Liquid Chromatograph Liquid Chromatograph Mass Spectrometer. CL Series. for In Vitro Diagnostic Use
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1 Liquid Chromatograph Liquid Chromatograph Mass Spectrometer CL Series for In Vitro Diagnostic Use
2 Consistency. Performance. Reliability. Shimadzu s CL Series LC, LC-MS, and LC-MS/MS for in vitro diagnostic use Analytical instrumentation such as LC-MS has become the tool of choice for many specific and sensitive clinical diagnostic tests. Quality manufacturing of medical devices requires strict adherence to procedures intended to ensure the performance and reliability of the finished product. Shimadzu s US factory in Canby, Oregon proudly performs its work in accordance with all accreditation guidelines. CL Series Class I Medical Devices are designed to deliver maximum performance resulting in reproducible and reliable data while reducing analytical run time to improve work efficiency. 2
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4 HPLC/UHPLC Users demanding speed and reliability from LC-MS analysis have two new choices in HPLC systems, Shimadzu s Nexera CL Series and Prominence CL Series. Whether your needs are high-throughput elite performance or affordable ruggedness and durability, Shimadzu offers the perfect fit for your in vitro diagnostic LC laboratory. All systems are modular, and can be configured for your exact needs. Nexera CL SIL-30ACMP CL System Ultra-High Performance Liquid Chromatography system for operation up to 19,000 PSI. The SIL-30ACMP CL autosampler holds up to six microtiter plates, offering your laboratory highcapacity and high-speed operation. Open-access design enables the loading of samples, even during analysis. Intelligent design and standard rinse pump virtually eliminate carryover. Shimadzu s LC-30AD CL liquid chromatograph pumps deliver precise and rapid gradients for stable retention times and optimized separations. SIL-20ACXR CL System High Performance Liquid Chromatography system for operation up to 9500 PSI. The SIL-20ACXR CL autosampler offers rapid and accurate injection and low carryover. Shimadzu s LC- 20ADXR CL liquid chromatograph pumps deliver outstanding gradient performance and exceptional durability for applications requiring higher than standard HPLC operating pressures. Advanced firmware enables rapid cycle times. Prominence CL SIL-20AC CL System High Performance Liquid Chromatography system for operation up to 6000 PSI. The SIL-20AC CL autosampler in combination with the LC-20AD CL liquid chromatography pumps represent an outstanding value in HPLC hardware. Durable and robust, these components offer low carryover and excellent gradient performance for applications requiring standard HPLC operating pressures. 4
5 LC-MS, LC-MS/MS CL Series Liquid Chromatograph Mass Spectrometers (LC-MS, LC-MS/MS) provide high performance and excellence in data quality, enabling dramatic improvements in laboratory throughput. Simultaneous multicomponent analysis using highperformance mass spectrometry enables the clinical laboratory to report quantitative data with efficiency and confidence. Single Quad LCMS-2020 CL An ultra-fast single-quadrupole mass spectrometer (MS) designed for ease of use with an HPLC or UHPLC system. The LCMS-2020 CL offers high performance at low cost for your routine laboratory analyses. Triple Quad LCMS-8030 CL An ultra-fast triple quadrupole mass spectrometer (MS/MS) for use with HPLC or UHPLC systems. The use of MS/MS in your laboratory allows for specific and highly sensitive Multiple Reaction Monitoring (MRM) multi-component analyses. With ultra-fast positive-negative polarity switching and ultrafast MRM times, the LCMS-8030 CL maximizes analytical throughput. LCMS-8040 CL An ultra-fast triple quadrupole mass spectrometer (MS/MS), incorporating improved ion optics systems for increased sensitivity. The LCMS-8040 CL is appropriate for laboratories requiring lower detection limits in specific and highly sensitive Multiple Reaction Monitoring (MRM) multi-component analyses. LCMS-8050 CL A next-generation triple quadrupole mass spectrometer (MS/ MS) offering unparalleled measurement speeds and highsensitivity performance. Specific and highly sensitive Multiple Reaction Monitoring (MRM) multi-component analysis is improved with a heated electrospray source and a newly designed collision cell. The LCMS-8050 CL redefines highsensitivity and high-speed analysis. 5
