Your Onsite Event Guide

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1 May St. Louis, MO Part of The Microbiome Movement Your Onsite Event Guide Join the #MicrobiomeMVNT Proud to Partner with: MICROBIOME

2 Megan Lyman Director, IP, Regulatory & Product Development AgTech Acclerator EXPERT SPEAKERS Bill Weldon COO Ascus Biosciences Jimmy Owens VP, Product Launch & Corporate Strategy Ascus Biosciences Holly Ganz AnimalBiome John Gregg BalinBac Therapeutics Steve Bartle Director of Livestock BalinBac Therapeutics Joseph Petrosino Associate Professor, Molecular Virology & Microbiology Baylor College of Medicine Scott Carter Director, Business Development Baylor College of Medicine Tuval Ben Yehezkel Loop Genomics Nathan McNulty Vice President of Matatu Christopher Belnap Resilient Biotics Jeff Brockman Principal Scientist Hills Pet Nutrition Megan Niederwerder Assistant Professor Kansas State University Todd Callaway Assistant Professor Georgia Janet Donaldson Associate Professor and Department Chair Southern Mississippi Tim Johnson Associate Professor Minnesota Aaron Ericsson Director MU Metagenomics Center Missouri Matthew Koci Associate Professor, Immunology, Virology & Host-Pathogen Interactions NC State Michael Kogut Lead Scientist/ Microbiologist USDA-ARS Sandrine Miller- Montgomery Executive Director, Centre for Microbiome Innovation & Professor of Practice, BioEngineering UC San Diego Jeffrey Watts Director, External Innovation Anti Infectives Zoetis Deborah Thompson Director, Partnerships NC State

3 The Microbiome Movement - Animal Health 2018 May St.Louis, MO CONFERENCE DAY ONE WEDNESDAY, 23 MAY 2018 Setting the Foundations Proving the Animal Microbiome as the Next Disruptive Innovation in Agriculture Despite high research activity, the animal microbiome field is still in it s infancy industrially. As researchers understand how the microbiome affects the health and productivity of domestic livestock, there is huge potential to advance new market opportunities gained through microbiome studies. As insights into nutrition can be fundamental to the health and wellbeing in livestock, the purpose of this theme will be to review the current knowledge gained through the microbiome Registration & Morning Coffee 8.20 Chair s Opening Remarks Jeffrey Watts Director, External Innovation Anti Infectives Zoetis Mike Seely Ascus Biosciences Sandrine Miller- Montgomery Executive Director, Centre for Microbiome Innovation & Professor of Practice, BioEngineering UC San Diego 8.30 Advancing Microbiome Based Leads into & Through the Pipeline 9.00 The Next Wave of Innovation in Animal Health 9.30 Using Human as an Animal Model Lessons Learnt from Studying Human Microbiome to Benefit Animal Health Morning Refreshments & Speed Networking Elucidating Mechanisms of Action Finding Function & Demonstrating Effects of the Gut Microbiota on the Host The microbial communities that live within the gut exert major impacts on health through modulating metabolism and immunity. In order to leverage associations between host and their microbiome for industrial applications, key scientific understandings around function and mode of action still need to be elucidated. The purpose of this theme will be to review work being done to help unlock the mechanistic secrets driving disease prevention in animal health. Steve Bartle Director of Livestock BalinBac Therapeutics Michael Kogut Lead Scientist/ Microbiologist USDA-ARS Megan Niederwerder Assistant Professor Kansas State University Overview of Current Beef Industry, Management Practices, & Opportunities for Microbiome Impacts Manipulation of the Microbiome to Modulate Immunity Role of the Microbiome in Swine Respiratory Disease

4 Screening Methodology Tools & Technologies to Mine the Microbiome New research in NGS and multi-omic technologies is expected to greatly assist with the accurate mining of the animal microbiome to help identify new industrial applications within nutrition, in-feed additives and pharmaceuticals. The purpose of this theme will be to review how researchers are applying new technologies to accelerate discovery and development. Joseph Petrosino Associate Professor, Molecular Virology & Microbiology Baylor College of Medicine Tuval Ben Yehezkel Loop Genomics Advances in the Human Microbiome & Key Learnings for Animal Health Next Generation Microbiome Profiling Lunch & Networking Matthew Koci Associate Professor, Immunology, Virology & Host-Pathogen Interactions NC State Connecting the Who with the Where and the What to Understand the Why A Renewed Demand for Probiotics & Nutrition Making Genuine Therapeutic Claims in Animal Health Livestock producers currently face many challenges including maintaining human food safety, maximizing growth and performance and preventing infectious disease. Pre- and probiotics have emerged as an alternative remedy to antibiotics in feed that boost immunity and promote growth. The purpose of this theme will be to review the key industrial applications of administering pre- and probiotics in animals to positively engineer the gut microbiome and promote growth performance. Todd Callaway Assistant Professor Georgia Probiotics, the Microbiome, & a Functional Approach to Future Applications to Improve Food Safety, Animal Health, and Productivity Tim Johnson Associate Professor Minnesota Microbiome-Based Approaches for Probiotic Development in Poultry Production Janet Donaldson Associate Professor and Department Chair Southern Mississippi Probiotics as Alternatives for Antimicrobials & Improving Energy Availability Deborah Thompson Director, Partnerships NC State The Animal Food & Nutrition Consortium: A Partnership Portal to Accessing the Latest in Animal Food & Nutrition Intel

