Chen, Hsien-Yeh ( 陳賢燁 ) Associate Professor. Ph.D. in Chemical Engineering. Research and Professional Interests. Journal Papers

Transcription

1 Chen, Hsien-Yeh ( 陳賢燁 ) Associate Professor B.S. in Chemical Engineering National Taiwan University, 1999 M.S. in Chemical Engineering University of Michigan, 2004 Ph.D. in Chemical Engineering University of Michigan, 2008 Research and Professional Interests Biointerface Engineering CVD Polymerization Process Biomolecular Engineering Biomaterials Bio-/Medical Device Development Journal Papers 1. Tsung-Yen Tsou, Hsien-Yeh Chen, Chih-Chen Hsieh* Bihydrogel particles as free-standing mechanical ph microsensors, Applied Physics Letters, 102(3), (2013). 2. Hsien-Yeh Chen,* Ting-Ju Lin, Meng-Yu Tsai, Chiao-Tzu Su, Ruei-Hung Yuan, Chih-Chen Hsieh, Yao-Jhen Yang, Cheng-Che Hsu, Hao-Ming Hsiao, and Yin-Chu Hsua Vapor-Based Tri-Functional Coatings, Chemical Communications, 49, (2013). 3. Hao-Ming Hsiao,* Chien-Han Lin, Ying-Chih Liao, Hsien-Yeh Chen and Tzu-Wei Wang Hemodynamic Behavior of Coronary Stents in Straight and Curved Arteries, Current Nanoscience, 7, (2013). 4. Chiao-Tzu Su, Ruei-Hung Yuan, Yung-Chih Chen, Ting-Ju Lin, Hsiu-Wen Chien, Chih-Chen Hsieh, Wei-Bor Tsai, Chih-Hao Chang, Hsien-Yeh Chen*. A Facile Approach toward Protein-Resistant Biointerfaces Based on Photodefinable Poly-p-xylylene Coating, Colloids and Surfaces B: Biointerfaces, 116, (2013). 5. Meng-Yu Tsai, Yung-Chih Chen, Ting-Ju Lin, Yin-Chu Hsu, Ching-Yu Lin, Ruei-Hung Yuan, Jiashing Yu, Ming-Sheng Teng, Michael Hirtz, Mark Hung-Chih Chen, Chih-Hao Chang, Hsien-Yeh Chen*. Vapor-Based Multicomponent Coatings for Antifouling and Biofunctional Synergic Modifications, Advanced Functional Materials, 24, (2013). 6. Yao-Jhen Yang, Meng-Yu Tsai, Wei-Chieh Liang, Hsien-Yeh Chen, and Cheng- Che Hsu*. Ultra-low-cost and flexible paper-based microplasma generation devices for maskless patterning of poly(ethylene oxide)-like films, ACS Applied Materials & Interfaces, 6, (2014). 7. Ho-Yi Sun, Cheng-Yuan Fang, Ting-Ju Lin, Yung-Chih Chen, Chih-Yeh Lin, Hsin-Ying Ho, M. H.-C. Chen, Jiashing Yu, Dai-Jen Lee, Chih-Hao Chang, and Hsien-Yeh Chen* Thiol-Reactive Parylenes as a Robust Coating for Biomedical Materials, Advanced Materials Interfaces, 1, (2014). 8. Chih-Hao Chang, Shu-Yun Yeh, Bing-Heng Lee, Che-Wei Hsu, Yung-Chih Chen, Chia-Jie Chen, Ting-Ju Lin, Mark Hung-Chih Chen, Ching-Tsan Huang, and Hsien-Yeh Chen*. Compatibility balanced antibacterial modification based on

