Nanotechnology & UIC (Engineering & Science)

Transcription

1 Nanotechnology & UIC (Engineering & Science) by G.Ali Mansoori, PhD mansoori@uic.edu BioEngineering, Chemical Engineering & Physics Departments at Livingston Nanotechnology Conference Chicago, IL, December 2014

2 ABSTRACT An overview of Speaker s R&D work on design of nanoparticles, nanoclusters, nanoconjugates and molecular building blocks and their applications in science, engineering and health.

3 Our Atomic Force Microscopes

4 Mansoori Group Research Topics 1. Cancer nanotechnology: a. Melanoma prevention through nanotechnology b. Applications of Azurin as an anti-cancer agent. c. Targeting the Folate Receptor. 2. Silver nanoparticles large-scale (industrial) production 3. Diamomdoids as molecular building block for nanotechnology

5 Mansoori Group Research Topics continued 4. Molecular based study of condensed matter in small confined systems 5. Applications of supercritical fluid technology for bioseparations 6. Environmental aspects of nanotechnology 7. Alzheimer s disease detection & treatment through nanotechnology.

6 Design, characterization and application of a folate-conjugated gold nanoparticle Gold Nanoparticles Conjugated with Folic Acid using Mercaptohexanol as the Linker Journal Nanotechnology Progress International (JONPI), 1: 13-23, Structural and optical characterization of folate-conjugated gold-nanoparticles Physica E: Low-dimensional Systems and Nanostructures, doi: /j.physe Cancerous Cells Targeting and Destruction Using Folate Conjugated Gold Nanoparticles Dynamic Biochemistry, Process Biotechnology and Molecular Biology, Vol. 4, 2010.(Article in Press) Folate-Conjugated Gold Nanoparticles (Synthesis, characterization and design for cancer cells nanotechnology-based targeting) Int'l J of Nanoscience & Nanotechnology, 2010.(Article in Press).

7 Design, characterization and application of a folate-conjugated gold nanoparticle continued

8 Melanoma prevention through nanotechnology Acrobat Document A patent pending.

9 Applications of Azurin as an anti-cancer agent Azurin: A Novel Anticancer Candidate (Molecular Characteristics, Apoptosis Mechanism and Nanotechnology) Prospects for Cancer Nanotechnology Treatment by Azurin Dynamic Biochemistry, Process Biotechnology and Molecular Biology, Vol. 4, 2010.

10 Silver Nanoparticles production and medical applications Biosynthesis of Silver Nanoparticles by Fungus Trichoderma Reesei (A Route for Large-Scale Production of SNP) (Left) TEM micrograph recorded from a drop-coated film of an aqueous solution incubated with Trichoderma reesei and reacted with Ag+ ions for 72 hours. (Right) Selected area of electron diffraction pattern recorded from one of the silver nanoparticles shown in the left Figure. The diffraction rings have been indexed with reference to the fcc silver. Patented

11 Alzheimer s Disease Nanotechnology: Early detection of AD through nanotechnology Sequential formation of globular amyloid aggregates RECENT PUBLICATIONS: Nanotechnology Building Blocks for Intervention with Alzheimer s Disease Pathology: Implications in Disease Modifying Strategies J Bioanal. & Biomed., Vol.6, Issue 2, 6: doi: / X , 2014 Nanotechnology for Alzheimer's disease detection and treatment (Invited paper) Nanotechnology Sec. / Insciences J. 2011, 1(4), ;doi: /insc Nanotechnology Solutions for Alzheimer's Disease: (Advances in research tools, diagnostic methods and therapeutic agents) Journal of Alzheimer's Disease, 13(2): pp , 2008.

12 Our team Our tools 1. Ab initio calculations 2. MD simulation 3. Molecular self-assembly 4. Scanning probe microcopy Diamomdoids as molecular building block for nanotechnology Measurement, Simulation and Prediction of Intermolecular Interactions and Structural Characteristics of Organic Nanostructures (Diamondoids and Derivatives) What we do 1. THEORY: Generating & testing the basis sets. Structure optimization. Comparing bond lengths with experiment. Creating and testing potentials for diamondoids & derivatives and pseudopotentials for metal tips. Testing different density functionals (B3LYP, GGA, LSDA & LDA). Testing and comparing results from the ab initio codes ( Molpro, Gaussian 03, etc.). Treating valence electrons exactly. 2. EXPERIMENTS: Preparing monolayers of diamondoids. Obtaining images with AFM and/or STM. Preparing samples using different solvents (THF, toluene, etc) with different degrees of concentration levels. Choosing substrates (Si, Mica, etc.). Choosing preparation techniques (drop, spinning, etc.). Force-distance calculations and characterization (through XPS, STM, and AFM). Testing versus THEORY results. 3. SIMULATIONS: Simulations to produce self-assemblies for new materials with desired optoelectronic properties as MEMS, NEMS and other micro- and nano-gears and devices. Utilizing the intermolecular potential data produced in the above sections.

13 Our samples: Our findings: Sense the hardness See the atoms Feel the potential Self-assembly Our goals: Supported by the U.S. Army Research Office

14 Applications of supercritical fluid technology for bio systems In this project we propose to apply supercritical fluid technology for vaporization and ionization of biological aerosols which will not require collection on a substrate or probe.

15 The basics of the process

16 Supercritical fluid screening system to be used in the experimental part of the project

17 Investigating Fate, Transport, Transformation, and Exposure of Engineered Nanomaterials Transport, Reactivity, Transformation, and Toxicity of Lactate-Modified Nanoscale Iron Particles In Field Contaminated Soils Structure of nzvi particles SEM image of nzvi particles Environmental Applications of Nanotechnology Annual Review of Nano Research, Vol.2, Chapter 2, 2008.

18 Molecular based study of condensed matter in small confined systems Behavior of confined fluids in nanoslit pores: the normal pressure tensor Microfluidics and Nanofluidics, 8(1): pp ,january 2010; DOI: /s BEHAVIOR OF THE CONFINED HARD-SPHERE FLUID WITHIN NANOSLITS: A FUNDAMENTAL-MEASURE DENSITY- FUNCTIONAL THEORY STUDY Int'l J of Nanoscience, 7(4-5): pp , 2008; DOI: /S X An Analytic Model for Nano Confined Fluids Phase-Transition: Applications for Confined Fluids in Nanotube and Nanoslit J. Comput'l & Theor'l Nanoscience, 3(1): , 2006.

19 Our Nano and Nanobio Courses at UIC BioE 405: Atomic & Molecular Nanotechnology 3 OR 4 hours. Nanoscale structures and phenomena. Simulation methods for nano systems, and molecular assemblies. Molecular building blocks, scanning probe and atomic force microscopy, quantum mechanical phenomena. 3 undergraduate hours. 4 graduate hours. Prerequisite(s): Senior standing or above. Recommended background: Engineering or physical science major. BioE 505: NanoBioTechnology 4 hours. Nanotechnology theory and applications in biology and medicine. Molecular simulations, combinatorial chemistry. Nanoscale structures, molecular building blocks, integrated nano-bio complexes. Positional and self-assembly, self-replication. Recommended background: Engineering or physical sciences

20 Our Nanotechnology & Nanobiotechnology Completed Projects

21 Nanotechnology books we have published

22 Nanotechnology books we have published

23 Thank you for your attention! Copy of this presentation is at: