MICRORNA RESEARCH TOOLS, DIAGNOSTICS AND THERAPEUTICS: GLOBAL MARKETS

Transcription

1 MICRORNA RESEARCH TOOLS, DIAGNOSTICS AND THERAPEUTICS: GLOBAL MARKETS BIO115A November 2012 Marianna Tcherpakov Project Analyst ISBN: BCC Research 49 Walnut Park, Building 2 Wellesley, MA , Custom Reports: carol.laverty@bccresearch.com

2 TABLE OF CONTENTS CHAPTER 1 INTRODUCTION 1 STUDY GOALS AND OBJECTIVES 1 REASONS FOR DOING THIS STUDY 1 SCOPE AND FORMAT 1 METHODOLOGY AND INFORMATION SOURCES 2 INTENDED AUDIENCE 2 ANALYST CREDENTIALS 2 RELATED REPORTS 2 BCC ON-LINE SERVICES 2 DISCLAIMER 3 CHAPTER 2 SUMMARY 5 SUMMARY TABLE GLOBAL MARKET FOR MICRORNA RESEARCH TOOLS, DIAGNOSTIC AND THERAPEUTIC PRODUCTS, THROUGH 2017 ($ SUMMARY FIGURE GLOBAL MARKET FOR MICRORNA RESEARCH TOOLS, DIAGNOSTIC AND THERAPEUTIC PRODUCTS, ($ 6 6 CHAPTER 3 INTRODUCTION TO MICRORNA RESEARCH 9 OVERVIEW 9 MICRORNA DISCOVERY 10 MICRORNA DEFINITION 10 BIOGENESIS OF MICRORNA 11 FIGURE 1 SCHEMATIC REPRESENTATION OF MICRORNA BIOGENESIS AND ITS EFFECT ON PROTEIN TRANSLATION FUNCTION OF MICRORNA 13 MICRORNA MARKET OVERVIEW 14 Tools for Research of MicroRNA Molecules 14 TABLE 1 GLOBAL MARKET FOR REAGENTS AND TOOLS FOR DNA/RNA RESEARCH, THROUGH 2016 ($ BILLIONS) MicroRNA as Biomarker and its Role in Bioprofiling and Diagnostics Products Development TABLE 2 MARKET FOR CANCER PROFILING TECHNOLOGIES, THROUGH 2015 ($ BILLIONS) 16 MicroRNA as Therapeutics Target in Drug Discovery 16 IMPORTANCE OF PATENTS IN MICRORNA RESEARCH 16 TABLE 3 PATENTS AND PATENT APPLICATION SEARCH IN MICRORNA RESEARCH USING SPECIFIC KEY WORDS, THROUGH 2012 mir-34 example 18 mir-122 Case 18 TABLE 4 NUMBER OF PATENTS AND PATENT APPLICATIONS IN MICRORNA RESEARCH ACCORDING TO ASSIGNEE CHAPTER 4 RESEARCH TOOLS AND REAGENTS FOR MICRORNA RESEARCH AND PRODUCT DEVELOPMENT OVERVIEW 24 TABLE 5 TYPES OF REAGENTS AND TOOLS FOR MICRORNA RESEARCH AND DRUG DISCOVERY AND THEIR RELATIVE MARKET SHARE, 2011 (%) 24 24

3 TABLE 6 EXAMPLES OF MICRORNA SAMPLE PREPARATION SERVICES AND THEIR PRICE RANGES ($) ANALYSIS OF MAIN SECTORS IN THE MICRORNA RESEARCH TOOLS AND TECHNOLOGIES MARKET qrt-pcr and Related Reagents for MicroRNA Research 25 RNA Extraction and Purification Products 26 TABLE 7 GLOBAL MARKET SHARES OF RNA ISOLATION PRODUCTS BY COMPANY (%) 27 Formalin Fixed Paraffin-Embedded Tissues as a Source for