2 vapor-deposited parylene coatings for biomaterials, Journal of Materials Chemistry B, 2, (2014). 9. Hsiu-Wen Chien, Ming-Chun Keng, Meng-Jiy Wang, Hsien-Yeh Chen, Sheng- Tung Huang, and Wei-Bor Tsai Conjugation of Monocarboxybetaine Molecules on Amino-Poly-p-xylylene Films to Reduce Protein Adsorption and Cell Adhesion, Langmuir, 30, (2014). 10. Yung-Chih Chen, Ting-Pi Sun, Chiao-Tzu Su, Jyun-Ting Wu, Chih-Yeh Lin, Jiashing Yu, Chao-Wei Huang, Chia-Jie Chen, and Hsien-Yeh Chen* Sustained Immobilization of Growth Factor Proteins Based on Functionalized Parylenes, ACS Applied Materials & Interfaces, 6, (2014). 11. Zhen-Yu Guan; Chih-Yu Wu; Yi-Jye Li; Hsien-Yeh Chen* ACS Applied Materials & Interfaces, 7, (2015). 12. Jyun-Ting Wu; Ting-Pi Sun; Chao-Wei Huang; Chiao-Tzu Su; Chih-Yu Wu; Shu-Yun Yeh; Deng-Kai Yang; Lin-Chi Chen; Shih-Torng Ding; Hsien-Yeh Chen* Biomaterials Science 2015, 3, 1266 (2015). 13. Jyun-Ting Wu; Chih-Yu Wu; Shih-Kang Fan; Chih-Chen Hsieh; Yu-Chih Hou; Hsien-Yeh Chen* Chemistry of Materials, 27, 7028 (2015). 14. Ruei-Hung Yuan; Yi-Jye Li; Ho-Yi Sun; Chih-Yu Wu; Zhen-Yu Guan; Hsin-Ying Ho; Cheng-Yuan Fang; Hsien-Yeh Chen* Colloids and Surfaces B: Biointerfaces, 139, 259 (2015). 15. Hsiu-Wen Chien, Ming-Chun Keng, Hsien-Yeh Chen*, Sheng-Tung Huang and Wei-Bor Tsai. Conjugation of mono-sulfobetaine to alkyne-ppx films via click reaction to reduce cell adhesion, Biomaterials and Biomechanics in Bioengineering, 3, (2015) 16. Ting-Pi Sun, Ching-Heng Tai, Jyun-Ting Wu, Chih-Yu Wu, Wei-Chieh Liang and Hsien-Yeh Chen*. Multifaceted and route-controlled "click" reactions based on vapor-deposited coatings, Biomaterials Science, 4, (2016). (SCI, EI) 17. Zhen-Yu Guan, Chih-Yu Wu, Jyun-Ting Wu, Ching-Heng Tai, Jiashing Yu and Hsien-Yeh Chen*. Multifunctional and Continuous Gradients of Biointerfaces Based on Dual Reverse Click Reactions, ACS Applied Materials & Interfaces, 8, (2016). 18. Chih-Yu Wu, Chao-Wei Huang, Zhen-Yu Guan, Jyun-Ting Wu, Shu-Yun Yeh, Chiao-Tzu Su, Chih-Hao Chang, Shih-Torng Ding and Hsien-Yeh Chen*. Vapor-based coatings for antibacterial and osteogenic functionalization and the immunological compatibility, Materials Science and Engineering C, 69, (2016). 19. Chih-Yu Wu, Ho-Yi Sun, Wei-Chieh Liang, Hung-Lun Hsu, Hsin-Ying Ho, Yu-Ming Chen and Hsien-Yeh Chen*. Electrically charged selectivity of poly-para-xylylene deposition, Chemical Communications, 52, (2016). 20. Ya-Ting Tsai, Chao-Wei Huang, Hui-Yu Liu, Mei-Ching Huang, Ting-Pi Sun, Wen-Chien Chen,* Chih-Yu Wu, Shih-Torng Ding and Hsien-Yeh Chen*. Enhanced Bone Morphogenic Property of Parylene-C, Biomaterials Science, 4, (2016)

