Brief History. Many people contributed to our understanding of DNA
|
|
- Jeffery Burke
- 6 years ago
- Views:
Transcription
1 DNA (Ch. 16)
2 Brief History Many people contributed to our understanding of DNA T.H. Morgan (1908) Frederick Griffith (1928) Avery, McCarty & MacLeod (1944) Erwin Chargaff (1947) Hershey & Chase (1952) Watson & Crick (1953) Meselson & Stahl (1958)
3 Chromosomes related to phenotype T.H. Morgan working with Drosophila associated phenotype with specific chromosome white-eyed male had specific X chromosome
4 Avery, McCarty & MacLeod Conclusion first experimental evidence that DNA was the genetic material Oswald Avery Maclyn McCarty Colin MacLeod
5 Martha Chase Alfred Hershey Hershey & Chase Hershey
6 Erwin Chargaff 1947 DNA composition: Chargaff s rules varies from species to species all 4 bases not in equal quantity bases present in characteristic ratio humans: A = 30.9% T = 29.4% G = 19.9% C = 19.8% That s interesting! What do you notice? Rules A = T C = G
7 Consider This Brief Film Strip
8 Structure of DNA Watson & Crick developed double helix model of DNA other leading scientists working on question: Rosalind Franklin Maurice Wilkins Linus Pauling Franklin Wilkins Pauling
9 Watson and Crick 1953 article in Nature Watson Crick
10 Rosalind Franklin ( )
11 It s Simple, No?
12 But how is DNA copied? Replication of DNA base pairing suggests that it will allow each side to serve as a template for a new strand It has not escaped our notice that the specific pairing we have postulated immediately suggests a possible copying mechanism for the genetic material. Watson & Crick
13 Meselson & Stahl Matthew Meselson Franklin Stahl Franklin Stahl Matthew Meselson
14 Scientific History March to understanding that DNA is the genetic material T.H. Morgan (1908): genes are on chromosomes Frederick Griffith (1928): a transforming factor can change phenotype Avery, McCarty & MacLeod (1944): transforming factor is DNA Erwin Chargaff (1947): Chargaff rules: A = T, C = G Hershey & Chase (1952): confirmation that DNA is genetic material Watson & Crick (1953): determined double helix structure of DNA Meselson & Stahl (1958): semi-conservative replication
15 The Central Dogma Flow of genetic information in a cell transcription translation DNA RNA protein replication
16 Directionality of DNA You need to number the carbons! it matters! PO 4 nucleotide N base This will be IMPORTANT!! 4 CH 2 O ribose 1 OH 2
17 Watson and Crick 1953 article in Nature
18 Double helix structure of DNA It has not escaped our notice that the specific pairing we have postulated immediately suggests a possible copying mechanism for the genetic material. Watson & Crick
19 The DNA backbone Putting the DNA backbone together refer to the and ends of the DNA the last trailing carbon Sounds trivial, but this will be IMPORTANT!! PO 4 CH 2 4 O C O O P O O CH 2 O 4 2 base 1 base 1 OH 2
20 Anti-parallel strands Nucleotides in DNA backbone are bonded from phosphate to sugar between & carbons DNA molecule has direction complementary strand runs in opposite direction
21 Bonding in DNA hydrogen bonds covalent phosphodiester bonds.strong or weak bonds? How do the bonds fit the mechanism for copying DNA?
22 Base pairing in DNA Purines adenine (A) guanine (G) Pyrimidines thymine (T) cytosine (C) Pairing A : T 2 bonds C : G 3 bonds
23 Copying DNA Replication of DNA base pairing allows each strand to serve as a template for a new strand new strand is 1/2 parent template & 1/2 new DNA semi-conservative copy process
24 DNA Replication Let s meet the team Large team of enzymes coordinates replication
25 Replication: 1st step Unwind DNA helicase enzyme unwinds part of DNA helix stabilized by single-stranded binding proteins helicase single-stranded binding proteins replication fork
26 Replication: 2nd step Build daughter DNA strand add new complementary bases DNA polymerase III DNA Polymerase III
27 Energy of Replication Where does energy for bonding usually come from? You remember ATP! Are there other energy ways nucleotides? to get energy You out of bet! it? We come with our own energy! energy energy GTP TTP CTP ATP modified nucleotide And we leave behind a nucleotide! ADP AMP GMP TMP CMP
28 Replication Adding bases can only add nucleotides to end of a growing DNA strand need a starter nucleotide to bond to strand only grows energy DNA Polymerase III energy DNA Polymerase III energy DNA Polymerase III DNA Polymerase III energy
29 Leading & Lagging strands Okazaki Limits of DNA polymerase III can only build onto end of an existing DNA strand ligase Lagging strand growing replication fork Lagging strand Okazaki fragments joined by ligase spot welder enzyme DNA polymerase III Leading strand Leading strand continuous synthesis
30 Replication fork / Replication bubble DNA polymerase III leading strand lagging strand growing replication fork lagging strand leading strand leading strand lagging strand growing replication fork
31 Replacing RNA primers with DNA DNA polymerase I removes sections of RNA primer and replaces with DNA nucleotides DNA polymerase I ligase growing replication fork RNA But DNA polymerase I still can only build onto end of an existing DNA strand
32 Chromosome erosion Houston, we have a problem! All DNA polymerases can only add to end of an existing DNA strand DNA polymerase I growing replication fork DNA polymerase III RNA Loss of bases at ends in every replication chromosomes get shorter with each replication limit to number of cell divisions?
