Corporate Overview. March 2017
|
|
- Tabitha Booth
- 6 years ago
- Views:
Transcription
1 Corporate Overview March 2017
2 Bionano Genomics Overview Commercial-stage company developing and selling instruments & consumables for whole genome analysis Addressing the needs for: A better understanding of genome biology More actionable results from genome analyses Enabling researchers & clinicians to see large structural variations for biomarker discovery & clinical diagnosis Market sizes range from $5 billion to over $100 billion 2
3 Unlocking the Promise of Precision Medicine Requires Better Tools THE DRIVER OF THE GENOMICS MARKET WHAT WOULD UNLOCK GENOMICS POTENTIAL? THE KEY $5B market $110B market * Precision Medicine Closing of the Genome Analysis Gap Improving Our Understanding of Genome Biology Which Will Require Better Tools * Midpoint of JPMorgan s research & clinical market opportunity (ILMN report, May 2016). 3
4 Something s Missing In Genomics Today = What s missing? The ability to see all genome variants 4
5 The Gaps Are Evident In a patient population of presumptive genetic disease: 74% Undiagnosed 26% Diagnosed 74% of genetic disorders go undiagnosed with sequencing Dec. 2014; 312:
6 Bionano Sees the Variants that Sequencing Misses Bionano provides the longrange genomic information that reveals the missing genome variants 6
7 Bionano Delivers Unprecedented Long-Range Genomic Information at Throughput Comparable with Illumina Read Length Gb Per Run (Log Scale) Throughput Kbp 1 Mbp Length (Log Scale) 7
8 A Powerful Combination: Bionano NGM Sees What Illumina Misses NGS NGM Variation Type SNPs & Indels (<2kb) Variation Type SVs (>2kb) Size of Variant All SNPs, Indels & SVs Bionano Customer Presentation: This graph depicts the density of SVs found (y axis) relative to the size of the SV found (x axis) for NGM (solid lines) against NGS (dotted lines). For SVs greater than 2,000bp, NGS has very significant drop in detection. NGM s ability to see SVs picks up where NGS drops off. 8
9 Bionano NGM Sees Large SVs with Analytical Performance that Is Unbeatable Throughout Genomics Sensitivity 7.3x Improvement in Sensitivity for SVs over Illumina Insertions Deletions Homozygous 99.0% 75.6% Heterozygous 83.6% 43.0% Homozygous 99.6% 82.8% Heterozygous 92.3% 67.3% 1,570 SVs Found (>5kb) 215 Publication: biorxiv, Rapid Automated Large Structural Variation Detection in a Diploid Genome by Nanochannel Based Next-Generation Mapping, Publication: Genetics, UCSF,
10 Examples of How Bionano Is Making a Significant Impact Duchenne Muscular Dystrophy Eric Vilain, M.D., Ph. D. Prostate Cancer Vanessa Hayes, Ph.D. Seminal data presented at 2017 AGBT 11 presumed genetic disorder patients that had been on long diagnostic odysseys were included in the study Whole genome, arrays and multiplex PCR had all failed in providing a diagnosis Bionano revealed that 2 of the 11 patients had novel SVs that explained each patient s developmental phenotype 8 year-old boy: a deletion and 2 deep intronic mutations in MED17 gene 13 year-old girl: a deletion in EZH1 gene associated with skeletal development Dr. Vilain commented on the amazing prowess and clinical usefulness of Bionano s tool Groundbreaking results released in March 2017 Bionano was added to an NGS-driven prostate cancer study effort that had been searching for putative SVs for years Within the first few patients tested, Bionano found hundreds of potentially important SVs (90% of which were missed by Illumina) Importantly, compared to Illumina, SVs called by Bionano had a 100x greater likelihood of impacting a putative oncogene Dr. Hayes now seeking to open the first-in-the-world Cancer Genome Mapping Facility based around the Bionano Genomics technology 10
11 Digital Solution for Karyotyping and FISH Example: Bionano can replace dual method (karyotyping & FISH) for finding the 8 lesions of AML Karyotyping Bionano DISEASE SVs DUAL METHOD TEST AML del(5q) inv(3) inv (16) t(8,21) t(15,17) t(9,11) t(6,9) t(1,22) Chromosome analysis (Karyotyping) + Fluorescence In Situ Hybridization (FISH) FISH Systematic SV detection to simplify hematological malignancy detection 11
12 Clinical Partnership in China with Berry Genomics to Create Digital Cytogenetic Products Genetic Disorders and Cancer Develop Submit Market Bionano and Berry will provide CFDA-approved alternatives to karyotyping, FISH and microarrays in reproductive health, inherited diseases and oncology in China and pave the way for U.S. FDA-cleared systems 12
13 Most Recent Accomplishments 60th Strategic alliance established VGP announces thousands of vertebrate genomes to be run on Bionano Bionano instrument installed Publication of Bionano s >90% SV sensitivity vs. PacBio s 54% Global product launch Aug 2016 Sep 2016 Oct 2016 Nov 2016 Dec 2016 Jan 2017 Feb 2017 Mar 2017 Former Illumina CSO becomes Bionano Chairman First purchase of next-generation beta instrument by Berry $7M Record annual revenues achieved UCLA presents putative SVs found in undiagnosed children Garvan publishes 10x more SVs found versus NGS in prostate cancer 13