3 21. Zhen-Yu Guan, Chao-Wei Huang, Mei-Ching Huang, Chih-Yu Wu, Hui-Yu Liu, Shih-Torng Ding and Hsien-Yeh Chen*. Controlling Multi-Function of Biomaterials Interfaces Based on Multiple and Competing Adsorption of Functional Proteins, Colloids and Surfaces B: Biointerfaces, 149, (2017). 22. Ruei-Hung Yuan, Chih-Yu Wu, Hsing-Ying Tung, Hung-Pin Hsieh, Yi-Jye Li, Yu-Chih Chiang and Hsien-Yeh Chen*. Multifunctional Surface Modification: Facile and Flexible Reactivity toward a Precisely Controlled Biointerface, Macromolecular Bioscience, 17, (2017) 23. Hsing-Ying Tung, Ting-Pi Sun, Ho-Yi Sun, Zhen-Yu Guan, Shu-Kai Hu, Ling Chao, Hsien-Yeh Chen*. Construction and Control of 3D Porous Structure Based on Vapor Deposition on Sublimation Solids Applied Materials Today, 7, (2017). 24. Chih-Yu Wu, Hui-Yu Liu, Chao-Wei Huang, Shu-Yun Yeh, Nai-Chen Cheng, Shih-Torng Ding, Hsien-Yeh Chen*. Synergistically Controlled Stemness and Multilineage Differentiation Capacity of Stem Cells on Multifunctional Biointerfaces, Advanced Materials Interfaces, (2017). 25. Chih-Yu Wu, Chun-Wei Chang, Ruei-Hung Yuan, Yu-Chih Chiang, Jiun-Tai Chen, Dun-Yen Kang, Hsien-Yeh Chen*. Multifunctional Nanoparticles with Controllable Dimensions and Tripled Orthogonal Reactivity, Nanoscale, 9, (2017). 26. Ya-Ting Tsai, Chih-Yu Wu, Zhen-Yu Guan, Ho-Yi Sun, Nai-Chen Cheng, Shu- Yun Yeh, Hsien-Yeh Chen*. Topologically Controlled Cell Differentiation Based on Vapor-Deposited Polymer Coatings, Langmuir, 33, (2017). 27. Chao-Wen Chang, Zhen-Yu Guan, Ming-Yang Kan, Li-Wei Lee, Hsien-Yeh Chen*, Dun-Yen Kang*, Vapor-Phase Synthesis of Poly(p-xylylene) Membranes for Gas Separations, Journal of Membrane Science, 539, (2017). 28. Zhen-Yu Guan, Chih-Yu Wu, Hsien-Yeh Chen*. Stepwise and Programmable Cell Differentiation Pathways of Controlled Functional Biointerfaces, ACS Biomaterials Science & Engineering, 3, (2017). 29. Hsien-Yeh Chen*, Micro- and Nano-Surface Structures Based on Vapor-Deposited Polymers, Beilstein Journal of Nanotechnology, 8, (2017). Conference Papers 1. Zhen-Yu Guan*, Hsien-Yeh Chen, "Displaceable Biointerface Properties by Using Disulfide-Functionalized Poly-p-xylylene Coating", 中華民國界面科學學會年會, 台北, Chih-Yu Wu*, Hsien-Yeh Chen, "Tunable Surface Densities of Immobilized Biomolecules for Advanced Biomaterials Design", 中華民國界面科學學會年會, 台北, Zhen-Yu Guan*, Hsien-Yeh Chen, "Displaceable Biointerface Properties by Using Disulfide-Functionalized Poly-p-xylylene Coating", 中國材料科學學會年會, 新竹, Chih-Yu Wu*, Hsien-Yeh Chen, "Tunable Surface Densities of Immobilized

4 Biomolecules for Advanced Biomaterials Design", 中國材料科學學會年會, 新竹, Ya-Ting Tsai*, Hsien-Yeh Chen, Enhanced Bone Morphogenic Property of Parylene-C, 台灣化學工程年會, 桃園, Zhen-Yu Guan*, Hsien-Yeh Chen, "Displaceable Biointerface Properties by Using Disulfide-Functionalized Poly-p-xylylene Coating", 中國機械工程學會 105 年度年會暨第 33 屆全國學術研討會, 新竹, Chih-Yu Wu*, Hsien-Yeh Chen, "Tunable Surface Densities of Immobilized Biomolecules for Advanced Biomaterials Design", 中國機械工程學會 105 年度年會暨第 33 屆全國學術研討會, 