Sowa Rigpa Drug Research its scope and Challenges

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1 Sowa Rigpa Drug Research its scope and Challenges By Tenzin Choedon Jamling PhD International Centre for Genetic Engineering and Biotechnology New Delhi

2 Complementary Alternative medicine : Complementary and alternative healthcare and medical practices (CAM) is a group of diverse medical and health care systems, practices, and products that are not presently considered to be part of conventional medicine. Healing practice "that does not fall within the realm of conventional medicine or that which has not been shown consistently to be effective.

3 Conventional Medicine A system in which medical doctors and other healthcare professionals (such as nurses, pharmacists, and therapists) treat symptoms and diseases using drugs, radiation, or surgery. Also called allopathic medicine, biomedicine, mainstream medicine, orthodox medicine, and Western medicine.

4 World Health Organization Policy Framework for action for WHO and its partners, to enable TM/CAM to play a far greater role. Four objectives: Policy: integrate TM/CAM with national health care systems. Safety, efficacy and quality: expand knowledgebase on TM/CAM; provide guidance on regulatory and quality assurance standards. Access: increase availability and affordability of TM/CAM, with an emphasis on access for poor populations. Rational use: promote therapeutically sound use of appropriate TM/CAM by providers and consumers.

5 Traditional Tibetan Medicine (Sowa Rigpa) Recognition in 2010 under Indian medical system Challenges: 3Ps -Pharmacological studies (Patient safety) -Preservation -Protection(IPR)

6 Pharmacological studies (Patient safety)- update age old traditional system Hepatitis B Virus X protein

7 Preliminary findings

8 Preservation-

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10 Protection(IPR) Patent The word patent originates from the Latin patere, which means "to lay open" (i.e., to make available for public inspection). A patent is a set of exclusive rights granted by a sovereign state or intergovernmental organization to an inventor or assignee for a limited period of time in exchange for detailed public disclosure of an invention. An invention is a solution to a specific technological problem and is a product or a process. Patents are a form of intellectual property.

11 Objectives of patents Giving a legal monopoly to the patentee to reap the economic benefits of his/her inventions. Facilitating the improvements or providing the alternate approaches to develop the new ideas or products Invention of new drugs The patent act 1970 (India) -A new invention -Should be new and non obvious -Must be useful -Not previously in use in India Non patentable in India -methods of detection, diagnosis -Analytical methods -methods of agriculture/cultivation -Products made by chemical synthesis -animals, plants and biological methods for growing and rearing them.

12 Patentable natural products Formulation of new composition or improved formulation Patents for new use of the herbal constituents

13 A novel isolation process A new application of an isolated compound Invention with novelties (Biopesticides) Industries for clinical development of a novel botanical drug, Cissampelos pariera (Cipa) for the treatment of dengue. Biotechnology related products Purification of the natural products

14 Traditional Tibetan Medicine (Sowa Rigpa) Recognition : High quality scientific research (new diseases) Research and Development facilities Funds Research : methods of testing Batch to batch variation refining and validating indigenous knowledge Counterfeit, poor quality or adulterated herbal products pose serious patients safety threats

15 Batch to batch variation- quality control 216 UV- Visible spectroscopy

16 Analytical RP-HPLC Profile at 220nm and 280nm mv(x100) Detector A Ch1:220nm 2.5 Detector A Ch2:280nm B.Conc.(Method) % min The fingerprints of YK samples were monitored on a Shimadzu reverse-phase HPLC system (C18 column - 250mm, 4.6mm) with SCl-10AVp system controller and SPD-10AVvp UV-Vis detector. The mobile phase (acetonitrile and water) was degassed and filtered through 0.2μm membrane filter before pumping into the HPLC system. A linear gradient of acetonitrile from 5% to 95% over 55 min at a flow rate of 1ml/min was maintained and the samples were monitored at 220 and 280 nm using Photo Diode Array (PDA) detector. The YK samples (20 µg in 200 µl of glass distilled water) were used for injection. 16

17 Scope: Identification of active compound (Vincristine) Combinatorial therapy (Caution Amygdalin, Paclitaxel) Positive impact on global healthcare Market Identification of active compound (Vincristine)

18 Combinatorial therapy (Caution Amygdalin, Paclitaxel) Systematic implementation of any therapy in consultation with the practitioner

19 Advantages over conventional therapy

20 Positive impact on global healthcare Contribution of plants derived drug in modern world -47% of around 300 million new prescriptions in USA, one or more active ingredients are of natural origin. More than 47% of all drugs used in Russia are obtained from botanical source. -Plant derived medicinal substance eg Morphine, L- Dopa, digitoxin Major population in Asia and African countries rely on herbal medicines as the primary medical care -Cheap and affordable

21 Future Integrative therapy Western Medicine (Offensive strategy) Sowa Rigpa (Defensive strategy) Improvised health care

22 Medical practitioners, Researchers, teachers, law makers, professional organizations of Sowa Rigpa Protection and preservation of Sowa Rigpa

23 Strength of Sowa Rigpa Complete Health care Low cost medication Life style and Dietary consultation Holistic approach Management of life style diseases Management of chronic and incurable diseases Management of adverse and toxic effects of drugs

24 Thank You All!