33 Telomeres Repeating, non-coding sequences at the end of chromosomes = protective cap limit to ~50 cell divisions growing replication fork telomerase Telomerase enzyme extends telomeres can add DNA bases at end different level of activity in different cells high in stem cells & cancers -- Why? TTAAGGG TTAAGGG
34 Replication fork DNA polymerase I DNA polymerase III Okazaki fragments lagging strand 5 ligase 3 5 primase 3 SSB 3 helicase leading strand direction of replication DNA polymerase III SSB = single-stranded binding proteins
35 DNA polymerases DNA polymerase III 1000 bases/second! main DNA builder DNA polymerase I 20 bases/second editing, repair & primer removal DNA polymerase III enzyme Thomas Kornberg?? Arthur Kornberg 1959
36 Editing & proofreading DNA 1000 bases/second = lots of typos! DNA polymerase I proofreads & corrects typos repairs mismatched bases removes abnormal bases repairs damage throughout life reduces error rate from 1 in 10,000 to 1 in 100 million bases
37 Fast & accurate! It takes E. coli <1 hour to copy 5 million base pairs in its single chromosome divide to form 2 identical daughter cells Human cell copies 6 billion bases & divide into daughter cells in only few hours remarkably accurate only ~1 error per 100 million bases ~30 errors per cell cycle
38 What does it really look like?
39 What Does It Really Look Like, (3D Animated Movie Version)
40
41
42
The Molecular Basis of Inheritance (Ch. 13)
The Molecular Basis of Inheritance (Ch. 13) Many people contributed to our understanding of DNA T.H. Morgan (1908) Frederick Griffith (1928) Avery, McCarty & MacLeod (1944) Erwin Chargaff (1947) Hershey
More informationDNA Replication AP Biology
DNA Replication 2007-2008 Watson and Crick 1953 article in Nature Double helix structure of DNA It has not escaped our notice that the specific pairing we have postulated immediately suggests a possible
More informationDNA Replication AP Biology
DNA Replication 2007-2008 Double helix structure of DNA It has not escaped our notice that the specific pairing we have postulated immediately suggests a possible copying mechanism for the genetic material.
More informationDouble helix structure of DNA
Replication Double helix structure of It has not escaped our notice that the specific pairing we have postulated immediately suggests a possible copying mechanism for the genetic material. Watson & Crick
More informationWatson & Crick. DNA Replication. Directionality of DNA. Double helix structure of DNA. The DNA backbone. Anti-parallel strands
Watson and Crick 1953 article in Nature Replication 2007-2008 Double helix structure of Directionality of You need to number the carbons! it matters! P 4 nucleotide N base This will be IMPRTANT!! 4 ribose
More informationDNA Replication AP Biology
DNA Replication 2007-2008 Watson and Crick 1953 1953 article in Nature Directionality of DNA You need to number the carbons! u it matters! u 3 refers to the 3 carbon on the sugar u 5 refers to the 5 carbon
More informationThe Molecular Basis of Inheritance
The Molecular Basis of Inheritance Scientific History The march to understanding that DNA is the genetic material T.H. Morgan (1908) Frederick Griffith (1928) Avery, McCarty & MacLeod (1944) Erwin Chargaff
More informationDNA The Genetic Material
DNA The Genetic Material 2006-2007 Chromosomes related to phenotype T.H. Morgan working with Drosophila fruit flies associated phenotype with specific chromosome white-eyed male had specific X chromosome
More informationWednesday, April 9 th. DNA The Genetic Material Replication. Chapter 16
Wednesday, April 9 th DNA The Genetic Material Replication Chapter 16 Modified from Kim Foglia Scientific History The march to understanding that DNA is the genetic material T.H. Morgan (1908) Frederick
More informationChapter 13 DNA The Genetic Material Replication
Chapter 13 DNA The Genetic Material Replication Scientific History The march to understanding that DNA is the genetic material T.H. Morgan (1908) Frederick Griffith (1928) Avery, McCarty & MacLeod (1944)
More informationTransformation: change in genotype & phenotype due to assimilation of external DNA by a cell.
