OUR WISH LIST RESEARCH EQUIPMENT

Transcription

1 OUR WISH LIST RESEARCH EQUIPMENT

2 WITH YOUR PHILANTHROPIC SUPPORT, WE CAN WORK TOGETHER TO COMPLETE OUR FULLY-FUNCTIONAL FACILITY BY PURCHASING THE CUTTING-EDGE EQUIPMENT AND RESOURCES TO SUPPORT SAHMRI S RESEARCH TEAMS. YOUR SUPPORT WILL HELP MAKE OUR RESEARCH POSSIBLE ONE PIECE OF EQUIPMENT AT A TIME! OUR WISH LIST - RESEARCH EQUIPMENT

3 You can make a tangible difference! The South Australian Health and Medical Research Institute (SAHMRI) is one of the most exciting developments in the field of health and medical research in Australia. We have a once in a lifetime opportunity to build an organisation from the ground up and create the best possible environment that our researchers need to excel. OUR CHALLENGE: Although our flagship facility is currently well-under construction and due for completion in late 2013, current funding does not support the purchasing of specialised equipment and resources needed to complete a fully-functional research facility. We want to be able to provide our researchers with the best equipment and resources they need to go above and beyond in their work. All equipment will be used by research groups who work for or are associated with SAHMRI. As a charity, we must rely on the generous support from the community to ensure our researchers have the right tools of the trade. OUR FUTURE: Together, we can make a real difference to the health of our community for generations to come across a range of some of the most pressing and critical problems that confront our health and wellbeing today: Aboriginal Health Cancer Healthy Mothers, Babies and Children Heart Health Infection and Immunity Mind and Brain Nutrition and Metabolism. WITH YOUR PHILANTHROPIC SUPPORT, WE CAN WORK TOGETHER TO COMPLETE OUR FULLY-FUNCTIONAL FACILITY BY PURCHASING THE CUTTING-EDGE EQUIPMENT AND RESOURCES TO SUPPORT SAHMRI S RESEARCH TEAMS. YOUR SUPPORT WILL HELP MAKE OUR RESEARCH POSSIBLE ONE PIECE OF EQUIPMENT AT A TIME!

4 Wish List : Research Equipment Your purchase and donation of the following equipment will greatly assist our researchers to achieve their goals. GOLD CLASS EQUIPMENT: VALUED AT $1,000,000 OR MORE PET/MR SCANNER $6,500,000 Function and research use: Imaging equipment that characterises the structure and function of organs. Used to monitor neurological, oncological and cardiac conditions of disease. Also used to develop new biomarkers and new therapeutic approaches through pre-clinical studies and in the imaging of neurological activity. Who will use this? All researchers. Why is this piece of equipment important? With a PET/ MR scanner, we can simultaneously scan the appearance and structural detail through MR, and cellular activity and metabolism through PET. PET/CT SCANNER $3,250,000 Function and research use: An imaging system that utilises X-rays to produce an image of a cross-sectional slice of the body along with PET acquisition for location and degree of metabolic or biochemical activity. CT is most useful for imaging hard tissues such as bone or calcification in the body. Who will use this? All researchers. Why is this piece of equipment important? With a PET/CT scanner, we can monitor oncological and cardiac conditions of disease and develop new biomarkers and new therapeutic approaches through pre-clinical studies. OUR WISH LIST - RESEARCH EQUIPMENT

5

6 SILVER CLASS EQUIPMENT: VALUED AT $100,000 - $1,000,000 BENCHTOP MRI IMAGING SYSTEM $900,000 PURCHASED Function and research use: A small desktop system for magnetic resonance imaging. Who will use this? Cancer, Heart Health and Mind and Brain themes. Why is this piece of equipment important? This benchtop magnetic resonance imaging system assists in identifying preclinical models of disease in cancer, neurology and heart disease. CONFOCAL MICROSCOPE $500,000 - $800,000 Function and research use: An optical imaging system that allows high resolution of cells and subcellular structures, and the reconstruction of 3D structures from the obtained images. Who will use this? All researchers. Why is this piece of equipment important? Confocal microscopy is used in many applications in medical research to enable cells and subcellular structures to be visualised and monitored. Cells and tissues can also be labeled using fluorescent dyes for visualisation purposes. MICRO CT $500,000 PURCHASED Function and research use: Using a micro CT, X-ray images are used to create a 3D model of the object using the same method that is used in CT scanners, but on a small scale with increased resolution. Who will use this? Cancer, Heart Health and Mind and Brain themes. Why is this piece of equipment important? The Micro CT assists in identifying preclinical models of disease that involve the imaging of structures such as bone, lung, tumours or the cardiovascular system. OUR WISH LIST - RESEARCH EQUIPMENT

7 SILVER CLASS EQUIPMENT: VALUED AT $100,000 - $1,000,000 IN VIVO IMAGING SYSTEM (IVIS) $400,000 PURCHASED Function and research use: Used in cancer studies to monitor disease progression (tumour growth rates, size, location) and the effect of therapeutic intervention. Who will use this? Cancer theme. Why is this piece of equipment important? Allows noninvasive imaging of disease progression, cell movement and gene expression in living animals. IRRADIATOR $400,000 PURCHASED Function and research use: Used in preclinical models to deplete specific cell populations (e.g. bone marrow) to allow the transplant of new cell types. It is also used as a source of radiotherapy for tumour treatment. Who will use this? Cancer theme. Why is this piece of equipment important? With an irradiator, we can deplete cell populations through DNA damage. CATHETERISATION LABORATORY $350,000 Function and research use: A catheterisation laboratory is a sophisticated set of imaging devices that enables catheterisation. An X-ray imaging system is used to guide the insertion of catheters into arteries, whereby other devices can be introduced via the catheter. This allows a variety of cardiac and vascular diagnostic procedures and measurements to be taken. Who will use this? Heart Health and Aboriginal Health themes. Why is this piece of equipment important? With a catheterisation laboratory, we can conduct research into heart rhythm disorders (specifically evaluating arrhythmia mechanisms). We can also use the laboratory for imaging and intervention in atherosclerosis.

