CASCINATION CAS-ONE SURGERY STEREOTACTIC NAVIGATION SYSTEM FOR ABDOMINAL SURGERY

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1 CASCINATION CAS-ONE SURGERY STEREOTACTIC NAVIGATION SYSTEM FOR ABDOMINAL SURGERY

2 SETTING NEW STANDARDS IN ONCOLOGICAL SURGERY CAS-One surgery supports surgeons in the performance of precise oncological treatments in abdominal surgery. It seamlessly combines the high precision of the latest stereotactic image guidance software with the convenience of intra-operative ultrasound imaging. CLINICAL BENEFITS Technical accuracy, intraoperative efficacy, and safety Realtime 3D vascular orientation Improves accuracy of both ablation and resection Accurate multiple needle placement Allows the treatment of small lesions that cannot be seen under ultrasound Treatment of patients initially deemed inoperable Provides local tumor control and improves longerterm survival Navigation provides therapy options for patients with extensive cancer disease within a multimodal treatment approach. Previously untreatable scenarios such as multiple small, bilobar lesions and so-called vanishing lesions come now within reach.

3 USE CT, ULTRASOUND AND 3D IMAGING FOR BETTER INTRA-OPERATIVE ORIENTATION See exactly what you need to see during surgery. Having all available patient information at your fingertips is crucial. CAS-ONE is the only image guidance system that provides seamlessly integrated state of the art sonography technology, conveniently displayed on two touch screen monitors. Use CT and 3D imaging for better intra-operative planning and navigation. No need to switch between different systems and monitors during the intervention. Enhance your orientation in the situs by fusing preoperative image data with real-time intraoperative ultrasound imaging Augment native sonography with features otherwise not visible e.g. vascular structures, functional volumes and vanishing lesions Alignment of image data and patient sonography enables seamless, intuitive and precise navigation CT-IMAGING 3D DATA INTERVENTION PLANNING

4 ADVANCED INTRA-OPERATIVE NAVIGATION SUPPORT FOR RESECTION AND ABLATION The computer assisted navigation of CAS-One Surgery improves the overall orientation especially in complex cancer surgeries. When using CAS-One Surgery the automatic acquisition of internal landmarks with the ultrasonic probe further fosters the efficiency of the smooth intra-operative workflow. With aspirator or needle the definition of additional internal landmarks for validation is quick and intuitive. The use of CAS-One Surgery supports advanced comprehensive treatments in liver surgery such as hemihepatectomy, ALPPS and atypical tumor resection that rely on a high degree precision to produce the desired outcomes for patients. REGISTRATION Automatic sonographic and/or landmark based registration 3D navigated imaging for precise instrument control Exact resection line definition while avoiding injury of vessels and healthy structures. NAVIGATION ABLATION/RESECTION

5 COMBINED ABLATION AND RESECTION OF MULTIPLE VAST BILOBAR LIVER METASTASES With technology becoming more advanced and accurate, scenarios so far considered untreatable come within reach. CAS-One Surgery enables the surgeon to treat patients who need combined treatment by ablation and resection. CAS-One Surgery also supports the targeting of multiple smaller lesions, distributed within both liver lobes, including resection and ablation of vanishing lesions e.g. after chemotherapy. Vanishing and very small, difficult to target lesions partially invisible in ultrasound can be co-registered with preoperative imaging data showing the lesions. Furthermore, the combination of preoperative 3D-reconstructed tissue structures and intraoperative ultrasound reduces the likeliness of vessel injuries. On top of that the use of 3D-planning ensures sufficient safety margins for resection to eliminate the complete tumor. Treatment of small, multiple and vanishing lesions Combination of ablation and resection for optimal patient treatment to safe healthy bparenchyma Reduced risk of vessel injuries TREAT MORE PATIENTS ENSURE SAFETY MARGINS SAFE HEALTHY PARENCHYMA

6 CONTACT CAScination AG Steigerhubelstrasse 3 CH-3008 Bern Phone Fax info@cascination.com FROM RESEARCH TO WORLDWIDE SUCCESS CAScination is dedicated to the development, manufacture and commercialization of innovations in computer-assisted and image-guided interventional radiology and surgery. Our trailblazing navigation systems and surgical robots are designed to improve outcomes for those undergoing surgical or interventional procedures and offer new perspectives to patients worldwide. Our CAS-One planning and navigation system is used to treat patients suffering from soft tissue cancer (e.g., liver cancer). We aim to provide physicians with the tools needed to ensure precise, reproducible and efficient therapy, and give more patients access to minimally invasive and effective treatments, helping them to recover fast and get back to enjoying life. Our CAS-One planning and navigation system is CE marked and FDA cleared, and is used in many hospitals across the world. Our portfolio of products and solutions includes navigation systems for open and minimally invasive cancer treatment, a new otological planning software OTOPLAN as well as surgical robots. CAScination is committed to continuously expanding the indications of precision navigation for the benefit of patients worldwide. 1 Banz V. et al. Computer planned, image-guided combined resection and ablation for bilobar colorectal liver metastases. World J Gastroenterol Oct 28; 20(40): Banz V. et al. Intraoperative image-guided navigation system: development and applicability in 65 patients undergoing liver surgery. Langenbecks Arch Surg Jun;401(4): Tinguely P. et al. Laparoscopic image-based navigation for microwave ablation on liver tumors A multi-center study. Surg Endosc Oct;31(10): ⁴ Freedman J. et al. A new technique for minimally invasive irreversible electroporation of tumors in the head and body of the pancreas. Surg Endosc Apr;31(4): ⁵ Huber T. et al. Computer-assisted 3D-navigated laparoscopic resection of a vanished colorectal liver metastasis after chemotherapy. Z Gastroenterol 2016; 54: Partner/Distributor CAS-One Surgery Brochure