DNA Replication Chapter 16: DNA as Genetic Material Genes are on Chromosomes T.H. Morgan o Working with Drosophila (fruit flies) o Genes are on chromosomes o But is it the protein or the DNA of the chromosomes
More informationFriday, April 17 th. Crash Course: DNA, Transcription and Translation. AP Biology
Friday, April 17 th Crash Course: DNA, Transcription and Translation Today I will 1. Review the component parts of a DNA molecule. 2. Describe the process of transformation. 3. Explain what is meant by
More informationNucleic Acids. The book of you. Nucleic Acids DNA RNA PROTEINS. Function: genetic material stores information genes blueprint for building proteins
ucleic Acids DA RA PRTEIS 1 The book of you 2 ucleic Acids Function: genetic material stores information genes blueprint for building proteins DA DA RA proteins transfers information blueprint for new
More informationDNA Replication. Packet #17 Chapter #16
DNA Replication Packet #17 Chapter #16 1 HISTORICAL FACTS ABOUT DNA 2 Historical DNA Discoveries 1928 Frederick Griffith finds a substance in heat-killed bacteria that transforms living bacteria 1944 Oswald
More informationChapter 16 The Molecular Basis of Inheritance
Chapter 16 The Molecular Basis of Inheritance Chromosomes and DNA Morgan s experiments with Drosophila were able to link hereditary factors to specific locations on chromosomes. The double-helical model
More informationCHAPTER 16 MOLECULAR BASIS OF INHERITANCE
CHAPTER 16 MOLECULAR BASIS OF INHERITANCE DNA as genetic material? Deducted that DNA is the genetic material Initially worked by studying bacteria & the viruses that infected them 1928 Frederick Griffiths
More informationMOLECULAR BASIS OF INHERITANCE
MOLECULAR BASIS OF INHERITANCE C H A P T E R 1 6 as genetic material? Deducted that is the genetic material Initially worked by studying bacteria & the viruses that infected them 1928 Frederick Griffiths
More informationBIOLOGY 101. CHAPTER 16: The Molecular Basis of Inheritance: Life s Operating Instructions
BIOLOGY 101 CHAPTER 16: The Molecular Basis of Inheritance: Life s Operating Instructions Life s Operating Instructions CONCEPTS: 16.1 DNA is the genetic material 16.2 Many proteins work together in DNA
More informationHow do we know what the structure and function of DNA is? - Double helix, base pairs, sugar, and phosphate - Stores genetic information
DNA: CH 13 How do we know what the structure and function of DNA is? - Double helix, base pairs, sugar, and phosphate - Stores genetic information Discovering DNA s Function 1928: Frederick Griffith studied
More informationThe Genetic Material. The Genetic Material. The Genetic Material. DNA: The Genetic Material. Chapter 14
DNA: Chapter 14 Frederick Griffith, 1928 studied Streptococcus pneumoniae, a pathogenic bacterium causing pneumonia there are 2 strains of Streptococcus: - S strain is virulent - R strain is nonvirulent
More informationDNA and Replication 1
DNA and Replication 1 History of DNA 2 History of DNA Early scientists thought protein was the cell s hereditary material because it was more complex than DNA Proteins were composed of 20 different amino
More informationDNA is a functional genetic material as it:
DNA DNA is a functional genetic material as it: varies between species and individuals can store information remains constant within a species Replicates undergoes mutations 1 `It has not escaped our notice
More informationDNA: The Genetic Material. Chapter 14. Genetic Material
DNA: The Genetic Material Chapter 14 Genetic Material Frederick Griffith, 1928 Streptococcus pneumoniae, a pathogenic bacterium causing pneumonia 2 strains of Streptococcus: - S strain virulent - R strain
More informationName: - Bio A.P. DNA Replication & Protein Synthesis
Name: - Bio A.P. DNA Replication & Protein Synthesis 1 ESSENTIAL KNOWLEDGE Big Idea 3: Living Systems store, retrieve, transmit and respond to information critical to living systems Enduring Understanding:
More informationChapter 16: The Molecular Basis of Inheritance
AP Biology Reading Guide Name Chapter 16: The Molecular Basis of Inheritance Concept 16.1 DNA is the genetic material 1. What are the two chemical components of chromosomes? 2. The search for identifying
