Seung Woo Lee, Ph. D 11/21/2018

Transcription

1 CURRENT POSITION Seung Woo Lee, Ph. D 11/21/2018 CONTACT INFORMATION Assistant Professor Lee.Seungwoo@mgh.harvard.edu Department of Neurosurgery, Phone: Harvard Medical School, Massachusetts General Hospital. RESEARCH INTERESTS Neural Engineering, Brain-Computer-Interface (Read & Write), Neural Prosthesis (Bionic Eye & Ear), Implantable Electronics, Flexible Electronics, Micro-Electrode-Array (MEA), Micro-Coil-Array (MCA), Microfabrication, Laser Micro-Machining, Implantable System Package (Metal, Ceramic, Polymer), Micro-Magnetic Stimulation (FEM simulation & Animal Experiments), Neural Signal Recording & Imaging, Deep Brain Stimulation (DBS). EDUCATION Seoul National University, Seoul, Korea Ph.D. Electrical Engineering Aug Seoul National University, Seoul, Korea B.S. Electrical Engineering Feb RESEARCH EXPERIENCE Harvard Medical School, Boston, MA, USA Massachusetts General Hospital, Boston, MA, USA Assistant Professor in Neurosurgery. Nov ~ present Instructor in Neurosurgery. Nov ~ Oct Theme: Development of Implantable Micro-Coils for Intra-cortical Magnetic Stimulation. Computational modeling of micro-coil designs for high resolution micro-magnetic stimulation of neural circuits in the cortex. Fabrication of micro-coil probe arrays for high resolution neural prosthetic devices. Implementation of micro-coil drive system (wired & wireless coil input signal generator). Demonstration of the feasibility of the fabricated micro-coils using physiological experiments in vitro and in vivo. Single Neuron Recordings: Patch-clamp electrode, Microelectrode Array (MEA). Optical Neural Imaging: Calcium Fluorescence Imaging (e.g. GCaMP6). Optimizing coil input parameters to provide precise control over the neural system. Harvard Medical School, Boston, MA, USA Jan ~ Oct Massachusetts General Hospital, Boston, MA, USA Jan ~ Oct Postdoctoral Fellow in Neurosurgery. (Lab PI: Prof. Shelley Irwin Fried) Theme 1: Development of Microscopic Magnetic Stimulation (µms) of Neural tissues. Development of a micro-magnetic stimulation (μms) that provides MRI-compatible and contact-less control over the neural response. Understanding neuronal responses to µms using in vitro patch clamp recording. Application 1: Artificial Retinal Implant System. Application 2: Deep Brain Stimulation System. 1

2 Application 3: Cortex Stimulation System. Application 4: Artificial Cochlear Implant System. Study on how spatial orientations of the micro-coil alter neural responses. Optimizing coil input parameters to provide precise control over the neural response. Theme 2: Investigation of Pulsatile Sub-Retinal Electric Stimulation. Understanding the retinal ganglion cell responses to sub-retinal pulsatile electric stimulations using in vitro patch clamp recording. Optimizing electric stimulation pulse parameters to provide precise control over the neural response. Theme 3: Investigation of Intra-cortical Electric Stimulation for Visual Prostheses. Understanding the cortical neurons responses to intra-cortical electric stimulations using in vitro patch clamp recording. Optimizing electric stimulation positions and pulse parameters to provide selective control over the different types of cortical neurons. Inter-University Semiconductor Research Center, Seoul, Korea Sep ~ Dec Postdoctoral Fellow. (Lab PI: Prof. Sung June Kim) Theme: Development of a Multi-channel Neural Stimulation System for Artificial Retinal Implant. Development of flexible polymer-based microelectrode arrays for artificial retinal implant using silicone, polyimide and LCP films. Demonstration of long-term reliability of flexible polymer-based multi-layered structures in aqueous environment using blister test and electrical leakage current measurement during in vitro accelerated soak tests. Design and fabrication of wireless retinal stimulator boards. Demonstration of the feasibility of multichannel electrical retinal stimulations using multichannel electrically evoked cortical potentials (EECPs) recording from rabbits visual cortex area. Seoul National University, Seoul, Korea Mar ~ Aug Ph.D. thesis research in Electrical Engineering (Thesis Advisor: Prof. Sung June Kim) Dissertation: Development of Long-term Implantable Neuroprosthetic Devices using Liquid Crystal Polymer (LCP). Development of microelectrode arrays for neural stimulation and recording using LCP. Development of a LCP-based implantable system package. Evaluation of the long-term reliability of the LCP-based encapsulation using blister test and electrical leakage current measurement during in vitro accelerated soak tests. Evaluation of the biocompatibility of the LCP-based neuroprosthetic devices using in vivo animal experiment. BOOK CHAPTERS Lee SW*, Fried SI. Precise and reliable activation of cortex with micro-coils Chapter 3 in Brain- Computer Interface Research: A State-of-the-Art Summary 6 (ISBN ), pp , Christoph Guger, Brendan Allison, Mikhail Lebedev, Eds. Springer Briefs in Electrical and Computer Engineering, Springer, Cham, doi.org/ / _3, Aug. 22, (*Corresponding Author) PATENTS 2

