SESSION I DESIGNING FOR IMPLEMENTATION
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1 SESSION I DESIGNING FOR IMPLEMENTATION Washington, November 19, 2015 By Marc LePage, President and CEO, Génome Québec
2 THE GENOMICS ENTERPRISE 6 regional centres 5 science and technology innovation centres 192+ large-scale research projects $2,3 billion in investments (including $1,3 billion by partners) 50+ new or improved companies 7 key economic sectors: health, agriculture, environment, fisheries and aquaculture, forestry, energy and mines University of Victoria/Genome BC Proteomics Centre Victoria Vancouver Edmonton Genomics Innovation Centre at the BCCA GSC The Metabolomics Innovation Centre The Centre for Applied Genomics Toronto Montreal McGill University and Génome Québec Innovation Centre Session I - Nov. 19,
3 QUÉBEC: KEY FACTS Population: 8,054,756 (2012) Main university research centres: o Concordia University o Université Laval o McGill University o Université de Montréal o Université de Sherbrooke Health care expenditures: $45 billion (75% Public 25% Private) 49% of provincial budget One of the lowest per capita expenditure rates in Canada Session I - Nov. 19,
4 GÉNOME QUÉBEC Large-scale genomics research Operates key platforms: o Sequencing at McGill University o Clinical genomics at CHU Sainte-Justine o Cohorts (40,000 population + 45,000 disease collections) o Biobank Raises local funding to match Genome Canada Determines local priorities Personalized medicine is top priority (8 of 17 Genome Canada projects) Session I - Nov. 19,
5 GENOMICS AND HEALTH PERSONALIZED MEDICINE 8 projects lead 4 projects co-lead $89M Prevention Diagnosis Genomics Treatment Prognosis Safer prenatal screening solution Optimal breast cancer screening strategy New diagnostic test for epilepsy New therapy for pediatric glioblastoma More accurate treatments for leukemia Session I - Nov. 19,
6 TECHNOLOGY PLATFORMS Montréal Biobanque Genizon Génome Québec clinical case-controls biobank (almost 50,000 samples) McGill University and Génome Québec Innovation Centre offers state-of-the-art genomic services CHU Sainte-Justine and Génome Québec Integrated Clinical Genomic Centre in Pediatrics, the first in Canadian CARTaGENE 40,000 randomly selected people for population genomic research Montréal Saguenay Québec Sherbrooke Saguenay Génome Québec and CHAU) Biobank (million samples capacity) Accessible technologies and expertise Session I - Nov. 19,
7 BUILDING IMPLEMENTATION INTO THE REQUEST FOR APPLICATIONS Clear demonstration of the clinical needs Measurable socioeconomic benefits Implementation roadmap Clinical outcomes within project timeframe Appropriate and integrated GE 3 LS program Substantial end-users engagement Session I - Nov. 19,
8 FROM PROJECTS TO AN ECOSYSTEM Step 5 Establish clinical platform Step 4 Post-competition engagement with regulatory and healthcare Step 3 Panel guidelines: making the socioeconomic benefits cost Step 2 Selecting clinically-oriented panel Step 1 Designing implementation in the RFA Session I - Nov. 19,
9 LESSONS LEARNED 2012 Genomics and Personalized Health Competition 7/8 projects lead by clinicians All have health economists, ethics and regulator experts in their team Focus on deliverable and outcomes instead of process and methods Ongoing dialogue with regulators (INESSS) and health system Session I - Nov. 19,
10 IT WENT WELL SO FAR BUT Aligning existing activities (projects/cohorts/platforms) Data harmonization Best practice Coordination across Canada and the world Communications Session I - Nov. 19,
11 630 René-Lévesque Blvd West, Suite 2660 Montréal (Québec) H3B 1S
12 PERSONALIZED MEDICINE PROJECTS GÉNOME QUÉBEC AND GENOME CANADA Principal Investigator University Name of project (Duration of competition: April 1, 2013 to March 31, 2017) Total Budget ($) Patrick Cossette Montréal/CHUM New diagnostic test for epilepsy 10,833,759 Nada Jabado McGill/MUHC New therapy for pediatric glioblastoma 5,074,844 Claude Perreault Montréal/HMR Revolutionary approach to improve the effectiveness of hematological cancer immunotherapy 13,486,784 John D. Rioux Montréal/MHI Personalized therapeutic approach to inflammatory bowel diseases 9,892,162 François Rousseau Laval/CHUQ Implementation of a safer prenatal screening for trisomy 21 10,459,731 Guy Sauvageau Montréal/IRIC Prognostic test for acute myeloid leukemia 11,325,631 Jacques Simard Laval/CHUQ Optimal breast cancer screening and treatment strategy 11,382,455 Jean-Claude Tardif Montréal/MHI Pharmacogenomic kit for cardiovascular disease 9,443,002 4 collaborations 6,666,950 Session I - Nov. 19,
13 GÉNOME QUÉBEC IN BRIEF Launched in 2000 Investment in genomic research in Québec: $750 million More than 90 projects 800 researchers funded Our core business Large-scale projects Platforms Human Health Agrifood Forestry Environment Session I - Nov. 19,
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