ibdreg: An R package for Genetic Linkage with Covariates
|
|
- Chester Flowers
- 6 years ago
- Views:
Transcription
1 ibdreg: An R package fr Genetic Linkage with Cvariates Jasn Sinnwell Daniel Schaid August 10, 2007
2 ibdreg: utline Intr t Linkage (brief) Why d linkage with cvariates? Methdlgy in ibdreg Dem f ibdreg n prstate cancer data 8/10/2007 Divisin f Bistatistics, May Clinic Cllege f Medicine 2
3 Linkage Intr: Genetic Analysis Types Segregatin Analysis - Use family data t determine the extent t which a disease is genetic Linkage Analysis Use family data t lcate a chrmsme segment that is inherited jintly with a disease lcus Assciatin Analysis Use unrelated data t find a genetic effect f a particular DNA marker(s) n a disease 8/10/2007 Divisin f Bistatistics, May Clinic Cllege f Medicine 3
4 Intr t Linkage: Recmbinatin Mendel prpsed genes (n peas) are inherited independently f ne anther Nt quite right -- genes / markers which are clse tgether shw assciatins During meisis, crrespnding DNA segments can recmbine in any lcatin Recmbinatin is smewhat cnstant ver the whle genme In general, clse markers have fewer recmbinatins 8/10/2007 Divisin f Bistatistics, May Clinic Cllege f Medicine 4
5 Intr t Linkage, basic plt 8/10/2007 Divisin f Bistatistics, May Clinic Cllege f Medicine 5
6 Linkage with Cvariates: illustrated Nuclear family with 4 children, 3 affected with disease ped1, early age-f-nset 1 2 If genetic linkage: persns 3,5 share mre alleles near disease lcus persns 3,4 share fewer alleles at disease lcus 3 age= age=31 6 age=24 8/10/2007 Divisin f Bistatistics, May Clinic Cllege f Medicine 6
7 Linkage with Cvariates: IBD Sharing Identity-By-Descent (IBD): alleles that have been inherited frm the same ancestr Estimate prbability f sharing 0, 1, and 2 alleles IBD: f 0, f 1, f 2 Use Merlin, Genehunter, etc. Estimated IBD sharing fr a relative pair: s = + r 2 f 1f r, 2 r,1 8/10/2007 Divisin f Bistatistics, May Clinic Cllege f Medicine 7
8 Linkage with Cvariates: illustrated ped2, late age-f-nset Nuclear family, tw affected siblings Late-nset frm f the disease age age-55 8/10/2007 Divisin f Bistatistics, May Clinic Cllege f Medicine 8
9 Linkage with Cvariates Ped1 and Ped2 culd be tw frms f disease: early and late nset Mixture f gene and envirnment effects, i.e. disease hetergeneity Assume the early nset is genetically linked at lcus L IBD sharing at L is: ped1: greater than null ped2: smewhere near null 8/10/2007 Divisin f Bistatistics, May Clinic Cllege f Medicine 9
10 Linkage with Cvariates The mre alike the cvariates, the mre allele sharing is expected Cnsider a functin f the age f nset fr affected siblings: 1. age1 + age2 2. age1 * age2 3. ( age1-60 * age2-60 ) 2 Define any functin that applies t the disease and cvariate impact 8/10/2007 Divisin f Bistatistics, May Clinic Cllege f Medicine 10
11 Linkage with Cvariates Intuitively, affected relative pairs with similar cvariates share mre alleles than the null Linear relatinship fr IBD sharing and pair-specific cvariates (X): m r, m r : Expected s r under linkage, n linkage = scaling factr fr the relatinship types c r X * r = c r 0 r m = m + c Xβ = [1 r X ] r X * r β 8/10/2007 Divisin f Bistatistics, May Clinic Cllege f Medicine 11
