The need for mobile devices for rapid diagnosis of febrile or infectious diseases in resource-poor countries
|
|
- Miranda Hunter
- 6 years ago
- Views:
Transcription
1 Dept. Medical Parasitology and Infection Biology Molecular Parasitology-Epidemiology Unit The need for mobile devices for rapid diagnosis of febrile or infectious diseases in resource-poor countries 2016 Healthcare IT News, HIMSS Media Hans-Peter Beck Seoul, 14 July 2016
2 Innovative mobile devices for resource limited settings? 3 examples: Prevention of over-prescription of inappropriate drugs leading to drug resistance Improvement of the management of childhood illness Identification of the unknow infectious reservoir for strategies to control or eliminate malaria Possible product development and product profile 25 July
3 Diagnosis of febrile illness in children 1005 children in Tanzania with febrile symptoms enrolled with 1225 diagnoses. recruited in Amana District Hospital (Dar es Salaam, area of low malaria endemicity, 1 to 4% point prevalence, 2.5 % Pf. of all febrile episodes). recruited in St. Francis Designated District Hospital (Ifakara, Kilombero District, intermediate endemicity, 7% of febrile patients had parasitemia). All children were treated according to the standard health facility procedures Samples from all children were collected and diagnostically analyzed by state-of-the-art technologies. For each sample the most appropriate method of detection of pathogens (bacteria, viruses, parasites) was used for each acute febrile episode (> laboratory tests (RT-PCR, serology, culture, microscopy)) D'Acremont V et al. N Engl J Med 2014;370:
4 Diagnosis of febrile illness in children Overlap among disease types and pathogen types in 1005 febrile children. Panel A: diseases diagnosed by state-of-the-art technology Panel B: final diagnoses at the health facility D'Acremont V et al. N Engl J Med 2014;370:
5 Most common diagnoses by age Correct diagnosis and treatment would prevent over-prescription of inappropriate drugs leading to drug resistance D'Acremont V et al. N Engl J Med 2014;370:
6 Improvement of the management of childhood illness ALMANACH ALgorithm for the MANAgement of CHildhood illnesses using mobile technology A project implemented by Swiss TPH in collaboration with ICRC and PMU 25 July
7 Aim: to improve quality of out-patient department (OPD) consultations and prevent drug resistance Method: develop and implement a mobile device-based medical algorithm (running on Android smartphones and tablets) Beneficiaries: Background In 2015, children worldwide under the age of five died every day despite of available cost-effective interventions (WHO) The impact of the Integrated Management of Childhood Illness (IMCI, WHO) has been less successful due to limited acceptance and poor adherence Children aged between 2 months and 5 years 25 July
8 What is ALMANACH? Improved IMCI support on Android Tailored to local settings and validated by authorities No simple focus on syndromes but focused on few meaningful clinical examinations and laboratory investigations. Support rational use of drugs, especially antibiotics. Hands-on training sessions for health workers. 25 July
9 Medical algorithm in the application Example: - The user interface is designed for user-friendliness and ease of navigation - The application guides the user through the steps of the medical algorithm - Upon completion, the collected data is sent to the server for monitoring and evaluation analysis 25 July
10 ALMANACH in Tanzania Control standard care Study ALMANACH Prescribed Antimalarials 7% 4% Prescribed Antibiotics 84% 15% Children cured on Day 7 92% 97% Shao et al, New Algorithm for Managing Childhood Illness Using Mobile Technology (ALMANACH): A Controlled Non- Inferiority Study on Clinical Outcome and Antibiotic Use in Tanzania, PLOS One, July
11 The unknown infectious reservoir of submicroscopic malaria parasites Shrinking the malaria map 25 July
12 Malaria in Korea North Korea: approx cases in July
13 Sub-microscopical parasitemia Solomon Island Microscopy prevalence: 2.7% (17% Pf, 18 % febrile; 82% Pv, 2.8% febrile) ~0.15% detected as febrile cases at health posts. PCR prevalence: 8.7% Harris I, Sharrock WW, Bain LM, Gray KA, Bobogare A, Boaz L, Lilley K, Krause D, Vallely A, Johnson ML, Gatton ML, Shanks GD, Cheng Q A large proportion of asymptomatic Plasmodium infections with low and sub-microscopic parasite densities in the low transmission setting of Temotu Province, Solomon Islands: challenges for malaria diagnostics in an elimination setting. Malaria Journal 2010, 9:254 Ethiopia Microscopy prevalence: 3.7% RDT 6.9% PCR prevalence: 19.2% Golassa L, Enweji N, Erko B, Aseffa A, Swedberg G Detection of a substantial number of submicroscopic Plasmodium falciparum infections by polymerase chain reaction: a potential threat to malaria control and diagnosis in Ethiopia Malaria Journal 12: July