MicroRNA 28 qrt-pcr Procedure for MicroRNA Analysis 28 TABLE 8 GLOBAL RT PCR MARKET SHARES BY COMPANY, 2011 (%) 29 TABLE 9 PLATFORMS AND VENDORS OF QRT PCR PRODUCST FOR MICRORNA RESEARCH 30 TABLE 10 GLOBAL MARKET FOR QRT PCR REAGENTS FOR MICRORNA RESEARCH, THROUGH 2017 ($ Microarrays as a Tool for Research and Product Development for microrna Diagnostics and Therapeutics TABLE 11 MAIN REPRESENTATIVE MICROARRAY PRODUCTS FOR MICRORNA RESEARCH 33 TABLE 12 ANNUAL REVENUES OF AFFYMETRIX, ($ 34 TABLE 13 GLOBAL MARKET FOR MICROARRAY REAGENTS AND PRODUCTS FOR MICRORNA RESEARCH, THROUGH 2017 ($ MicroRNA Sequencing as a Tool for MicroRNA Research, Diagnostics and Drug Discovery NGS Platforms for mirnaseq 37 TABLE 14 GLOBAL MARKET FOR NGS SEQUENCING, THROUGH 2016 ($ BILLIONS) 39 TABLE 15 NGS MARKET SHARE BY COMPANY, 2011 (%) 40 TABLE 16 PLATFORMS AND VENDORS USED FOR MICRORNA SEQUENCING 40 Sample Preparation for microrna Sequencing 41 TABLE 17 VALUE OF GLOBAL NGS SAMPLE PREP MARKET, THROUGH 2016 ($ 42 Summary and Comparison of microrna Profiling Techniques 42 TABLE 18 SUMMARY OF MICRORNA PROFILING TECHNIQUES ADVANTAGES AND DISADVANTAGES Functional Assay for MicroRNA Research 44 TABLE 19 EXAMPLES OF PRODUCTS FOR FUNCTIONAL ASSAYS AND THEIR REPRESENTATIVE VENDORS SUMMARY OF LIFE SCIENCE TOOLS AND REAGENTS MARKET FOR MICRORNA RESEARCH TABLE 20 GLOBAL MARKET FOR RESEARCH TOOLS IN MICRORNA RESEARCH, THROUGH 2017 ($ FIGURE 2 GLOBAL MARKET FOR RESEARCH TOOLS IN MICRORNA RESEARCH, ($ CHAPTER 5 MICRORNA DIAGNOSTICS AND BIOMARKER MARKET 49 OVERVIEW 49 TABLE 21 NUMBER OF PUBLICATIONS IN MICRORNA RESEARCH BASED ON DIFFERENT SEARCH CRITERIA MICRORNA AND CANCER DIAGNOSTICS 49 TABLE 22 EXAMPLES OF DIFFERENTIALLY EXPRESSED MICRORNA IN DIFFERENT CANCER TYPES IMPORTANCE OF MICRORNA SIGNATURES IN DIFFERENT DISEASES 51 TABLE 23 EXAMPLES OF MICRORNA EXPRESSION IN CVS CONDITIONS

4 TABLE 24 EXAMPLES OF MICRORNA DOWNREGULATED OR UPREGULATED IN DIFFERENT NEURODEGENERATIVE PATHOLOGIES CURRENT STATE OF MICRORNA DIAGNOSTIC AND BIOMARKER PRODUCT DEVELOPMENT MARKET TABLE 25 GLOBAL BIOMARKERS MARKET, THROUGH 2015 ($ BILLIONS) 54 TABLE 26 CHALLENGES ASSOCIATED WITH MICRORNA MEASUREMENTS AS BIOMARKER 55 CURRENT DIAGNOSTIC MICRORNA PRODUCTS AND PIPELINES 56 TABLE 27 DIAGNOSTICS PRODUCTS BY ROSETTA GENOMICS 56 mirview Lung Test 56 mirview Meso Test 