COLLEGE OF SCIENCE, ENGINEERING AND TECHNOLOGY

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1 COLLEGE OF SCIENCE, ENGINEERING AND TECHNOLOGY 1. DEPARTMENT OF BIOLOGICAL SCIENCES Curriculum for B.Sc. Degree in Microbiology 100 LEVEL HARMATTAN SEMESTER CODE COURSE TITLE PRE- REQUISITE UNITS STATUS BIO 101 Basic Biology I - 3 C BIO 107 Experimental Biology I - 1 C CHM 101 General Chemistry I - 3 C CHM 107 Experimental Chemistry I - 1 C MTH 101 General Mathematics 1-3 C PHY 101 General Physics I - 3 C PHY 107 Experimental Physics I - 1 C FRN 221 Basic French - 2 R GNS 101 Use of English I - 2 R CIT 111 Introduction to Information & Communication Technology - 2 R LIB 101 Use of Library - 1 R TOTAL

2 100 LEVEL RAIN SEMESTER CODE COURSE TITLE PRE- REQUISITE UNITS STATUS BIO 102 Basic Biology II - 3 C BIO 108 Experimental Biology II - 1 C CHM 102 General Chemistry II - 3 C CHM108 Experimental Chemistry II - 1 C MTH 102 General Mathematics II - 3 C PHY 102 General Physics II - 3 C PHY108 Experimental Physics II - 1 C CIT112 Introduction to Computer Programming - 2 R FRN 222 French for Specific Purposes - 2 R GNS 102 Use of English - 2 R TOTAL

3 200 LEVEL HARMATTAN SEMESTER CODE COURSE TITLE PRE- REQUISITE UNITS STATUS MCB 201 General Microbiology I - 3 C BIO 201 General Ecology - 2 C BIO 203 Introductory Genetics - 2 C CHM 205 Physical Chemistry I - 2 C CHM 207 Inorganic Chemistry I - 2 C CHM 291 STA 201 Experimental Physical/Inorganic Chemistry Statistics for Agricultural & Biological Students - 1 C - 4 C GNS 201 Nigerian peoples and Culture - 2 R EPS 201 Entrepreneurship Studies - 2 R TOTAL

4 200 LEVEL RAIN SEMESTER CODE COURSE TITLE PRE- REQUISITE UNITS STATUS MCB 202 General Microbiology II MCB C MCB 204 Introduction to Food Science - 2 C MCB 206 Introductory Virology - 2 C BIO 202 Biological Techniques - 2 C BIO 204 Cell Physiology - 2 C CHM 202 Organic Chemistry I - 2 C CHM 292 Experimental Organic Chemistry - 1 C ZOO 202 Invertebrate Zoology - 3 C GNS 202 Osun peoples and Culture - 2 R GNS 302 Introduction to Logic and Philosophy - 2 R Electives: One of the following MCB 208 Introductory Biotechnology - 2 E Ethnobotany - 2 E TOTAL

5 300LEVEL HARMATTAN SEMESTER CODE COURSE TITLE PRE- REQUISITE UNITS STATUS MCB 301 Bacteriology - 3 C MCB 303 Soil Microbiology - 3 C MCB 305 Microbial Genetics and Molecular Biology - 3 C MCB 307 Mycology - 3 C MCB 311 Microbial Ecology MCB C MCB 309 Food Microbiology MCB C GNS 301 Entrepreneurial Skill development & Practice - 2 R TOTAL LEVEL RAIN SEMESTER CODE COURSE TITLE UNITS STATUS MCB 399 Industrial Attachment 16 C TOTAL

6 4OO LEVEL HARMATTAN SEMESTER CODE COURSE TITLE PRE- REQUSITE UNITS STATUS MCB 401 MCB 403 Immunology and Immunochemistry Principles of Epidemiology and Public Health - 3 C - 2 C MCB 405 Pharmaceutical Microbiology - 3 C MCB 407 Pathogenic Microbiology - 3 C MCB 409 Environmental Microbiology MCB C MCB 411 Microbiological Quality Assurance - 2 C MCB 413 Essay in Microbiology/Biotechnology - 2 C Electives: One of the following Parasitology - 2 E Introduction to Plant Diseases - 2 E TOTAL