14 Bionano s Installed Base Includes Leading Academic and Industrial Genome Researchers Around the World EXAMPLES OF USERS 68 Bionano systems adopted 14
15 Bionano s Key Technology: Nanochannels Bionano s chips are fabricated from standard semiconductor silicon wafers A Bionano chip contains up to 150,000 nanochannels, each 50 nanometers wide DNA is deposited into the well of the chip and moved into the nanochannels via electrophoresis As the DNA passes into the nanochannel, it linearizes and is then imaged 15
16 Bionano Workflow 16
17 Bionano Genomics Overview Commercial-stage company developing and selling instruments & consumables for whole genome analysis Addressing the needs for: A better understanding of genome biology More actionable results from genome analyses Enabling researchers & clinicians to see large structural variations for biomarker discovery & clinical diagnosis Market sizes range from $5 billion to over $100 billion 17
18 Appendix 18
19 Mapping Was a Foundational Concept Limited By Throughput & Cost Until Now FISH RFLP BAC YAC acgh 70 s-90 s Genome Mapping 2000 s Shotgun Sequencing & SBS Next-Generation Mapping RFLP, FISH, BAC, YAC, acgh Mapping + Nanotechnology NGS, SNPs, Genes Optical Mapping + Nanotechnology 2013 Launch /3 Human/Day Human/Day Humans/Day 19
20 Genome Complexity Is the Issue 55% of human genome is repeats 55% repeats Repeats hide the order & orientation of functional elements of the genome, including genes NGS spans only 5% of repeats 5% NGS misses the Structural Variations (SVs) that drive biology and pathology Illumina primarily provides SNP & small SV detection. Going beyond requires long-range information 20
21 A Mosaic of Technologies Is Needed to Succeed NGS SNPs Small SVs Mapping Small to Long SVs CNVs Bionano Mapping Is Being Readily Added to the Mosaic Because of Its: Arrays Gene Expression Synthetic Reads Additional Small SVs Long Read Sequencing Small to Medium SVs Proven utility Straight forward adoption Ease of use Low cost per genome 21
22 SNP Detection Alone Is Not Enough: SVs Need to Be Seen Which Requires Additional Technology SNPs: Biology of Therapeutic Response SVs: Biology of Disease 22
23 Comprehensive Genome Assembly Bionano Complements All Three NGS Approaches APPROACH 1 APPROACH 2 APPROACH 3 NGS NGM Unprecedented levels of completion for human and non-human genome assemblies Eliminates need for laborious, time-consuming and extremely costly clone methods (BAC, YAC, etc) Essential for creating gold standards for biomarker discovery and for building reference genomes for non-model organisms Bionano is the essential component for achieving these results 23
24 Bionano Selected By Dr. Erich Jarvis to Be an Anchor Technology for 66,000 Vertebrate Genome References 24
25 Management Erik Holmlin, PhD President & Chief Executive Officer Han Cao, PhD Founder & Chief Scientific Officer Mike Ward Chief Business Officer Mark Borodkin VP Systems Development Sean Paolino VP Finance Domain Associates Exiqon BD GeneOhm Applied Proteomics Xagenic Dupont Princeton U Penn Peking Univ USTC Credit Suisse Wasserstein Leerink Partners Brooks Life Science Affymetrix Siemens Healthcare Life Technologies Life Technologies Applied Biosystems 25
26 Board and Scientific Advisors David Barker, PhD Chairman; Independent Director Former CSO Illumina Darren Cai, PhD Legend Capital Brian Halak, PhD Domain Associates Albert Luderer, PhD Independent Director CEO Integrated Dx Pui-Yan Kwok, M.D., Ph.D. Henry Bachrach Distinguished Professor, University of California, San Francisco Charles Lee, Ph.D. Director, The Jackson Laboratory for Genomic Medicine Co-chair of the Structural Genomic Variation Analysis group for the 1000 Genomes Project ( 26
27 Historical and Projected Financials In million of U.S. dollars 27
28 Thank You! Contact: Erik Holmlin, Ph.D., CEO 28
Corporate Overview of BioNano Genomics, Inc. September 2016
Corporate Overview of BioNano Genomics, Inc. September 2016 BioNano Is the Key to Unlocking the $100+ Billion Potential of the Genomics Market Market Size Growth Catalyst Key Driver Bottleneck $40B- $110B
More informationCorporate Overview. December Erik Holmlin President & CEO
Corporate Overview December 2018 Erik Holmlin President & CEO Forward-Looking Statements This presentation contains forward-looking statements. Forward-looking statements describe future expectations,
More informationBionano Genomics Reports Financial Results for the Fourth Quarter and Year Ended December 31, 2018
