UvA-DARE (Digital Academic Repository) Minimally invasive pancreatic surgery van Hilst, J. Link to publication

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1 UvA-DARE (Digital Academic Repository) Minimally invasive pancreatic surgery van Hilst, J. Link to publication Citation for published version (APA): van Hilst, J. (2019). Minimally invasive pancreatic surgery: Introduction, development, and outcome assessment. General rights It is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), other than for strictly personal, individual use, unless the work is under an open content license (like Creative Commons). Disclaimer/Complaints regulations If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library: or a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible. UvA-DARE is a service provided by the library of the University of Amsterdam ( Download date: 14 Apr 2019

2 Minimally invasive pancreatic surgery: introduction, development, and outcome assessment UITNODIGING Voor het bijwonen van de openbare verdediging van het proefschrift Minimally invasive pancreatic surgery: introduction, development, and outcome assessment Minimally invasive pancreatic surgery: introduction, development, and outcome assessment door Op vrijdag 1 februari om 12:00 Agnietenkapel Universiteit van Amsterdam Oudezijds Voorburgwal EZ Amsterdam Aansluitend bent u van harte uitgenodigd voor de receptie ter plaatse Overtoom HK Amsterdam j.vanhilst@amc.nl Paranimfen Timo van Hilst Timoxtxt@hotmail.com Floor Mansvelder Floormansvelder@gmail.com

3 MINIMALLY INVASIVE PANCREATIC SURGERY: INTRODUCTION, DEVELOPMENT, AND OUTCOME ASSESSMENT

4 Minimally invasive pancreatic surgery: introduction, development, and outcome assessment This thesis was written at the Department of Surgery, Amsterdam UMC, University of Amsterdam, the Netherlands, and in collaboration with the Dutch Pancreatic Cancer Group. Copyright 2018 ISBN: Paranimfen: Cover design: Layout: Printing: Timo van Hilst Floor J. Mansvelder Peter van Drumpt ProefschriftMaken, ProefschriftMaken, All rights reserved. No part of this thesis may be reproduced, stored or transmitted in any form or by any means without prior permission of the author or publishers of the included scientific papers. Part of the research described in this thesis was financially supported by Johnson & Johnson / Ethicon, and Medtronic / Covidien. The printing of this thesis was financially supported by the Department of Surgery (Amsterdam UMC, Academical Medical Center/University of Amsterdam), the Dutch Pancreatic Cancer Group (DPCG), Stichting pancreas, the Living With Hope Foundation (LWH), the Dutch Society of Endoscopic Surgery (NVEC), de Nederlandse Vereniging voor Gastroenterologie (NVGE), Integraal Kankercentrum Nederland (IKNL), Castor EDC, ChipSoft, KARL STORZ Endoscopie Nederland B.V., Mylan Healthcare B.V., IPSEN, TRAMEDICO B.V. and Krijnen Medical Innovations B.V.

5 MINIMALLY INVASIVE PANCREATIC SURGERY: INTRODUCTION, DEVELOPMENT, AND OUTCOME ASSESSMENT ACADEMISCH PROEFSCHRIFT ter verkrijging van de graad van doctor aan de Universiteit van Amsterdam op gezag van de Rector Magnificus prof. dr. ir. K.I.J. Maex ten overstaan van een door het College voor Promoties ingestelde commissie, in het openbaar te verdedigen in de Agnietenkapel op vrijdag 1 februari 2019, te 12:00 uur door geboren te Nigtevecht

6 Promotiecommissie: Promotor(es): Prof. dr. M.G.H. Besselink, AMC-UvA Prof. dr. O.R.C. Busch, AMC-UvA Copromotor(es): dr. S. Festen, OLVG Prof. dr. M. Abu Hilal, University of Southampton Overige leden: Faculteit: Prof. dr. W.A. Bemelman, AMC-UvA Prof. dr. M.A. Boermeester, AMC-UvA Prof. dr. M.A. Cuesta, Vrije Universiteit Amsterdam Dr. S.S. Gisbertz, AMC-UvA Prof. dr. H.G. Gooszen, Radboud Universiteit Nijmegen Prof. Dr. I.Q. Molenaar, Universiteit Utrecht Geneeskunde

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8 TABLE OF CONTENT Part I Introduction 9 General introduction and outline of the thesis 10 Chapter 1 Worldwide survey on opinions and use of minimally invasive pancreatic resection HPB, Part II Minimally invasive distal pancreatectomy 33 Chapter 2 Chapter 3 Chapter 4 Chapter 5 Chapter 6 Chapter 7 Impact of a nationwide training program in minimally invasive distal pancreatectomy (LAELAPS) Annals of Surgery, 2016 Minimally invasive versus open distal pancreatectomy (LEOPARD): a multicenter patient-blinded randomized controlled trial Annals of Surgery, 2018 Cost-effectiveness, cost-utility, and disease-specific quality of life in minimally invasive versus open distal pancreatectomy in the LEOPARD trial Submitted Minimally invasive versus open distal pancreatectomy for ductal adenocarcinoma (DIPLOMA): a pan-european propensity score matched study Annals of Surgery, 2017 Minimally invasive versus open distal pancreatectomy for pancreatic ductal adenocarcinoma: a systematic review and metaanalysis European Journal of Surgical Oncology, 2018 Distal pancreatectomy, minimally invasive or open, for malignancy (DIPLOMA): study protocol for a randomized controlled trial Submitted

9 Part III Minimally invasive pancreatoduodenectomy 157 Chapter 8 Chapter 9 Chapter 10 Chapter 11 Chapter 12 Outcomes of a multicenter training program in laparoscopic pancreatoduodenectomy (LAELAPS-2) Annals of Surgery, 2017 Laparoscopic pancreatoduodenectomy with open or laparoscopic reconstruction during the learning curve: a multicenter propensity score matched study HPB, 2018 Outcomes after minimally-invasive versus open pancreatoduodenectomy: a pan-european propensity score matched study Annals of Surgery, 2018 Laparoscopic versus open pancreatoduodenectomy (LEOPARD-2): a multicentre, patient-blinded, randomised controlled trial Submitted The inflammatory response after laparoscopic and open pancreatoduodenectomy and the association with complications in a multicenter randomized controlled trial Submitted Part IV Summary and discussion 261 Summary Discussion and future perspectives Nederlandse samenvatting List of co-authors List of publications PhD Portfolio Dankwoord Curriculum Vitae