobetaine methacrylate-co-acrylic acid) to reduce fibrinogen adsorption, platelet adhesion, and plasma coagulation, Biomacromolecules, 12(12): , (SCI,EI) 35. Peng-Yuan Wang, Wei-Bor Tsai*, Nicolas H. Voelcker*, Screening of rat mesenchymal stem cell behaviour on polydimethylsiloxane stiffness gradients, Acta Biomaterialia, 8(2): , (SCI) 36. Lauren R. Clements, Peng-Yuan Wang, Wei-Bor Tsai, Helmut Thissen and Nicolas H. Voelcker, Electrochemistry-enabled fabrication of orthogonal nanotopography and surface chemistry gradients for high-throughput screening, Lab on a Chip, 12: , Pavadai Elumalai, Hsuan-Liang Liu, Zheng-Li Zhou, Jian-Hua Zhao, Wilson Chen, Chih-Kuang Chuang, Wei-Bor Tsai, Yih Ho, Ligand and Structure-Based Pharmacophore Modeling for the Discovery of Potential Human HNMT Inhibitors, Letters in Drug Design & Discovery, 9(1): 17-29, Hsiu-Wen Chien, Wei-Hsuan Kuo, Meng-Jiy Wang, Shiao-Wen Tsai, and Wei-Bor Tsai*, Tuneable micropatterned substrates based on poly(dopamine) deposition via microcontact printing, Langmuir, 28(13): , (SCI,EI) 39. Wei-Hsuan Kuo, Meng-Jiy Wang, Da-Chin Wei, Juin-Yih Lai, Wei-Bor Tsai*, Chiapyng Lee*, Improvement of hemocompatibility on materials by photoimmobilization of polyethylene glycol, Journal of Materials Chemistry, 22: , Wei-Bor Tsai*, Yi-Ru Chen, Wen-Ting Li, Juin-Yih Lai, Hsuan-Liang Liu*, RGD-conjugated UV-crosslinked chitosan scaffolds inoculated with mesenchymal stem cells for bone tissue engineering, Carbohydrate Polymers, 89(2): , (SCI,EI) 41. Pavadai Elumalai, Hsuan-Liang Liu, Jian-Hua Zhao, Wilson Chen, Dar Shong Lin, Chih-Kuang Chuang, Wei-Bor Tsai, Yih Ho, Pharmacophore modeling, virtual

5 screening and docking studies to identify novel HNMT inhibitors, Journal of the Taiwan Institute of Chemical Engineers, , (SCI,EI) 42. Peng-Yuan Wang, Helmut Thissen, Wei-Bor Tsai*, The roles of RGD and grooved topography in the adhesion, morphology and differentiation of C2C12 skeletal myoblasts, Biotechnology and Bioengineering, 109(8): , (SCI,EI) 43. Hsiu-Wen Chien, Wei-Bor Tsai*, and Shaoyi Jiang*, Direct cell encapsulation in biodegradable and functionalizable carboxybetaine hydrogels, Biomaterials, 33: , (SCI,EI) 44. Peng-Yuan Wang, Lauren R. Clements, Helmut Thissen, Andrew Jane, Wei-Bor Tsai*, Nicolas H. Voelcker*, Screening mesenchymal stem cell attachment and differentiation on porous silicon gradients, Advanced Functional Materials, 22: , (SCI,EI) 45. Hsiu-Wen Chien, Wei-Bor Tsai*, Fabrication of tunable micropatterned substrates for cell patterning via microcontact printing of polydopamine with poly(ethylene imine) grafted copolymers, Acta Biomaterialia, 8(10): , 2012.(SCI) 46. Peng-Yuan Wang, Lauren R. Clements, Helmut Thissen, Shih-Chieh Hung, Nai-Chen Cheng, Wei-Bor Tsai*, Nicolas H. Voelcker*, High-throughput screening of pore size-dependent attachment of mesenchymal stem cells using porous silicon gradients, RSC Advances, 2: , Peng-Yuan Wang, Wen-Tyng Li, Jiashing Yu, Wei-Bor Tsai*, Modulation of osteogenic, adipogenic and myogenic differentiation of mesenchymal stem cells by Submicron-grooved Topography, Journal of Materials Science: Materials in Medicine, 23(12): , (SCI,EI) ( 合著 ) 48. Hsiu-Wen