CELL & TISSUE CULTURE SYSTEMS

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1 1997/8 US MSPPSA SERIES CELL & TISSUE CULTURE SYSTEMS AN ANALYSIS OF MARKET SIZE & GROWTH, MARKET SHARE, PURCHASE PLANS & SUPPLIER ASSESSMENT FOR THE U.S. LIFE SCIENCE RESEARCH MARKET A Multi-Client Report by PhorTech International San Carlos, California July 3, 1998 Copyright 1998 by PhorTech International, 238 Crestview Drive, San Carlos CA All rights reserved. No material contained in this report may be reproduced in whole or in part without the written permission of the publisher. This report is not intended to be, and should not be construed as a recommendation for the purchase or sale of any securities mentioned herein. The information has been derived from statistical and other sources which we deem reliable but their completeness cannot be guaranteed. Opinions expressed herein are based upon our interpretation of available information and are subject to change.

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3 TABLE OF CONTENTS I. BACKGROUND... 7 A. Survey Objectives... 9 B. Survey Methodology II. DEMOGRAPHIC SEGMENTATION #17. Distribution by Organizational Type #18. Distribution by Scientific Discipline III. MARKET SIZE & GROWTH #1+. Current Use of Cell/Tissue Culture Procedures #10. Current Use of Cell/Tissue Culture Equipment, Market Size.. 22 #11. Respondents Basis for Answering IV. MARKET SHARE #10+. Cell Culture Equipment Supplier Shares #11+. Cell Culture Media Supplier Shares V. PURCHASE PLANS #20. Current Users Projected Changes in Products VI. CURRENT METHODOLOGY #2. Current Use of Various Cell Type #3. Cell Lines Cultured for Various Applications #4. Analysis Methods Used for Cellular Studies #5. Current Use of Anchorage Dependent Cells #6. Batch vs Continuous Flow in Culture Cells #7. Current Use of Mammalian Transfection Experiments #8. Frequency of Mammalian Transfection Experiments #9. Preferred Format for Growing Cells VII. SUPPLIER ASSESSMENT #12. Reasons Given for Brand Selections #13. Satisfaction With Selected Brand #16. Ranked Suppliers Performance VIII. FUTURE EXPECTATIONS #7. Desired Improvements in Cell Biology Reagents IX. THE QUESTIONNAIRE

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5 LIST OF TABLES & GRAPHS I. BACKGROUND... 7 Survey Objectives... 8 Survey Methodology II. DEMOGRAPHIC SEGMENTATION Distribution by Type of Organization, Cell/Culture Users Scientific Discipline, Cell/Culture Users Other Scientific Disciplines Listed by Respondents III. MARKET SIZE & GROWTH Cell/Tissue Culture Users, All Respondents Population Size Estimate for U.S. Cell/Tissue Culture Users Instruments Categories, Percentage of Respondents Population Size Estimates for Cell/Tissue Culture Instruments Instrument Categories, Unit Market Share Instrument Categories, Dollar Market Share Mean Expenditure per Respondent On Microscopes Basis for Audit Data, All Respondents Microscopes Used for Cell/Tissue Culture, Annual Purchase Microscopes Used for Cell/Tissue Culture, Annual Expenditure Annual U.S. Sales Estimates for Microscopes Used for Cell/Tissue Cult.. 28 Mean Expenditure per Respondents On Shaker Tables Shaker tables Used for Cell/Tissue Culture, annual Purchases Shaker tables Used for Cell/Tissue Culture, annual Expenditure Annual U.S. Sales Estimates for Shaker Tables Used for Cell/Tissue Cult 31 Mean Expenditure per Respondent On Bottle Rotator Bottle Rotators Used for Cell/Tissue Culture, Annual Purchases Bottle Rotators Used for Cell/Tissue Culture, Annual Expenditure Mean Expenditure per Respondent on Incubators Incubators Used for Cell/Tissue Culture, Annual Purchases Incubators Used for Cell/Tissue Culture, Annual Expenditure Market Size Estimate for Cell/Tissue Culture Equipment Population Size Estimates for Cell/Tissue Culture Media Cell & Tissue Culture Media, Percentage of Respondents Cell & Tissue Culture Media, Unit Market Share Cell & Tissue Culture Media, Dollar Market Share Liters Consumed Monthly per Respondent, Serum Dollar Spent Monthly per Respondent, Serum Liters Consumed Monthly per Respondent, Cell Culture Reagents Dollar Spent Monthly per Respondent, Cell Culture reagents Liters Consumed Monthly per Respondent, Serum-free Media Dollar Spent Monthly per Respondent, Serum-free Media Liters Consumed Monthly per Respondent, Serum Substitute Dollar Spent Monthly per Respondent, Serum Substitute Annual Market Size Estimates for Various Cells & Tissue Cult. Media