8 OUR WISH LIST - RESEARCH EQUIPMENT

9 SILVER CLASS EQUIPMENT: VALUED AT $100,000 - $1,000,000 FLOW CYTOMETER $350,000 - $400,000 PURCHASED Function and research use: A flow cytometer uses laser excitation to sort cells on the basis of size, markers present and intercellular contents. Who will use this? Infection and Immunity theme. Why is this piece of equipment important? A flow cytometer is routinely used in fields such as infection and immunity to characterise and count the different cell types in the blood and tissues. SPHYGMOCOR SYSTEM $250,000 Function and research use: A sphygmocor system is a non-invasive cardiovascular assessment instrument which measures the stiffness of arteries within the cardiovascular system and the balance of sympathetic and parasympathetic control of the heart. Who will use this? Heart Health and Aboriginal Health themes, including prospective PhD and masters students. Why is this piece of equipment important? This system can be set up in clinical laboratories or used in field work settings. The non-invasive assessment of risk is important to guide therapy in individuals with cardiovascular risk and can improve the appropriate diagnoses in high risk individuals. It can also improve access to specialist care for vulnerable communities.

10 SILVER CLASS EQUIPMENT: VALUED AT $100,000 - $1,000,000 EMBRYONIC STEM CELL $200,000 MICROINJECTION SYSTEM Function and research use: A high-resolution microscope adapted for live cell imaging combined with micromanipulation and microinjection systems to allow injection of early embryos with genetically modified embryonic stem cells. Who will use this? Cell-based researchers. Why is this piece of equipment important? Used to generate new preclinical models of disease. VIVID I PORTABLE ECHO $150,000 CARDIOGRAPHY MACHINE Function and research use: Portable cardiac ultrasound machine that can be used to measure the thickness and dynamic responses of the arteries of the body. Who will use this? Clinical researchers across the Heart Health, Aboriginal Health, Nutrition and Metabolism and Healthy Mothers, Babies and Children themes. Why is this piece of equipment important? Cardiac ultrasound is an essential clinical and research tool for assessing heart structure and function in the context of rheumatic heart disease, coronary disease, heart failure and cardiomyopathy. This is critical to improve access for disadvantgaed people and can be used in functional clinical research. OUR WISH LIST - RESEARCH EQUIPMENT

11

12 BRONZE CLASS EQUIPMENT: VALUED AT UP TO $100,000 INTEGRATED CARDIOVASCULAR $50,000 CLINICAL DATA SYSTEM Function and research use: System for recording and holding a range of results and images of clinical cardiovascular tests (such as angiograms, ultrasounds, holter monitoring, ECGs). Who will use this? Clinical reseachers, PhD students and biobanking research staff in Heart Health and Aboriginal Health themes. Why is this piece of equipment important? The system holds everything in one place, improves data security and linkages. ENDOPATH 200 NON-INVASIVE $30,000 ENDOTHELIAL FUNCTION ASSESSOR Function and research use: Non-invasive cardiovascular assessment device which can determine the functionality of blood vessels and the endothelium (lining of blood vessels). Who will use this? Heart Health, Nutrition and Metabolism and Aboriginal Health themes. Why is this piece of equipment important? Endothelial function is a critical target for therapy and has utility in determining response to treatment and exploring the impact of various risk factors on blood vessel activity. PORTABLE 24 HR HOLTER $15,000 MONITORS AND ANALYSIS SOFTWARE Quantity needed: 2 Function and research use: A non-invasive device which records the heart rhythm and rate over an extended period of time. Who will use this? Heart Health and Aboriginal Health themes. Why is this piece of equipment important? Heart rhythm disorders are a critical part of the Heart Health theme and can be used to investigate predictors of sudden cardiac death. We can also use the device to explore the links between the heart and mind. OUR WISH LIST - RESEARCH EQUIPMENT

13 WISHLIST FOR 2014/15 Name Total cost Quantity PCR cabinet $500 1 Incubator, dry (for $4,000 1 bacteria) Shaker, Orbital $6,000 1 (with heating) Microscope, $23,432 1 upright, fluorescence Fluorescent plate $30,000 2 reader Tapestation $42,798 1 DEXA scanner $50,000 1 Microwave fixation $65,352 1 system (brain) Germ Free room $200,000 1 animal house (caging and modifications) Laser Capture $311,873 1 Microdisection System PCR machine, $369,000 1 digital PCR IVC (caging), $735,600 3 completion Microscope, confocal $1,100,000 1 TOTAL $2,938,555 MORE INFORMATION If you d like to know more about SAHMRI and the purchase of research equipment, please contact: Kay Gerard, Manager - Development and Communications E: kay.gerard@sahmri.com P: (08)

14 SAHMRI ABN: North Terrace Adelaide SA 5000 PO Box 11060, Adelaide, SA 5001 P Follow us on: Aboriginal Health Cancer Healthy Mothers, Babies & Children Heart Health Infection & Immunity Mind & Brain Nutrition & Metabolism OUR WISH LIST - RESEARCH EQUIPMENT