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1 Fare clic per modificare lo stile del sottotitolo dello schema THE BIOTECH SECTOR IN ITALY AND

2 TABLE OF CONTENT 1. THE BIOTECH SECTOR IN ITALY 2. : A LAND OF OPPORTUNITIES 3. : BIOTECH FACTS AND FIGURES 4. ITALY AND TODAY: INCENTIVES AND REASONS TO INVEST All Rights reserved.

3 THE BIOTECH SECTOR IN ITALY All Rights reserved.

4 THE BIOTECH SECTOR IN ITALY: KEY FIGURES 3.8 Bln Biotech R&D firms Turnover 256 dedicated biotech R&D firms 9.4 Bln Biotech Industry Turnover 489 firms 489 Biotech companies active within the sector $38b v n employees Involved in biotech activities p. 4 Source: Assobiotech Report All Rights reserved.

5 United States (*) Spain France (*) Korea Germany Japan Italy United Kingdom (*) New Zealand Belgium Netherlands (*) Ireland Israel Switzerland Norway Finland Mexico (*) Brazil (*) Portugal Austria Denmark (*) Poland Czech Republic Sweden (*) Estonia South Africa Slovenia Slovak Republic THE BIOTECH SECTOR IN ITALY: FIRMS The Italian Biotech Industry is competitive Worldwide: we are the 7 th global power in terms of number of firms active in the biotech sectors p. 5 Source: OECD Key Biotech Indicators All Rights reserved.

6 THE BIOTECH SECTOR IN ITALY: GROWTH The Italian Biotech Industry has grown spectacularly in the last 15 years: the number of R&D firms has more than doubled p. 6 Source: Assobiotech Report All Rights reserved.

7 THE BIOTECH SECTOR IN ITALY: R&D FIRMS More than 60% of the Italian Biotech Industry is made up by Dedicated Biotechnology firms (firms that devote at least 75% of activities on Biotech). Only Germany and France have a higher percentage out of 8 top global producers 90,0 80,0 70,0 60,0 50,0 40,0 30,0 20,0 10,0 0,0 USA Spain France Korea Germany Italy New Zeland Belgium p. 7 Source: OECD Key Biotech Indicators All Rights reserved.

8 THE BIOTECH SECTOR IN ITALY: A RESEARCH INTENSIVE INDUSTRY The Italian Biotech Industry is research intensive compared to the whole industrial sector 30,00% 25,00% 25,50% 20,00% 15,00% 12,50% 10,00% 8,20% 5,00% 0,00% 0,40% 1,10% Italian Industry 0,90% 2,40% Italian manufacturing Industry 2,10% Italian Biotech Industry Dedicated Biotech R&D firms Intra-muros R&D investment on overall turnover R&D employees on total employees p. 8 Source: Assobiotech Report All Rights reserved.

9 United States (*) France (*) Switzerland Korea Germany (*) Japan Denmark (*) Spain Belgium Italy Netherlands (*) Sweden (*) Israel Ireland Canada (*) Russian Federation (*) Poland Czech Republic Austria Norway Australia Finland Portugal South Africa Slovenia Mexico (*) Estonia Slovak Republic THE BIOTECH SECTOR IN ITALY: R&D EXPENDITURES Italy is a top ten global investor for R&D Biotechnology expenditures ( Million USD PPP) p. 9 Source: OECD Key Biotech Indicators All Rights reserved.

10 THE BIOTECH SECTOR IN ITALY: SECTOR COMPOSITION 9% Green Firms 13% GPET Biotech Firms 24% White Biotech Firms BIOTECH SECTOR 53% Red Biotech firms Most of the Italian biotech firms are active in healthcare biotechnology (53%). Others are engaged in industrial biotechnology (24%), in GPET - Genomics, Proteomics and Enabling Technologies (13%) and in Green biotechnology, including agriculture and livestock (9%). p. 10 Source: Assobiotech Report All Rights reserved.

11 THE BIOTECH SECTOR IN ITALY: FIRMS SIZE The Italian Biotech Sector is dominated by micro/small companies, in particular within the GPET sector. Almost one in two micro- sized company is an academic spin-off 10% Big companies (> 250 employees) 13% Medium companies ( employees) 17% Small companies ( < 50 employees) 58% Micro companies ( < 10 employees) p. 11 Source: Assobiotech Report All Rights reserved.