Bionano Genomics Reports Financial Results for the Fourth Quarter and Year Ended December 31, 2018 Highlights: Record quarterly revenue of $4.0 million; 41% increase over 4Q17 Record annual revenue of
More informationto precision medicine
QIAGEN at the AMP 2018 Annual Meeting yourpath Discover to precision medicine Sample to Insight Discover your path to precision medicine Lead the way with QIAGEN, from Sample to Insight Every day, data
More informationSEQUENCING. M Ataei, PhD. Feb 2016
CLINICAL NEXT GENERATION SEQUENCING M Ataei, PhD Tehran Medical Genetics Laboratory Feb 2016 Overview 2 Background NGS in non-invasive prenatal diagnosis (NIPD) 3 Background Background 4 In the 1970s,
More informationJefferies Healthcare Conference. Frank Witney, President & CEO
Jefferies Healthcare Conference Frank Witney, President & CEO Forward Looking Statement This presentation contains statements that are "forward-looking statements" within the meaning of the Securities
More informationAn innovative approach to genetic testing for improved patient care
An innovative approach to genetic testing for improved patient care Blueprint Genetics Blueprint Genetics is changing diagnostics by providing fast, affordable and comprehensive genetic knowledge Who we
More informationIntroduction to Bioinformatics
Introduction to Bioinformatics Richard Corbett Canada s Michael Smith Genome Sciences Centre Vancouver, British Columbia June 28, 2017 Our mandate is to advance knowledge about cancer and other diseases
More informationStructural variation. Marta Puig Institut de Biotecnologia i Biomedicina Universitat Autònoma de Barcelona
Structural variation Marta Puig Institut de Biotecnologia i Biomedicina Universitat Autònoma de Barcelona Genetic variation How much genetic variation is there between individuals? What type of variants
More informationTargeted Sequencing in the NBS Laboratory
Targeted Sequencing in the NBS Laboratory Christopher Greene, PhD Newborn Screening and Molecular Biology Branch Division of Laboratory Sciences Gene Sequencing in Public Health Newborn Screening February
More informationNUCLEOTIDE RESOLUTION STRUCTURAL VARIATION DETECTION USING NEXT- GENERATION WHOLE GENOME RESEQUENCING
NUCLEOTIDE RESOLUTION STRUCTURAL VARIATION DETECTION USING NEXT- GENERATION WHOLE GENOME RESEQUENCING Ken Chen, Ph.D. kchen@genome.wustl.edu The Genome Center, Washington University in St. Louis The path
More informationThe Diploid Genome Sequence of an Individual Human
The Diploid Genome Sequence of an Individual Human Maido Remm Journal Club 12.02.2008 Outline Background (history, assembling strategies) Who was sequenced in previous projects Genome variations in J.
More informationThe Irys System. Rapid Genome Wide Mapping for de novo Assembly and Structural Variation Analysis. Jack Peart, Ph.D. Director of Sales EMEA
The Irys System Rapid Genome Wide Mapping for de novo Assembly and Structural Variation Analysis Jack Peart, Ph.D. Director of Sales EMEA BioNano Snapshot Developed & Commercialized the Irys System for
More informationSingle Cell Genomics (SCG): Market Size, Segmentation, Growth, Competition and Trends ( )
Single Cell Genomics (SCG): Market Size, Segmentation, Growth, Competition and Trends (2013-2021) May, 2017 3 rd Edition Information contained in this market report is believed to be reliable at the time
More informationHuman Genomics, Precision Medicine, and Advancing Human Health. The Human Genome. The Origin of Genomics : 1987
Human Genomics, Precision Medicine, and Advancing Human Health Eric Green, M.D., Ph.D. Director, NHGRI The Human Genome Cells Nucleus Chromosome DNA Human Genome: 3 Billion Bases (letters) The Origin of
More informationMegan Schmidt Vice President of Product Management, CompuGroup Medical
Thursday April 6, 2017 A01 Molecular and Genetic Testing: How to Position your Laboratory for New Technology Megan Schmidt Vice President of Product Management, CompuGroup Medical DESCRIPTION: Molecular
More informationLecture #1. Introduction to microarray technology
Lecture #1 Introduction to microarray technology Outline General purpose Microarray assay concept Basic microarray experimental process cdna/two channel arrays Oligonucleotide arrays Exon arrays Comparing
More informationQIAGEN s NGS Solutions for Biomarkers NGS & Bioinformatics team QIAGEN (Suzhou) Translational Medicine Co.,Ltd
QIAGEN s NGS Solutions for Biomarkers NGS & Bioinformatics team QIAGEN (Suzhou) Translational Medicine Co.,Ltd 1 Our current NGS & Bioinformatics Platform 2 Our NGS workflow and applications 3 QIAGEN s
More informationDNA Diagnostics Market - Global Industry Analysis, Size, Share, Growth, Trends And Forecast,
DNA Diagnostics Market - Global Industry Analysis, Size, Share, Growth, Trends And Forecast, 2013-2019 The completion of human genome project resulted in discovery of several human disease causing genes.
More informationExome Sequencing Exome sequencing is a technique that is used to examine all of the protein-coding regions of the genome.
Glossary of Terms Genetics is a term that refers to the study of genes and their role in inheritance the way certain traits are passed down from one generation to another. Genomics is the study of all
More informationInvitae Corporation (Exact name of registrant as specified in its charter)
UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report: March 12, 2018 (Date
More informationGenomics Market Share, Size, Analysis, Growth, Trends and Forecasts to 2024 Hexa Research
Genomics Market Share, Size, Analysis, Growth, Trends and Forecasts to 2024 Hexa Research " Increasing usage of novel genomics techniques and tools, evaluation of their benefit to patient outcome and focusing
More informationBD Strategy Overview. Advancing the world of health. Vincent A. Forlenza Chairman, Chief Executive Officer and President
BD Strategy Overview Advancing the world of health Vincent A. Forlenza Chairman, Chief Executive Officer and President BD IS AT THE VERY BEGINNING OF AN AMAZING JOURNEY WHERE WE CAN HAVE A PROFOUND IMPACT
More informationThe Expanded Illumina Sequencing Portfolio New Sample Prep Solutions and Workflow
The Expanded Illumina Sequencing Portfolio New Sample Prep Solutions and Workflow Marcus Hausch, Ph.D. 2010 Illumina, Inc. All rights reserved. Illumina, illuminadx, Solexa, Making Sense Out of Life, Oligator,
More informationIntroducing combined CGH and SNP arrays for cancer characterisation and a unique next-generation sequencing service. Dr. Ruth Burton Product Manager
Introducing combined CGH and SNP arrays for cancer characterisation and a unique next-generation sequencing service Dr. Ruth Burton Product Manager Today s agenda Introduction CytoSure arrays and analysis
More informationOutline General NGS background and terms 11/14/2016 CONFLICT OF INTEREST. HLA region targeted enrichment. NGS library preparation methodologies
Eric T. Weimer, PhD, D(ABMLI) Assistant Professor, Pathology & Laboratory Medicine, UNC School of Medicine Director, Molecular Immunology Associate Director, Clinical Flow Cytometry, HLA, and Immunology
More informationFundamentals of Next-Generation Sequencing: Technologies and Applications
Fundamentals of Next-Generation Sequencing: Technologies and Applications Society for Hematopathology European Association for Haematopathology 2017 Workshop Eric Duncavage, MD Washington University in
More informationComplementary Technologies for Precision Genetic Analysis
Complementary NGS, CGH and Workflow Featured Publication Zhu, J. et al. Duplication of C7orf58, WNT16 and FAM3C in an obese female with a t(7;22)(q32.1;q11.2) chromosomal translocation and clinical features
More informationWhole genome sequencing in the UK Biobank
Whole genome sequencing in the UK Biobank Part of the UK Government s Industrial Strategy Challenge Fund (ISCF) for the Data to Early Diagnosis and Precision Medicine initiative Aim to produce deep characterisation
More informationWelcome to the NGS webinar series
Welcome to the NGS webinar series Webinar 1 NGS: Introduction to technology, and applications NGS Technology Webinar 2 Targeted NGS for Cancer Research NGS in cancer Webinar 3 NGS: Data analysis for genetic
More informationFREQUENTLY ASKED QUESTIONS
FREQUENTLY ASKED QUESTIONS Q: WHAT IS HUMAN LONGEVITY INC.? A: Human Longevity, Inc. (HLI) is the genomic-based, health intelligence company empowering proactive healthcare and enabling a life better lived.
More informationThe New Genome Analyzer IIx Delivering more data, faster, and easier than ever before. Jeremy Preston, PhD Marketing Manager, Sequencing
The New Genome Analyzer IIx Delivering more data, faster, and easier than ever before Jeremy Preston, PhD Marketing Manager, Sequencing Illumina Genome Analyzer: a Paradigm Shift 2000x gain in efficiency
More informationThe 100,000 Genomes Project
The 100,000 Genomes Project Dr Tom Fowler, Deputy Chief Scientist Genomics England Jillian Hastings Ward, Chair, National 100K Participant Panel The Kings Fund, 6th October 2017 Our Mission 100,000 whole
More informationDNA. bioinformatics. genomics. personalized. variation NGS. trio. custom. assembly gene. tumor-normal. de novo. structural variation indel.