14 Parasitemia by RDT and PCR On average, microscopy captured 87% (95% confidence interval = %) of rapid diagnostic test-positive infections. Lindsey W. et al Comparison of diagnostics for the detection of asymptomatic Plasmodium falciparum infections to inform control and elimination strategies. Nature 528, S86 S93 25 July
15 Diagnostic tools are needed Point-of-care devices are needed for: Non-malarial fevers Rapid diagnosis of viral diseases Detection (and quantification) of bacterial infections Highly sensitive detection of parasitic diseases with emphasis on malaria Detection of drug resistance associated SNPs Envisaged applications: to improve diagnosis/health in general to avoid unneccessary antibiotic and malaria treatment diagnosis to use for malaria surveillance and control to monitor effects of drugs/vaccines in clincial trials for molecular-epidemiological research 25 July
16 Diagnostic tools are needed robust (and to be run on car batteries/mobile devices) cheap (at least consumables) linked to mobile technology highly sensitive (in some instances, e.g. malaria) easy-to-perform at point of care multiplexed assays possible for parallelization adaptable to various diagnostic assays 25 July
17 Examples of already available tools Used for Ebola detection, identification and phylogenetic studies Oxford nanopores provides devices with nanoscale holes through which an ionic current passes through. When biological molecules (e.g. DNA, RNA) passes through the changes in current are measured. The information about the change in current can be used to identify these molecules (DNA strand sequencing). The whole assay is powered and run by a laptop computer. ( Quick J et al Real-time, portable genome sequencing for Ebola surveillance. Nature. 2016; 530 (7589): July
18 Examples of already available tools FilmArray multiplex PCR system Closed pouches store all reagents for cell lysis, DNA/RNA extraction and purification, amplification, and detection. Turnaround time: 1hr Hands-on: 2 min all-in-one assay commercially available Piralla A, et al FilmArray respiratory panel performance in respiratory samples from neonatal care units. Diagn Microbiol Infect Dis. Jun;79(2):183-6.
19 Examples of already available tools prevalence Nm1 (sensitivity/ Cellscope (sensitivity/ (microscopy) specificity) specificity) Diagnosis: S. haematobium / /99.5 S. mansoni / /100 Giardia intestinalis /100 n.d. Entamoeba histolytica/ E. dispar /100 n.d. Coulibaly JT. et al Accuracy of Mobile Phone and Handheld Light Microscopy for the Diagnosis of Schistosomiasis and Intestinal Protozoa Infections in Côte d Ivoire. PLoS Negl Trop Dis 10(6): e
20 Korean innovations Noul, Korea Nanonbiosys/Korea Seegene, Korea Quantamatrix, Korea 25 July
21 Conclusion Control of infectious diseases relies on high quality diagnosis Diagnosis is often of low quality and of poor sensitivity Diagnosis is often not available or affordable at peripheral health facilities No easy to use POC tests are available Hardly any link to mobile technology Urgent need for affordable and reliable devices 25 July
22 Thank you for your attention 25 July
Integrated human diagnostics and vector control towards OneHealth
Integrated human diagnostics and vector control towards OneHealth Dr. Konstantinos Mitsakakis, et al. University of Freiburg & Hahn-Schickard, Germany 3 rd WHO Global Forum on Medical Devices, 12.05.2017,
More informationMolecular tools for the diagnosis of malaria and monitoring of parasite dynamics under drug pressure Mens, P.F.
UvA-DARE (Digital Academic Repository) Molecular tools for the diagnosis of malaria and monitoring of parasite dynamics under drug pressure Mens, P.F. Link to publication Citation for published version
More informationESCMID Online Lecture Library. Molecular diagnosis of malaria. by author
Molecular diagnosis of DNA malaria Aldert Bart Parasitology Medical Microbiology Academic Medical Center Amsterdam ESCMID course 05-06-12 Putative advantages of molecular diagnosis of malaria correct (unequivocal?)
