COURSE GUIDE Universidad Católica de Valencia Pharmaceutical Engineering and Drug Design THIS SUBJECT IS NOT OFFERED DURING THIS ACADEMIC YEAR

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1 1 COURSE GUIDE Universidad Católica de Valencia Pharmaceutical Engineering and Drug Design THIS SUBJECT IS NOT OFFERED DURING THIS ACADEMIC YEAR

2 COURSE GUIDE Pharmaceutical Engineering and Drug Design Year ECTS SUBJECT: Pharmaceutical Engineering and Drug Design 6 Field: Pharmaceutical Engineering and Drug Design 6 Module: OPTIONAL MODULE IN BIOMEDICINE Type of learning: Optional Professor: Dr. Antonio Pineda-Lucena MODULE ORGANIZATION 42 YEAR: 3-4 Semester: 1º Department: Applied and Technological Sciences antonio.pineda@ucv.es Biomedicine 42 ECTS Duration and placement within the study plan: The optional module in Biomedicine takes place during the 3 rd and 4 th grade years. Subjects and Courses Subject ECT Subject PHARMACOLOGY AND TOXICOLOGY BIOMOLECULAR MODELIZATION MOLECULAR PHYTOPATHOLOGY PHARMACEUTICAL ENGINEERING AND DRUG DESIGN PHARMACOLOGY AND TOXICOLOGY BIOMOLECULAR MODELIZATION MOLECULAR PHYTOPATHOLOGY PHARMACEUTICAL ENGINEERING AND DRUG DESIGN Subj ect Subject 6 3-4/ / / /1 GENE THERAPY 6 GENE THERAPY 6 3-4/1 MOLECULAR PATHOLOGY CLINICAL BIOTECHNOLOGY 6 MOLECULAR PATHOLOGY 6 3-4/1 6 CLINICAL BIOTECHNOLOGY 6 3-4/1

3 3 INMUNOLOGY 6 INMUNOLOGY 6 3-4/1 COURSE GUIDE TO THE SUBJECT: Principles of food biotechnology Pri Prerequisites: Not have established GENERAL GOALS 1. To facilitate an overall understanding of the drug discovery process and the contribution of different disciplines (bioinformatics, structural biology, molecular modelling, computational chemistry, etc.) 2. To develop specific competences in scientific research, as well as in the methods and techniques currently used in drug design. 3. To transfer abilities facilitating the integration of the students in mutidisciplinary teams carrying out activities in the pharmaceutical and medical fields. 4. To capacitate the student for self-learning pharmaceutical engineering and drug design during his/her professional career. COMPETENCES Competence measuring scale CG01-Capacity to analyze and synthesize

4 CB1-Students acquire and understand knowledge in their field of study based on general secondary education but usually reaching a level that, although supported on advanced tet books, also includes aspects involving state-of-the-art knowledge specific to their area. CB2-Students are able to apply knowledge to their work in a professional way and have the competences enabling them to state and defend views and opinions as well as perform problem-solving tasks in their field of study. CB3-Students are able to collect and interpret relevant data (generally in their field of study) and give opinions that involve reflection on relevant social, scientific or ethical issues. CB4-Students can communicate information, ideas, problems and solutions to a specialized or non-specialized audience. CB5-Students develop the necessary learning skills to undertake further studies with a high level of autonomy. CT02-Capacity to organize and plan CT03-Mastering Spanish oral and written communication CT05-Knowing and applying Basic ITC skills related to Biotechnology CT06-Capacity to manage information (capacity to look for and analyze information coming from different types of sources) CT07-Problem solving CT08-Decision making CT09-Capacity to work in interdisciplinary and multidisciplinary team CT10-Interpersonal skills CT11 - Appreciation of diversity and multiculturalism CT12-Critical and self-critical capacity CT13-Ethics CT14-Capacity to learn CT16-Capacity to produce new ideas (creativity) CT15 - Ability to adapt to new situations CT19-Capacity to apply theoretical knowledge

