OIE Reference Laboratory Reports Activities

Transcription

1 OIE Reference Laboratory Reports Activities Activities in 2013 This report has been submitted : :17:50 Name of disease (or topic) for which you are a designated OIE Reference Laboratory: Peste des petits ruminants Address of laboratory: Campus International de Baillarguet TA A-15/G Montpellier Cedex 5 FRANCE Tel.: +33 (0) Fax: +33 (0) address: genevieve.libeau@cirad.fr website: Name (including Title) of Head of Laboratory (Responsible Official): Dr Thierry Lefrançois Name (including Title and Position) of OIE Reference Expert: Dr Geneviève Libeau Which of the following defines your laboratory? Check all that apply: OIE Reference Laboratory Reports Activities,

2 ToR: To use, promote and disseminate diagnostic methods validated according to OIE Standards 1. Did your laboratory perform diagnostic tests for the specified disease/topic for purposes such as disease diagnosis, screening of animals for export, surveillance, etc.? (t for quality control, proficiency testing or staff training) Diagnostic Test Indicated in OIE Manual (/) Total number of test performed last year Indirect diagnostic tests Nationally Internationally c-elisa YES Direct diagnostic tests Nationally Internationally RT-PCR gene N and H YES Real-time RT-PCR gene N NO 0 33 Capture ELISA YES 0 33 Sequences N gene 0 60 Lateral Flow device NO 0 33 ToR: To develop reference material in accordance with OIE requirements, and implement and promote the application of OIE Standards. To store and distribute to national laboratories biological reference products and any other reagents used in the diagnosis and control of the designated pathogens or disease. 2. Did your laboratory produce or supply imported standard reference reagents officially recognised by the OIE? NOTE: Currently, there are 22 laboratories that produce Standard Reference Reagents officially recognised by the OIE for 19 diseases/pathogens. Please click the following link to the list of OIE-approved International Standard Sera: If the reagent is not listed on this page, it is NOT considered OIE-approved. The next two questions allow you to indicate non-oie-approved diagnostic reagents. OIE-approved SRR producing laboratory Select your lab from list: 2 OIE Reference Laboratory Reports Activities, 2013

3 Disease Test Available from Peste des petits ruminants Enzyme-linked immunosorbent assay Dr Genevieve Libeau CIRAD/EMVT, Campus international de Baillarguet, Montferriez-sur-Lez, B.P. 5035, Montpellier Cedex 01, France Tel: 33 (0) Fax: 33 (0) Type of reagent available Related diagnostic test Produced/ Supply imported Amount supplied nationally (ml, mg) Amount supplied internationally (ml, mg) Name of recipient OIE Member Countries Control positive sera (OIE-approved international sera) c-elisa Produced <10mL mL mL <500mL <10mL mL mL <500mL 3. Did your laboratory supply standard reference reagents (non OIE-approved) and/or other diagnostic reagents to OIE Member Countries? 4. Did your laboratory produce vaccines? 5. Did your laboratory supply vaccines to OIE Member Countries? Vaccine name Amount supplied nationally (ml, mg) (including for own use) Amount supplied to other countries (ml, mg) Name of recipient OIE Member Countries PPRV Nigeria 75-1 vaccine strain 0 20 IRAQ PPRV Nigeria 75-1 vaccine strain ETHIOPIA PPRV Nigeria 75-1 vaccine strain 0 60 ETHIOPIA ToR: To develop, standardise and validate, according to OIE Standards, new procedures for diagnosis and control of the designated pathogens or diseases 6. Did your laboratory develop new diagnostic methods validated according to OIE Standards for the designated pathogen or disease? OIE Reference Laboratory Reports Activities,

4 7. Did your laboratory develop new vaccines according to OIE Standards for the designated pathogen or disease? ToR: To provide diagnostic testing facilities, and, where appropriate, scientific and technical advice on disease control measures to OIE Member Countries 8. Did your laboratory carry out diagnostic testing for other OIE Member Countries? Name of OIE Member Country seeking assistance Date (month). samples received for provision of diagnostic support. samples received for provision of confirmatory diagnoses COMOROS 01/ SENEGAL 03/ SUDAN 10/ Did your laboratory provide expert advice in technical consultancies on the request of an OIE Member Country? Name of the OIE Member Country receiving a technical consultancy Purpose How the advice was provided ETHIOPIA Vaccine quality consultancy ToR: To carry out and/or coordinate scientific and technical studies in collaboration with other laboratories, centres or organisations 10. Did your laboratory participate in international scientific studies in collaboration with OIE Member Countries other than the own? Title of the study Duration Purpose of the study Partners (Institutions) Spread of PPRV and genome evolution in populations of domestic ruminants in Senegal. 3 years Molecular epidemiology of PPRV and surveillance of the disease ISRA-LNRV, Dakar Spread of PPRV and genome evolution in populations of domestic ruminants in Mauritania 3 years Molecular epidemiology of PPRV and surveillance of the disease CNERV, uakchott OIE Twinning Project 2 years PPR diagnosis quality assurance systems, as a support for the delivery of reliable results and PPR epidemiology. BIOPHARMA, Rabat 4 OIE Reference Laboratory Reports Activities, 2013