More informationRapid Diagnostic Tests in malaria case management
Rapid Diagnostic Tests in malaria case management Planning, Procuring and Implementing Suggestions for incorporation of malaria RDT-based diagnosis into proposals to the Global Fund Foundation for Innovative
More informationGlobal response plan for pfhrp2/3 deletions
Global response plan for pfhrp2/3 deletions Jane Cunningham MPAC 17-19 October, 2017 The global response plan for pfhrp2/3 mutations that limit the effectiveness of HRP2- based RDTs comprises a global
More informationMULTIECHELON DIAGNOSTICS (MEDx) TECHNOLOGY DEVELOPMENT AND TIERED EVALUATION
NRL BAA Announcement #61-17-06 MULTIECHELON DIAGNOSTICS (MEDx) TECHNOLOGY DEVELOPMENT AND TIERED EVALUATION Recent advances in diagnostic technologies are blurring the standard definitions of Echelons
More informationQuality Assessment of Malaria Diagnosis on the Thai-Burma Border. Jaime Moo-Young Noon Conference, Harborview Medical Center June 1, 2010
+ Quality Assessment of Malaria Diagnosis on the Thai-Burma Border Jaime Moo-Young Noon Conference, Harborview Medical Center June 1, 2010 Background: Malaria Situation in Thailand Overall incidence decreasing
More informationIntroduction to Lassa fever
Introduction to Lassa fever Managing infectious hazards Store food in containers with lids OpenWHO.org WHO2017 1 Learning objectives Describe signs, symptoms, and transmission of Lassa fever List 4 preventive
More informationAUDREY FARBOS JEREMIE POSCHMANN PAUL O NEILL KONRAD PASZKIEWICZ KAREN MOORE
We provide: AUDREY FARBOS JEREMIE POSCHMANN PAUL O NEILL KONRAD PASZKIEWICZ KAREN MOORE State of the art genomics and bioinformatics analysis Training in experimental techniques, analysis and modelling
More informationEnabling the adoption of new diagnostics within the UK healthcare system:
Enabling the adoption of new diagnostics within the UK healthcare system: The key role of diagnostics in the AMR challenge Fiona Carragher FRCPath @DepCSOFiona Deputy Chief Scientific Officer for England
More informationAugust 25, International conference on parasitology,2015 Philadelphia,USA. By: Meslo Sema (BSc, MSc)
Evaluation of non-instrumented nucleic acid amplification by loop-mediated isothermal amplification (NINA-LAMP) for the diagnosis of malaria in Northwest Ethiopia By: Meslo Sema 1 Evaluation of non-instrumented
More informationSURVEILLANCE AND LABORATORY DIAGNOSTICS OF INFECTIOUS DISEASES IN THE RUSSIAN FEDERATION I. DYATLOV
SURVEILLANCE AND LABORATORY DIAGNOSTICS OF INFECTIOUS DISEASES IN THE RUSSIAN FEDERATION FEDERAL SERVICE OF SURVAILLANCE IN THE FIELD OF CONSUMER RIGHT PROTECTION & HUMAN WELFARE, RUSSIA I. DYATLOV Russia
More informationSystem Overview. cobas Liat
System Overview cobas Liat cobas Liat System A complete POC PCR solution from sample in to result out ANALYZER 19.0 cm ASSAY 1 1 0 1 0 0 1 0 1 1 SOFTWARE 11.4 cm cobas Liat System A complete solution from
More informationInnovations in Molecular Lab Operation. Joseph M. Campos, PhD, D(ABMM), F(AAM)
Innovations in Molecular Lab Operation Lessons in the Best Ways to Blend Automation, Lean Workflow, and Paperless Processes Joseph M. Campos, PhD, D(ABMM), F(AAM) Interim Chief, Division of Laboratory
More informationApplication of Real-Time Quantitative PCR (qpcr) in Anti-malarial Clinical Trial
Application of Real-Time Quantitative PCR (qpcr) in Anti-malarial Clinical Trial Davis Nwakanma, Eniyou Oriero, Sanie Sesay, Lesong Conteh, David Conway MALARIA DIAGNOSIS CLINICAL DIAGNOSIS: BASED ON SYMPTONS
More informationPublic private partnerships
THE INTERNATIONAL CONFERENCE ON (RE-)EMERGING INFECTIOUS DISEASES 14 March 2018 in Addis Ababa, Ethiopia Public private partnerships Engaging the private research sector to scale up infectious diseases
More informationDiagnostics: Learning from successful experiences which made it to market. Mark Miller, MD Chief Medical Officer biomérieux France
Diagnostics: Learning from successful experiences which made it to market Mark Miller, MD Chief Medical Officer biomérieux France Diagnostics: Learning from unsuccessful experiences which almost made it
More informationSustainable Health Care Systems: Research and Innovation
Backgroundpaper B7-Communiqué Sustainable Health Care Systems: Research and Innovation Version II BDI, BUSINESSEUROPE Canadian Chamber of Commerce CBI CONFIDUSTRIA Keidanren MEDEF US Chamber of Commerce
More informationForecast diagnostics for antimicrobial resistance (AMR)
Forecast diagnostics for antimicrobial resistance (AMR) Authors: Ann Van den Bruel, Philip Turner NIHR Diagnostic Evidence Cooperative Oxford, University of Oxford Context When asked to make forecasts
More informationRole of DIAGNOSTICS in BIOPREPAREDNESS Mark Miller, MD Chief Medical Officer biomerieux
Role of DIAGNOSTICS in BIOPREPAREDNESS Mark Miller, MD Chief Medical Officer biomerieux 29.09.2016 IMI Stakeholder Forum 2016 Brussels, Belgium A distant history lesson Those who cannot remember the past
More informationStrategies For Improved Diagnostics For Malaria, Including Rapid Diagnosis
Strategies For Improved Diagnostics For Malaria, Including Rapid Diagnosis John W. Barnwell, Louise Causer and Peter B. Bloland Malaria Branch Division of Parasitic Diseases National Center for Infectious
More informationDiagnostics gathering intelligence to fight antimicrobial resistance
Diagnostics gathering intelligence to fight antimicrobial resistance Arjon van Hengel European Commission DG Research and Innovation, Health Directorate Unit "Fighting Infectious Diseases and Advancing
More informationUK AMR Diagnostics Collaborative:
UK AMR Diagnostics Collaborative: Maximising the use of diagnostic technology to tackle AMR Fiona Carragher FRCPath @DepCSOFiona Deputy Chief Scientific Officer for England england.amrdiagnostics@nhs.net
More informationBy Dr. Zainab khalid
By Dr. Zainab khalid Introduction to PCR PCR was invented in 1984 by ( Kary mullis ) & he received the Nobel Prize in chemistry in 1993, for his invention What is PCR? PCR is an exponentially progressing
More informationDedicated to Molecular Diagnostics
Dedicated to Molecular Diagnostics For Europe Sample & Assay Technologies QIAGEN s growing role in molecular diagnostics At QIAGEN, one of our key goals is to support clinical decision-making and improve
More informationMalaria Research Capability Strengthening in Africa
July 2005 UNICEF/UNDP/World Bank/WHO Special Programme for Research & Training in Tropical Diseases (TDR) Multilateral Initiative on Malaria (MIM) Malaria Research Capability Strengthening in Africa INTRODUCTION
More informationIntroductie en Toepassingen van Next-Generation Sequencing in de Klinische Virologie. Sander van Boheemen Medical Microbiology
Introductie en Toepassingen van Next-Generation Sequencing in de Klinische Virologie Sander van Boheemen Medical Microbiology Next-generation sequencing Next-generation sequencing (NGS), also known as
More informationStimulating introduction of new, innovative in vitro diagnostics Supporting product development
Stimulating introduction of new, innovative in vitro diagnostics Supporting product development Gonzalo Domingo Diagnostics gdomingo@path.org 09/18/2017 PATH: Accelerating global health innovation E X
More informationEvidence that PCR diagnostics underestimate infection prevalence of Ichthyophonus in Yukon River Chinook salmon.
Evidence that PCR diagnostics underestimate infection prevalence of Ichthyophonus in Yukon River Chinook salmon. R.M. Kocan, Ph.D. Professor Emeritus School of Aquatic & Fishery Sciences University of
More informationDespite enormous efforts over many years, Can a non-invasive urine-based test become the next-generation diagnostic tool for malaria?
Le Infezioni in Medicina, n. 3, 199-203, 2018 REVIEW 199 Can a non-invasive urine-based test become the next-generation diagnostic tool for malaria? Nitika Pradhan 1,2, Rupenangshu K. Hazra 2 1 KIIT School
More informationSelection and use of Ebola in vitro diagnostic (IVD) assays
EMERGENCY GUIDANCE Selection and use of Ebola in vitro diagnostic (IVD) assays June 2015 World Health Organization 2015. All rights reserved. The designations employed and the presentation of the material
More information16S rdna Sequencing Diagnosis of Spirochetemia in Lyme and related Borrelioses
16S rdna Sequencing Diagnosis of Spirochetemia in Lyme and related Borrelioses Sin Hang Lee, MD, F.R.C.P.(C)* Pathologist, Milford Hospital and Director, Milford Medical Laboratory, Inc. Milford, CT Email:
More informationVivax Working Group Workplan
Vivax Working Group Workplan 2017-2019 Why Does The VxWG Exist? The choice before us is clear. If we continue with a business as usual approach employing the same level of resources and the same interventions
More informationGrowing Needs for Practical Molecular Diagnostics: Indonesia s Preparedness for Current Trend
Growing Needs for Practical Molecular Diagnostics: Indonesia s Preparedness for Current Trend Dr. dr. Francisca Srioetami Tanoerahardjo, SpPK., MSi Essential Practical Molecular Diagnostics Seminar Hotel
More informationOn-site detection of Potato spindle tuber viroid in a disease outbreak using loop-mediated isothermal amplification (LAMP)
On-site detection of Potato spindle tuber viroid in a disease outbreak using loop-mediated isothermal amplification (LAMP) Linda Zheng, Fiona Constable, Angela Freeman, Brendna Rodoni Department of Economic
More informationRapid Diagnostic Tests in Microbiology (PAs & PHs) I.Afeke UHAS
Rapid Diagnostic Tests in Microbiology (PAs & PHs) I.Afeke UHAS Positive Negative Objective: Upon completion of this topic, the student should be able to: What a rapid diagnostic test (RDT) is When a RDT
More informationSyndromic Testing System
Syndromic Testing System System Overview What is syndromic testing? Most often, patients with infectious illnesses have signs and symptoms that are indicative of a disease, but are not specific enough
More informationSWACM MOLECULAR METHODS
SWACM - 2017 Lynnegarcia2@verizon.net LYNNE S. GARCIA, MS, FAAM, CLS, BLM Medical Chemical Corporation www.med-chem.com MOLECULAR METHODS 1 Where are we now? Over the last 10 to 15 years, many diagnostic
More informationAlere q. A platform to answer global health needs: TB and beyond. Duncan Blair Director, Public Health Initiatives
Alere q A platform to answer global health needs: TB and beyond Duncan Blair Director, Public Health Initiatives 7 th FIND Symposium, Barcelona, October 2014 Alere q platform overview Comprising the Alere
More informationNear-Care Molecular Testing for Dengue, Zika, and Related Pathogens
Brent Swails, CNN Near-Care Molecular Testing for Dengue, Zika, and Related Pathogens Jesse Waggoner, MD Assistant Professor Department of Medicine, Division of Infectious Diseases Emory University School
More informationChapter 2 Molecular Diagnostics of Parasitic Infections
Chapter 2 Molecular Diagnostics of Parasitic Infections Jaco J. Verweij Abstract DNA-based methods have been available for many years in most clinical microbiology laboratories. However, until recently,
More informationi) Wild animals: Those animals that do not live under human supervision or control and do not have their phenotype selected by humans.