3 Fried SI, Lee SW. Magnetic neural stimulator and method of activation of neural tissue with same registered in United States (Registration#: US 9,993,656 B2), Jun 12, Lee SW, Fried SI. Selective Activation of Cortex using Bent Micro-wires to Magnetically Stimulate Neurons PCT/US17/23605, Mar 22, Kim SJ, Lee SW, Lee CJ, An S. Micro-electrode Array Package using Liquid Crystal Polymer and Manufacturing Method thereof registered in United States (Registration#: US 8,886,277 B2), Nov 11, Fried SI, Lee SW. Magnetic neural stimulator and method of activation of neural tissue with same PCT/US14/40622, Jun 3, Fried SI, Lee SW. Magnetic neural stimulator and method of activation of neural tissue with same published in United States, May 12, (US patent publication#: US 2016/ A1) Lee SW, Bonmassar G, Fried SI. Microscopic magnetic stimulation of neural tissue published in United States, Dec 4, (US patent publication#: US 2014/ A1) Park SI, Chang JW, Kim SJ, Lee SE, Moon H, Shin HC, Kim JW, Lee SW, Kim S, Min K. Liquid Crystal Polymer-based electro-optrode neural interface, and Method for producing same published in United States, Sep 12, (US patent publication#: US 2013/ A1) Park SI, Chang JW, Kim SJ, Lee SE, Moon H, Shin HC, Kim JW, Lee SW, Kim S, Min K. Liquid Crystal Polymer-based electro-optrode neural interface, and Method for producing same PCT/KR2011/007778, Jul 1, Park SI, Chang JW, Kim SJ, Lee SE, Moon H, Shin HC, Kim JW, Lee SW, Kim S, Min K. Liquid Crystal Polymer-based electro-optrode neural interface, and Method for producing same registered in Republic of Korea (Registration#: ), Aug 30, Eom KS, Kim SJ, Jeong JS, Lee SW. Apparatus and System for Wireless Power Transmission Using Dual Transmitter Coils registered in Republic of Korea (Registration#: ), Jan 31, Kim SJ, Lee SW, Lee CJ, An S. Micro-electrode Array Package using Liquid Crystal Polymer and Manufacturing Method thereof PCT/KR2009/004558, Aug 14, Kim SJ, Lee SW, Lee CJ, An S. Micro-electrode Array Package using Liquid Crystal Polymer registered in Republic of Korea (Registration#: ), May 2, Kim SJ, Lee SW, Lee CJ, An S. Micro-electrode Array Package using Liquid Crystal Polymer and Manufacturing Method thereof registered in Republic of Korea (Registration#: ), Nov 25, AWARDS The 10 th World Congress on the Relationship between Neurobiology and Nano-Electronics Focusing on Artificial Vision (2017 The Eye and The Chip), Sep , 2017, Detroit, MI, USA. - Bill and Happy Rands Outstanding Poster Awards Award for Clinical Potential. 6 th Brain-Computer Interface Meeting, May Jun. 3, 2016, Pacific Grove, CA, USA. 3

