Final project topics

Transcription

1 Final project topics BIOEN 327 Autumn Mechanical heart valve Clinical relevance: replace failing valves Physiological principles: heart as a pump, blood viscosity, vascular dynamics Engineering principles: Fluid dynamics, including transient flow and laminar/turbulent transition; solid mechanics (static and dynamic) of hard or soft materials; engineering standards.. Engineering tools: Inventor, COMSOL, 3D printing, elastomer molding Demo: Valve in test system (collaborators) 1

2 Heart valve 3 Heart valve Heart Valve Lab Report, Trevor Cronrath, Ellen Nolan, and Menko Ypma BIOEN 327, Section B,

3 Clinical relevance: Ensures prosthetic valves have proper flow properties Physiology: heart as a pump, blood properties, vascular dynamics Engineering principles: Fluid dynamics, especially pumps and flow resistance; instrumentation for pressure & flow measurement; tubular structures; user interfaces; engineering standards. Engineering tools: LabView; circuit test suite. Demo: Test collaborators valves. 8 3

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5 Scaffold for cell culture Clinical relevance: Implantation of engineered tissues, esp. cartilage, bone & cardiac muscle Physiology: cell growth & motility, implant dimensions, biocompatibility & degradation. Engineering principles: Varies by technology. May include fluid dynamics, heat & mass transfer, structural statics, chemical degradation. Engineering tools: Inventor & 3DP, other? Demo: Show fabrication procedure, ideally with product at multiple stages (like cooking show). Prosthetic finger, hand, or flipper Clinical relevance: Replacement for lost digit or hand Physiology: Dimensions and functions of missing part; skin/prosthetic interface; user psychology. Engineering principles: Statics of deformable solids; solid dynamics; capacitive interaction (swipe screen). Engineering tools: 3D modeling; elastomeric casting or machine tools. Demo: Show fabrication procedure, ideally with product at multiple stages (like cooking show). 5

6 Impedance plethysmograph Clinical relevance: a) Chest dynamics for defibrillator; b) Vascular collapse pressure in arms & legs. Physiology: Electrical conduction in tissue; vascular and thoracic compliance; blood pressure. Engineering principles: Electrode behavior; electrical conductivity; analog circuit design & fabrication, including amplifiers, filters, and patient isolation; digital signal processing; nonlinear compliant structures. Engineering tools: COMSOL, LabView, electronics test, circuit board fabrication. Demo: Plethysmograph in action. Spirometer Clinical relevance: Evaluation of respiratory disorders, such as COPD; lung-strengthening therapy. Physiology: Pulmonary dynamics, respiratory characteristics (e.g. lung volume, expiration rate). Engineering principles: Fluid (gas) statics; Transient flow dynamics (compressible?); Compliance of extensible structures; Flow & pressure instrumentation. Engineering tools: Hardware or software (LabView) based instrumentation; COMSOL; mechanical fabrication. Demo: Breathe in breathe out... 6

7 Coulter counter The pump is optional; gravity flow may be used instead. You may choose any size particles for a prototype, they do not need to be microscopic. The system also needs a source that drives current from one electrode to the other. Pulse processing and display may be done using LabView 18 7