7 400 LEVEL RAIN SEMESTER CODE COURSE TITLE PRE- REQUISITE UNITS STATUS MCB 402 Virology and Tissue Culture MCB C MCB 404 Industrial Microbiology - 3 C MCB 406 Petroleum Microbiology - 3 C MCB 408 Microbial Physiology and Metabolism MCB C MCB 499 Research - 6 C Electives: One of the following MCB 410 Biodeterioration - 2 E OR Any other 2 unit course - 2 E TOTAL 20 COURSE DESCRIPTION BIO 101: Basic Biology I 3 Units L 2 T 0 P 3 A generalized survey of plant and animal kingdom. Basic cell types. Prokaryotic and Eukaryotic cells. Cell structure and organization. Functions of cellular organelles. Mitosis, Meiosis and Heredity. Characteristics and classification of living things. General characteristics of microorganisms: structure, ecology and reproduction. Cell division and Reproduction. Diversity, morphology and general characteristics of algae, bryophytes, pteridophytes, gymnosperms and angiosperms. Basic principles of Zoological Nomenclature Outline classification of Animal kingdom. Diagnostic features of major animal phyla and their classes. 280

8 BIO 102: Basic Biology II 3 Units L 2 T 0 P 3 Similarities and differences in external features of plant and animal kingdoms. Nature of living and non living things. Homeostatis. Growth and development. Endocrine system, Respiration, Reproduction, Nutrition and enzymes, Digestion and excretion. Aims and scope of ecology. Basic units of ecology (Population, Community and Ecosystem). Biotic and abiotic components of an ecosystem. Energy flow and nutrient cycling. Dynamics of population and communities. Distributions of microorganisms in nature. Microbes as friends and foes. Man and environment. BIO 107 Experimental Biology I 1 Unit L 0 T 0 P 3 Simple experiments illustrating the topics covered in BIO 101. BIO 108 Experimental Biology II 1 Unit 0 T 0 P 3 Simple experiments illustrating the topics covered in BIO 102. BIO 201 General Ecology 2 Units L 1 T 0 P 3 Aims and Scope of ecology, Basic units of ecology (population, Community and Ecosystem) Biotic and Abiotic components of an ecosystem. Production in ecosystem. Energy flow and nutrient cycling. Dynamicsof population and communities. BIO 202 Biological Techniques 2 Units L 1 T 0 P 3 Microscopy and calibration of the light microscope. Preparation of slides. Sectioning of plant tissues. Techniques in culturing plant tissues. Botanical drawings, Herbarium. Experimental designs. BIO 203 Introductory Genetics 2 Units L 1 T 0 P 3 History of genetics, simple mendelian inheritance, chromosomes, genes, gene expressions and combination, dominance (complete and incomplete), linkage and crossing over, gene classification and mapping, hereditable and non-hereditable characters of organisms, Changes in gene and chromosomes, Alleles (simple and 281

9 multiple), sex determination, sex ratio, sex linked inheritance, sex influenced and sex-limited traits, lethal genes, sex-linked lethal, inherited defects and gene interactions. Practicals to include collection and classification of indigenous goats within Osun State University and its environs. ZOO 202: Invertebrate Zoology 3 Units L 2 T 0 P 3 Identification, phylogeny, general biology, organization, behaviour and economic importance of some important phyla, including Protozoa, Porifera, Coelenterates, Platyhelminths, Annelida, Mollusca, Arthropoda and Echinodermata. MCB 201: General Microbiology I 3 Units L 2 T 0 P 3 Origin and scope of Microbiology. Introduction to various forms and characteristics of representative genera including bacteria, viruses, fungi, protozoa and algae. Nutrition and biochemical activities of microorganisms. Biology of microorganisms metabolism, growth and reproduction in microorganisms; role of microorganisms in nature-how they affect people, property, and the environment; Microbial variation and heredity. MCB 202: General Microbiology II 3 Units L 2 T 0 P 3 Systematic classification of microorganisms. Principles and methods of microbiology; microscopy and microscopic techniques; staining techniques for differentiation of microorganisms; culturing of microbes: preparation of culture media for microbial growth, enrichment and cultivation of microbes, isolation of pure cultures; factors affecting growth of microorganisms enumeration of microorganisms; maintenance of cultures; identification of microorganisms to include colonial and cellular morphology as well as biochemical and molecular identification procedures; principles of sterilization and disinfection. MCB 204: Introduction to Food Science 2 Units L 1 T 0 P 3 Introduction to the microflora of foods. Physical, chemical and biological principles of food processing and preservation. Introduction to the concept of Engineering units 282