4 - The Annual BCI Research Award nd Annual Minnesota Neuromodulation Symposium, Apr , 2014, Minneapolis, MN, USA. - Best Poster Award 2nd Place. 2 nd Annual Minnesota Neuromodulation Symposium, Apr , 2014, Minneapolis, MN, USA. - Domestic and International Travel Award. Association for Research in Vision and Ophthalmology (ARVO) 2010 Annual Meeting, May 2-6, 2010, Fort Lauderdale, FL, USA. - International Travel Grant Award. 2 nd International Conference on Neuroprosthetic Devices, Feb , 2010, Beijing, China. - Best Student Paper Award. (Invited to Poster Blitz Oral presentation at the Neural Interfaces Conference (NIC) 2010 in Long Beach, CA, USA) JOURNAL PUBLICATIONS Lee SW, Thyagarajan K, Fried SI. Micro-coil design influences the spatial extent of responses to intracortical magnetic stimulation. IEEE Transactions on Biomedical Engineering, (in print), doi: /tbme , Oct Freeman DK, O Brien JM, Kumar P, Daniels B, Irion RA, Shraytah L, Ingersoll BK, Magyar AP, Czarnecki A, Wheeler J, Coppeta JR, Abban MP, Gatzke R, Fried SI, Lee SW, Duwel AE, Bernstein JJ, Widge AS, Hernandez-Reynoso A, Kanneganti A, Romero-Ortega MI, Cogan SF. A Sub-millimeter, Inductively Powered Neural Stimulator. Frontiers in Neuroscience, Vol. 11, no. 659, doi: /fnins , Nov Lee SW, Fried SI. Enhanced control of cortical pyramidal neurons with micromagnetic stimulation. IEEE Transactions on Neural Systems and Rehabilitation Engineering, Vol. 25, no. 9, pp , Sep Lee SW, Fallegger F, Casse BDF, Fried SI. Implantable microcoils for intracortical magnetic stimulation. Science Advances, Vol. 2, no. 12, e , doi: /sciadv , Dec Featured in IEEE Spectrum, entitled Tiny Implantable "Microcoils" in the Brain Activate Neurons Via Magnetic Fields on Dec 9, Featured as Cover Story in MIT Technology Review, entitled This Technology Could Finally Make Brain Implants Practical on Feb 9, Featured in Popular Science, entitled THE NEXT GENERATION OF BRAIN IMPLANT IS A TEENY TINY COIL: THE MICRO COILS MAKE MIND-CONTROLLED PROSTHETICS EASIER TO USE on Dec 9, Featured in Medical Xpress, entitled Magnetic stimulation may provide more precise, reliable activation of neural circuitry on Dec 9, Featured in News Medical Life Sciences, entitled MGH researchers develop magnetic coils for selective and reliable neural stimulation on Dec 9, Featured in Vocativ, entitled New Magnetic Brain Implants Pave The Way For Our Cyborg Future on Dec 9, Featured in Massachusetts General Hospital News Release, entitled Magnetic stimulation may provide more precise, reliable activation of neural circuitry on Dec 9, Lee SW, Fried SI. Suppression of subthalamic nucleus activity by micromagnetic stimulation. IEEE 4