56 mirview Kidney Test 57 mirview Mets 57 Rosetta Genomics 57 TABLE 28 REVENUES FOR ROSETTA GENOMICS, ($ 57 TABLE 29 GLOBAL MICRORNA DIAGNOSTICS MARKET THROUGH 2017 ($ 59 FIGURE 3 GLOBAL MICRORNA DIAGNOSTICS MARKET, ($ 60 Bioprofiling Services as a Positive Drive for Diagnostics Industry 60 TABLE 30 EXAMPLE OF EXIQON REVENUES, ($ CHAPTER 6 MICRORNA THERAPEUTICS IN RNA DRUG DISCOVERY MARKET 64 OVERVIEW 64 RNA THERAPEUTICS 64 ANTISENSE OLIGONUCLEOTIDE APPROACH 64 Mechanisms of Action of Antisense Oligonucleotides 65 Antisense Drugs as a Proof of Concept 66 TABLE 31 EXAMPLE OF LIPITOR SALES AS AN ESTIMATE FOR KYNAMRO, ($ BILLIONS) TABLE 32 EXAMPLES FOR ISIS PHARMACEUTICALS REVENUES, ($ 68 RNA INTERFERENCE AS DRUG DISCOVERY PLATFORM 70 Mechanism of Action for RNA Interference (RNAi) 70 RNAi as Therapeutics Approach 71 TABLE 33 REVENUES OF ALNYLAM PHARMACEUTICALS AND TEKMIRA PHARMACEUTICALS, ($ RIBOZYMES APPROACH FOR RNA BASED THERAPEUTICS 74 MARKET EVALUATION FOR ANTISENSE AND RNAI BASED DRUGS 75 TABLE 34 EXAMPLES OF DRUG CANDIDATES IN ANTISENSE AND RNA INTERFERENCE BASED APPROACHES TABLE 35 GLOBAL MARKET FOR ANTISENSE DRUG DISCOVERY THROUGH 2017 ($ TABLE 36 EXAMPLES OF DEALS AND COLLABORATION IN RNAI THERAPEUTICS, TABLE 37 GLOBAL MARKET FOR RNAI THERAPEUTIC APPROACH, THROUGH 2017 ($ MICRORNA APPROACH IN DRUG DISCOVERY 78 TABLE 38 EXAMPLES OF MICRORNA DIFFERENTIAL EXPRESSION IN DIFFERENT CELLULAR PROCESSES STABILITY ASPECTS AND CHEMICAL MODIFICATION 81 "DECOY" TRANSCRIPTS: COMPETITION FOR ENDOGENOUS MICRORNAS 81 MICRORNA REPLACEMENT THERAPY AS THERAPEUTIC APPROACH 82 MICRORNA REGULATION AS A TOOL FOR TRADITIONAL GENE THERAPY APPROACH

5 TABLE 39 DIFFERENT APPROACHES FOR DEVELOPMENT OF MICRORNA BASED THERAPEUTICS Delivery Aspects of microrna and RNA Based Therapeutics 83 TABLE 40 GLOBAL MARKET FOR RNA DRUG DELIVERY, THROUGH 2017 ($ BILLIONS) 85 TABLE 41 MAIN APPROACHES AND TECHNIQUES IN NONVIRAL RNA DRUG DELIVERY 86 TABLE 42 RNA DRUG DELIVERY SYSTEMS BY COMPANY 87 TABLE 43 SUMMARY OF MAIN DRUG DEVELOPMENT PLATFORMS FOR MICRORNA THERAPEUTICS: LIMITATIONS AND ADVANTAGES EVALUATION OF MICRORNA DRUG DISCOVERY MARKET AND ITS PARTICIPANTS 88 TABLE 44 MAIN MARKET PARTICIPANTS IN MICRORNA DRUG DISCOVERY AND EXAMPLES OF THEIR DRUG CANDIDATES Santaris Pharma 89 TABLE 45 SALES OF INCIVEK AND VICTRELIS, 2011 AND 2012 ($ 