DNA Sequencing T TM variation DNA amplicon mendelian trio genomics NGS bioinformatics tumor-normal custom SNP resequencing target validation de novo prediction personalized comparative genomics exome private
More informationUnderstanding the science and technology of whole genome sequencing
Understanding the science and technology of whole genome sequencing Dag Undlien Department of Medical Genetics Oslo University Hospital University of Oslo and The Norwegian Sequencing Centre d.e.undlien@medisin.uio.no
More informationMolecular Pathology Coding Workgroup Fly-In
Molecular Pathology Coding Workgroup Fly-In What CPT Is Role of Current Procedural Terminology Nomenclature: Coding CPT is a listing of descriptive terms and identifying codes for reporting medical services
More informationPersonalized Human Genome Sequencing
Personalized Human Genome Sequencing Dr. Stefan Platz DABT, Global Head Drug Safety & Metabolism Biomedical research: strengths & limitations of non-animal alternatives 06 December 2016 The Human Genome
More informationCentre for NanoHealth
Steve Conlan PhD An integrated collaborative base for businesses in Wales Director - Reproductive Biology & Cancer Research Institute of Life Science School of Medicine Unique interdisciplinary R&D environment,
More informationBiotechnology Chapter 20
Biotechnology Chapter 20 DNA Cloning DNA Cloning AKA Plasmid-based transformation or molecular cloning First off-let s sum up what happens. A plasmid is taken from a bacteria A gene is inserted into the
More informationInnovations in Molecular Lab Operation. Joseph M. Campos, PhD, D(ABMM), F(AAM)
Innovations in Molecular Lab Operation Lessons in the Best Ways to Blend Automation, Lean Workflow, and Paperless Processes Joseph M. Campos, PhD, D(ABMM), F(AAM) Interim Chief, Division of Laboratory
More informationTarget Enrichment Strategies for Next Generation Sequencing
Target Enrichment Strategies for Next Generation Sequencing Anuj Gupta, PhD Agilent Technologies, New Delhi Genotypic Conference, Sept 2014 NGS Timeline Information burst Nearly 30,000 human genomes sequenced
More informationGenomes contain all of the information needed for an organism to grow and survive.
Section 3: Genomes contain all of the information needed for an organism to grow and survive. K What I Know W What I Want to Find Out L What I Learned Essential Questions What are the components of the
More informationTotal genomic solutions for biobanks. Maximizing the value of your specimens.
Total genomic solutions for biobanks. Maximizing the value of your specimens. Unlock the true potential of your biological samples. Greater understanding. Increased value. Value-driven biobanking. Now
More informationTRANSFORMING GLOBAL GENETIC DATA INTO MEDICAL DECISIONS
TRANSFORMING GLOBAL GENETIC DATA INTO MEDICAL DECISIONS THE DOORS ARE OPEN: FEEL FREE TO COME IN CENTOGENE UNLOCKS THE POWER OF GENETIC INSIGHTS TO IMPROVE THE QUALITY OF LIFE OF PATIENTS WITH GENETIC
More informationAgilent NGS Solutions : Addressing Today s Challenges
Agilent NGS Solutions : Addressing Today s Challenges Charmian Cher, Ph.D Director, Global Marketing Programs 1 10 years of Next-Gen Sequencing 2003 Completion of the Human Genome Project 2004 Pyrosequencing
More informationOutline. Impact on Human Diseases Basis for Molecular Assay Novel Biomarkers
MOLECULAR DIAGNOSITICS 1 Outline Concept of Molecular Diagnostics History of Molecular Diagnostics Impact on Human Diseases Basis for Molecular Assay Novel Biomarkers 2 Molecular Diagnosis Molecular diagnosis
More informationGenomic solutions for complex disease
Genomic solutions for complex disease Power your with our genomic solutions Access a breadth of applications. Gain a depth of insights. To enhance their understanding of complex disease, researchers are
More informationHaloPlex HS. Get to Know Your DNA. Every Single Fragment. Kevin Poon, Ph.D.
