Berlin-Buch health location in the northeast of Berlin

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1 Welcome

2 Berlin-Buch health location in the northeast of Berlin Hennigsdorf Buch D HMI Prenzlauer Berg Mitte TU HU Charlottenburg Dahlem Adlershof FU WISTA Golm Potsdam Luckenwalde

3 Berlin-Buch health and resaerch for about 100 years Since 1914: Europe s largest hospital city composed of 5 large sites with more than bedsides Centre of medical maximum and special care Since 1930: Centre of medical sciences Since 1945: Centre of training and education in medical professions and of research in cardiovascular, cancer, and cell biology

4 Heath Location Berlin-Buch International recognized basic research in life sciences at MDC and FMP, translational research in Charité and BIH Center of clinical of maximum care and specialized medical care One of the largest Biotechnology Park in Europe with currently 54 Biotech companies

5

6 Berlin-Buch facts and figures Research Institutions MDC, FMP, Charité Institutional funding 100 Mio. Third party funding 32 Mio. Personnel thereof scientists Research Institutions MDC, FMP, Charité Companies 54 Revenue per year 140 Mio. Personnel 800

7 Translational Research Charité University Medicine Berlin ECRC, Experimental and Clinical Research Center BIH, Berlin Institute of Health Biotech Park with 54 companies Basic Research MDC, Max Delbrück Center for Molecular Medicine FMP, Leibniz Institute for Molecular Pharmacology

8 Cardiovascular diseases Cancer resaerch Diseases of the nervous system Systems biology (BIMSB) Translation Technology Platforms

9 Leibniz-Institute for Molecular Pharmakology Molecular Physioloy und Cell Biology Structural Biology Chemical Biology Focus of Research : Identification, characterization, and manipulation of biological targets for pharmacological interference Development of novel chemical tools, probes and experimental strategies that address biological function Integration of structural biology, genetic, biochemical, chemical, and bioimaging approaches Method development (e.g. NMR, MRI, chemical synthesis) (Patho-) Mechanisms Small Molecule Screening Preclinical Phase Clinical Phase Approval / Marketing

10 EXPERIMENTAL AND CLINICAL RESEARCH CENTER (ECRC) Joint institution of Charité and MDC Budget: 10 Mio. per year Protected time for clinicians Research groups and project groups Funding of collaborative projects of basic scientists and clinicians Infrastructure for research with patients and probands Clinical research unit 11 Interdisciplinary university ambulances GMP-Facility for cell based immune therapy Ultra high field MRI Epidemiology (German National Cohort)

11 National center for biomedical translational research Charité - largest university hospital in Europe Max Delbruck Center ranks #14 in the top 20 list of research institutes for molecular biology and genetics (53.91 citations per paper) Biomedical researchers, clinical researchers, and clinical practitioners in joint locations Source: MPIKG $ 325 Mio. funding until % by BMBF $ 120 Mio. in BIH research $ 100 Mio. in research infrastructure Source: Berliner Zeitung /01/18 Source: 2010 Thompson Reuters: Page 11 be Innovative! be International! be Berlin!

12 Scientific Excellence 21 ERC awardees 4 Leibniz awardees 6 awardees of the German Cancer Prize 12 EMBO members 7 Leopoldina members Humboldt-Ranking : rank 2 in life sciences

13 SCIENTIFIC TECHNOLOGY PLATTFORMS Imaging Light microskopy MRT EM NMR Omics Genomics Proteomics Metabolomics Animal models Generierung von Tiermodellen (Maus, Ratte) Pathophysiology & Phenotyping Etc. FACS, Interactomics, Microarrays, Protein Sample Production ipscs Bioinformatics Chemical Biology & Screening Seite 13

14 LEIBNIZ-INSTITUT FÜR MOLEKULARE PHARMAKOLOGIE Joint MDC & FMP Chemical Biology Unit From Target-to-Clinic The translational drug discovery value chain Target Identification &Validation HTS Screening Hit to Lead Identification Candidate Identification Pre-clinical Phase I / IIa Phase IIb / III Registration & Approval Drug Design Assay Dev. Compoundmanagement Processautomation Screening Medicinal Chemistry Database/ IT CC MC SU SU SU MC SU/CC CC: Computational Chemistry SU: Screening Unit MC: Medicinal Chemistry

15 BiotechPark Berlin-Buch m² branch specific laboratory und office space 5 state of the art buildings with separated units currently 54 companies with about 800 employees

16 Dynamic Growth of the BiotechPark No. of Companies No. of Emploees

17 54 Biotech companies Medical Technology Eckert & Ziegler AG Other Patent Attorneys Drug Development Silence, MerLion, Glycotope,Evotec Drug Discovery Service KfBB, epo Service Imagenes, emp, Biosyntan Molecular Diagnostic Invitek; BioTeZ, Congen, Human Drug Delivery ALRISE, Celares

18 Hidden Champions of the BiotechPark One of the largest provider of isotope technique compounds for radiotherapy Revenue: 126 Mio Euro in 2013 Employees: 560 Spin off company from MDC developing specific antibodies against cancer Employees: 130 Spin off company from MDC leading in preclinical cancer research in Germany, Service provider for the development of novel antitumor substances or treatment concepts Employees: 43

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22 Cell Isolation Pre- ScreenedCells Cell Assays RNA Preparation

23

24 Berlin Cures GmbH, Berlin, Germany Pipeline: BC007 - A 15mer Aptamer that neutralizes Autoantibodies against GPCR Receptors Preclinical studies concluded - Phase 1 study immanent First indication: Autoantibody-pos. Congestive Heart Failure US and EP patent granted Other indications to follow info@berlincures.de

25 Extension of the BiotechPark Requirements: lab and office space, functional space, cold rooms, as well storage space special space: clean rooms, special experimental equipment etc. Flexibel modular units Rental space: ca m 2

26 Extension Area of the BiotechPark

27 Gläsernes Labor Life Science Learning Lab Place of extracurricular learning with five laboratories und more than 20 different experiments for more than pupils per year Lab courses for pupils in chemistry, genetics, cell biology, neurobiology, ecology Learning programs and programs for very talented pupils in natural sciences from kindergarten to high school graduation Certified specific advanced training for Job & further career in Life Sciences

28 Many thanks for your attention. Dr. Christina Quensel Robert-Rössle-Straße 10 D Berlin Phone: +49 (0) Fax: +49 (0) Mail: Web:

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