Chien, Xuewei Xu, Jean-Rene Ella-Menye, Wei-Bor Tsai,* Shaoyi Jiang*, High viability of cells encapsulated in degradable poly(carboxybetaine) hydrogels, Langmuir, 28(51): , (SCI, EI) 49. Peng-Yuan Wang, Tsung-Han Wu, Pen-Hsiu Grace Chao, Wei-Hsuan Kuo, Meng-Jiy Wang, Cheng-Che Hsu, Wei-Bor Tsai*, Modulation of cell attachment and collagen production of anterior cruciate ligament cells via nano-grooves/ridges structures with different cell affinity, Biotechnology and Bioengineering, 110(1): , (SCI,EI) 50. Wei-Bor Tsai*, Yi-Ru Chen, Hsuan-Liang Liu*. RGD-conjugated crosslinked chitosan scaffolds for culture and osteogenic differentiation of mesenchymal stem cells, Journal of the Taiwan Institute of Chemical Engineers, 44:1-7, (SCI, EI) 51. Chih-Yuan Chien, Tse-Ying Liu, Wei-Hsuan Kuo, Meng-Jiy Wang, Wei-Bor Tsai*. Dopamine-assisted immobilization of hydroxyapatite nanoparticles and RGD peptides to improve the osteoconductivity of titanium, Journal of Biomedical Materials Research: Part A, 101A(3): , 2013.(SCI, EI) 52. Hsiu-Wen Chien, Chih-Chi Tsai, Wei-Bor Tsai*, Meng-Jiy Wang, Wei-Hsuan Kuo, Ta-Chin Wei, Sheng-Tung Huang. Surface conjugation of poly(sulfobetaine methacrylate) to inhibit cell adhesion and protein adsorption, Colloids and Surfaces B: Biointerfaces, 107: , (SCI, EI) 53. Peng-Yuan Wang, Wei-Bor Tsai*. Modulation of the proliferation and matrix synthesis

6 of chondrocytes by dynamic compression on genipin-crosslinked chitosan/collagen scaffolds, Journal of Biomaterials Science: Polymer Edition, 24(5): (SCI, EI) 54. Peng-Yuan Wang, Tsung-Han Wu, Wei-Bor Tsai*, Wei-Hsuan Kuo, Meng-Jiy Wang. Grooved PLGA films incorporated with RGD/YIGSR peptides for potential application on skeletal muscle tissue engineering, Colloids and Surfaces B: Biointerfaces, 110:88-95, 2013.(SCI, EI) 55. J-Y Li, Y-C Ho, Y-C Chung*, F-C Lin, W-L Liao, W-B Tsai. Preparation of micron/submicron hybrid patterns via a two-stage UV-imprint technique and their dimensional effects on cell adhesion and alignment, Biofabrication, 5(3):035003, 2013.(SCI, EI) 56. Wei-Han Lin, Wei-Bor Tsai*. In situ UV-crosslinking gelatin electrospun fibers for tissue engineering applications, Biofabrication, 5:035008, (SCI, EI) 57. Peng-Yuan Wang, Lauren R. Clements, Helmut Thissen, Wei-Bor Tsai*, Nicolas H. Voelcker*. High-throughput characterisation of osteogenic differentiation of human mesenchymal stem cells using pore size gradients on porous alumina, Biomaterials Science, 1: , 2013.(SCI, EI) 58. Chih-Yuan Chien, Wei-Bor Tsai*. Poly(dopamine)-assisted immobilization of RGD peptides, hydroxyapatite and BMP-2 on titanium to improve the osteogenesis of bone marrow stem cells, ACS Applied Materials & Interfaces, 5: , 2013.