5 CT20-Research skills CT21-Sensitivity to environmental issues CE32-Knowing how to use different specific operating systems and software packages designed for Biotechnology CE33-Knowing and complying with legislation and ethics of biotechnological processes and applications CE34-Knowing main characteristics of Molecular biosciences and biotechnology communication CE30-Solving and analyzing problems posed by biotechnology CE31-Describing and calculating important variables of processes and eperiments CE22-Knowing and understanding contents, principles and theories related to biotechnology CE23-Knowing how to use laboratory equipment and to carry out basic operations for each discipline including: safety measures, handling, waste disposal and activity register CE24-Knowing basic and instrument laboratory techniques in the different areas of biotechnology CE25-Knowing how to analyze and understand scientific data related to biotechnology CE27-Knowing and applying action plans and assessment criteria of biotechnology processes CE28-Integrating life science and Engineering into processes of development of biotechnological products and applications CE29-Contrasting and checking results of biotechnological eperimentation LEARNING OUTCOMES 3F COMPETENCES R-1 Students have understood and acquired the subject s contents. CG01, CB1, CB2, CB3, CB4, CB5, CT03, CT06, CT12, CT14, CT19, CT20, CE22, CE25, CE28 R-2 Students are able to solve problems or cases related to those contents by using various resources (literature, computerbased, etc.). CG01, CB2, CB3 CB4, CT02, CT03, CT05, CT06, CT07, CT12, CT14, CT16, CT19, CT20, CT21, CE25, CE28, CE30, CE31, CE32, CE33

6 R-3 Students are able to work and correctly perform basic activities in a lab in compliance with the relevant safety requirements. They can plan, develop and understand the purpose for the eperience as well as contrast and validate the results obtained. R-4 Students are able to write a clear and well-organized tet on diverse aspects of the subject. CG01, CB5, CT02, CT05, CT07, CT09, CT10, CT12, CT13, CT14, CT16, CT19, CT20, CT21, CE23, CE24, CE25, CE27, CE28, CE29, CE30, CE32, CE33, CE31 CG01, CB1, CB2, CB3, CB4, CB5, CT02, CT03, CT05, CT06, CT09, CT12, CT14, CT16, CT18, CT20, CE25, CE34 R-5 Students are able to adequately present and defend their work. CG01, CB1, CB2, CB3, CB4, CB5, CT02, CT03, CT05, CT06, CT09, CT12, CT14, CT16, CT18, CT20, CE25, CE34 R-6 Students seek bibliographic information from several sources and can analyse it with a critical, constructive attitude. CG01, CB1, CB2, CB3, CB5, CT02, CT05, CT06, CT07, CT12, CT14, CT16, CT18, CT20, CE25, CE31, CE32, CE34 R-7 Students cooperate with the teacher and peers throughout the learning process. They can work as members of a team. They are respectful, proactive and comply with the subject s organizational rules. CT09, CT10, CT12, CT13, CT15, CT16, CT17, CT18 ON-CAMPUS EDUCATIONAL ACTIVITIES ACTIVITY Teaching-Learning Methodology Relationship With Learning Outcomes for the subject ECTS ON-CAMPUS CLASS Teacher presentation of contents, analysis of competences,eplanation and in-class display of skills, abilities and knowledge. R-1,R-2,R-3,R-4, R-5,R-6,R-7,R PRACTICAL CLASSES Group work sessions supervised by the professor. Case studies, diagnostic tests, problems, field work, computer room, visits, data search, libraries, on-line, Internet, etc. Meaningful construction of knowledge through interaction and student activity. R-1,R-2,R-3,R-4,R-5, R-6,R-7,R-8,R

7 7 Course Guide BIOREACTORS PCA-27-F-01 Ed.00 LABORATORY Activities carried out in spaces with specialized equipment. R-6,R-7,R SEMINAR Supervised monographic sessions with shared participation R-1,R-3,R-4,R- 5,R-7,R-8,R GROUP PRESENTATION OF PAPERS Application of multidisciplinary knowledge R-1,R-7,R OFFICE ASSISTANCE Personalized and small group attention. Period of instruction and/or orientation carried out by a tutor to review and discuss materials and topics presented in classes, seminars, readings, papers, etc. R-1,R-2,R-3,R-4,R- 5,R-6,R-7,R-8,R ASSESSMENT Set of oral and/or written tests used in initial, formative or additive assessment of the student R-1,R-2,R-3,R-6, R Total 2.42 INDEPENDENT WORK ACTIVITIES ACTIVITY GROUP WORK Teaching-Learning Methodology Group preparation of readings, essays, problem solving, seminars, papers, reports, etc. to be presented or submitted in theoretical lectures, practical and/or small-group tutoring sessions. Relationship of Course with Learning Outcomes R-1,R-5,R-6,R- 7,R-9 ECTS 0.73 Work done on the university e- learning platform ( ) INDEPENDENT WORK Student study: Group Individual preparation of readings, essays, problem R-1,R-2,R-3,R-4, R-5,R-6,R-7,R-8,R