HaloPlex HS Get to Know Your DNA. Every Single Fragment. Kevin Poon, Ph.D. Sr. Global Product Manager Diagnostics & Genomics Group Agilent Technologies For Research Use Only. Not for Use in Diagnostic
More informationKonica Minolta to Acquire Invicro (US)
Konica Minolta to Acquire Invicro (US) Acceleration of expansion of precision medicine business Offering new value for drug discovery and development in immuno-oncology and neurodegenerative disease September
More informationDesign a super panel for comprehensive genetic testing
Design a super panel for comprehensive genetic testing Rong Chen, Ph.D. Assistant Professor Director of Clinical Genome Sequencing Dept. of Genetics and Genomic Sciences Institute for Genomics and Multiscale
More informationKonica Minolta and INCJ Agree to Acquire Ambry Genetics in a Deal Valued at US$1 billion
News Release Konica Minolta and INCJ Agree to Acquire Ambry Genetics in a Deal Valued at US$1 billion Advances Konica Minolta strategy to establish a leadership position in precision medicine Contributes
More informationAmerican Board of Medical Genetics and Genomics
American Board of Medical Genetics and Genomics Logbook Guidelines for Certification in Laboratory Genetics and Genomics for the 2019 Examination as of 11/10/2016 Purpose: The purpose of the logbook is
More informationSample to Insight. Dr. Bhagyashree S. Birla NGS Field Application Scientist
Dr. Bhagyashree S. Birla NGS Field Application Scientist bhagyashree.birla@qiagen.com NGS spans a broad range of applications DNA Applications Human ID Liquid biopsy Biomarker discovery Inherited and somatic
More informationPerformance of the Newly Developed Non-Invasive Prenatal Multi- Gene Sequencing Screen
1 // Performance of the Newly Developed Non-Invasive Prenatal Multi- Gene Sequencing Screen ABSTRACT Here we describe the analytical performance of the newly developed non-invasive prenatal multi-gene
More informationDelivering on the Promise of Precision Medicine
Delivering on the Promise of Precision Medicine Bay Area Council Economic Institute Spring 2016 The Promise of Precision Medicine The Bay Area is one of the world s biggest hubs for innovation in research
More informationEmployment in the biopharma industry grew almost 5 percent in 2014, the last full year for which we have data. This is the highest annual growth rate
Thank you, Mr. Chairman, and members of the committee. I m Sarah MacDonald, Executive Vice President at MassBio, the life sciences trade association now representing over 700 member organizations. First,
More informationTitelstijl van model bewerken
Generate Titelstijl van and verify model your bewerken data Solutions for all your genetic analysis needs Sanger Sequencing Microarray technology QuantStudio real-time and digital PCR Ion Torrent NGS systems
More informationGENE EXPRESSION REAGENTS MARKETS (SAMPLE COPY, NOT FOR RESALE)
TriMark Publications April 2007 Volume: TMRGER07-0401 GENE EXPRESSION REAGENTS MARKETS (SAMPLE COPY, NOT FOR RESALE) Trends, Industry Participants, Product Overviews and Market Drivers TABLE OF CONTENTS
More informationThe Human Genome and its upcoming Dynamics
The Human Genome and its upcoming Dynamics Matthias Platzer Genome Analysis Leibniz Institute for Age Research - Fritz-Lipmann Institute (FLI) Sequencing of the Human Genome Publications 2004 2001 2001
More informationPowering the Synthetic Biology and Genomics Revolutions
Powering the Synthetic Biology and Genomics Revolutions Advances in Genome Biology and Technology Marco Island, Florida February 28, 2019 Safe Harbor Statement This presentation contains forward-looking
More informationCancer Genetics Solutions
Cancer Genetics Solutions Cancer Genetics Solutions Pushing the Boundaries in Cancer Genetics Cancer is a formidable foe that presents significant challenges. The complexity of this disease can be daunting
More informationIllumina Genome Analyzer. Progenika Experience. - Susana Catarino -
Illumina Genome Analyzer Progenika Experience - Susana Catarino - Who are we? 2000 PROGENIKA BIOPHARMA Development, production and commercialization of new genomic tools for diagnosis, prognosis and drug-response
More informationFDA Regulation of Companion Diagnostics
FDA Regulation of Companion Diagnostics Paul Radensky October 11, 2017 Disclosure + Slideset drawn from Part I of presentation made by Janice Hogan, HoganLovells, October 2016 + Updated where appropriate
More informationDetecting Structural Variants in PacBio Reads Tools and Applications
Detecting Structural Variants in PacBio Reads Tools and Applications Aaron Wenger 2017-06-28 For Research Use Only. Not for use in diagnostics procedures. Copyright 2017 by Pacific Biosciences of California,
More informationNGS-based innovations within the Leiden Network
NGS-based innovations within the Leiden Network A strong bridge between two partners Dr. Mark de Jong 2017-09-29 Design accurate and robust NGS tests and generate data sets essential for Diagnostics &
More information3. human genomics clone genes associated with genetic disorders. 4. many projects generate ordered clones that cover genome
Lectures 30 and 31 Genome analysis I. Genome analysis A. two general areas 1. structural 2. functional B. genome projects a status report 1. 1 st sequenced: several viral genomes 2. mitochondria and chloroplasts
More informationCertification in Laboratory Genetics and Genomics Logbook Guidelines 2019 Examination
Certification in Laboratory Genetics and Genomics Logbook Guidelines 2019 Examination Purpose: The purpose of the logbook is to document that the applicant has had direct and meaningful involvement in
More informationE2ES to Accelerate Next-Generation Genome Analysis in Clinical Research
www.hcltech.com E2ES to Accelerate Next-Generation Genome Analysis in Clinical Research whitepaper April 2015 TABLE OF CONTENTS Introduction 3 Challenges associated with NGS data analysis 3 HCL s NGS Solution
More informationresequencing storage SNP ncrna metagenomics private trio de novo exome ncrna RNA DNA bioinformatics RNA-seq comparative genomics
RNA Sequencing T TM variation genetics validation SNP ncrna metagenomics private trio de novo exome mendelian ChIP-seq RNA DNA bioinformatics custom target high-throughput resequencing storage ncrna comparative
More informationINTRODUCTION NEW GENETIC TECHNIQUES IN METABOLIC DISEASES 26/01/2016 FROM ONE GENERATION TO THE NEXT. Image challenge of the week D.