10 and dimensions applicable to the food industry. Review of global food situation with emphasis on Nigeria. MCB 206: Introductory Virology 2 Units L 1 T 0 P 3 General characteristics of plant, animal and bacterial viruses; viral replication, spread and cytopathic effects. Virus classification, purification and assay. Regulation of lytic development and maintenance of lysogenic state in bacteriophages lamda, P2 and 14 single stranded DNA and RNA phageviroids as pathogens. MCB 208: Introductory Biotechnology 2 Units L 1 T 0 P 3 Definitions of Biotechnology; historical development of biotechnology; the interdisciplinary nature of biotechnology; benefits of biotechnology to man; biotechnology and development; the importance of microbiology in biotechnological pursuit; applications of biotechnology. MCB 301: Bacteriology 3 Units L 2 T 0 P 3 A detailed coverage of classification and characteristics of bacteria; the morphology, life cycle and biochemical characteristics of bacteria and other prokaryotes to include their isolation and identification; the significant role of bacteria in agriculture, industry, medicine, pharmaceuticals and foods; bacterial infections and methods in diagnostic bacteriology; aspects of molecular bacteriology. MCB 303: Soil Microbiology 3 Units L 2 T 0 P 3 The characteristics of the soil environment. Microbial flora and fauna of soil. Microbial activities in the soil. Biogeochemical cycles and mineral transformation by microorganisms, organic matter decomposition; ecological relationships among the soil pathogens; effects of pesticides on soil microorganisms; biodegradation of pesticides; biofuel generation; techniques in soil microbiology; microbiology of the rhizosphere. MCB 305: Microbial Genetics and Molecular Biology 3 Units L 2 T 0 P 3 283

11 Principles of genetic analysis. Plasmids and transposable genetic elementgs, mutagenesis and DNA repairs, bacteriphage genetics and genetics of Nitrogen fixation. Mechanism and nature of mutation, induction, isolation and characterization of mutants. Genetic recombination in prokaryotes including transformation, transduction, phage conversion and conjugation. Recent techniques in microbial genetics. Chemical coding and expression of genetic information. Principles and applications of genetic engineering in Medicine, Industry and Agriculture. MCB 307 Mycology 3 Units L 2 T 0 P 3 The major groups of fungi and their probable relationships. Structure, function, life cycles, physiology and classification of fungi. Economic and ecological importance of fungi in agriculture, food and industry; reference to Nigerian examples. Importance of fungi to man. MCB 309: Food Microbiology 3 Units L 2 T 0 P 3 Pre-requisite: MCB 204 A survey of microorganisms important in foods. Intrinsic and extrinsic properties of foods affecting microbial activities. Indices of food sanitary quality and microbiological standards. Food spoilage and food-borne diseases. Food sanitation control and inspection. Methods of food preservation. Single cell protein. Emphasis should be on new developments in food microbiology such as exploitation of microorganisms in novel processes for the production of food ingredients. MCB 311: Microbial Ecology 3 Units L 2 T 0 P 3 Microbes and ecological theory. Physiological, morphological and genetic adaptations of microorganisms to their environment. Microbial interactions. Microorganisms in natural ecosystems. The life of microorganisms in air, springs, rivers, lakes and seas. Cycling of elements in water and sediments. Microbial bioconversions in nature and biofueling. MCB 399: Industrial Work Experience (SIWES) (15 units) 284

12 Students will be posted to industrial establishments such as food processing, brewing, distillery, pharmaceutical, research institutes or medical and health institutions for six months of supervised training. A report must be submitted after completion of the programme for grading MCB 401: Immunology and Immunochemistry 3 Units L 2 T 0 P 3 Basic concepts of immunology. Structure of antigens. Antigenic determinants; cellular immune response; genetics of response to specified antigenic stimulation. Structure and classification of immunoglobulins. Mechanisms and theories of antibody formation. Antigen and antibody interactions; primary and secondary lymphoid tissues and organs. Immediate and delayed hypersensitivity. Immunopathology; autopathology; autoimmunity. Histocompatibility genes and gene products; transplantation immunology. Immunodeficiency and immunoprophylaxis. MCB 402: Virology and Tissue culture 3 Units L 2 T 0 P 3 Pre-requisite: MCB 206 Origin and nature of viruses; structure, properties and classification of viruses; the chemical and physical properties of bacterial, animal and plant viruses; principles of isolation, cultivation, purification and maintenance of bacteriophages and other viruses in vivo; transmission of viral diseases in plants and animals; interference phenomenon and interferon; systematic virology especially those endemic in Africapolio, measles, rabies oncogenic viruses, lassa virus; AIDS virus etc; Viral genetics; viruses and genetic engineering; application of cell culture technique in virology. MCB 403: Principles of Epidemiology and Public Health 3 Units L 2 T 0 P 3 Statistical application to epidemiology. Nature of epidemics. Epidemiological investigations. spectrum of infection; latency of multifactorial systems in epidemics. Zoonoses. Antigenic drifts/shifts. immunity; recommended immunization schedules. Biological products for immunization; herd MCB 404: Industrial Microbiology 3 Units L 2 T 0 P 3 285