12 : A LAND OF OPPORTUNITIES All Rights reserved.

13 : A LAND OF OPPORTUNITIES Lombardy is a land alive with opportunities. Italy s wealthiest region, it generates 22% of national GDP, higher than Austria, Denmark, Finland, Ireland and Portugal. With more than foreign invested companies, Lombardy is an important market for investors able to absorb 60% of FDI coming to Italy. Out of 100 top multinationals that have invested in Italy, 92 are housed in Lombardy Milan is an ultimate hub for innovative sectors, life sciences in particular, and a serious candidate to host the next EMA - European Medicines Agency - headquarters in the Brexit scenario. p. 13 Source: Why Invest in Milan by JLL; Booklet Italy, Lombardy and Milan by Assolombarda All Rights reserved.

14 : A DYNAMIC AND PRODUCTIVE REGION p. 14 Source: Why Invest in Milan by JLL; Booklet Italy, Lombardy and Milan by Assolombarda; Research Unit of Milan Chamber of Commerce All Rights reserved.

15 : AN INNOVATIVE REGION Lombardy leads the way in innovation and development: 6 sciences and technology parks, 182 innovative business, 11 National Research Councils and 267 in-house research institutes 500 research and development centres 6 science and technology parks 10 sciences and tech clusters More than a third of Italian patents recognised by the EU are registered in Lombardy p. 15 Source: Booklet Italy, Lombardy and Milan by Assolombarda; Research Unit of Milan Chamber of Commerce All Rights reserved.

16 : AN INTERNATIONAL HUB Lombardy is an international hub and is one of the top regions in Europe for hard and soft infrastructure. p. 16 Source: Booklet Italy, Lombardy and Milan by Assolombarda; Research Unit of Invest in Lombardy All Rights reserved.

17 : LEADING THE WAY IN EDUCATION 13 10% 17% 28% 13 UNIVERSITIES within the Lombardy Region, 8 within Milan with more than students enrolled 10% POPULATION Milan universities represent 10% of Italian university population 17% INTERNATIONALS Almost 1 in 5 international students in Italy are enrolled in Milan universities 28% SCIENTIFIC PUBLICATIONS Lombardy produces knowledge: almost 1 in 3 high- impact scientific publications produced in Italy come from the region p. 17 Source: Booklet Italy, Lombardy and Milan by Assolombarda; Research Unit of Milan Chamber of Commerce All Rights reserved.

18 : BIOTECH FACTS AND FIGURES All Rights reserved.

19 THE BIOTECH SECTOR IN : FIRMS Lombardy is where the Italian Biotech Industry excels: 29% of firms are located within the region Italian Regions Number Firms Percentage Lombardy ,83% Piedmont 57 11,66% Lazio 45 9,20% Emilia - Romagna 44 9,00% Tuscany 39 7,98% Veneto 38 7,77% Friuli - Venezia Giulia 25 5,11% Campania 23 4,70% Sicily 13 2,66% Sardinia 13 2,66% Trentino - Alto Adige 12 2,45% Apulia 11 2,25% Marche 10 2,04% Liguria 5 1,02% Other Italian Regions 10 2,67% Total % p. 19 Source: Assobiotech Report All Rights reserved.

20 THE BIOTECH SECTOR IN : TURNOVER Lombardy produces more than 50% of the Italian Biotech Industry turnover Italian Regions Biotech turnover Lombardy 51,11% Piedmont 3,25% Lazio 25,96% Emilia - Romagna 1,92% Tuscany 12,16% Veneto 1,89% Friuli - Venezia Giulia 0,18% Campania 0,48% Sicily 0,08% Sardinia 0,03% Trentino - Alto Adige 1,33% Apulia 0,00% Marche 0,90% Liguria 0,03% Other Italian Regions 0,68% Total 100% p.20 Source: Assobiotech Report All Rights reserved.

21 THE BIOTECH SECTOR IN : INVESTMENTS Lombardy is the first region for R&D Investments, accounting for 29% over the total Italian Regions R&D Investments Lombardy 29,43% Piedmont 6,61% Lazio 18,48% Emilia - Romagna 2,90% Tuscany 23,31% Veneto 1,97% Friuli - Venezia Giulia 4,22% Campania 2,34% Sicily 0,38% Sardinia 0,55% Trentino - Alto Adige 0,54% Apulia 0,36% Marche 0,70% Liguria 8,10% Other Italian Regions 0,68% Total 100% p. 21 Source: Assobiotech Report All Rights reserved.