The OIE Validation Recommendations provide detailed information and examples in support of the OIE Validation Standard that is published as Chapter 1.1.6 of the Terrestrial Manual, or Chapter 1.1.2 of
More informationFUTURE PROSPECTS IN MOLECULAR INFECTIOUS DISEASES DIAGNOSIS
FUTURE PROSPECTS IN MOLECULAR INFECTIOUS DISEASES DIAGNOSIS Richard L. Hodinka, Ph.D. University of South Carolina School of Medicine Greenville Greenville Health System, Greenville, SC hodinka@greenvillemed.sc.edu
More informationCHAPTER 24. Immunology
CHAPTER 24 Diagnostic i Microbiology and Immunology Growth-Dependent Diagnostic Methods Isolation of Pathogens from Clinical Specimens Proper sampling and culture of a suspected pathogen is the most reliable
More informationWhat Can I Do With My Data?
What Can I Do With My Data? Utilizing Existing Data for Analysis and Hypothesis Development Falgunee Parekh, MPH, PhD Agenda My Research Background Background on Analysis of Surveillance (or Initial) Data
More informationMethods in virus diagnosis PCR techniques
Methods in virus diagnosis PCR techniques 450 MBIO PRACTICAL LESSON 5 Molecular Methods Methods based on the detection of viral genome are also commonly known as molecular methods. It is often said that
More informationLoop-mediated Isothermal Amplification (LAMP) as a diagnostic tool in detection of infectious diseases
Loop-mediated Isothermal Amplification (LAMP) as a diagnostic tool in detection of infectious diseases Dorota DRAPAŁA, Milena KORDALEWSKA Keywords: LAMP; DNA amplification; isothermal reaction Abstract:
More informationCourse outlines for senior Microbiology and Virology units of study within the Bachelor of Medical Science Last updated 18 November 2006
Course outlines for senior Microbiology and Virology units of study within the Bachelor of Medical Science Last updated 18 November 2006 These course outlines are a guide only. They are provided for the
More informationToday s topics. Readings and Assignments. Homework 7: SMS Reporting. Medication Adherence. Homework 7: Solutions 2/18/2015
Today s topics Computing and Global Health Lecture 7 Treatment support and mobile devices Winter 2015 Richard Anderson Aditya Vashistha Voice based messaging Treatment Support Adherence Protocol Support
More informationHarmonisation of PCR-based detection of intestinal pathogens: experiences from the Dutch external quality assessment scheme
Harmonisation of PCR-based detection of intestinal pathogens: experiences from the Dutch external quality assessment scheme on molecular diagnosis of protozoa in stool samples Theo A. Schuurs 1#, Rob Koelewijn
More informationDevelopments in Science and Technology - Diagnostics
Developments in Science and Technology - Diagnostics Submitted by the United States of America I. Background 1. The Seventh Review Conference called for review of developments in the field of science and
More informationGlobal Update on P.falciparum HRP2 deletions
Global Update on P.falciparum HRP2 deletions Jane Cunningham XV Reunion Annual de Evaluacion de AMI/RAVREDA Bogota, Colombia 3 5 May 2016 What is histidine rich protein 2 (HRP2)? Malaria protein specific
More informationMicrofluidics as an enabler for Medical Diagnostics
Microfluidics as an enabler for Medical Diagnostics Henne van Heeren, enablingmnt Microfluidics: The ability to create complex channel manifolds on a single substrate with no dead volume between connecting
More informationHELINI Hepatitis B virus [HBV] Real-time PCR Kit (Genotype A to H)
HELINI Hepatitis B virus [HBV] Real-time PCR Kit (Genotype A to H) Quantitative In vitro diagnostics Instruction manual Cat. No: 8001-25/50/100 tests Compatible with: Agilent, Bio-Rad, Applied Bio systems
More informationMolecular Diagnostics for Global Heath Problems. Proactive Investors Forum 5 October 2017
