BenchMark XT the flexible, networked workflow solution

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1 BENCHMARK XT STAINING PLATFORM BenchMark XT the flexible, networked workflow solution A member of the BenchMark family of staining platforms.

2 The BenchMark of productivity Platform Overview The BenchMark XT automated slide preparation system is a fully automated slide preparation system with the flexibility you need to expand your test menu, process more slides, and improve your turnaround time. Flexible Automation Completely automate any or all preparation steps of your IHC, ISH, and FITC slides Process IHC, ISH, and FITC tests independently or simultaneously Optimize protocols with flexible options including extended incubation times and varying temperatures Choose your own primary antibody or a ready-to-use antibody from Ventana Choose one or more BenchMark systems for your specific capacity/throughput requirements, and manage up to 8 systems with a single computer One touch dual color protocols Ventana Medical Systems a member of the Roche Group

3 Measurable Results Time (hours) Staining only Slide Stainer hr. Shift Baking 1st Run Dewax Epitope Retrevial Cell Conditioning 2nd Run Set-Up Staining 1 staining run = 48 slides Compared to a common stain-only slide system. 25% increase in slides per 8 hour shift. >80% decrease in manual steps. BenchMark XT Slide Preparation System Set-Up Baking through Staining Set-Up Baking through Staining 2 staining runs = 60 slides Measurable Results Central Management Eliminate over 80% of the labor required by staining-only slide systems. Ventana Connectivity Solutions can increase laboratory productivity and reduce potential errors. Manage multiple systems from a single point. Share reagents and protocols across instruments, optimizing inventory control and workflow. LIS Connectivity Download patient accession and test information from LIS to slide staining system. Upload test status information to LIS while eliminating redundant data entry and improving patient safety. VIAS Connectivity Facilitate networked slide identification and patient information flow between instrument and Image Analysis System. Populate integrated patient report with patient demographics, slide images, and pathologist comments. The connected workflow solution

4 Staining Module The staining module creates an optimized environment for the automated preparation of IHC, ISH, and FITC slides. The reagent carousel holds up to 35 ready-to-use reagent dispensers, each individually bar-coded to save time and avoid errors associated with manual data entry. XT throughput 30 slides per run, up to 60 slides in 6 hours, up to 30 additional slides overnight. The benchmark of quality The precisely controlled and kinetically optimized reaction environment of the BenchMark staining module speeds slide turnaround time and enhances staining consistency and reproducibility for IHC, ISH, and FITC applications. Fluidics Module Seven bottles provide on-board bulk fluid capacity for up to 90 slides. Bottle sensors monitor fluid Liquid Coverslip levels. Front panel access allows convenient replacement and service. Slide-Specific Label Air Vortex Mixing Waste Module Level-sensing containers provide walk-away capacity for up to 90 slides. ThermoFlex Pad Slide-Specific Label provides automatic programming, patient and case identification. Air Vortex Mixing blends the aqueous layer under the Liquid Coverslip, mixing reagents and ensuring uniform reaction kinetics across the entire surface of the slide. Liquid Coverslip creates a reaction chamber on the surface of each slide controlling evaporation and protecting tissue integrity. ThermoFlex Pad 30 unique slide heaters provide highly precise, individual slide heating for synchronized IHC, ISH, and FITC protocols

5 A single BenchMark XT run with multiple technologies. Multiple protocols, multiple technologies, complete cases all at once. Procedure * IHC Red IHC DAB mrna ISH DNA ISH Fluorescent IHC DAB/Red Dual Stains * indicates all ancillary reagents needed to complete tests Random processing allows for all BenchMark XT capabilities such as IHC, ISH, FITC assays, and Dual Stains to be performed simultaneously yet independent of one another

6 Ventana Medical Systems, Inc E. Innovation Park Drive Tucson, Arizona USA +1 (520) (800) VENTANA and BENCHMARK are trademarks of Roche. N C