22 : CHEMICALS AND PHARMA FACTS AND FIGURES All Rights reserved.

23 CHEMICALS AND PHARMA IN 1/3 Italy is one of the world s top producers of chemicals and pharmaceuticals: the industry generated 82billion in 2015 and employed people. Within this framework of excellence, Lombardy is a leading player within the European context Lombardy generates 40.7 billion of turnover, equal to 52% of Chemical and Pharma Italian industry Within Lombardy, the Chemical sector accounts for 28 billion of turnover, whilst the Pharma for 12.3 billion Other regions Lombardy 52% Chemical 68% Pharma 31% Italy Lombardy Chemical Pharma p. 23 Source: The Chemical and Pharmaceutical Industry in Lombardy by Assolombarda Research Unit All Rights reserved.

24 CHEMICALS AND PHARMA IN 2/3 Amongst major Chemical and Pharmaceutical Regions in Europe, Lombardy ranks 2 nd in terms of number of employees North Rhine Westphalia (Germany) Lombardy (Italy) Hesse (Germany) Bayer (Germany) Rhineland-Palatinate (Germany) Baden-Württemberg (Germany) Cataluña (Spain) Île-de-France (France) Flanders (Belgium) Rhône-Alpes (France) p. 24 Source: The Chemical and Pharmaceutical Industry in Lombardy by Assolombarda Research Unit All Rights reserved.

25 CHEMICALS AND PHARMA IN 3/3 Thanks to an excellent and talented workforce, the value added per employee within the industry exceeds against the average of for the manufacturing sector. This is considerably higher that the labour cost per employee 160 Value added and labour cost per employee for the chemical and pharmaceutcal industry in Lombardy Chemical Pharmaceutical Chemical & Pharma Total manufacturing Value added per employee Labour cost per employee p. 25 Source: The Chemical and Pharmaceutical Industry in Lombardy by Assolombarda Research Unit All Rights reserved.

26 ITALY AND TODAY: INCENTIVES AND REASONS TO INVEST All Rights reserved.

27 RECENT TAX INCENTIVES FOR COMPANIES Patent box: a regime aimed at encouraging the development of Intellectual Property by providing a 50% tax exemption for income derived from direct or indirect exploitation of IP. R&D tax credit: this incentive has been strengthened since 2016, by providing for a tax credit of 50% of the increase of all R&D expenses and by raising the maximum annual credit amount to 20 million (up from 5 million). Super and hyper amortization: these measures are intended to facilitate industrial investment providing for a 40% increase in the acquisition costs of assets (super amortization) and for a 150% increase in the acquisition costs of capital goods necessary for technological and digital transformation (hyper amortization). Startups and innovative SMEs regime: new tax regimes have been introduced for startups and innovative SME s, providing a simplification of companies compliance and tax, labour and investments incentives. p All Rights reserved.

28 RECENT TAX INCENTIVES FOR INDIVIDUALS New tax forfait regime for High Net Worth Individuals: under this regime, new Italian residents can opt for a substitute tax on all income produced abroad which implies a bullet payment of 100,000 for each tax year, reduced to 25,000 to all family members. This can bring significant tax savings, especially if combined with the extremely low rates of taxation in Italy on gifts and inheritance. Fast-track visa for investors: a series of incentives related to entry and residence visas for those intending to invest in Italy, has been recently introduced. The current regulatory framework on immigration inflow has been modified including a special premium regime that lasts two years for incoming immigrants who are going to stay longer than three months (renewable, under certain circumstances, for a further three years) and intend to invest in Italy either by investing in government bonds, in participation to the share capital of a company residing and operating in Italy, in the share capital of a company that is an innovative startup or in philanthropic donations in the fields of culture, education, immigration management, scientific research or cultural heritage restoration. p All Rights reserved.

29 RECENT TAX INCENTIVES FOR INDIVIDUALS New tax regime for qualified employees: three-year tax exemption on 90 percent of the remuneration for professors and researchers moving to Italy. New special inbound tax regime for managers and professionals: five-year tax exemption on 50 percent of the remuneration for managers and professionals moving to Italy. p All Rights reserved.

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