More informationDNA The Genetic Material
DNA The Genetic Material Replication, Amplification, and Sequencing Scientific History The march to understanding that DNA is the genetic material T.H. Morgan (1908) Frederick Griffith (1928) Avery, McCarty
More informationDNA: The Primary Source of Heritable Information. Genetic information is transmitted from one generation to the next through DNA or RNA
DNA and Replication DNA: The Primary Source of Heritable Information Genetic information is transmitted from one generation to the next through DNA or RNA Chromosomes Non-eukaryotic (bacteria) organisms
More informationcopyright cmassengale 2
1 copyright cmassengale 2 History of DNA Early scientists thought protein was the cell s hereditary material because it was more complex than DNA Proteins were composed of 20 different amino acids in long
More informationThe Molecular Basis of Inheritance
The Molecular Basis of Inheritance Chapter 16 Objectives Describe the contributions of the following people: Griffith; Avery, McCary, and MacLeod; Hershey and Chase; Chargaff; Watson and Crick; Franklin;
More informationDNA Structure. DNA: The Genetic Material. Chapter 14
DNA: The Genetic Material Chapter 14 DNA Structure DNA is a nucleic acid. The building blocks of DNA are nucleotides, each composed of: a 5-carbon sugar called deoxyribose a phosphate group (PO 4 ) a nitrogenous
More informationChromosomes. Nucleosome. Chromosome. DNA double helix. Coils. Supercoils. Histones
Chromosomes Chromosome Nucleosome DNA double helix Coils Supercoils Histones Evidence That DNA Can Transform Bacteria Frederick Griffith s experiment 1928 Griffith called the phenomenon transformation
More information4) separates the DNA strands during replication a. A b. B c. C d. D e. E. 5) covalently connects segments of DNA a. A b. B c. C d. D e.
1) Chargaff's analysis of the relative base composition of DNA was significant because he was able to show that a. the relative proportion of each of the four bases differs from species to species. b.
More informationChapter 16: The Molecular Basis of Inheritance
Name Period Chapter 16: The Molecular Basis of Inheritance Concept 16.1 DNA is the genetic material 1. What are the two chemical components of chromosomes? 2. Why did researchers originally think that
More informationChapter 16 Molecular Basis of. Chapter 16. Inheritance (DNA structure and Replication) Helicase Enzyme
Chapter 16 Chapter 16 Molecular Basis of Inheritance (DNA structure and Replication) Helicase Enzyme The Amazing Race What is the genetic material? DNA or protein? 1928 Griffith transformation of pneumonia
More informationDNA: The Genetic Material. Chapter 14
DNA: The Genetic Material Chapter 14 The Genetic Material Frederick Griffith, 1928 studied Streptococcus pneumoniae, a pathogenic bacterium causing pneumonia there are 2 strains of Streptococcus: - S strain
More information3.A.1 DNA and RNA: Structure and Replication
3.A.1 DNA and RNA: Structure and Replication Each DNA polymer is made of Nucleotides (monomer) which are made of: a) Phosphate group: Negatively charged and polar b) Sugar: deoxyribose- a 5 carbon sugar
More informationChapter 9. Topics - Genetics - Flow of Genetics - Regulation - Mutation - Recombination
Chapter 9 Topics - Genetics - Flow of Genetics - Regulation - Mutation - Recombination 1 Genetics Genome Chromosome Gene Protein Genotype Phenotype 2 Terms and concepts gene Fundamental unit of heredity
More informationDNA The Genetic Material
DNA The Genetic Material 2006-2007 Scientific History The march to understanding that DNA is the genetic material T.H. Morgan (1908) Frederick Griffith (1928) Avery, McCarty & MacLeod (1944) Erwin Chargaff
More informationDNA The Genetic Material
DNA The Genetic Material 2006-2007 Scientific History The march to understanding that DNA is the genetic material T.H. Morgan (1908) Frederick Griffith (1928) Avery, McCarty & MacLeod (1944) Erwin Chargaff
More informationScientific History. Chromosomes related to phenotype 1/5/2015. DNA The Genetic Material. The march to understanding that DNA is the genetic material