12 ibdreg methd Quasi-likelihd scre functin: n T 1 U = Di Vi ( Si Mi) i= 1 where i = 1..n pedigrees S i, M i : vectrs f estimated and expected (H ) allele sharing D i : derivative f M i with respect t β V i : cvariance matrix f the S i vectr 8/10/2007 Divisin f Bistatistics, May Clinic Cllege f Medicine 12
13 ibdreg methd Develp a chi-square test: where V u T n = X i= 1 * T i = V 1 0, i U T V 1 U u With q degrees f freedm: X * i q=1 fr intercept-nly (linkage) q=2 fr intercept with 1 cvariate etc. 8/10/2007 Divisin f Bistatistics, May Clinic Cllege f Medicine 13
14 ibdreg methd Available tests (degrees f freedm) 1. Linkage withut cvariates (q=1) 2. Linkage with p cvariates (q=1+p) 3. Effect f p cvariates n IBD sharing, adjusting fr linkage (p) 8/10/2007 Divisin f Bistatistics, May Clinic Cllege f Medicine 14
15 ibdreg applied Data: sample f pedigrees ascertained at May Clinic (SE MN) fr having multiple cases f prstate cancer 159 pedigrees (max 21 peple) 495 affected relative pairs (ARPs) Cvariate: age-f-nset (dxage) 8/10/2007 Divisin f Bistatistics, May Clinic Cllege f Medicine 15
16 ibdreg applied LODPAL, f S.A.G.E., apprximates a pseud-likelihd f IBD sharing prbabilities by a trinmial lgistic regressin mdel (blue line) Cmpare t ibdreg (green line), bth using sum(dxage) as a cvariate Als include ibdreg, linkage-nly (black line) Same c scale (genetic effect between dminant and recessive) 8/10/2007 Divisin f Bistatistics, May Clinic Cllege f Medicine 16
17 Ibdreg, applied 8/10/2007 Divisin f Bistatistics, May Clinic Cllege f Medicine 17
18 ibdreg applied Fr figure abve, nte a few things: LODPAL and ibdreg generally clse Differences: 1. Narrw peaks (ch6, ch20) 2. Ends f chrmsmes (ch5) Bth may be attributable t instability f maximizing pseudlikelihd f LODPAL 8/10/2007 Divisin f Bistatistics, May Clinic Cllege f Medicine 18
19 ibdreg applied: R cde # lad the library R> library(ibdreg) # lad cvariate data, cntaining ped id and persn id t match file R> cv.data <- read.table("cv.data.csv", sep=",") # create data.frame with id (ped and persn) and IBD data with Merlin results R> ibd.dat.bj <- create.ibd.dat(pstfile="chr20.pst.ibd", prirfile="chr1.prir.ibd") # simulate ibd.var bject using gene-drpping # requires a.pre file fr pedigree specs R> ibd.var.bj <- sim.ibd.var("ch.20.pre", n.sim=10000) 8/10/2007 Divisin f Bistatistics, May Clinic Cllege f Medicine 19
20 ibdreg applied: R cde # define a functin fr the sum f cvariates R> pairsum <- functin(cv1,cv2) {cv1+cv2} # run ibdreg fr AA relatives, # with cvariate sum(dxage), minimax c scaling R> sum.dxage.aa <- ibdreg(frmula=~pairsum(dxage), status.methd="aa", c.scale="minimax", status=pcstat, ped.id=ped.id, persn.id=persn.id, data=cv.data, ibd.dat=ibd.dat.bj, ibd.var=ibd.var.bj) 8/10/2007 Divisin f Bistatistics, May Clinic Cllege f Medicine 20
21 ibdreg applied: chrmsme 20 Linkage signal different lcatin frm linkage w/cv In nn-peak, linkage w/cv is smaller --1 mre deg. f freedm Cv Effect has small cntributin t linkage signal 8/10/2007 Divisin f Bistatistics, May Clinic Cllege f Medicine 21
22 ibdreg applied: all ARPs Disregarding cvariates, we can test linkage n all 495 relative pairs in the example, which cntain sub-grups AA: Affected-Affected (429) UU: Unaffected-Unaffected (7) AU: Affected-Unaffected (59) Sharing under linkage is expected as AA: Mre than null UU: Mre than null, but less than AA UU: Less than null 8/10/2007 Divisin f Bistatistics, May Clinic Cllege f Medicine 22
