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1 BIOPAC Systems, Inc

2 How to get High Quality Brain Imaging Data Alex Dimov BIOPAC Systems, Inc. Hasan Ayaz, PhD Associate Research Professor, Drexel University BIOPAC Systems, Inc

3 Housekeeping Attendees are on Mute Headset is Recommended! Questions addressed at end of Webinar and in a Q&A follow-up document Open and hide your control panel Join audio: Your Participation Choose Mic & Speakers to use VoIP Choose Telephone and dial using the information provided Submit questions and comments via the Questions panel Note: Today s presentation is being recorded and will be provided when available. BIOPAC Systems, Inc

4 Our Agenda Today Principles of Optical Brain Imaging Experiment Setup and Data Acquisition Signal Processing and Data Analysis BIOPAC Systems, Inc

5 Principles of Optical Brain Imaging Hasan Ayaz, PhD Associate Research Professor, Drexel University BIOPAC Systems, Inc

6 Functional Near-Infrared Monitor [fnir] >> Cortical activation-related to hemodynamic changes in natural environments and diverse field conditions Brain Activity Monitor BIOPAC Systems, Inc

7 Brain Activity Monitor Functional Near-Infrared Monitor [fnir] >> Cortical activation-related to hemodynamic changes in natural environments and diverse field conditions BIOPAC Systems, Inc

8 Physiological Principles of fnir: Neural Activity & Hemodynamic Response Neurons consume energy (glucose) when activated Oxygen is required to metabolize the glucose As clusters of neurons are activated, there is an increased need for oxygen in that area Oxygen is transported to neural tissue via oxyhemoglobin in the blood The oxygen exchange occurs in the capillary beds As oxy-hemoglobin gives up oxygen to the neural tissue, it is transformed into deoxygenated hemoglobin David J. Heeger & David Ress. (2002) What does fmri tell us about neuronal activity? Nature Reviews Neuroscience 3, Oxy-Hb and deoxy-hb are correlates of brain activity through oxygen consumption by neurons BIOPAC Systems, Inc

9 Physical Principles of fnir: Photon Migration in Tissue BIOPAC Systems, Inc

10 fnir Instrumentation Modern Portable System (Desktop) 2015 BIOPAC Systems, Inc

11 fnir Instrumentation Modern Portable System (Desktop) 2015 Select References McKendrick, R., Ayaz, H., Olmstead, R., & Parasuraman, R. (2014). Enhancing dual-task performance with verbal and spatial working memory training: Continuous monitoring of cerebral hemodynamics with NIRS. Neuroimage, 85, Part 3(0), Ayaz, H., Onaral, B., Izzetoglu, K., Shewokis, P. A., McKendrick, R., & Parasuraman, R. (2013). Continuous monitoring of brain dynamics with functional near infrared spectroscopy as a tool for neuroergonomic research: Empirical examples and a technological development. Frontiers in Human Neuroscience, 7,, Ayaz, H., Shewokis, P. A., Bunce, S., Izzetoglu, K., Willems, B., & Onaral, B. (2012). Optical brain monitoring for operator training and mental workload assessment. Neuroimage, 59(1), BIOPAC Systems, Inc

12 fnir Instrumentation Mini Wireless system (Pocket) Cell-phone sized, Battery operated, Fast-setup/no gel required Suitable for field applications BIOPAC Systems, Inc

13 fnir Instrumentation Mini Wireless system (Pocket) Cell-phone sized, Battery operated, Fast-setup/no gel required Suitable for field applications Select References Mckendrick, R., Parasuraman, R., Murtza, R., Formwalt, A., Baccus, W., Paczynski, M., & Ayaz, H. (2016). Into The Wild: Neuroergonomic Differentiation of Hand-Held and Augmented Reality Wearable Displays During Outdoor Navigation with Functional Near Infrared Spectroscopy. Frontiers in Human Neuroscience, 10. McKendrick, R., Parasuraman, R., & Ayaz, H. (2015). Wearable functional Near Infrared Spectroscopy (fnirs) and transcranial Direct Current Stimulation (tdcs): Expanding Vistas for Neurocognitive Augmentation. Frontiers in Systems Neuroscience, 9(27). Ayaz, H., Onaral, B., Izzetoglu, K., Shewokis, P. A., McKendrick, R., & Parasuraman, R. (2013). Continuous monitoring of brain dynamics with functional near infrared spectroscopy as a tool for neuroergonomic research: Empirical examples and a technological development. Frontiers in Human Neuroscience, 7, BIOPAC Systems, Inc

14 fnir Signal Processing Raw fnir signals are light intensity values at detectors The physiologically irrelevant data (such as respiration and heart pulsation effects) and equipment noise, etc. are first eliminated from the raw fnir measurements Saturation, motion artifact and other noise needs to be eliminated (or excluded from analysis Ayaz, H., Shewokis, P. A., Curtin, A., Izzetoglu, M., Izzetoglu, K., & Onaral, B. (2011). Using MazeSuite and Functional Near Infrared Spectroscopy to Study Learning in Spatial Navigation. J Vis Exp(56), e3443. doi: /3443 BIOPAC Systems, Inc

15 fnir Signal Processing Motion Artifact Detection & Removal Low-pass / Band-pass Filters Wavelet Analysis Independent Component Analysis (ICA) Principle Component Analysis (PCA) Coefficient of Variance related (SMAR, etc.) Optimal Filtering (Adaptive; Wiener; Kalman) BIOPAC Systems, Inc

16 fnir Signal Processing Motion Artifact Detection & Removal Low-pass / Band-pass Filters Wavelet Analysis Independent Component Analysis (ICA) Principle Component Analysis (PCA) Coefficient of Variance related (SMAR, etc.) Optimal Filtering (Adaptive; Wiener; Kalman) BIOPAC Systems, Inc

17 Experiment Setup and Data Acquisition: Alex Dimov BIOPAC Systems, Inc. BIOPAC Systems, Inc

18 Signal Processing and Data Analysis: Hasan Ayaz, PhD Associate Research Professor, Drexel University BIOPAC Systems, Inc

19 How to get High Quality Brain Imaging Data For more information: -Information on fnir systems -Other BIOPAC webinars Thank you for your time and attention! BIOPAC Systems, Inc