新竹, Chih-Yu Wu, Ho-Yi Sun*, Wei-Chieh Liang, Hung-Lun Hsu, Hsin-Ying Ho, Yu-Ming Chen, and Hsien-Yeh Chen, Electrically-Induced Selectivity of Functional Poly-p-xylylenes Deposition, 251st American Chemical Society National Meeting & Exposition, San Diego, CA, USA, Zhen-Yu Guan*, Hsien-Yeh Chen, "Displaceable Biointerface Properties by Using Disulfide-Functionalized Poly-p-xylylene Coating", International Conference on Advances in Functional Materials, Jeju Island, South Korea, Chih-Yu Wu*, Hsien-Yeh Chen, "Tunable Surface Densities of Immobilized Biomolecules for Advanced Biomaterials Design", International Conference on Advances in Functional Materials, Jeju Island, South Korea, Hsing-Ying Tung*, Hsien-Yeh Chen, "Construction and control of 3D porous structure based on vapor deposition onsublimation solids", The 7th Asian Conference on Colloid and Interface Science, Kuala Lumpur, Malaysia, Zhen-Yu Guan, Hsien-Yeh Chen, "Directional Gradients of Biointerfaces Based on Dual Reverse Click Reactions", 2017 MRS Fall Meeting, Boston, MA, USA Shih-Ting Chen, Hsien-Yeh Chen, "Fabrication of Functional Nanostuctured Surfaces based on Selective Vapor Deposition", 2017 MRS Fall Meeting, Boston, MA, USA Hsing-Ying Tung*, Hsien-Yeh Chen, "Construction and control of 3D porous structure based on vapor deposition on sublimation solids", 13th International Conference on Materials Chemistry, Liverpool, United Kingdom, 2017 Patents 1. Joerg Lahann, Hsien-Yeh Chen. Reactive Coatings for Regioselective Surface Modification U.S. Patent (2011), US B2. 2. Joerg Lahann, Himabindu Nandivada, Hsien-Yeh Chen. Dry Adhesion Bonding U.S. Patent (2011), US B2. 3. 陳賢燁 林庭如 蔡孟諭 多官能基聚合物組成及其合成方法 中華民國專利 (2015), 發明第 I 號

5 4. 陳賢燁 黄聲東 蔡孟諭. 基材上的聚合物組成及表面改質方法, 中華民國發明專利, (2015), I Hsien-Yeh Chen, Sheng-Tung Huang, Meng-Yu Tsai Polymer Composition on Substrate and Surface Modification Method, U.S. Patent (2015), US B2. 6. 陳賢燁 范士岡 吳軍霆. 眼内レンズ及びその製造方法, 日本發明專利, (2015), JP 陳賢燁 官振禹. 位在基材上的化學膜及其形成方法, 製作具有雙硫鍵官能基的對環芬的方法, 中華民國發明專利, (2016), Honors and Others 1. 指導學生蘇巧慈 陳勇智同學參加 2013 年生物醫學工程科技研討會暨國科會醫學工程學門成果發表會榮獲論文海報獎項 2. 指導學生吳軍霆同學參加 2014 年中華民國高分子學會年會海報展示競賽榮獲優勝獎 3. 多功能生物界面的研究成果刊登於國際期刊 Advanced Functional Materials 並且榮獲該期刊登於該雜誌內頁封面 4. 抗菌生醫鍍膜的研究成果刊登於國際期刊 Journal of Materials Chemistry B 並且榮獲該期刊登於該雜誌封底封面 5. 抗刮耐磨之生醫鍍膜技術的研究成果刊登於國際期刊 Advanced Materials Interfaces 並且榮獲該期刊登於該雜誌內頁封面. 6. 與謝之真教授合作開發全球首創的新型人工水晶體登上美國化學學會知名材料期刊 Chemistry of Materials 7. Enhanced Bone Morphogenic Property of Parylene-C 研究成果刊登於國際期刊 Biomaterials Science (RSC) 並且榮獲該期刊登於該雜誌內頁封面 8. 指導學生官振禹同學參加 2016 年中華民國高分子學會年會, 獲得口頭競賽佳作 9. 指導學生官振禹同學參加 2016 年中華民國界面科學學會年會, 獲得海報競賽佳作獎 10. 指導學生官振禹同學參加 2016 年中國材料科學學會年會, 獲得海報論文優等獎 第 13 屆國家新創獎 - 可調控光學特性及生物功能之人工水晶體 科技部 - 吳大猷先生紀念獎 李長榮福聚教育基金會 - 傑出教授獎