EMS MICROSCOPY ACADEMY PHARMACEUTICAL CHEMICAL IMAGING WORKSHOP

Transcription

1 Examples of Tablet Chemical Images Energy dispersive x-ray chemical map of a sectioned multivitamin tablet. Fluorescence microscopy image of a sectioned multivitamin tablet. Cross-sectioned Naproxen Sodium tablet imaged by SEM backscattered electron detection. EDS spectrum of Naproxen Sodium tablet.

2 Details Please contact us if you would like to take this workshop. Targeted Participants This course is intended for all analysts and managers who are interested in the details of chemical imaging. Scope of Class This workshop is designed as an intensive introduction to chemical imaging in pharmaceutical development. The workshop topics include theory, sample preparation, image generation, digital image analysis, and data presentation. It exclusively treats chemical imaging of pharmaceutical tablets. The workshop is conducted over 2 days with a mixture of theory, demonstrations, and hands-on work. The emphasis is on laboratory exercises with real samples and attendees are encouraged to bring their own samples. The laboratory work uses SEM/EDS to illustrate chemical imaging although other images such as fluorescence and Raman maps will be discussed and illustrated. The goal of the workshop is to teach the basic operations of chemical imaging to prepare the student to generate and interpret such images in their own laboratory. The EMS Microscopy Academy Located in Hatfield, Pennsylvania, the Academy provides electron microscopy classes, workshops and training sessions for all fields of microscopy, including materials science and biological science. Format Laboratory exercises and demonstrations are the primary teaching tools. Brief lectures on pertinent subjects are presented. Participants are encouraged to bring their own samples if possible. Laboratory exercises are designed to teach the student how to collect and interpret chemical images.

3 Instruments Available Leica and RMC Ultramicrotomes Hitachi S3500 SEM Bruker SDD EDS Image Analysis Software NightSea Fluorescence Main Curriculum Theory of chemical imaging using SEM/EDS, fluorescence microscopy and IR/Raman micro-spectroscopy Tablet sample preparation for SEM/EDS, fluorescence microscopy and IR/Raman micro-spectroscopy. Image generation using SEM/EDS. Image analysis techniques to generate quantitative values. Data presentation Faculty Robert Carlton Robert worked for nearly 40 years in the research and development of fiberglass insulation, orthopedics, and pharmaceuticals. His specialty is solid-state analysis with a particular interest in microscopy. Robert retired from full-time employment in early He is now teaching microscopy and consulting on solid-state analysis in pharmaceutical development. Robert s education is in chemistry, with a Ph.D. from Lehigh University. He has taken numerous courses at McCrone Research Institute on microscopy from Skip Palenik and Walter McCrone. Robert worked for pharmaceutical companies Rhone-Poulenc Rorer (Aventis, Sanofi), Elan (Nanocrystal), and GlaxoSmithKline in microscopy and solid-state analysis for 24 years. He published a book on Pharmaceutical Microscopy in 2011 with Springer. Michael Kostrna was the program director of the Electron Microscopy Technician program at Madison Area Technical College and has more than more than 35 years in EM technical education and research experience. He has been training EM students for 30 years and has developed curricula and lab exercises for TEM, SEM, OLM, lab safety, introductory and advanced biological EM, EM, maintenance, and x-ray microanalysis. He has worked with companies such as SC Johnson Polymer, Dow Chemicals, Io Genetics, Virent Technologies, ABS Global, NanoOnocology, and Microscopy Innovations, and in the process gained insight to the various applications of EM. Al Coritz has been doing Electron Microscopy for 39 years, beginning at the Yale School of Medicine and ending up on the commercial side with several key EM companies. His specialty is Cryo-techniques and Thin Film Technology: i.e. Freeze Fracture/Rotary Shadowing, High Pressure Freezing, and more He is currently with Electron Microscopy Sciences where he has been the Technical Director for over 20 years.

4 Registration Fee: $ Includes Workshop syllabus All supplies Reagents and solutions Lunches Coffee Tea Dinner on the first evening of the workshop Lodging Participants are responsible for making their own hotel reservations. The following hotel has been designated as the host hotel: Homewood Suites 1200 Pennbrook Parkway Lansdale, PA Phone: The special rate is $ per night (plus tax) which includes a hot breakfast and a light dinner in the evening. Please make your reservations and mention you are participating in the EMS Workshop. GROUP CODE: EMS WORKSHOP Everyone should plan to arrive the night before class begins. Enrollment Note Registration will be limited to a maximum of 15 participants. EMS will provide samples to those who prefer not to bring their own.

5 Printable Registration Form M / F Name / Title Institution Department Mailing address City / Zip Country Telephone / Fax Will you bring your own specimens? Yes / No (See Note on prior page) What Samples are you bringing and most interested in? All registrations must include payment. Rate $ per Person Number of Participants Total $ Pay by check: make payable to EMS and reference Pharmaceutical Imaging. Pay by credit card: Credit Card Type Credit Card Number Expiration Date 3 Digit Code Signature / Date Return your registration to: Stacie Kirsch 1560 Industry Road Hatfield, PA USA Phone: info@emsdiasum.com or Fax: PLEASE CONTACT US IF YOU WOULD LIKE TO TAKE THIS WORKSHOP.