DNA The Genetic Material 2006-2007 Scientific History The march to understanding that DNA is the genetic material T.H. Morgan (1908) Frederick Griffith (1928) Avery, McCarty & MacLeod (1944) Erwin Chargaff
More information2015 Biology Unit 4 PRACTICE TEST DNA, Structure, Function, Replication Week of December
Name: Class: Date: 2015 Biology Unit 4 PRACTICE TEST DNA, Structure, Function, Replication Week of 14-18 December 1. Which scientists figured out the three-dimensional structure of DNA by using a model
More informationDNA The Genetic Material
DNA The Genetic Material 2006-2007 Scientific History: The march to understanding that DNA is the genetic material u T.H. Morgan (1908) u Frederick Griffith (1928) u Avery, McCarty & MacLeod (1944) u Erwin
More informationAP Biology Chapter 16 Notes:
AP Biology Chapter 16 Notes: I. Chapter 16: The Molecular Basis of Inheritance a. Overview: i. April 1953 James Watson and Francis Crick great the double helix model of DNA- deoxyribonucleic acid ii. DNA
More informationThe Molecular Basis of Inheritance
Chapter 16 The Molecular Basis of Inheritance PowerPoint Lectures for Biology, Seventh Edition Neil Campbell and Jane Reece Lectures by Chris Romero Overview: Life s Operating Instructions In 1953, James
More informationBrief History. Many people contributed to our understanding of DNA
DNA (Ch. 12) Brief History Many people contributed to our understanding of DNA T.H. Morgan (1908) Frederick Griffith (1928) Avery, McCarty & MacLeod (1944) Erwin Chargaff (1947) Hershey & Chase (1952)
More informationOverview: Life s Operating Instructions Concept 16.1: DNA is the genetic material The Search for the Genetic Material: Scientific Inquiry
Overview: Life s Operating Instructions In 1953, James Watson and Francis Crick introduced an elegant double-helical model for the structure of deoxyribonucleic acid, or DNA DNA, the substance of inheritance,
More informationAll This For Four Letters!?! DNA and Its Role in Heredity
All This For Four Letters!?! DNA and Its Role in Heredity What Is the Evidence that the Gene Is DNA? By the 1920s, it was known that chromosomes consisted of DNA and proteins. A new dye stained DNA and
More informationDNA Structure and Replication
DA Structure and Replication WHAT IS DA We know: DA is the hereditary material DA has a double helix structure Made of four bases; A,T,C,G Sugar-Phosphate backbone DA replication is semi-conservative Timeline
More informationMolecular Genetics I DNA
Molecular Genetics I DNA Deoxyribonucleic acid is the molecule that encodes the characteristics of living things. It is the molecule that is passed from a mother cell to daughter cells, and the molecule
More informationThe Molecular Basis of Inheritance
Chapter 16 The Molecular Basis of Inheritance PowerPoint Lecture Presentations for Biology Eighth Edition Neil Campbell and Jane Reece Lectures by Chris Romero, updated by Erin Barley with contributions
More informationDNA. Discovery of the DNA double helix
DNA Replication DNA Discovery of the DNA double helix A. 1950 s B. Rosalind Franklin - X-ray photo of DNA. C. Watson and Crick - described the DNA molecule from Franklin s X-ray. What is DNA? Question:
More informationThe Development of a Four-Letter Language DNA
The Development of a Four-Letter Language DNA The Griffith Experiment Chromosomes are comprised of two types of macromolecules, proteins and DNA, but which one is the stuff of genes? the answer was discovered
More informationDNA stands for deoxyribose nucleic acid
DNA DNA stands for deoxyribose nucleic acid This chemical substance is present in the nucleus of all cells in all living organisms DNA controls all the chemical changes which take place in cells DNA Structure
More informationDivision Ave. High School AP Biology
DNA The Genetic Material 2006-2007 Scientific History The march to understanding that DNA is the genetic material u T.H. Morgan (1908) u Frederick Griffith (1928) u Avery, McCarty & MacLeod (1944) u Erwin
More informationBacteriophage = Virus that attacks bacteria and replicates by invading a living cell and using the cell s molecular machinery.