NEW GENETIC TECHNIQUES IN METABOLIC DISEASES D. RYMEN, MD, PHD Pentalfa session Leuven, January 21 st 2016 INTRODUCTION Image challenge of the week 1 INTRODUCTION But what about Hypotonia Facial dysmorphism
More informationSatellite Education Workshop (SW4): Epigenomics: Design, Implementation and Analysis for RNA-seq and Methyl-seq Experiments
Satellite Education Workshop (SW4): Epigenomics: Design, Implementation and Analysis for RNA-seq and Methyl-seq Experiments Saturday March 17, 2012 Orlando, Florida Workshop Description: This full day
More informationInformed Consent for Columbia Combined Genetic Panel (CCGP) for Adults Please read the following
Informed Consent for Columbia Combined Genetic Panel (CCGP) for Adults Please read the following form carefully and discuss with your ordering physician/genetic counselor before signing consent. 1. The
More informationAIT - Austrian Institute of Technology
BIOMARKER DISCOVERY, BIOINFORMATICS, AND BIOSENSOR DEVELOPMENT Technology Experience AIT Austrian Institute of Technology Low-Emission Transport AIT - Austrian Institute of Technology Energy Health & Bioresources
More informationChapter 5. Structural Genomics
Chapter 5. Structural Genomics Contents 5. Structural Genomics 5.1. DNA Sequencing Strategies 5.1.1. Map-based Strategies 5.1.2. Whole Genome Shotgun Sequencing 5.2. Genome Annotation 5.2.1. Using Bioinformatic
More informationPreanalytical Variables in Blood Collection: Impact on Precision Medicine
Preanalytical Variables in Blood Collection: Impact on Precision Medicine Carolyn Compton, MD, PhD Chair, Scientific Advisory Committee, Indivumed GmbH Professor of Life Sciences, ASU Professor of Laboratory
More informationLong-range gene regulation
Long-range gene regulation Short Course in Medical Genetics Melbourne, June 2011 Question Why should long-range regulation of gene expression be of interest to Clinical Scientists and Pathologists interested
More informationSeptember 8, General Comments:
September 8, 2009 AMP Comments on the draft report from the Agency for Healthcare Research and Quality (AHRQ): AHRQ Draft Report on Quality, Regulation and Clinical Utility of Laboratorydeveloped Tests.
More informationTechnology funding opportunities at the National Cancer Institute
Technology funding opportunities at the National Cancer Institute Through the Cancer Diagnosis Program http://cancerdiagnosis.nci.nih.gov/index.html Avraham Rasooly Ph.D. National Cancer Institute, Cancer
More informationComplex Adaptive Systems Forum: Transformative CAS Initiatives in Biomedicine
Complex Adaptive Systems Forum: Transformative CAS Initiatives in Biomedicine January 18, 2013 Anna D. Barker, Ph.D. Director, Transformative Healthcare Networks C-Director, Complex Adaptive Systems Initiative
More informationSuperior detection of chromosomal aberrations using the latest generation of exon-focused constitutional arrays
Superior detection of chromosomal aberrations using the latest generation of exon-focused constitutional arrays Investigation of exon-level resolution microarray technology for the identification of important
More informationCrash-course in genomics
Crash-course in genomics Molecular biology : How does the genome code for function? Genetics: How is the genome passed on from parent to child? Genetic variation: How does the genome change when it is
More informationIllumina Diagnostics. Emily Winn-Deen, PhD Vice President, Product Development Diagnostics
Introduction ti to Illumina Diagnostics Emily Winn-Deen, PhD Vice President, Product Development Diagnostics 2010 Illumina, Inc. All rights reserved. Illumina, illuminadx, Solexa, Making Sense Out of Life,
More informationDr. Stephen Kingsmore a vision for transforming medicine with rapid genome sequencing
Dr. Stephen Kingsmore a vision for transforming medicine with rapid genome sequencing Dr. Stephen Kingsmore, MD, DSc, is the President and CEO of the Rady Pediatric Genomics and Systems Medicine Institute.