Molecular Diagnostics for Global Heath Problems Proactive Investors Forum 5 October 2017 2 Document Information The information contained in this document and made verbally to you (together the Presentation
More informationRDTs for use in areas with P.falciparum HRP2 deletions and P.vivax infections
RDTs for use in areas with P.falciparum HRP2 deletions and P.vivax infections Jane Cunningham XV Reunion Annual de Evaluacion de AMI/RAVREDA Bogota, Colombia 3 5 May 2016 Introduction High prevalence of
More informationCurrent molecular diagnostic system
LAMP-BART Name: Chris Wong Supervisor: Prof. Margaret Ip Joint Graduate Seminar Department of Microbiology The Chinese University of Hong Kong 18 th December 2012 Current molecular diagnostic system Detection
More informationComparing Traditional Culture Methods and New Molecular Testing Techniques to Analyze Biofilm Composition on Uninfected IPPs
Comparing Traditional Culture Methods and New Molecular Testing Techniques to Analyze Biofilm Composition on Uninfected IPPs Martin S. Gross 1, Gerard D. Henry 2 1: Dartmouth-Hitchcock Medical Center;
More informationPositioning of TB Diagnostics within a Tiered System Integrated Approach from Reference to District Laboratory. Giorgio Roscigno CEO FIND
Positioning of TB Diagnostics within a Tiered System Integrated Approach from Reference to District Laboratory Giorgio Roscigno CEO FIND Integrated Laboratory Network Definition An integrated laboratory
More informationCURRENT STATE AND FUTURE PROSPECTS IN VIRAL DIAGNOSIS
CURRENT STATE AND FUTURE PROSPECTS IN VIRAL DIAGNOSIS Richard L. Hodinka, Ph.D. University of South Carolina School of Medicine Greenville Health System Isolation of Viruses in Culture Science 1949; 109:85-87
More informationMALARIA DIAGNOSTIC TECHNOLOGY LANDSCAPE DECEMBER 2011
MALARIA DIAGNOSTIC TECHNOLOGY LANDSCAPE DECEMBER 2011 UNITAID Secretariat World Health Organization Avenue Appia 20 CH-1211 Geneva 27 Switzerland T +41 22 791 55 03 F +41 22 791 48 90 unitaid@who.int www.unitaid.eu
More informationInvesting in Research, Development and Innovation for Global Health
The Malaria Advocacy Working Group (MAWG) of the Roll Back Malaria Partnership s (RBM) contribution to the European Commission consultation on the Green Paper - From Challenges to Opportunities: Towards
More informationReport from the Global Malaria Programme
Report from the Global Malaria Programme Malaria Policy Advisory Committee Meeting WHO HQ Geneva, 5 March 2015 Pedro Alonso Director, Global Malaria Programme alonsop@who.int On behalf of the global malaria
More informationFLUXERGY ANALYZER BETA A MODULAR PLATFORM FOR POINT-OF-CARE PCR
ß BETA FLUXERGY ANALYZER BETA A MODULAR PLATFORM FOR POINT-OF-CARE PCR Fluxergy LLC 13766 Alton Parkway Suite 15 Irvine, CA 92618 USA (949) 5-41 inquire@fluxergy.com www.fluxergy.com OBJECTIVE To introduce
More informationEvaluation of Ebola virus Inactivation Procedures for Plasmodium falciparum Malaria. Diagnostics. Toronto, Ontario, Canada;
JCM Accepted Manuscript Posted Online 28 January 2015 J. Clin. Microbiol. doi:10.1128/jcm.00165-15 Copyright 2015, American Society for Microbiology. All Rights Reserved. 1 2 3 Evaluation of Ebola virus
More informationThe effectiveness of microscopy: Rapid diagnostic test and molecular assay in diagnosing malaria.
Research Article http://www.alliedacademies.org/parasitic-diseases-diagnosis-therapy/ The effectiveness of microscopy: Rapid diagnostic test and molecular assay in diagnosing malaria. Obimakinde ET*, Simon-Oke
More informationCritical Issues in Product Development
Critical Issues in Product Development Partnership for Dengue Control Workshop 4 May 2017 Fondation Mérieux Annecy Courtesy of FIND Five Lessons in Product Development 1 The easy problems have been solved.