5 Transactions on Neural Systems and Rehabilitation Engineering, Vol. 23, no. 1, pp , Jan Selected as a featured article in IEEE Transactions on Neural Systems and Rehabilitation Engineering on Jan 6, 2015 Jeong J, Lee SW, Min KS, Kim SJ. A novel multilayered planar coil based on biocompatible liquid crystal polymer for chronic implantation. Sensors and Actuators A: Physical, Vol. 197, no. 1, pp , Aug Lee SW, Eddington DK, Fried SI. Responses to pulsatile subretinal electric stimulation: effects of amplitude and duration. Journal of Neurophysiology, Vol. 109, no. 7, pp , Apr Fang Y, Cho K-S, Tchedre K, Lee SW, Fried SI, Sun X, Chen DF. Ephrin-A3 Suppresses Wnt Signaling to Control Retinal Stem Cell Potency. Stem Cells, Vol. 31, no. 2, pp , Feb Lee SE, Jun SB, Lee HJ, Kim J, Lee SW, Shin HC, Chang JW, Kim SJ. A Flexible Neural Depth Probe using Liquid Crystal Polymer. IEEE Transactions on Biomedical Engineering, Vol. 59, no. 7, pp , Jul Bonmassar G*, Lee SW*, Freeman DK, Polasek M, Fried SI, Gale JT. Microscopic Magnetic Stimulation of Neural Tissue. Nature Communications, 3, article no. 921, doi: /ncomms1914, Jun (*equally contributed to the paper) Featured in press release for Nature Communications, entitled Neuroscience: Magnetising neurons on June 26, Featured in Massachusetts General Hospital News Release, entitled Tiny Magnetic Coils Modulate Neural Activity, May Be Safer for Deep-Brain Implants on June 26, Featured in Science Daily, entitled Tiny Magnetic Coils Modulate Neural Activity, May Be Safer for Deep-Brain Implants on June 26, Featured as Headline news in Scientific American Mind, entitled Stimulating the Brain with Microscopic Magnets on Jan. 31, Bae SH, Che J-H, Jeong J, Kim ET, Lee SW, Koo K-I, Seo J-M, Suaning GJ, Lovell NH, Cho D-ID, Kim SJ, Chung H. In Vitro Biocompatibility of Various Polymers based Microelectrode Arrays for Retinal Prosthesis. Investigative Ophthalmology & Visual Science, Vol. 53, no. 6, pp , May Jeong J, Lee SW, Min K, Shin S, Jun SB, Kim SJ. Liquid Crystal Polymer (LCP), an Attractive Substrate for Retinal Implant. Sensors and Materials, Vol. 24, no. 4, pp , Apr Lee SW, Min K, Jeong J, Kim J, Kim SJ. Monolithic Encapsulation of Implantable Neuroprosthetic Devices Using Liquid Crystal Polymers. IEEE Transactions on Biomedical Engineering, Vol. 58, no. 8, pp , Aug Lee SW, Seo J-M, Ha S, Kim ET, Chung H, Kim SJ. Development of Microelectrode Arrays for Artificial Retinal Implants using Liquid Crystal Polymers. Investigative Ophthalmology & Visual Science, Vol. 50, no. 12, pp , Dec Kim ET, Kim C, Lee SW, Seo J-M, Chung H, Kim SJ. Feasibility of Micro Electrode Array (MEA) Based on Silicone-Polyimide Hybrid for Retina Prosthesis. Investigative Ophthalmology & Visual Science, Vol. 50, no. 9, pp , Sep

6 REVIEWER ACTIVITIES IEEE Transactions on Biomedical Engineering (IEEE-TBME), IEEE Transactions on Neural Systems and Rehabilitation Engineering (IEEE-TNSRE), IEEE/ASME Journal of Microelectromechanical Systems (IEEE-JMEMS-ASME), Investigative Ophthalmology & Visual Science (IOVS), Journal of Sensors and Materials (JSM), Physica Medica: European Journal of Medical Physics (EJMP). RESEARCH SUPPORT DoD Vision Research Program (VRP) 01/01/ /31/2021 Title: A Micro-Coil Based Cortical Visual Prosthesis. Role: Principal Investigator (a site PI) NIH / NEI 1 R01 EY /01/ /31/2023 Title: Optimization of micro-coil arrays for precise stimulation of visual cortex. Role: Principal Investigator NIH / NINDS 1 U01 NS /01/ /31/2019 Title: Micro-coil implants for cortical activation. (PI: Fried) Role: Co-Investigator (Key Person) NIH / NEI 1 R01 EY /01/ /31/2017 Title: HRS targeting of ON and OFF ganglion cells. (PI: Fried) Role: Post-doctoral Scholar NIH / NEI 1 R01 EY /01/ /31/2014 Title: The mechanism by which electric stimulation activates retinal neurons. (PI: Fried) Role: Post-doctoral Scholar ORAL PRESENTATIONS Lee SW, Fried SI. Development of Implantable Microcoils for Precise Activation of Cortex. The 39 th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, International Convention Center, Jeju, South Korea, Jul. 12, Lee SW, Fried SI. Precise Activation of Primary Visual Cortex using Implantable Micro-coils. The 6 th Military Vision Symposium on Ocular & Vision Injury, Schepens Eye Research Institute of Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA, Mar. 30, Lee SW, Kim SJ. Flexible Polymer-based Retinal Prostheses. Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Korea, Jul. 13, (Invited Seminar) Lee SW, Bae SH, Jeong J, Eom KS, Seo J-M, Chung H, Kim SJ. Monolithically Encapsulated Retinal Implant System using Liquid Crystal Polymers. The 39 th Neural Interfaces Conference, Long Beach, CA, USA, Jun , (Invited Poster blitz oral presentation) Lee SW, Kim ET, Jang J, Jeong J, Seo J-M, Chung H, Kim SJ. Flexible Microelectrode Arrays for Retinal Prostheses. The 2 nd International Conference on Neuroprosthetic Devices, Beijing, China, Feb , (Best student paper award) 6