Hershey-Chase Bacteriophage Experiment - 1953 Bacteriophage = Virus that attacks bacteria and replicates by invading a living cell and using the cell s molecular machinery. Bacteriophages are composed
More informationGenetic material must be able to:
Genetic material must be able to: Contain the information necessary to construct an entire organism Pass from parent to offspring and from cell to cell during cell division Be accurately copied Account
More informationEssential Questions. DNA: The Genetic Material. Copyright McGraw-Hill Education
Essential Questions Which experiments led to the discovery of DNA as the genetic material? What is the basic structure of DNA? What is the basic structure of eukaryotic chromosomes? Vocabulary Review nucleic
More informationDNA and Biotechnology
DNA and Biotechnology What makes us human? Our DNA! It codes for our genes. (Gene = a piece of DNA that codes for a protein) What is DNA and why is it so important? DNA is the blueprint for an organism.
More informationChapter 13 Active Reading Guide The Molecular Basis of Inheritance
Name: AP Biology Mr. Croft Chapter 13 Active Reading Guide The Molecular Basis of Inheritance Section 1 1. What are the two chemical components of chromosomes? 2. Why did researchers originally think that
More informationwhat are proteins? what are the building blocks of proteins? what type of bond is in proteins? Molecular Biology Proteins - review Amino Acids
Molecular Biology The Study of Proteins and Nucleic Acids what are proteins? what are the building blocks of proteins? what type of bond is in proteins? Proteins - review functions include: catalysts for
More informationThe Central Dogma: This explains how the information to make proteins is carried: DNA RNA proteins
7.1 DNA and RNA The Central Dogma: This explains how the information to make proteins is carried: DNA RNA proteins Discovering DNA It was not always known that DNA contains all of the genetic material.
More information1. True or False? At the DNA level, recombination is initiated by a single stranded break in a DNA molecule.
1. True or False? At the DNA level, recombination is initiated by a single stranded break in a DNA molecule. 2. True or False? Dideoxy sequencing is a chain initiation method of DNA sequencing. 3. True
More information2. Why did researchers originally think that protein was the genetic material?
AP Biology Chapter 13 Reading Guide The Molecular Basis of Inheritance Concept 13.1 DNA is the Genetic Material 1. What are the two chemical components of chromosomes? 2. Why did researchers originally
More informationChapter 16 The Molecular Basis of Inheritance
Chapter 16 The Molecular Basis of Inheritance Question? Traits are inherited on chromosomes, but what in the chromosomes is the genetic material? Two possibilities: Protein DNA Qualifications Protein:
More information3. Replication of DNA a. When a cell divides, the DNA must be doubled so that each daughter cell gets a complete copy. It is important for this
DNA 1. Evidence for DNA as the genetic material. a. Until the 1940s, proteins were believed to be the genetic material. b. In 1944, Oswald Avery, Maclyn McCarty, and Colin MacLeod announced that the transforming
More informationThe Molecul Chapter ar Basis 16: The M of olecular Inheritance Basis of Inheritance Fig. 16-1
he Chapter Molecular 16: he Basis Molecular of Inheritance Basis of Inheritance Fig. 16-1 dditional Evidence hat DN Is the Genetic Material It was known that DN is a polymer of nucleotides, each consisting
More informationLecture Series 8 DNA and Its Role in Heredity
Lecture Series 8 DNA and Its Role in Heredity DNA and Its Role in Heredity A. DNA: The Genetic Material B. The Structure of DNA C. DNA Replication D. The Mechanism of DNA Replication E. DNA Proofreading
More information3.a.1- DNA and RNA 10/19/2014. Big Idea 3: Living systems store, retrieve, transmit and respond to information essential to life processes.
3.a.1- DNA and RNA Big Idea 3: Living systems store, retrieve, transmit and respond to information essential to life processes. EU 3.A: Heritable information provides for continuity of life. EU 3.B: Expression
More informationDNA and Its Role in Heredity. DNA and Its Role in Heredity. A. DNA: The Genetic Material. A. DNA: The Genetic Material.
DNA and Its Role in Heredity A. DNA: The Genetic Material Lecture Series 8 DNA and Its Role in Heredity B. The Structure of DNA C. DNA E. DNA Proofreading and Repair F. Practical Applications of DNA A.