More informationBlood cultures: past, present and future. Dr Natalia Solomon MD, FRCPSC Medical Microbiologist DynaLIFE Dx
Blood cultures: past, present and future Dr Natalia Solomon MD, FRCPSC Medical Microbiologist DynaLIFE Dx Faculty/ Presenter Disclosure Faculty: Dr Natalia Solomon Relationships with commercial interests:
More informationGHIT の活動から新薬開発へのファンディングを考える. BT Slingsby, CEO, GHIT Fund
GHIT の活動から新薬開発へのファンディングを考える BT Slingsby, CEO, GHIT Fund Anti-Infectives Over 100 Years Development of antibacterial agents in Japan 八木澤守正 : 抗菌薬を概観する : 過去, 現在, そしてこれから 日化療会誌 2016 60: 149-167 舘田一博 : 抗菌薬開発停滞の打破へ向けて
More informationGenMark Diagnostics TRANSFORMING MULTIPLEX MOLECULAR TESTING. J.P. Morgan Healthcare Conference 2018
GenMark Diagnostics TRANSFORMING MULTIPLEX MOLECULAR TESTING J.P. Morgan Healthcare Conference 2018 1 Forward-Looking Statements This presentation contains forward-looking statements about GenMark Diagnostics,
More informationBIOPHARMACEUTICAL PROCESS EVALUATED FOR VIRAL CLEARANCE
The purpose of Viral Clearance evaluation is to assess the capability of a manufacturing production process to inactivate and/or remove potential viral contaminants. Experience and knowledge in selecting
More informationRegional Disease Surveillance workshop for banana Rwanda 25 th -29 th January IITA-pathology,Uganda
Regional Disease Surveillance workshop for banana Rwanda 25 th -29 th January 2010 Fen Beed Idd Ramathani IITA-pathology,Uganda Why lab-based diagnostic tools??? Field Diagnostic tools symptoms expression-bbtd
More informationManual. rapidstripe TBE Assay
Manual rapidstripe TBE Assay Contents Content 1 Introduction... 3 2 Test description and principle... 3 3 Performance assessment, spectrum of application and specificity... 5 4 Kit components, storage
More informationChanging Concept of FMD diagnostics: from Central to Local. Aniket Sanyal Project Directorate on FMD Mukteswar, India
Changing Concept of FMD diagnostics: from Central to Local Aniket Sanyal Project Directorate on FMD Mukteswar, India OBJECTIVES OF DIAGNOSIS IN THE FIELD/LOCAL 1. To arrive at quick diagnosis 2. To implement
More informationGlobal Health Technologies Invention saving lives
Global Health Technologies Invention saving lives Applying the unique advantages of Global Good and Intellectual Ventures Lab to eliminate disease and improve healthcare outcomes Photo credit: Alexander
More informationBenefits of Culture- Independent Diagnostic Testing to Public Health: A State Perspective
Benefits of Culture- Independent Diagnostic Testing to Public Health: A State Perspective Mike Rauch Microbiologist WI State Lab of Hygiene InFORM Meeting Nov 21, 2015 Objectives Discuss the impact of
More informationEvidence-based TB Diagnosis: how evidence informs practice and policy Madhukar Pai, MD, PhD
Evidence-based TB Diagnosis: how evidence informs practice and policy Madhukar Pai, MD, PhD Assistant Professor, McGill University, Montreal Co-Chair, Evidence Subgroup, New Diagnostics Working Group 1
More informationImproving the development and deployment of rapid diagnostic tests in LMICs. Workshop report 21 November 2016 London, United Kingdom
Improving the development and deployment of rapid diagnostic tests in LMICs Workshop report 21 November 2016 London, United Kingdom The Academy of Medical Sciences is the independent body in the UK representing
More informationMicrobiology of Healthcare-associated Infections
Microbiology of Healthcare-associated Infections William A. Rutala, Ph.D., M.P.H. Director, Statewide Program for Infection Control and Epidemiology and Professor of Medicine, University of North Carolina
More informationProduction and sales demonstration of STH-PAS, genetic testing kit in Vietnam
2018.12.17 Vietnam-Japan joint pilot project for nurturing new industries Production and sales demonstration of STH-PAS, genetic testing kit in Vietnam TBA Co. Ltd., Introduction of TBA, Co. Ltd. TBA Co.,
More informationRapid Diagnosis of Tuberculosis
Rapid Diagnosis of Tuberculosis Ed DESMOND Richmond, US I. Rapid Diagnosis Methods I would like to discuss rapid diagnosis methods of tuberculosis. The traditional method is acid fast microscopy. However,
More informationMolecular Diagnostics at the Point of Need
Molecular Diagnostics at the Point of Need 24 November 2016 David Budd CEO d.budd@genedrive.com 1 DOCUMENT INFORMATION The information contained in this document and made verbally to you (together the
More information11/19/2018 1:59 PM Approved (Changed Course) MICRO 5 Course Outline as of Fall 2017
11/19/2018 1:59 PM Approved (Changed Course) MICRO 5 Course Outline as of Fall 2017 CATALOG INFORMATION Dept and Nbr: MICRO 5 Title: GENERAL MICROBIOLOGY Full Title: General Microbiology Last Reviewed:
More informationMolecular test to detect Dengue, Zika & Chikungunya and run on the QuRapID LV platform. Dr David Edge BioGene Dr Emily Adams LSTM
Molecular test to detect Dengue, Zika & Chikungunya and run on the QuRapID LV platform. Dr David Edge BioGene (david@biogene.com) Dr Emily Adams LSTM 03/05/17 Technology was initially developed for the
More informationSchool of Allied Medical Sciences. Course Description Guide Associate in Medical Laboratory Sciences. Page 1 of 15
School of Allied Medical Sciences Course Description Guide Associate in Medical Laboratory Sciences Page 1 of 15 Program Name & Definition: Associate in Medical Laboratory Sciences Laboratory sciences
More informationWHO Prequalification of Diagnostics Programme PUBLIC REPORT. Product: SD Bioline Malaria Ag P.f Number: PQDx Abstract
WHO Prequalification of Diagnostics Programme PUBLIC REPORT Product: SD Bioline Malaria Ag P.f Number: PQDx 0031-012-00 Abstract SD BIOLINE Malaria Ag P.f with product codes 1 05FK50 and 05FK53, manufactured
More informationTHE EFFECT OF DIFFERENT GIEMSA STAINING CONDITIONS ON THIN BLOOD FILM MALARIA IDENTIFICATION
THE EFFECT OF DIFFERENT GIEMSA STAINING CONDITIONS ON THIN BLOOD FILM MALARIA IDENTIFICATION Tippawan Sungkapong, Natpasit Chaianantakul, Tarinee Dangsompong and Nalinnipa Weaingnak Department of Medical
More informationJoy Allen, William Jones, Michael Power, Stephen Rice, Greg Mantiapolous, Mark Wilcox, and Ashley Price
What is the potential for point of care diagnostics to improve testing protocols for C. difficile infection, with particular reference to the English NHS? Joy Allen, William Jones, Michael Power, Stephen
More informationGENOMERA TM MRSA/SA PRODUCTS A NEW ERA IN DIRECT MRSA DNA TESTING. Bringing genetic MRSA results in less than 1 hour!