More informationPharmacogenetics: A SNPshot of the Future. Ani Khondkaryan Genomics, Bioinformatics, and Medicine Spring 2001
Pharmacogenetics: A SNPshot of the Future Ani Khondkaryan Genomics, Bioinformatics, and Medicine Spring 2001 1 I. What is pharmacogenetics? It is the study of how genetic variation affects drug response
More informationUniversity of Athens - Medical School. pmedgr. The Greek Research Infrastructure for Personalized Medicine
University of Athens - Medical School pmedgr The Greek Research Infrastructure for Personalized Medicine - George Kollias - Professor of Experimental Physiology, Medical School, University of Athens President
More informationSubmission to House of Lords Science and Technology Select Committee Oxford Nanopore Technologies Ltd April 2008
(Previously Oxford NanoLabs) Genomic Medicine Submission to House of Lords Science and Technology Select Committee Oxford Nanopore Technologies Ltd April 2008 Introduction Oxford Nanopore Technologies
More informationREIMAGINING DRUG DEVELOPMENT:
Biology Reconstructed REIMAGINING DRUG DEVELOPMENT: Accurate Disease Modeling To Drive Successful Therapies Julia Kirshner, CEO julia@zpredicta.com 1 SUCCESS RATES OF DRUG DEVELOPMENT ARE LOW, " PARTICULARLY
More informationSolutions will be posted on the web.
MIT Biology Department 7.012: Introductory Biology - Fall 2004 Instructors: Professor Eric Lander, Professor Robert A. Weinberg, Dr. Claudette Gardel NAME TA SEC 7.012 Problem Set 7 FRIDAY December 3,
More informationChapter 15 The Human Genome Project and Genomics. Chapter 15 Human Heredity by Michael Cummings 2006 Brooks/Cole-Thomson Learning
Chapter 15 The Human Genome Project and Genomics Genomics Is the study of all genes in a genome Relies on interconnected databases and software to analyze sequenced genomes and to identify genes Impacts
More informationOxford Gene Technology The Molecular Genetics Company
Oxford Gene Technology The Molecular Genetics Company CYTOCELL USER GROUP MEETING 2017 Spencer Howell VP European Sales April 2017 1 Welcome everybody Many thanks for your huge interest and fantastic feedback!
More informationPioneering Clinical Omics
Pioneering Clinical Omics Clinical Genomics Strand NGS An analysis tool for data generated by cutting-edge Next Generation Sequencing(NGS) instruments. Strand NGS enables read alignment and analysis of
More information14 March, 2016: Introduction to Genomics
14 March, 2016: Introduction to Genomics Genome Genome within Ensembl browser http://www.ensembl.org/homo_sapiens/location/view?db=core;g=ensg00000139618;r=13:3231547432400266 Genome within Ensembl browser
More informationIntegrated Course of HUMAN AND MEDICAL GENETICS
Integrated Course of HUMAN AND MEDICAL GENETICS Scientific Fields: MEDICAL GENETICS (MED/03) APPLIED BIOLOGY (BIO/13) European Credit Transfer and Accumulation System = 7 Coordinator: Prof. BRUNELLA FRANCO,
More informationIntegrated Radiology & Pathology Diagnostic Services: The Time is Now at UCLA
Integrated Radiology & Pathology Diagnostic Services: The Time is Now at UCLA Scott W Binder MD Pritzker Professor of Clinical Pathology and Dermatology Senior Vice Chair Director, Pathology Clinical Services
More informationMatthew Tinning Australian Genome Research Facility. July 2012
Next-Generation Sequencing: an overview of technologies and applications Matthew Tinning Australian Genome Research Facility July 2012 History of Sequencing Where have we been? 1869 Discovery of DNA 1909
More informationTHE WHITE HOUSE Office of the Vice President
FOR IMMEDIATE RELEASE October 17, 2016 THE WHITE HOUSE Office of the Vice President FACT SHEET: Vice President Biden Delivers Cancer Moonshot Report, Announces Public and Private Sector Actions to Advance
More informationUnlocking the Power of the Genome
Unlocking the Power of the Genome Sam Samad, Chief Financial Officer William Blair Growth Stock Conference, 13 June 2018 2018 Illumina, Inc. All rights reserved. Safe Harbor Statement This presentation
More informationlatestdevelopments relevant for the Ag sector André Eggen Agriculture Segment Manager, Europe
Overviewof Illumina s latestdevelopments relevant for the Ag sector André Eggen Agriculture Segment Manager, Europe Seminar der Studienrichtung Tierwissenschaften, TÜM, July 1, 2009 Overviewof Illumina
More informationTREE CODE PRODUCT BROCHURE
TREE CODE PRODUCT BROCHURE Single Molecule, Real-Time (SMRT) Sequencing technology offers: Long read sequencing ~10 Gb with 20 kb average read lengths for WGS ~20 Gb with 40 kb average read length for
More informationILLUMINA SEQUENCING SYSTEMS
ILLUMINA SEQUENCING SYSTEMS PROVEN QUALITY. TRUSTED SOLUTIONS. Every day, researchers are using Illumina next-generation sequencing (NGS) systems to better understand human health and disease, as well
More information