8 solving, seminars, papers, reports, etc. to be presented or submitted in theoretical lectures, practical and/or small-group tutoring sessions. Work done on the university e- learning platform ( ) Total 3.58 SYSTEM FOR ASSESSING THE ACQUISITION OF THE COMPETENCES AND ASSESSMENT SYSTEM* Assessment Tool LEARNING OUTCOMES AND COMPETENCIES ASSESSED Allocated Percentage Written test of R-1,R-2 50%* knowledge a Practical test and report (laboratory) b R-3, R-4 10% Group work, presentation and additional activities c R-4, R-5, R-6, R-7 40%

9 9 * You must obtain a score> 5 tests indicated to average. ** MENTION OF DISTINCTION: The mention of Distinction will be awarded to students who have achieved a score equal to or greater than 9.0. The number of Distinctions granted will not eceed 5% of students enrolled in a subject in the corresponding academic year unless enrollment is under 20, in which case only one Distinction may be granted (Royal Decree 1125/2003). DESCRIPTION OF CONTENTS COMPETENCES UD.1. INTRODUCTION 1.- Introduction to phamaceutical engineering and drug design 2.- Databases UD.2. NOMENCLATURE 1.- Chemical nomenclature for amino acids 2.- Chemical nomenclature for small molecules CG01, CB1, CB2, CB3, CB4, CB5, CT02, CT03, CT05, CT06, CT07, CT09, CT10, CT12, CT13, CT14, CT15, CT16, CT17, CT18, CT19, CT20, CT21, CE22, CE25, CE28, CE30, CE31, CE32, CE33 CG01, CB1, CB2, CB3, CB4, CB5, CT02, CT03, CT05, CT06, CT07, CT09, CT10, CT12, CT13, CT14, CT15, CT16, CT17, CT18, CT19, CT20, CT21, CE22, CE25, CE28, CE30, CE31, CE32, CE33 UD.3. MODELLING 1.- Modelling of protein structures 2.- Docking 3.- Structure-activity relationships 4.- Analysis of protein structures and protein-drug complees CG01, CB1, CB2, CB3, CB4, CB5, CT02, CT03, CT05, CT06, CT07, CT09, CT10, CT12, CT13, CT14, CT15, CT16, CT17, CT18, CT19, CT20, CT21, CE22, CE25, CE28, CE30, CE31, CE32, CE33 LABORATORY SESSIONS CG01, CB1, CB2, CB3, CB4, CB5, CT02, CT03, CT05, CT06, CT07, CT09, CT10, CT12, CT13, CT14, CT16, CT18, CT19, CT20, CT21, CE23, CE24, CE25, CE27, CE28, CE29, CE30, CE32, CE33, CE31, CE34

10 GROUP WORK, PRESENTATION AND ADDITIONAL ACTIVITIES CG01, CB1, CB2, CB3, CB4, CB5, CT02, CT03, CT05, CT06, CT07, CT09, CT10, CT12, CT13, CT14, CT15 CT16, CT17, CT18, CT20, CE25, CE31, CE32, CE34 REFERENCES BASIC BIBIOGRAPHY: 1. Rang HP., Dale MM., Ritter M., Flower R. Farmacología Elsevier. ADDITIONAL BIBLIOGRAPHY: 2. Flórez, J., Armijo. JA., Mediavilla, A., Farmacología humana Elsevier. 3. Brunton, LL., Lazo, JS., Parker, KL. Goodman & Gilman. Las bases farmacológicas de la terapéutica McGraw-Hill Interamericana. 4. Color Atlas of Pharmacology, Heinz Luellmann (Editor). Thieme Medical Publishers; 3ª edición, Concepts in Clinical Pharmacokinetics, 5th Edition, Joseph T. DiPiro Pharm.D. FCCP Tresguerres,J., Martínez Fernández, V., Navas Serrano, V. Biotecnología aplicada a la medicina Ediciones Díaz de Santos S.A. Principles of Biochemical Toicology, Fourth Edition by John A. Timbrell (Nov 18, 2008) TEMPORAL ORGANIZATION OF LEARNING: CONTENT/TEACHING UNIT # OF MEETINGS UD.1. INTRODUCTION TO FOOD BIOTECHNOLOGY 4 UD.2. TECHNOLOGY, LAW AND FOOD SECURITY 4 UD.3. BIOTECHNOLOGY APPLICATIONS IN THE FOOD INDUSTRY 23