Professional Air Purification

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1 Professional Air Purification

2 OUR MISSION We protect people, processes and the environment by producing clean air.

3 WE WORK WITH Hospitals and laboratories Indoor Air Quality Industry

4 HOSPITALS Protection of immunocompromised patients Prevention of transmission of infectious airborne pathogens Improvement of hospital hygiene in critical areas Renovation projects

5 Environmental INFECTION CONTROL against AIRBORNE PATHOGENS Haematology/oncology BMT Organ transplantation Operative units Patient isolation Burn units Renovation projects

6 HOSPITAL ISOLATION ROOMS

7 LABORATORIES / CLEANROOMS Prevention of process and product contamination Clean room quality improvement (ISO / ACH target) Protection of people from process emissions

8 INDOOR AIR QUALITY First-aid for Sick Building Syndrome Prevention of adverse health effects of air pollution Improvement of cognitive performance and work efficiency

9 INDUSTRY Minimizing and isolating process emissions (e.g. metal workshops) Process quality and protection of people GENANO SOLUTIONS

10 GENANO TECHNOLOGY A Finnish innovation for air purification Developed in collaboration with universities and research centers Is based on a powerful electric field within the unit does not use filters

11 PURIFICATION WITHOUT FILTERS Special 3-layer active carbon collector removes VOC gases and odours. Particles are charged negatively in powerful corona discharges. The negatively charged particles are attached to the positive collection surface. Contaminated air is led inside the unit Outcoming ultrapure air is free from microbes, particles and gaseous substances.

12 ADVANTAGES 1 Catches particles down to nanosize 2 Eliminates microbes they do not stay alive inside the unit 3 Removes gases and odours

13 COCKTAIL OF AIR IMPURITIES Fine particles Pollen Ultrafine particles Mould Synthetic fibers Bacterias Fungi VOC gases Viruses Fine dust

14 HEALTH ISSUES Large particles are mostly captured by mucous membranes of nose and throat Inhalable particles < 10 µm (called PM 10 ) can enter the lungs Fine particles < 2,5 µm (called PM 2.5 ) can penetrate into alveoles Ultrafine particles < 0,1 µm (100 nm) can be absorbed directly into bloodstream and are the most dangerous ones, according to WHO

15 Genano air purifiers have been tested with these microorganisms

16 Genano Active Carbon Filter effectively removes VOCs and odours

17 STUDIES ON GENANO AIR PURIFIERS Cleanroom classification / ASTQ, Finland Customer evaluation / Rawalpindi, Pakistan High-risk hospital room investigation / Istanbul Kinetics of microbiol. decont. / LNE, France

18 MOBILE INSTALLATION Continuous nanoscale purification of the room air Enhancing the room ventilation

19 FIXED WALL MOUNT INSTALLATION Continuous nanoscale purification of the room air Enhancing the room ventilation

20 POSITIVE PRESSURE INSTALLATION Enhancing positive pressurization when needed Creating positive pressurization Securing quality of the supply air

21 NEGATIVE PRESSURE INSTALLATION Enhancing negative pressurization when needed Creating negative pressurization Preventing airborne viruses from entering other premises

22 GENANO REFERENCE CASE: MANNHEIM UNIVERSITÄTSKLINIKUM GERMANY The clinical Radiopharmacy deparment in Mannheim Universitätsklinikum needed to reduce the number of particles in the production process according to Good Manufacturing Practice (GMP) guidelines. When Genano 5250 air purifier was installed in the laboratory, purification level of ISO class 7 and a significantly lower deviation of the GMP limits was achieved. We achieved much better results than we had to achieve following GMP. Prof. Björn Wängler

23 GENANO REFERENCE CASE: COPERNICUS LODZ POLAND Genano has delivered a total of over 150 air purifiers to Polish hospitals responsible for hematology and oncology They are used to protect immunosuppressed patients after bone marrow transplantation We have seen the effect of Genano in practice and we are very happy. Without them there would be very high risk of infections for the patients. Head Nurse of Hematology District Katarzyna Stępień, Provincial Specialist Hospital Copernicus, Lodz

24 GENANO REFERENCE CASE: UZ LEUVEN BELGIA UZ Leuven, Belgium s largest hospital & first to get JCI accreditation Genano is used to protect patients in critical condition, to prevent spreading of diseases and in IVF laboratories. Routine measurements show that Genano performs very well We do see a difference when Genano is in the room or not. Head Nurse Carine Breunig, Abdominal Transplant Surgery and Coordination Unit and the Nephrology Unit

25 GENANO REFERENCE CASE: BUILDING MERS ISOLATION ROOMS IN SAUDI When the MERS epidemic struck Saudi Arabia, hospitals were not ready for the amount of patients that needed isolation Existing rooms which utilized HEPA were not functioning as expected With the help of Genano air decontamination units, Saudi Arabian hospitals have been able to treat patients safely and without the risk of additional virus infections After these experiences, the Saudi Arabian Ministry of Health has given an official recommendation for using Genano units in hospitals.

26 Are you aware of HAI? Healthcare-associated infections (HAI) are a huge cost for health care systems worldwide. Of every 100 hospitalized patients, 7 in developed and 10 in developing countries will acquire at least one healthcare-associated infection (WHO). In Europe alone: 16 million extra hospital days and unnecessary deaths/year Current fiber filter (HEPA) based systems are not sufficient in preventing airborne transmission of infectious agents.

27 ISOLATION ROOM CHARACTERTICS Specialized application of a hospital s HVAC system The control is achieved by adjusting the pressure differential between supply and exhaust air % pressure difference between supply and exhaust air Differential pressure with respect to an adjacent space, usually the hallway or an anteroom Ideally the pressure difference should be 8 Pa Continuous pressurization monitoring required - the most efficient way to measure, monitor, and alarm on room pressure conditions is using a monitor that can support two rooms The isolation rooms must be practically air tight (ACH 6-12) You may be able to feel air being sucked into the room or air blowing out of the room under a closed door Practical tests may be performed by using paper or smoke

28 Immunodeficiencies by affected component Affected component Cause Main pathogens of infections Neutropenia (Neutrophil granulocytes) T cell deficiency (T lymphocite) B cell deficiency (B lymphocite, plasma cell) Chemotherapy Bone marrow transplantation Chronic granulomatous disease Marrow / organ transplantation AIDS Cancer chemotherapy Lymphoma Primary humoral Multiple myeloma Chronic lymphoid leukemia AIDS Enterobacteriaceae Oral Streptococci Pseudomonas aeruginosa Aspergillus species Enterococcus species Candida species Intracellular pathogens Mycobacterium Fungal infections Streptococcus pneumoniae Haemophilus influenzae Pneumocystis jirovecii Giardia intestinalis (water)

29 Immunodeficiencies by affected component Affected component Cause Main pathogens of infections Asplenia (Spleen) Complement deficiency (Complement system) Splenectomy Trauma Sickle-cell anemia Streptococcus pneumoniae Haemophilus influenzae Neisseria meningitidis Plasmodium species Babesia species Congenital deficiencies Neisseria species Streptococcus pneumoniae Immunosuppression is a reduction of the activation or efficacy of the immune system A person who is undergoing immunosuppression is said to be immunocompromised

30 GENANO TUBE XS IN TONGEREN ONCOLOGY DAY HOSPITAL One Tube XS unit in small pt rooms Two Tube XS units in large pt rooms Control box placed in bathroom Tube XS in small room with all chemotherapy waste bags & containers causing severe issues for caregivers and other hospital staff Hospital hygiene made an internal comparison between several air purifiers Genano Tube XS superiored the hospital driven tests for air purification