More informationChapter 16. The Molecular Basis of Inheritance. Biology Kevin Dees
Chapter 16 The Molecular Basis of Inheritance DNA Life s instructions!!!! Deoxyribonucleic Acid Nucleic acid polymer from nucleotide monomers Unique in that it can: Self replicate Carry information History
More informationUnit 5 DNA, RNA, and Protein Synthesis
1 Biology Unit 5 DNA, RNA, and Protein Synthesis 5:1 History of DNA Discovery Fredrick Griffith-conducted one of the first experiment s in 1928 to suggest that bacteria are capable of transferring genetic
More informationCHAPTER 11 LECTURE SLIDES
CHAPTER 11 LECTURE SLIDES Prepared by Brenda Leady University of Toledo To run the animations you must be in Slideshow View. Use the buttons on the animation to play, pause, and turn audio/text on or off.
More informationThe structure, type and functions of a cell are all determined by chromosomes:
DNA Basics The structure, type and functions of a cell are all determined by chromosomes: They are found in the nucleus of a cell. These chromosomes are composed of DNA, the acronym for deoxyribonucleic
More informationDNA Replication semiconservative replication conservative replication dispersive replication DNA polymerase
DNA Replication DNA Strands are templates for DNA synthesis: Watson and Crick suggested that the existing strands of DNA served as a template for the producing of new strands, with bases being added to
More informationThe Molecular Basis of Inheritance
LECTURE PRESENTATIONS For CAMPBELL BIOLOGY, NINTH EDITION Jane B. Reece, Lisa A. Urry, Michael L. Cain, Steven A. Wasserman, Peter V. Minorsky, Robert B. Jackson Chapter 16 The Molecular Basis of Inheritance
More informationChapter 16 DNA: The Genetic Material. The Nature of Genetic Material. Chemical Nature of Nucleic Acids. Chromosomes - DNA and protein
Chapter 16 DNA: The Genetic Material The Nature of Genetic Material Chromosomes - DNA and protein Genes are subunits DNA = 4 similar nucleotides C(ytosine) A(denine) T(hymine) G(uanine) Proteins = 20 different
More informationChapter 9: DNA: The Molecule of Heredity
Chapter 9: DNA: The Molecule of Heredity What is DNA? Answer: Molecule that carries the blueprint of life General Features: DNA is packages in chromosomes (DNA + Proteins) Gene = Functional segment of
More information1. The search for genetic material lead to DNA
1. The search for genetic material lead to DNA Once Morgan s group showed that genes are located on chromosomes, the next question was Is it the DNA or the proteins in chromosomes that is the stuff of
More informationE - Horton AP Biology
E - Bio @ Horton AP Biology Unit Molecular Genetics Notes DNA The Genetic Material A. Genetic material must be: 1. able to store information used to control both the development and the metabolic activities
More informationI. DNA as Genetic Material Figure 1: Griffith s Experiment. Frederick Griffith:
I. DNA as Genetic Material Figure 1: Griffith s Experiment Frederick Griffith: a) Frederick Griffith suspected that some component of the S strain was being passed along to the R strain, causing it to
More informationCH 4 - DNA. DNA = deoxyribonucleic acid. DNA is the hereditary substance that is found in the nucleus of cells
CH 4 - DNA DNA is the hereditary substance that is found in the nucleus of cells DNA = deoxyribonucleic acid» its structure was determined in the 1950 s (not too long ago).» scientists were already investigating
More informationPurines vs. Pyrimidines
Introduction to Genetics/DNA Replication The DNA molecule is found in the nucleus and is composed of nucleotides The DNA Molecule Composed of 2 polymers of nucleotides Polymers are oriented in antiparallel
More informationA. Incorrect! Garrod s experiment linked genes to enzymes. It is important to be familiar with the milestone experiments in genetics.
Genetics - Problem Drill 11: DNA - The Chemical Basis of Genetics No. 1 of 10 1. Which scientist first gave evidence that DNA is the genetic material? (A) Garrod, who postulated that Alcaptonuria, or black
More informationAP BIOLOGY RNA, DNA, & Proteins Chapters 16 & 17 Review
AP BIOLOGY RNA, DNA, & Proteins Chapters 16 & 17 Review Enzyme that adds nucleotide subunits to an RNA primer during replication DNA polymerase III Another name for protein synthesis translation Sugar
More informationDNA vs. RNA B-4.1. Compare DNA and RNA in terms of structure, nucleotides and base pairs.