13 Scope of industrial Microbiology. Microorganisms of industrial importance and fermentation processes. Propagation, maintenance and improvement of industrial microorganisms. Optimization of fermentation processes. Study of selected industrial processes involving microorganisms. Bioassay in industrial production and quality control. Microbiological standards and specifications. Shelf-life and spoilage of industrial products. Principles and applications of genetic engineering. MCB 405: Pharmaceutical Microbiology 3 Units L 2 T 0 P 3 The chemistry and production of synthetic chemotherapeutic agents, antibiotics. Quality control of pharmaceutical products. Concepts of growth and death in microorganisms; control of microorganisms; disinfection; sterilization and asepsis. Sterility and sterility tests. The mode of action and assay of anti-microbial agents. Concepts of antibiotic sensitivity and resistance as related to microbial physiology. Mechanism of drug resistance. MCB 406: Petroleum Microbiology 3 Units L 2 T 0 P 3 Petroleum prospecting by means of microbial indicators and secondary recovery. Microbial corrosion of pipes and equipment microbiology of the process. Methanogenesis and methanotrophy. Effects of oil spills on microbial activities in aquatic and terrestrial ecosystems. Biodeterioration of aviation fuels, lubricants and cutting fluids. Biotransformation of hydrocarbons. MCB 407: Pathogenic Microbiology 3 Units L 2 T 0 P 3 Study of some microbial pathogens of plants and animals with emphasis on those prevalent in Nigeria. Host parasite relationship. The geographical distribution, isolation, identification, morphology, life cycle, source of infection, transmission and the host. Ecology, clinical manifestations of specific bacterial, viral and fungal pathogens of man. MCB 408: Microbial Physiology and Metabolism 3 Units L 2 T 0 P 3 (Pre-requisite: MCB 401) 286

14 Dynamics of growth. Nutrition and energy metabolism of microorganisms. Effect of physical and chemical factors on growth. Biochemistry of various microbial processes such as transport regulation and respiration. Biosynthesis of microbial products. Buffer preparation and standardization. Basic separation techniques in microbiology, dialysis, salting out, gel filtration, electrophoresis etc. Assay techniques for various metabolites including microbial enzymes, acids etc. MCB 409: Environmental Microbiology 2 Units L 2 T 0 P 3 Pre-requisite: MCB 311 Impact assessment of microbial contamination of soil, air and water in relation to the deterioration of the environment. Soil, water and air pollution. Microbiology of water supplies, water supply and public health sewage and sewage disposal in the hot climates. Methods of water and sewage treatment with emphasis on specific organisms involved. Disease transmission by water. Biological and Chemical Oxygen Deficiency. MCB 410: Biodeterioration 2 Units L 2 T 0 P 3 Principles of microbial deterioration of materials. Materials subject to microbial deterioration: Foods, jet fuels, paper, paints, textiles and leather, metals etc. Factors favouring deterioration of materials. Major microbial groups involved in deterioration. Impact of processing and new technologies on biodeterioration. Biodeterioration control. MCB 411: Microbiological Quality Assurance 2 Units L 1 T 0 P 3 A theoretical and practical consideration of the management of microbiological quality assurance. HACCP, cleaning and sanitation. Microbiological specifications and regulations. Local and international approaches to obtaining safe food. Management and quality assurance in the microbiology laboratory. MCB 413: Seminars in Microbiology and Biotechnology 2 Units 287

15 Under the supervision of staff the student is expected to select a seminar topic which must be of microbiological or biotechnological interest for detailed study. The course is expected to give the student the opportunity for independent thought and expression. MCB 499: Research Projects in Microbiology and Biotechnology 6 Units Under the supervision of staff the student is expected to carry out a research on any topic of microbiological or biotechnological interest. A detailed report on the research in form of a dissertation is to be submitted and examined before a panel of external and internal examiners in an oral examination at the end of the research. 288