(SCI, EI) 59. Szu-Wei Fu, Hsiu-Wen Chien, Wei-Bor Tsai*, Fabrication of poly(n-isopropylacrylamide) films containing submicro-grooves for constructing aligned cell sheets, Langmuir, 29(47): , (SCI, EI) 60. Wei-Bor Tsai*, Wen-Tung Chen, Hsiu-Wen Chien, Wei-Hsuan Kuo, Meng-Jiy Wang. Poly(dopamine) coating to biodegradable polymers for bone tissue engineering, Journal of Biomaterials Applications, 28(6): , Chiao-Tzu Su, Ruei-Hung Yuan, Yung-Chih Chen, Ting-Ju Lin, Hsiu-Wen Chien, Chih-Chen Hsieh, Wei-Bor Tsai, Chih-Hao Chang, Hsien-Yeh Chen. A Facile Approach toward Protein-Resistant Biointerfaces Based on Photodefinable Poly-pxylylene Coating. Colloids and surfaces B, accepted, ( 合著 ) 62. Cindy Yi Chi Hsieh, Fang-Wei Hu, Wen-Shiang Chen, Wei-Bor Tsai*. Reducing the foreign body reaction by surface modification with collagen/hyaluronic acid multilayered films. ISRN Biomaterials, accepted, Conference Papers 1. Hsiu-Wen Chien, Tsung-Yao Chang, Wei-Bor Tsai, Spatial control of cellular adhesion using photo-crosslinked micropatterned polyelectrolyte multilayer films, at the 2009 annual meeting of Society for Biomaterials, San Antonio, Texas, April 22-25, Peng-Yuan Wang, Hung-Te Yu, Wei-Bor Tsai, The influences of nano-groove/ride surfaces on the alignment and differentiation of skeletal myovlasts, at the 2009 annual

7 meeting of Society for Biomaterials, San Antonio, Texas, April 22-25, 王鵬元 余虹德 蔡偉博, Alignment and differentiation of skeletal myoblasts on submicron grooved surface, 台灣化學工程學會第 56 屆年會暨國科會化工學門成 果發表會, 台中, 11/27-28, Peng-Yuan Wang, Lauren R. Clements, Wei-Bor Tsai, Helmut Thissen, Nicolas H. Voelcker, "Mesenchymal Stem Cell Differentiation on Laterally Graded Porous Silicon with Submicron Pore Sizes" TERMIS-AP Annual Conference, Sydney, Australia, September 15-17, Peng-Yuan Wang, Lauren R. Clements, Wei-Bor Tsai, Helmut Thissen, Nicolas H. Voelcker, "Stiffness gradient polydimethylsiloxane (PDMS) for mesenchymal stem cell culture and differentiation" at TERMIS-AP Annual Conference, Sydney, Australia, September 15-17, Peng-Yuan Wang, Jia-Hua Lin, Wei-Bor Tsai, "Interactive effects of surface topography and substrate elasticity on orientation and beating of neonatal rat cardiomycotes" at International Symposium of Materials on Regenerative Medicine, Zhunan, Taiwan, November 3-5, Peng-Yuan Wang, Wei-Bor Tsai, "Osteogenesis, adipogenesis, and myogenesis of rat mesenchymal stem cells on the nanogrooved surfaces" at The Annual Meeting of the Society For Biomaterials, Orlando, Florida, April 13-16, 王鵬元 蔡偉博, Osteogenesis, adipogenesis, and myogenesis of rat mesenchymal stem cells on the nanogrooved surfaces 生醫材料與藥物釋放年度會議, 台北, 4/27-28, Wei-Bor Tsai, "UV-Crosslinked Scaffolds for Tissue Engineering" at International Membrane Conference in Taiwan, Chungli, Taiwan, May 26-28, (Invited talk) 10. Peng-Yuan Wang, Wei-Bor Tsai, "Osteogenesis, adipogenesis, and myogenesis of rat mesenchymal stem cells on the nanogrooved surfaces" at International Membrane Conference in Taiwan, Chungli, Taiwan, May 26-28, 王鵬元 蔡偉博, Osteogenesis, adipogenesis, and myogenesis of rat mesenchymal stem cells on the nanogrooved surfaces, 第 16 屆生化工程會議, 台北, 6/24-25, 簡志遠 蔡偉博, 多巴胺輔助固定聚乙烯亞胺接枝聚合物以調控細胞與表面的交互作用, 第 16 屆中華生化工程研討會, 台北, 6/24-25, 王鵬元 蔡偉博, Osteogenesis, adipogenesis, and myogenesis of rat mesenchymal stem cells on the nano/submicron grooved surfaces, 100 年度生醫工程與技術會議, 台南, 8/19-20, 簡志遠 蔡偉博, 多巴胺輔助固定聚乙烯亞胺接枝聚合物以調控細胞與表面的交