90 miragen 91 Regulus Therapeutics 91 Drug Development for Fibrosis Treatment 92 Anti-Hepatitis C Virus Drug Development 92 Immune System Related Diseases 92 Metabolic Diseases Drug Development 93 Development of MicroRNA Therapeutics for Oncology Market 93 Rosetta Genomics 94 Mirna Therapeutics 94 InteRNA Technologies 95 Additional Drug Discovery Companies 95 TABLE 46 REVENUES FOR SANTARIS PHARMA AND REGULUS THERAPEUTICS, ($ TABLE 47 RECENT COLLABORATIONS, DEALS AND AGREEMENTS IN THE MICRORNA DRUG DISCOVERY MARKET, TABLE 48 GLOBAL MARKET FOR MICRORNA DRUG DISCOVERY THROUGH 2017 ($ FIGURE 4 GLOBAL MARKET FOR MICRORNA DRUG DISCOVERY ($ 101 DEVELOPMENT OF ADDITIONAL SUB MARKETS IN MICRORNA DRUG DISCOVERY MARKET Sistemic 101 Cenix BioScience CRO 102 Pyxant Labs 102 Polyplus Transfection 103 Accelero Bioanalytics 103 SUMMARY OF GENERAL RNA THERAPEUTICS DRUG DISCOVERY MARKET 103 TABLE 49 GLOBAL MARKET FOR RNA BASED THERAPEUTICS, THROUGH 2017 ($ 104 FIGURE 5 GLOBAL MARKET FOR RNA BASED THERAPEUTICS, ($ 104 TABLE 50 GEOGRAPHICAL DISTRIBUTION OF RNA-BASED DRUG DISCOVERY COMPANIES (%) CHAPTER 7 IMPORTANCE OF BIOINFORMATICS TOOLS AND RECOURSES FOR MICRORNA RESEARCH AND PRODUCT DEVELOPMENT OVERVIEW 107 TABLE 51 GLOBAL BIOINFORMATICS MARKET, THROUGH 2016 ($ BILLIONS) 107 TABLE 52 DATABASES FOR MICRORNA RESEARCH

6 TABLE 53 EXAMPLES OF COMPUTATIONAL TOOLS FOR MICRORNA PREDICTION AND TARGET IDENTIFICATION EFFECT OF NGS TREND ON MICRORNA RESEARCH AND BIOINFORMATICS TOOL DEVELOPMENT CHAPTER 8 NEW TECHNOLOGIES, APPLICATIONS AND MARKETS IN MICRORNA RESEARCH AND PRODUCT DEVELOPMENT NEW TECHNOLOGIES AND DRUG DISCOVERY APPROACHES 112 TABLE 54 PROTEIN TARGETS FOR DRUG DISCOVERY RESEARCH IN MICRORNA 112 NEW APPLICATIONS AND TARGET MARKETS IN MICRORNA RESEARCH 114 AGRICULTURAL MARKET FOR MICRORNA 114 BIOFUEL MARKET FOR MICRORNA 115 TABLE 55 GLOBAL MARKET FOR BIOFUELS, THROUGH 2017 ($ BILLIONS) 116 LIVESTOCK MARKET FOR MICRORNA 117 FORENSICS AS A TARGET MARKET IN MICRORNA RESEARCH AND DEVELOPMENT CHAPTER 9 MARKET SUMMARY FOR MICRORNA RESEARCH AND PRODUCT DEVELOPMENT 121 TABLE 56 GLOBAL MARKET FOR MICRORNA RESEARCH TOOLS, DIAGNOSTIC AND THERAPEUTIC PRODUCTS, THROUGH 2017 ($ FIGURE 6 GLOBAL MARKET FOR MICRORNA RESEARCH TOOLS, DIAGNOSTIC AND THERAPEUTIC PRODUCTS, ($ TABLE 57 MAIN MARKET PARTICIPANTS IN MICRORNA RESEARCH MARKET CHAPTER 