5 The Microbiome Movement - Animal Health 2018 May St.Louis, MO Afternoon Refreshments & Networking End of Day Roundtable Discussions With the size and complexity of harnessing the potential of the microbiome in animal health, there still remains a number of fundamental questions to allow scientific researchers to forge a successful path in demonstrating causality for a number of disease indications. The purpose of this theme will be to address questions in an informal setting to build a better understanding of this explosive field of research. Areas of Discussions Include: The impact of the animal microbiome on the companion animal market Building academic/industry partnerships to accelerate product development Blurring the lines between nutrition and therapeutics, what lies next? Holly Ganz AnimalBiome Michael Kogut Lead Scientist/ Microbiologist USDA-ARS Bill Weldon COO Ascus Biosciences Chair s Closing Remarks End of Conference Day One & Evening Drinks Reception Hosted by The Microbiome Movement It is one of the best meetings I ve been to! Great Job! Yanjiao Zhou, Scientist, The Jackson Laboratory, Previous Speaker & Attendee, Microbiome Gut-Brain Axis Summit, San Francisco 2017

6 CONFERENCE DAY TWO THURSDAY, 24 MAY 2018 Building a Discovery Therapeutics Platform to Identify Novel Targets Despite the current focus on probiotics in animal feed, advanced translational microbiome research could also lead to a new category of animal pharmaceuticals, which represents an exciting market opportunity. Many emerging biotech organizations are beginning to leverage the power of emerging technologies to identify, culture and develop new bacterial strains and generate a scientific foundation to create breakthrough therapeutics. The purpose of this theme will be to outline cutting edge organizations who are investigating the animal microbiome to develop breakthrough therapeutics Registration & Morning Coffee 8.50 Chair s Opening Remarks Christopher Belnap Resilient Biotics 9.00 Novel Therapeutic Discovery in Animal Health 9.30 From Microbiome to Medicine: A New Innovation Platform, Dedicated to Animal Health Christopher Belnap Resilient Biotics Nathan McNulty Vice President of Matatu Scott Carter Director, Business Development Baylor College of Medicine 9.50 Panel Discussion: Product Development & Registration of Live Bio Therapeutics in Animal Health Morning Refrements & Networking Navigating Regulatory Uncertainty A Hurdle to Successful Application of the Microbiome With regulatory pressures on the use of antibiotic growth promoters increasing in the US, many organizations are looking to find a new process to go from exploratory studies in the animal microbiome to a fully marketed product. With a number of successful case studies in pre- and probiotics, the purpose of this theme will be to review current regulatory thinking on natural strategies built around modulation of the animal microbiome that prevent disease. John Gregg BalinBac Therapeutics A History of Regulating Animal Health Products: Adapting Effectively for the Microbiome

7 The Microbiome Movement - Animal Health 2018 May St.Louis, MO Patentability of the Animal Microbiome With several promising efforts to manipulate microbial communities within animal health, there has been a significant increase in the need for clear and effective intellectual property protection. Though a number of microbiome-focused organizations have built significant patent portfolios to protect product development, the purpose of this theme will be to review the main concerns and strategies in patent law when dealing with microbiome-based products. Megan Lyman Director, IP, Regulatory and Product Development AgTech Acclerator How to Harness Novel Microbiome Opportunities & Build a Robust IP Strategy Lunch & Networking Managing Uncertainty & Creating a Long Term Strategy Within the Companion Animal Microbiome With market confidence of the microbiome still hinging on a handful of key human therapeutic applications, there are still huge scientific and product development challenges that need to be met before the microbiome becomes part of preventing disease in animal health. Given the current focus on the livestock market, the purpose of this concluding theme will be to review the current research and commercial efforts in studying the companion animal microbiome for future product development. Jeff Brockman Principal Scientist Hills Pet Nutrition Host-Microbiome Interactions: Influencing the Function of the Dog Microbiome Through Nutiriton to Impact Health and Behaviour Holly Ganz AnimalBiome Mining Microbiome Data to Create Better Diagnostics to Identify and Manage Chronic Health Conditions in Companion Animals Aaron Ericsson Director MU Metagenomics Center Missouri Potential Prophylactic and Therapeutic Probiotics in Companion Animals Chair s Closing Remarks Close of inaugural Microbiome Movement - Animal Health 2018

8 The Microbiome Movement - Animal Health 2018 May St.Louis, MO PROUD TO PARTNER WITH Founding Partner Accelerate and transform your research across the entire project lifecycle and capitalize on the diverse opportunities of the microbome. Diversigen provides comprehensive microbiome, metagenomics, host genetic services, customized study design, and complex data analysis - all focused on solutions to improve human and animal health, environmental conditions, and agriculture production worldwide. Building on the research conducted at the Alkek Center for Metagenomics and Microbiome at Baylor College of Medicine, the company has established a reputation for expertise, quality, and customer focus. Diversigen is platform agnostic and provides flexible sequencing, advanced bioinformatics, and the capacity to handle difficult sample types. Innovation Partner Loop Genomics is a DNA sequencing company with a vision to provide products that deliver the most complete and accurate Agbio microbiome data. Loop technology meets the critical need for highresolution phylogenetic data using long-read sequencing and single molecule abundance quantification, with an innovative approach that transforms existing shortread sequencing machines. Our long-read single-molecule microbiome sequencing products enable Agbio R&D pipelines to discover previously inaccessible metagenomics information at unprecedented scale, while leveraging their existing sequencing systems and workflows. MICROBIOME Exhibition Partner Microbiome Insights provides state-of the art microbiome analysis and bioinformatics. Our end-to-end service starts from experimental design and sample collection to data analysis and bioinformatics interpretation. Microbiome Insights is focused on providing our clients with a deeper understanding of functions and interactions of microbial communities across a range of human, animal, agricultural and environmental research applications. Our team of experts and testing methods combine to provide fast, dependable, cost-effective results with highly comprehensive, publication quality bioinformatics.