6 Designed for Outstanding Performance Shimadzu s CL Series devices are registered with the United States Food and Drug Administration as Class I medical devices. Our CL Series products deliver reliable results, meeting the demands of today s clinical laboratories. Ultra-fast acquisition data speeds enable optimum throughput, allowing sensitive quantitative analyses with exceptional robustness and ease of use. Exceptional Durability Shimadzu CL Series instruments, proudly manufactured in the United States of America, are engineered for long lifetimes and easy maintenance. Clinical laboratories benefit from minimal downtime and low total cost of ownership. These compact platforms are designed to be clinical workhorses consistently delivering precise and reliable data. Confidence in Clinical Measurements A critical parameter of instrument performance is carryover of patient samples. Ultra-low carryover is required in highly sensitive LC-MS/MS assays. The SIL-30ACMP CL autosampler standard injection cycle demonstrates exceptional carryover performance even on compounds that are very prone to adsorption. Additionally, the SIL-30ACMP CL can employ an additional rinsing mechanism to mitigate carryover. These features ensure that accurate quantitation is possible even for the most complex biological matrices. A Continuing Commitment to Improving Human Health For the past 140 years, Shimadzu Corporation has maintained the pioneering spirit of our founders. Shimadzu has more than 100 years experience in the medical field, providing a broad range of X-ray systems, including: Cardiovascular Fluoroscopy General Radiography Angiography Surgical mobile C-arm Mobile X-ray systems. We continue this tradition with our CL Series products, delivering outstanding performance and quality to clinical laboratories for accurate and reliable quantitative analysis of clinical biospecimens. 6
7 Powerful Software for Quantitative Analyses with Ease and Efficiency Shimadzu s family of software allows easy operation of analytical instrumentation including auto-tuning, acquisition parameters, data review, and report generation. The software also allows the creation of quantitation methods for multi-component analysis, enabling laboratories to perform quantitative analyses with easily and efficiently. Real-Time Analysis Window with Instrument Status The data acquisition window displays chromatograms in real time, as well as instrument status information such as pressure, temperature, and analytical run time. Instrument status logs are permanently stored in each data file, making audit retrieval and troubleshooting secure and intuitive. Progress of analysis queue displayed Current instrument status displayed Chromatograms and MS spectra displayed in real time Analysis Window (Quantitation Browser) for Multiple Data File Review The Quantitation Browser allows users to analyze and compare entire data sets in a single window. Rapid review and simultaneous calculation of multiple compound results from multiple sample injections is possible. In addition to calculating a complete batch of analytical data, it enables quick, easy confirmation of data quality. The browser provides efficient quantitative processing of multiple analytes. Statistical results for multiple data files can be displayed Quantitative parameters can be displayed and/or changed Calibration curve information can be verified Chromatogram for selected component data is displayed 7
8 CL Series Liquid Chromatograph and Mass Spectrometry Listed Devices: CL Series Single Quad LC-MS LCMS-2020 CL Triple Quad LC-MS/MS LCMS-8030 CL Triple Quad LC-MS/MS LCMS-8040 CL Triple Quad LC-MS/MS LCMS-8050 CL Column Oven CTO-20AC CL Communications CBM-20A CL Communications CBM-20Alite CL Degassing Unit DGU-20A3R CL Degassing Unit DGU-20A5R CL Diode Array Detector SPD-M20A CL Low Volume LPGE LC-30AD CL Nexera CL Autosampler SIL-20ACXR CL Nexera CL Autosampler SIL-30AC CL Nexera CL Autosampler SIL-30ACMP CL Nexera CL Column Oven CTO-30A CL Nexera CL Diode Array Detector SPD-M30A CL Nexera CL Liquid Chromatograph LC-20ADXR CL Nexera CL Liquid Chromatograph LC-30AD CL Prominence CL Autosampler SIL-20AC CL Prominence CL Autosampler SIL-20ACHT CL Prominence CL Autosampler SIL-20AHT CL Prominence CL Liquid Chromatograph LC-20AD CL Reservoir Switching Valve for LC-30AD CL UV-VIS Detector SPD-20A CL UV-VIS Detector SPD-20AV CL Valve Unit FCV-20AH2 CL Valve Unit FCV-32AH CL This brochure may contain references to products that are not available in your country. Please contact us to check the availability of these products in your country. Shimadzu Corporation Shimadzu Scientific Instruments 7102 Riverwood Drive, Columbia, Maryland 21046, U.S.A. Phone: / , Fax: Company names, product/service names and logos used in this publication are trademarks and trade names of Shimadzu Corporation or its affiliates, whether or not they are used with trademark symbol TM or. Third-party trademarks and trade names may be used in this publication to refer to either the entities or their products/services. Shimadzu disclaims any proprietary interest in trademarks and trade names other than its own. The contents of this publication are provided to you as is without warranty of any kind, and are subject to change without notice. Shimadzu does not assume any responsibility or liability for any damage, whether direct or indirect, relating to the use of this publication. Shimadzu Corporation 2015
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