10 PROFILES OF SELECT COMPANIES 126 ALNYLAM PHARMACEUTICALS 126 ASURAGEN, INC. 126 EXIQON A/S 128 ISIS PHARMACEUTICALS 129 MIRNA THERAPEUTICS 130 REGULUS THERAPEUTICS 130 ROSETTA GENOMICS 131 SANTARIS PHARMA A/S 133 CHAPTER 11 LIST OF COMPANIES MENTIONED IN REPORT 136 ACCESS PHARMACEUTICALS 136 AEGERA THERAPEUTICS 136 AFFYMETRIX 136 AGILENT TECHNOLOGIES 136 ALNYLAM PHARMACEUTICALS 136 ANTISENSE PHARMA GMBH 136 APARNA BIOSCIENCES CORP. 137 APPLIED BIOLOGICAL MATERIALS INC. 137 ASTRAZENECA PHARMACEUTICALS LP 137 ASURAGEN INC. 137 AVI BIOPHARMA/SAREPTA THERAPEUTICS 137 BENITEC BIOPHARMA 137 BIOCANCELL THERAPEUTICS INC. 138 BIOGEN IDEC 138

7 CALANDO PHARMACEUTICALS INC. 138 CBC COMPREHENSIVE BIOMARKER CENTER GMBH 138 CENIX BIOSCIENCE GMBH 138 CLONTECH LABORATORIES 139 COVANCE INC. 139 DICERNA PHARMACEUTICALS INC. 139 EGEN INC. 139 ELI LILLY AND CO. 139 EMD4BIOSCIENCES 139 ENZO BIOCHEM 140 ENZON PHARMACEUTICALS INC. 140 EXIQON A/S 140 F. HOFFMAN-LA ROCHE AG 140 FLUIDIGM 140 GENECOPOEIA INC. 140 GENOSENSOR CORP. 141 GENSIGNIA INC. 141 GENTA INC. 141 GROOVE BIOPHARMA 141 GSK U.S. 141 HTG MOLECULAR DIAGNOSTICS INC. 141 ICO THERAPEUTICS INC. 141 IDERA PHARMACEUTICALS 142 ILLUMINA INC. 142 INOVIO 142 INTERNA TECHNOLOGIES B.V. 142 ISIS PHARMACEUTICALS 142 LC SCIENCES 142 LIFE TECHNOLOGIES CORP. 143 LORUS THERAPEUTICS INC. 143 MARINA BIOTECH 143 MERCK 143 MIRAGEN THERAPEUTICS 143 MIRNA THERAPEUTICS 143 NANOSTRING TECHNOLOGIES 144 NORGEN BIOTEK 144 NOVARTIS INTERNATIONAL AG 144 OPKO HEALTH INC. 144 PFIZER 144 PHALANX BIOTECH GROUP 144 PHASERX 145 PROLIAS TECHNOLOGIES 145 QIAGEN 145 QUARK PHARMACEUTICALS INC. 145 REGULUS THERAPEUTICS 145 ROSETTA GENOMICS 145 RXI PHARMACEUTICALS CORP. 146

8 SANOFI U.S. 146 SANTARIS PHARMA A/S 146 SENESCO TECHNOLOGIES INC. 146 SIGMA-ALDRICH 146 SILENCE THERAPEUTICS 146 SIRNAOMICS INC. 147 SIRNASENSE 147 SYLENTIS 147 TACERE THERAPEUTICS INC. 147 TEKMIRA PHARMACEUTICALS CORP. 147 THERADIAG 147 THERMO FISHER SCIENTIFIC INC. 148 TRAVERSA THERAPEUTICS INC. 148 WAFERGEN BIOSYSTEMS INC. 148