7 POSTER PRESENTATIONS (last 3 years) Fried SI, Lee SW. Towards a microcoil-based cortical visual prosthesis Joint meeting of NYC Neuromodulation Conference & NANS Summer Series, New York, NY, USA, Aug 24-26, Zaeimbashi M, Wang Z, Lee SW, Cash SS, Fried SI, Sun N. Micro-solenoid inductors with magnetic core for neural stimulation. The 40 th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC 18), Honolulu, HI, USA, Jul 17-21, Lee SW, Thyagarajan K, Fried SI. Micro-coil implants for precise and reliable neural prostheses. The 43 rd Neural Interfaces Conference, Minneapolis, MN, USA, Jun 25-27, Fried SI, Raghuram V, Werginz P, Lee SW. The morphological and biophysical properties that underlie sensitivity to electric stimulation. The 43 rd Neural Interfaces Conference, Minneapolis, MN, USA, Jun 25-27, Thyagarajan K, Lee SW, Fried SI. Implantable coils for intra-cortical magnetic stimulation. Gordon Research Conference on Neuroelectric Interfaces, Galveston, TX, USA, Mar , Lee SW, Thyagarajan K, Fried SI. Precise activation of primary visual cortex using implantable micro-coils. TEATC 2017 The 10 th World Congress on the Relationship between Neurobiology and Nano-Electronics Focusing on Artificial Vision, Detroit, MI USA, Sep , Lee SW, Fried SI. Enhanced intra-cortical stimulation with implantable micro-coils. The 5th Annual Minnesota Neuromodulation Symposium, Minneapolis, MN, USA, Apr 13-14, Lee SW, Fried SI. Precise Activation of Primary Visual Cortex using Implantable Micro-coils. The 6 th Military Vision Symposium on Ocular & Vision Injury, Schepens Eye Research Institute of Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA, Mar , Lee SW, Fallegger F, Casse BDF, Fried SI. Magnetic neural interface with intracortical micro-coil probes. TEATC 2016 Biennial International Research Congress on Artificial Vision, Detroit, MI, USA, Sep Fried SI, Lee SW. Selective targeting of cortical neurons with micro-magnetic stimulation. The 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC 16), Orlando, FL, USA, Aug 17-20, Fried SI, Lee SW. Effective cortical activation with implanted microcoils. The 42 nd Neural Interfaces Conference, Baltimore, MD, USA, Jun 25-29, Fried SI, Lee SW. Responses of L5 pyramidal neurons of V1 to electrical stimulation. ARVO 2016 Annual Meeting, Seattle, WA, USA, May Fried SI, Lee SW, Fallegger F, Casse BDF. Micro-Coil Based Activation of Cortex. The 4th Annual Minnesota Neuromodulation Symposium, Minneapolis, MN, USA, Apr 14-15,

8 REFERENCES Dr. Shelley Irwin Fried (Post-doc Advisor) Associate Professor, Department of Neurosurgery, Harvard Medical School, Massachusetts General Hospital; Research Scientist, Boston Retinal Implant Project & VA Boston Healthcare system, Boston, MA, USA. [ ] [Tel] Dr. Sung June Kim (Ph.D. Advisor) Professor, School of Electrical Engineering and Computer Science, Seoul National University, Seoul, Korea. [ ] [Tel] Dr. Jong-Mo Seo (Research Advisor) Associate Professor, Electrical Engineering, Seoul National University, Seoul, Korea. [ ] [Tel]