6 1997/8 US MSPPSA Cell & Tissue Culture Systems IV. MARKET SHARE Cell Culture Equipment Unit Market Share for Bottle Rotators Cell Culture Equipment $$ Market Share for Bottle Rotators Average Reported Price for Bottle Rotators Cell Culture Equipment Unit Market Share for Shaker Tables Cell Culture Equipment $$ Market Share for Shaker Tables Average Reported Prices for Shaker Tables Cell Culture Equipment Unit Market Share for Microscopes Cell Culture Equipment $$ Market Share for Microscopes Average Reported Prices for Microscopes Cell Culture Equipment Unit Market Share for Incubators Cell Culture Equipment $$ Market Share for Incubators Cell Culture Media Unit Market Share for Serum Cell Culture Media $$ Market Share for Serum Cell Culture Media Unit Market Share for Serum-Free Media Cell Culture Media $$ Market Share for Serum-Free Media Cell Culture Media Unit Market Share for Cult. Reagents Cell Culture Media $$ Market Share for Cult. Reagents Cell Culture Media Unit Market Share for Serum Substitute Cell Culture Media $$ Market Share for Serum Substitute V. PURCHASE PLANS Forecast Change in Product Use, Cell & Tissue Culture Users VI. CURRENT METHODOLOGY Use of Various Cell Types, Number of Respondents Percent Use of Bacterial Cells, Among All Users Percent Use of Mammalian Cells, Among All Users Percent Use of Various Cell Types, Among All Users Percent Use of Cell Types in Other Category Use of Various Cell Types, Average Percentage of Use Use of Various Applications, Percentage of Respondents Cell Lines Cultured for Cellular Studies Cell Lines Cultured for Protein Expression Cell Lines Cultured for Protein Production Cell Lines Cultured for Cell/Gene Therapy Cell Lines Cultured for Cell Transplantation Analysis Method for Cellular Studies Labels Used for Cellular Studies Fluorescent Labels Used for Cellular Analysis Radioisotopic Labels Used for Cellular Analysis Colorimetric Labels Used for Cellular Analysis Luminescent Labels Used for Cellular Analysis Use of Anchorage Dependent Cells Attachment System Used for Anchorage Dependent Cells Batch vs Continuous Flow Cultures Batch vs Continuous Flow, According to Cell Type Transfection Experiments on Mammalian Cells

7 Frequency of Mammalian Transfection, Experiments per Month Method Used for Mammalian Transfection Transfection Methods Listed in the Other Category Preferred Format for Growing Cells Alternate Choices for Cell Culture Vessel Format VII. SUPPLIER ASSESSMENT Verbatim Comments Regarding Respondents Choice of Brands Rejection of Cell/Tissue Culture Brands Verbatim Reasons for Not Purchasing Specific Brands Satisfaction Ratings Satisfaction Rates & 65% Confidence Intervals for Major Suppliers Ranked Suppliers Performance, Best Value for Money Ranked Suppliers Performance, Best Sales Support Ranked Suppliers Performance, Most Consistent Quality Ranked Suppliers Performance, Fastest Delivery Ranked Suppliers Performance, Best Application Support Ranked Suppliers Performance, Widest Product Range VIII. FUTURE EXPECTATIONS Verbatim Comments Regarding Desired Improvements IX. THE QUESTIONNAIRE