9 LIST OF TABLES TABLE HEADING SUMMARY TABLE GLOBAL MARKET FOR MICRORNA RESEARCH TOOLS, DIAGNOSTIC AND THERAPEUTIC PRODUCTS, THROUGH 2017 ($ TABLE 1 GLOBAL MARKET FOR REAGENTS AND TOOLS FOR DNA/RNA RESEARCH, THROUGH 2016 ($ BILLIONS) TABLE 2 MARKET FOR CANCER PROFILING TECHNOLOGIES, THROUGH 2015 ($ BILLIONS) 16 TABLE 3 PATENTS AND PATENT APPLICATION SEARCH IN MICRORNA RESEARCH USING SPECIFIC KEY WORDS, THROUGH 2012 TABLE 4 NUMBER OF PATENTS AND PATENT APPLICATIONS IN MICRORNA RESEARCH ACCORDING TO ASSIGNEE TABLE 5 TYPES OF REAGENTS AND TOOLS FOR MICRORNA RESEARCH AND DRUG DISCOVERY AND THEIR RELATIVE MARKET SHARE, 2011 (%) TABLE 6 EXAMPLES OF MICRORNA SAMPLE PREPARATION SERVICES AND THEIR PRICE RANGES ($) TABLE 7 GLOBAL MARKET SHARES OF RNA ISOLATION PRODUCTS BY COMPANY (%) 27 TABLE 8 GLOBAL RT PCR MARKET SHARES BY COMPANY, 2011 (%) 29 TABLE 9 PLATFORMS AND VENDORS OF QRT PCR PRODUCST FOR MICRORNA RESEARCH 30 TABLE 10 GLOBAL MARKET FOR QRT PCR REAGENTS FOR MICRORNA RESEARCH, THROUGH 2017 ($ TABLE 11 MAIN REPRESENTATIVE MICROARRAY PRODUCTS FOR MICRORNA RESEARCH 33 TABLE 12 ANNUAL REVENUES OF AFFYMETRIX, ($ 34 TABLE 13 GLOBAL MARKET FOR MICROARRAY REAGENTS AND PRODUCTS FOR MICRORNA RESEARCH, THROUGH 2017 ($ TABLE 14 GLOBAL MARKET FOR NGS SEQUENCING, THROUGH 2016 ($ BILLIONS) 39 TABLE 15 NGS MARKET SHARE BY COMPANY, 2011 (%) 40 TABLE 16 PLATFORMS AND VENDORS USED FOR MICRORNA SEQUENCING 40 TABLE 17 VALUE OF GLOBAL NGS SAMPLE PREP MARKET, THROUGH 2016 ($ 42 TABLE 18 SUMMARY OF MICRORNA PROFILING TECHNIQUES ADVANTAGES AND DISADVANTAGES TABLE 19 EXAMPLES OF PRODUCTS FOR FUNCTIONAL ASSAYS AND THEIR REPRESENTATIVE VENDORS TABLE 20 GLOBAL MARKET FOR RESEARCH TOOLS IN MICRORNA RESEARCH, THROUGH 2017 ($ TABLE 21 NUMBER OF PUBLICATIONS IN MICRORNA RESEARCH BASED ON DIFFERENT SEARCH CRITERIA TABLE 22 EXAMPLES OF DIFFERENTIALLY EXPRESSED MICRORNA IN DIFFERENT CANCER TYPES TABLE 23 EXAMPLES OF MICRORNA EXPRESSION IN CVS CONDITIONS 51 TABLE 24 EXAMPLES OF MICRORNA DOWNREGULATED OR UPREGULATED IN DIFFERENT NEURODEGENERATIVE PATHOLOGIES TABLE 25 GLOBAL BIOMARKERS MARKET, THROUGH 2015 ($ BILLIONS) 54 TABLE 26 CHALLENGES ASSOCIATED WITH MICRORNA MEASUREMENTS AS BIOMARKER 55 TABLE 27 DIAGNOSTICS PRODUCTS BY ROSETTA GENOMICS 56 TABLE 28 REVENUES FOR ROSETTA GENOMICS, ($ 57 TABLE 29 GLOBAL MICRORNA DIAGNOSTICS MARKET THROUGH 2017 ($ 59 TABLE 30 EXAMPLE OF EXIQON REVENUES, ($ 61 TABLE 31 EXAMPLE OF LIPITOR SALES AS AN ESTIMATE FOR KYNAMRO, ($ BILLIONS) TABLE 32 EXAMPLES FOR ISIS PHARMACEUTICALS REVENUES, ($ 68 TABLE 33 REVENUES OF ALNYLAM PHARMACEUTICALS AND TEKMIRA PHARMACEUTICALS, ($