8 互作用,100 年度生物醫學工程科技研討會, 台南, 8/19-20, 林威翰 劉澤英 蔡偉博, UV-crosslinking electrospun gelatin fibers for tissue engineering, 2011 生物醫學工程科技研討會暨國科會醫學工程學門成果發表會, 臺南, 8/19-20, Wei-Bor Tsai, Modulation of Cell Behaviors via Surface Topography and Chemistry at The 4th Asian Conference on Colloid and Interface Science, Tainan, Taiwan, November 23-26, (Invited talk) 17. Peng-Yuan Wang, Hung-Te Yu, Tsung-Han Wu, Jia-Hua Lin, Wei-Bor Tsai, Modulation of Cell Behaviors via Surface Topography and Chemistry at The 4th Asian Conference on Colloid and Interface Science, Tainan, Taiwan, November 23-26, Wei-Bor Tsai, Chih-Yuan Chien, Peng-Yuan Wang, Dopamine-assisted immobilization of poly(ethylene imine) based polymers for control of cell surface interactions, at The 4th Asian Conference on Colloid and Interface Science, Tainan, Taiwan, November 王鵬元, 蔡偉博 Osteogenesis, adipogenesis, and myogenesis of rat mesenchymal stem cells on the nano/submicron grooved surfaces, 台灣化學工程學會第 58 屆年會 暨國科會化工學門成果發表會, 台南, 11/25-26, 簡志遠 蔡偉博, 多巴胺輔助固定聚乙烯亞胺接枝聚合物以調控細胞與表面的交 互作用, 台灣化學工程學會 58 週年年會暨國科會化學工程學門成果發表會, 台南, 11/25-26, 林威翰 劉澤英 蔡偉博, UV-crosslinking electrospun gelatin fibers for tissue engineering, 臺灣化學工程學會第 58 屆年會暨國科會化工學門成果發表會, 臺南, 11/25-26, Jiashing Yu, Wei-Bor Tsai, The application of peptide-modified electrospinning scaffold on cardiac tissue engineering, at the ninth World Biomaterials Congress, Chendu, China, June 1-5, Peng-Yuan Wang, Wei-Bor Tsai, Modulation of cell behaviors through grooved topography, at the ninth World Biomaterials Congress, Chendu, China, June 1-5, Hsiu-Wen Chien, Wei-Bor Tsai, Modulation of cells-biomaterials interactions by surface biofunctionalization via layer-by-layer deposition technique, at the ninth World Biomaterials Congress, Chendu, China, June 1-5, Chih Yuan Chien, Wei-Bor Tsai, Dopamine-assisted immobilization of biomolecules for biomaterials applications, at the ninth World Biomaterials Congress, Chendu, China, June 1-5, Wei-Hsuan Kuo, Chiapyng Lee, Wei-Bor Tsai, Meng-Jiy Wang, Improvement of hemocompatibility by coatings of zwitterionic and PEG based copolymers under

9 physiological flow conditions, at the ninth World Biomaterials Congress, Chendu, China, June 1-5, Wei-Han Lin, Wei-Bor Tsai, UV-crosslinked electrospun gelatin fibers for tissue engineering, at the ninth World Biomaterials Congress, Chendu, China, June 1-5, Chih Yuan Chien, Wei-Bor Tsai, Dopamine-assisted immobilization of biomolecules for biomaterials applications, at the 2012 Asian BioCeramics symposium, Tainan, Taiwan, Nov 18-21, Wei-Bor Tsai, Novel Zwitterionic Polymers for Cell/Tissue Engineering, 4th International Forum of Regional and Targeting Therapies for Cancer (RTTC), Shanghai, November 10-12, (Invited talk) 35. H. W. Chien, S. T. Huang, S. Jiang, W. B. Tsai, Degradable poly(carboxybetaine) hydrogels for tissue engineering. at The 2 nd International Conference on Biomaterials Science, Epochal Tsukuba, Ibaraki, Japan, March 19-22, S. W. Fu, H. W. Chien, W. B. Tsai, Fabrication of aligned myoblast sheets by temperature-responsive poly(n-isopropylacrylamide). at The 2 nd International Conference on Biomaterials Science, Epochal Tsukuba, Ibaraki, Japan, March 19-22, W. B. Tsai, Novel Zwitterionic Polymers for Cell Culture and Tissue Engineering. at The 22 nd Annual Conference of the Australasian Society for Biomaterials & Tissue Engineering, Barossa Valley, South Australia, Australia, April 