5 ToR: To collect, process, analyse, publish and disseminate epizootiological data relevant to the designated pathogens or diseases 11. Did your Laboratory collect epizootiological data relevant to international disease control? 12. Did your laboratory disseminate epizootiological data that had been processed and analysed? 13. What method of dissemination of information is most often used by your laboratory? (Indicate in the appropriate box the number by category) a) Articles published in peer-reviewed journals: 4 1) Peste des Petits Ruminants, the next eradicated animal disease? Albina E, Kwiatek O, Minet C, Lancelot R, Servan de Almeida R, Libeau G. Vet Microbiol Jul 26;165(1-2): doi: /j.vetmic Epub 2012 Dec 22. 2) Peste des Petits Ruminants Virus, Mauritania. Ahmed Salem El Arbi, Ahmed Bezeid El Mamy, Habib Salami, Ekatarina Isselmou, Olivier Kwiatek, Geneviève Libeau, Yaghouba Kane, and Renaud Lancelot EID. 2014; 20(2) : doi: 3) Evolutionary genetics underlying the spread of peste des petits ruminants virus. Geneviève Libeau, Adama Diallo, and Satya Parida. Animal Frontiers January :14-20; doi: /af ) The incursion, persistence and spread of peste des petits ruminants in Tanzania: epidemiological patterns and predictions. Kivaria FM, Kwiatek O, Kapaga AM, Swai ES, Libeau G, Moshy W, Mbyuzi AO, Gladson J.Onderstepoort J Vet Res. 2013;80(1):593. doi: /ojvr.v80i1.593 b) International conferences: 4 1)Role of Reference laboratories CIRAD G.Libeau. Launching meeting of the project Vaccine Standards and Pilot Approach to Peste des Petits Ruminants (PPR) Control in Africa (VSPA) February 2013, Addis Ababa, Ethiopia 2)Anti-PPRV therapy based on in vivo efficiency of sirna: proof of concept using a small animal model. C.Minet1,2, R. Servan de Almeida1,2, C. Holz1,2, G. Libeau1,2 and E. Albina1,2. 1.CIRAD, UMR15 CMAEE, F Montpellier, France ; 2.INRA, UMR1309 CMAEE, F Montpellier, France. Poster Global PPR Research Alliance (GPRA),Second GPRA Meeting, April 2013 in Nairobi, Kenya. 3)Improved Understanding of the Epidemiology of PPR (IUEPPR). Task 2.2: Develop and evaluate tests based on non-invasive strategy (screening fecal specimens) to detect PPRV infection in wildlife: G. Libeau & N. Gaidet. London Kick-off meeting 26 v 2013, Pirbright, UK. 4)Peste des Petits Ruminants Vaccine Quality Control. O. Kwiatek. Launching Meeting OIE Sub-Grant to AU/PANVAC Strengthen AU/PANVAC capacities to guarantee the quality of PPR vaccines produced in Africa Dakar-Senegal February c) National conferences: 0 d) Other: (Provide website address or link to appropriate information) 0 OIE Reference Laboratory Reports Activities,

6 ToR: To provide scientific and technical training for personnel from OIE Member Countries To recommend the prescribed and alternative tests or vaccines as OIE Standards 14. Did your laboratory provide scientific and technical training to laboratory personnel from other OIE Member Countries? a) Technical visits: 4 b) Seminars: 20 c) Hands-on training courses: 10 d) Internships (>1 month): 2 Type of technical training provided (a, b, c or d) Country of origin of the expert(s) provided with training. participants from the corresponding country a Technical visit La Reunion 1 a Technical visit Ethiopia 1 a Technical visit Algeria 1 a Technical visit Tunisia 1 d Internships Côte d Ivoire 1 d Internships Mauritania 1 b Seminars France 20 c Hands-on training courses Tunisia 10 ToR: To maintain a system of quality assurance, biosafety and biosecurity relevant for the pathogen and the disease concerned 15. Does your laboratory have a Quality Management System certified according to an International Standard? Quality management system adopted ISO Is your laboratory accredited by an international accreditation body? 6 OIE Reference Laboratory Reports Activities, 2013