10 TABLE HEADING TABLE 34 EXAMPLES OF DRUG CANDIDATES IN ANTISENSE AND RNA INTERFERENCE BASED APPROACHES TABLE 35 GLOBAL MARKET FOR ANTISENSE DRUG DISCOVERY THROUGH 2017 ($ 77 TABLE 36 EXAMPLES OF DEALS AND COLLABORATION IN RNAI THERAPEUTICS, TABLE 37 GLOBAL MARKET FOR RNAI THERAPEUTIC APPROACH, THROUGH 2017 ($ TABLE 38 EXAMPLES OF MICRORNA DIFFERENTIAL EXPRESSION IN DIFFERENT CELLULAR PROCESSES TABLE 39 DIFFERENT APPROACHES FOR DEVELOPMENT OF MICRORNA BASED THERAPEUTICS TABLE 40 GLOBAL MARKET FOR RNA DRUG DELIVERY, THROUGH 2017 ($ BILLIONS) 85 TABLE 41 MAIN APPROACHES AND TECHNIQUES IN NONVIRAL RNA DRUG DELIVERY 86 TABLE 42 RNA DRUG DELIVERY SYSTEMS BY COMPANY 87 TABLE 43 SUMMARY OF MAIN DRUG DEVELOPMENT PLATFORMS FOR MICRORNA THERAPEUTICS: LIMITATIONS AND ADVANTAGES TABLE 44 MAIN MARKET PARTICIPANTS IN MICRORNA DRUG DISCOVERY AND EXAMPLES OF THEIR DRUG CANDIDATES TABLE 45 SALES OF INCIVEK AND VICTRELIS, 2011 AND 2012 ($ 90 TABLE 46 REVENUES FOR SANTARIS PHARMA AND REGULUS THERAPEUTICS, ($ TABLE 47 RECENT COLLABORATIONS, DEALS AND AGREEMENTS IN THE MICRORNA DRUG DISCOVERY MARKET, TABLE 48 GLOBAL MARKET FOR MICRORNA DRUG DISCOVERY THROUGH 2017 ($ 101 TABLE 49 GLOBAL MARKET FOR RNA BASED THERAPEUTICS, THROUGH 2017 ($ 104 TABLE 50 GEOGRAPHICAL DISTRIBUTION OF RNA-BASED DRUG DISCOVERY COMPANIES (%) 105 TABLE 51 GLOBAL BIOINFORMATICS MARKET, THROUGH 2016 ($ BILLIONS) 107 TABLE 52 DATABASES FOR MICRORNA RESEARCH 108 TABLE 53 EXAMPLES OF COMPUTATIONAL TOOLS FOR MICRORNA PREDICTION AND TARGET IDENTIFICATION TABLE 54 PROTEIN TARGETS FOR DRUG DISCOVERY RESEARCH IN MICRORNA 112 TABLE 55 GLOBAL MARKET FOR BIOFUELS, THROUGH 2017 ($ BILLIONS) 116 TABLE 56 GLOBAL MARKET FOR MICRORNA RESEARCH TOOLS, DIAGNOSTIC AND THERAPEUTIC PRODUCTS, THROUGH 2017 ($ TABLE 57 MAIN MARKET PARTICIPANTS IN MICRORNA RESEARCH MARKET

11 LIST OF FIGURES FIGURE TITLE SUMMARY FIGURE GLOBAL MARKET FOR MICRORNA RESEARCH TOOLS, DIAGNOSTIC AND THERAPEUTIC PRODUCTS, ($ FIGURE 1 SCHEMATIC REPRESENTATION OF MICRORNA BIOGENESIS AND ITS EFFECT ON PROTEIN TRANSLATION FIGURE 2 GLOBAL MARKET FOR RESEARCH TOOLS IN MICRORNA RESEARCH, ($ FIGURE 3 GLOBAL MICRORNA DIAGNOSTICS MARKET, ($ 60 FIGURE 4 GLOBAL MARKET FOR MICRORNA DRUG DISCOVERY ($ 101 FIGURE 5 GLOBAL MARKET FOR RNA BASED THERAPEUTICS, ($ 104 FIGURE 6 GLOBAL MARKET FOR MICRORNA RESEARCH TOOLS, DIAGNOSTIC AND THERAPEUTIC PRODUCTS, ($