2-5, (Invited Talk) 38. H. W. Chien, S. T. Huang, S. Jiang, W. B. Tsai, Degradable poly(carboxybetaine) hydrogels for tissue engineering. at The 22 nd Annual Conference of the Australasian Society for Biomaterials & Tissue Engineering, Barossa Valley, South Australia, Australia, April 2-5, S. W. Fu, H. W. Chien, W. B. Tsai, Fabrication of aligned myoblast sheets by temperature-responsive poly(n-isopropylacrylamide). at The 22 nd Annual Conference of the Australasian Society for Biomaterials & Tissue Engineering, Barossa Valley, South Australia, Australia, April 2-5, 簡秀紋 蔡偉博 黃聲東, Degradable poly(carboxybetaine) hydrogels for cell encapsulation, 中華民國生醫材料及藥物制放年會, 高雄,5/4-5, 耿明雋 陳賢燁 黃聲東 蔡偉博, Conjugation of sulfobetaine molecules on an alkyne-functionalized surface for decreasing cell attachment, 中華民國生醫材料及 藥物制放年會, 高雄,5/4-5, W. B. Tsai, Y. R. Chen, Enrichment and Collection of Germline Stem Cells from Mouse Testes on PAH/PAA Polyelectrolyte Multilayer Films. at TERMIS-AP 2013 Annual Conference, in Shanghai, China, Oct, W. B. Tsai, A. Y. Shih, RGD-conjugated UV-crosslinked Chitosan Scaffolds Inoculated with Mesenchymal Stem Cells for Bone Tissue Engineering. at TERMIS-AP 2013 Annual Conference, Shanghai, China, October 23-26, H. W. Chien, H. L. Sung, W. B. Tsai, Controlling the adhesion and differentiation of

10 mesenchymal stem cells by displaying cell-adhesive signals on a non-fouling poly(carboxybetaine methacrylate) substrate. at TERMIS-AP 2013 Annual Conference, Shanghai, China, October 23-26, H. W. Chien, S. T. Huang, S. Jiang, W. B. Tsai, Degradable poly(carboxybetaine) hydrogels for tissue engineering. at TERMIS-AP 2013 Annual Conference, Shanghai, China, October 23-26, 耿明雋 陳賢燁 黃聲東 蔡偉博, Conjugation of sulfobetaine molecules on an alkyne-functionalized surface for decreasing cell attachment, 生物醫學工程科技年 會, 新竹,11/15-16, 蔡偉博 陳怡如, RGD-conjugated UV-crosslinked Chitosan Scaffolds Inoculated with Mesenchymal Stem Cells for Bone Tissue Engineering, 生物醫學工程科技年會, 新 竹,11/15-16, 耿明雋 陳賢燁 黃聲東 蔡偉博, Conjugation of sulfobetaine molecules on an alkyne-functionalized surface for decreasing cell attachment, 台灣化學工程學會第 60 屆年會, 台北,11/22-23, 蔡偉博 陳怡如, RGD-conjugated UV-crosslinked Chitosan Scaffolds Inoculated with Mesenchymal Stem Cells for Bone Tissue Engineering, 台灣化學工程學會第 60 屆 年會, 台北,11/22-23, Wei-Bor Tsai, In Situ Cell Encapsulation with Zwitterionic Polymers for Tissue Engineering Applications. at International Conference on Bioinspiredand Zwitterionic Materials, Hangzhou, China, December 1-4, (Invited Talk) Books 1. Weng-Jiy Wang and W.-B. Tsai*. Biomaterials in Blood-Contacting Devices complications and Solutions. in Biomaterials Properties, production and devices series. Nova Science Publishers, Inc, New York ISBN: Glattauer, V., Tsai, W.-B., White, J.F., Nigro, J., Tebb, T.A., Werkmeister, J.A. and Ramshaw, J.A.M. (2011) Direct use of resorbable collagen-based beads for cell delivery in tissue engineering and cell therapy applications. In; Regenerative medicine and tissue engineering -cells and biomaterials (Eberli, D., Ed.), InTech Publishing, Rijeka Cr, pp Patents 1. 使用一裝置在製造一醫藥用品上之用途 製造一供修補一主體中害病的或受損 的組織之裝置的方法以及具類似組織特性之裝置, 中華民國專利, 證書號 :

11 I258372, 2006/07/ /02/