GENOMERA TM MRSA/SA PRODUCTS A NEW ERA IN DIRECT MRSA DNA TESTING Bringing genetic MRSA results in less than 1 hour! IMPROVING PATIENT CARE THROUGH EARLIER DETECTION OF MRSA AND SA FAST MRSA AND SA DETECTION
More informationThe following is an overview of diagnostic techniques for Ebola infection in humans.
IBM Deep Dive Topic 1/14/2015 Alex // operonlabs.com Diagnostics and Ebola: The following is an overview of diagnostic techniques for Ebola infection in humans. Current Status: The current status of Ebola
More informationMicrobiology, Molecular Biology and Biochemistry
Microbiology, Molecular Biology and Biochemistry Bruce L. Miller, Interim Dept. Head, Dept. of Microbiology, Molecular Biology and Biochemistry (142 Life Sc. Bldg. 83844-3052; phone 208/885-7966; mmbb@uidaho.edu;
More informationRoche in Australia Innovation Leader
Roche in Australia Innovation Leader About Roche Innovation: it s in our DNA 7,000,874 hours of work 6,587 experiments 423 researchers 1 drug For nearly 120 years, Roche has been committed to improving
More informationESCMID Online Lecture Library. by author
New methods for the diagnosis of malaria Tom van Gool Academic Medical Centre, Amsterdam Rogier van Doorn The importance of malaria diagnosis Without vaccines being available the major strategy to combat
More informationUltraFast Molecular Diagnostic System
UltraFast Molecular Diagnostic System CONTENTS 01 PCR vs Real-time PCR 02 NANOBIOSYS Sample Prep G2-16TU 03 NANOBIOSYS Real-time PCR G2-4 01 PCR vs Real-time PCR What is DNA & What is PCR? NANOBIOSYS 4
More informationThe WHO Global Observatory on Health Research and Development (R&D)
The WHO Global Observatory on Health Research and Development (R&D) Taghreed Adam Scientist Research, Ethics, Knowledge Uptake (REK) Health Systems and Innovation Cluster David Schellenberg Scientific
More informationContamination Prevention and Decontamination
Contamination Prevention and Decontamination Introduction FilmArray is an automated in vitro diagnostic (IVD) system that utilizes nested multiplex PCR (nmpcr) and high-resolution melting analysis to detect
More informationEvaluation of a New Primer In Comparison With Microscopy for the Detection of Giardia lamblia Infection in Stool Samples
Iran J Parasitol Tehran University of Medical Sciences Publication http:// tums.ac.ir Open access Journal at http:// ijpa.tums.ac.ir Iranian Society of Parasitology http:// isp.tums.ac.ir Original Article
More informationBATTLING BUGS: INROADS IN INFECTIOUS DISEASES
UW MEDICINE PATIENTS ARE FIRST BATTLING BUGS: INROADS IN INFECTIOUS DISEASES UW MINI-MEDICAL SCHOOL Brad T. Cookson M.D., Ph.D. February 11, 2014 FEVER: THE HOST RESPONDS Humanity has but three great enemies:
More informationInterim Technical Note The Use of Cholera Rapid Diagnostic Tests November 2016
Objective Interim Technical Note The Use of Cholera Rapid Diagnostic Tests November 2016 To provide interim guidance to Ministries of Health and other organizations on the potential use of commercially
More informationAssessing quality-assured diagnoses made by TB laboratories
Assessing quality-assured diagnoses made by TB laboratories Quality-assured TB laboratory Objectives: at the end of the assessment reviewers should comment on the laboratory network and its structure;
More information