7 Test for which your laboratory is accredited c-elisa tests Accreditation body COFRAC 17. Does your laboratory maintain a biorisk management system for the pathogen and the disease concerned? (See Manual of Diagnostic Tests and Vaccines for Terrestrial Animals 2012, Chapter or Manual of Diagnostic Tests for Aquatic Animals 2012, Chapter 1.1.1) ToR: To organise and participate in scientific meetings on behalf of the OIE 18. Did your laboratory organise scientific meetings on behalf of the OIE? 19. Did your laboratory participate in scientific meetings on behalf of the OIE? Title of event Date (mm/yy) Location Role (speaker, presenting poster, short communications) Title of the work presented Launching meeting of the project Vaccine Standards and Pilot Approach to Peste des Petits Ruminants (PPR) Control in Africa (VSPA) February 2013, Addis Ababa, Ethiopia Speaker, G. Libeau Role of Reference laboratories CIRAD Launching Meeting OIE Sub-Grant to AU/PANVAC Strengthen AU/PANVAC capacities to guarantee the quality of PPR vaccines produced in Africa February Dakar-Senegal Speaker, O. Kwiatek. Peste des Petits Ruminants Vaccine Quality Control. ToR: To establish and maintain a network with other OIE Reference Laboratories designated for the same pathogen or disease and organise regular inter-laboratory proficiency testing to ensure comparability of results 20. Did your laboratory exchange information with other OIE Reference Laboratories designated for the same pathogen or disease? OIE Reference Laboratory Reports Activities,

8 21. Was your laboratory involved in maintaining a network with OIE Reference Laboratories designated for the same pathogen or disease by organising or participating in proficiency tests? Purpose of the proficiency tests: 1 Role of your Reference Laboratory (organiser/ participant). participants Participating OIE Ref. Labs/ organising OIE Ref. Lab. C-ELISA Organiser 2 Pirbright, other laboratory Sebata, Ethiopia 1 validation of a diagnostic protocol: specify the test; quality control of vaccines: specify the vaccine type, etc. 22. Did your laboratory collaborate with other OIE Reference Laboratories for the same disease on scientific research projects for the diagnosis or control of the pathogen of interest? Title of the project or contract Scope Name(s) of relevant OIE Reference Laboratories Improved Understanding of the Epidemiology of PPR (IUEPPR) Molecular and quantitative epidemiology of PPR, role of wildlife. n invasive sampling procedures implemented Pirbright Laboratory and CIRAD ToR: To organise inter-laboratory proficiency testing with laboratories other than OIE Reference Laboratories for the same pathogens and diseases to ensure equivalence of results 23. Did your laboratory organise or participate in inter-laboratory proficiency tests with laboratories other than OIE Reference Laboratories for the same disease? te: See Interlaboratory test comparisons in: Laboratory Proficiency Testing at: see point 1.3 ToR: To place expert consultants at the disposal of the OIE 24. Did your laboratory place expert consultants at the disposal of the OIE? 8 OIE Reference Laboratory Reports Activities, 2013

9 Kind of consultancy Location Subject (facultative) Attendence at the PPR Ad hoc meeting OIE Headquarters, Paris Several tasks including to advise the OIE on the steps to be taken to develop a global PPR control strategy Consultation to define the Procedures for the quality control of PPR vaccines in Africa OIE Headquarters, Paris DEFINE A QUALITY CONTROL STRATEGY for PPR VACCINES PRODUCED IN AFRICA Update of the Terrestrial Manual OIE Headquarters, Paris Participation in the Launching meeting of the project 'Vaccine Standards and Pilot Approach to Peste des Petits Ruminants (PPR) Control in Africa (VSPA)' Addis Ababa (Ethiopia), African Union Headquarters, February 2013 Scientific support in epidemiology (April 2013) Accra and inland Ghana Definition of assessment protocol for PPR vaccination strategies in Ghana (VSPA) Scientific support in epidemiology (September 2013) Ouahigouya (Burkina Faso) Definition of assessment protocol for PPR vaccination strategies in Burkina Faso (VSPA) - Training in participative epidemiology. 25. Additional comments regarding your report: OIE Reference Laboratory Reports Activities,