DNA vs. RNA B-4.1 Compare DNA and RNA in terms of structure, nucleotides and base pairs. Key Concepts l Nucleic Acids: l deoxyribonucleic acid (DNA) l ribonucleic acid (RNA) l Nucleotides: l nitrogen base,
More informationDNA The Genetic Material
DNA The Genetic Material 2006-2007 Genes are on chromosomes Morgan s conclusions genes are on chromosomes but is it the protein or the DNA of the chromosomes that are the genes? initially proteins were
More informationDNA Structure & Replication (Outline)
DNA Structure & Replication (Outline) Historical perspective (DNA as the genetic material): Genetic transformation DNA as the transforming agent DNA is the genetic material in bacterial viruses (phage)
More informationPowerPoint Notes on Chapter 9 - DNA: The Genetic Material
PowerPoint Notes on Chapter 9 - DNA: The Genetic Material Section 1 Identifying the Genetic Material Objectives Relate Griffith s conclusions to the observations he made during the transformation experiments.
More informationDNA: Structure and Replication - 1
DNA: Structure and Replication - 1 We have briefly discussed that DNA is the genetic molecule of life. In eukaryotic organisms DNA (along with its histone proteins) is found in chromosomes. All cell activities
More informationDNA STRUCTURE AND REPLICATION
AP BIOLOGY EVOLUTION/HEREDITY UNIT Unit 1 Part 2 Chapter 16 Activity #2 BUILDING BLOCKS OF DNA: Nucleotides: NAME DATE PERIOD DNA STRUCTURE AND REPLICATION 1. 5 carbon sugar (deoxyribose) 2. Nitrogenous
More informationFig. 16-7a. 5 end Hydrogen bond 3 end. 1 nm. 3.4 nm nm
Fig. 16-7a end Hydrogen bond end 1 nm 3.4 nm 0.34 nm (a) Key features of DNA structure end (b) Partial chemical structure end Fig. 16-8 Adenine (A) Thymine (T) Guanine (G) Cytosine (C) Concept 16.2: Many
More informationThe Molecular Basis of Inheritance
Chapter 16 The Molecular Basis of Inheritance PowerPoint Lecture Presentations for Biology Eighth Edition Neil Campbell and Jane Reece Lectures by Chris Romero, updated by Erin Barley with contributions
More informationSTUDY GUIDE SECTION 10-1 Discovery of DNA
STUDY GUIDE SECTION 10-1 Discovery of DNA Name Period Date Multiple Choice-Write the correct letter in the blank. 1. The virulent strain of the bacterium S. pneumoniae causes disease because it a. has
More informationTHE SEARCH FOR THE GENETIC MATERIAL "IF I HAVE SEEN FURTHER, IT IS BY STANDING ON THE SHOULDERS OF GIANTS." ISAAC NEWTON
THE SEARCH FOR THE GENETIC MATERIAL "IF I HAVE SEEN FURTHER, IT IS BY STANDING ON THE SHOULDERS OF GIANTS." ISAAC NEWTON WHAT WAS KNOWN SO FAR Chromosomes are made up of DNA and protein Protein is the
More informationNucleic acids and protein synthesis
THE FUNCTIONS OF DNA Nucleic acids and protein synthesis The full name of DNA is deoxyribonucleic acid. Every nucleotide has the same sugar molecule and phosphate group, but each nucleotide contains one
More informationBIOLOGY. The Molecular Basis of Inheritance CAMPBELL. Reece Urry Cain Wasserman Minorsky Jackson
CAMPBELL BIOLOGY TENTH EDITION Reece Urry Cain Wasserman Minorsky Jackson 16 The Molecular Basis of Inheritance Lecture Presentation by Nicole Tunbridge and Kathleen Fitzpatrick Life s Operating Instructions
More informationHershey & Chase Avery, MacLeod, & McCarty DNA: The Genetic Material
DA: The Genetic Material Chapter 14 Griffith s experiment with Streptococcus pneumoniae Live S strain cells killed the mice Live R strain cells did not kill the mice eat-killed S strain cells did not kill
More informationGenetic Information: DNA replication
Genetic Information: DNA replication Umut Fahrioglu, PhD MSc DNA Replication Replication of DNA is vital to the transmission of genomes and the genes they contain from one cell generation to the other.
More informationActive Learning Exercise 9. The Hereditary Material: DNA
Name Biol 211 - Group Number Active Learning Exercise 9. The Hereditary Material: DNA Reference: Chapter 16 (Biology by Campbell/Reece, 8 th ed.) 1. a.) What is a nucleotide? b.) What is a nitrogen base?
More informationThe Molecular Basis of Inheritance
Chapter 16 The Molecular Basis of Inheritance PowerPoint Lecture Presentations for Biology Eighth Edition Neil Campbell and Jane Reece Lectures by Chris Romero, updated by Erin Barley with contributions
More information