23 Ibdreg applied, all ARPs Linkage tests fr all relative pairs Test fr linkage in directin expected under linkage: AA-mre UU-mre AU-less Overall linkage is driven by AA pairs 8/10/2007 Divisin f Bistatistics, May Clinic Cllege f Medicine 23
24 ibdreg applied: unexpected sharing IBD allele sharing can be invalid by: 1. Mis-specify marker allele freq when parents missing 2. Incrrect pedigree relatinships 3. Unaccunted inbreeding The χ 2 test fr linkage given as bth uncnstrained and cnstrained t favr linkage (1-sided, smaller p-value) If p uncnstrained < p cnstrained, indicates unexpected IBD sharing (chrms 1, 7, 12) 8/10/2007 Divisin f Bistatistics, May Clinic Cllege f Medicine 24
25 8/10/2007 Divisin f Bistatistics, May Clinic Cllege f Medicine 25
26 ibdreg, cncluded Allws multiple tests fr linkage Prvides ptins fr specifying cvariates and scaling (c r ) Scaling avids fitting new regressin line fr each relatinship type Linear regressin is easy t fit, and easy t apply weights t accunt fr dependence f variance n cvariates Returned S3 bject with print and plt methds Perl scripts supplied t wrk with Merlin. 8/10/2007 Divisin f Bistatistics, May Clinic Cllege f Medicine 26
27 Thank Yu Fr mre details and references see: Schaid DJ, Sinnwell JP, Thibdeau SN. Testing genetic linkage with relative pairs and cvariates by quasilikelihd scre statistics. Hum Hered. 2007;64(4): Epub 2007 Jun 12. 8/10/2007 Divisin f Bistatistics, May Clinic Cllege f Medicine 27
Chapter 7 DNA Fingerprinting By the end of this chapter you will be able to:
Chapter 7 DNA Fingerprinting By the end f this chapter yu will be able t: Explain hw crime scene evidence is cllected and prcessed t btain DNA Describe hw radiactive prbes are used in DNA fingerprinting
More informationBIOLOGY 111. CHAPTER 7: Darwinian Evolution. Life Changes
BIOLOGY 111 CHAPTER 7: Darwinian Evlutin Life Changes BIOLOGY 101 CHAPTER 7b: Evlutin f Ppulatins: Evlutin f Ppulatins: CONCEPTS: 7.5 Genetic Variatin Makes Evlutin Pssible 7.6 Frces that can alter allele
More informationHigh Throughput Gene Mapping Brian S. Yandell
High Thrughput Gene Mapping Brian S. Yandell Summer Research Prgram in Bistatistics June 2004 www.stat.wisc.edu/~yandell/statgen UW-Madisn Yandell 2004 1 central dgma via micrarrays (Bchner 2003) UW-Madisn
More informationGenetics Lecture Notes
Bilgy Genetics Lecture Ntes Name Per Learning Gals Yu will be able t explain hw ffspring receive genes frm their parents Yu will be able t calculate prbabilities f passing genes frm ffspring t ffspring
More informationGenetics Lecture Notes
Bilgy Genetics Lecture Ntes Name Per Learning Gals FOR BIWEEKLY QUIZ #7 Yu will be able t explain hw ffspring receive genes frm their parents Yu will be able t calculate prbabilities f simple Mendelian
More informationIMI2 PROPOSAL TEMPLATE FIRST STAGE PROPOSAL
IMI2 PROPOSAL TEMPLATE FIRST STAGE PROPOSAL IN TWO-STAGE PROCEDURE (TECHNICAL ANNEX) RESEARCH AND INNOVATION ACTIONS & INNOVATION ACTIONS Nte: This is fr infrmatin nly. The definitive template fr yur call
More information5. EXAMPLE OF A DEGREE DAY MODEL: HINTEREISFERNER, AUSTRIA
Glacial Gelgy 5. Example f a Degree Day Mdel 5. EXAMPLE OF A DEGREE DAY MODEL: HINTEREISFERNER, AUSTRIA 30 + 25 = 55 Pints Objective: t create a psitive degree-day mdel f glacial mass balance. Yu shuld
More informationVI. ALTERNATIVES TO THE MASTER PLAN A. INTRODUCTION
VI. ALTERNATIVES TO THE MASTER PLAN A. INTRODUCTION INTRODUCTION As stipulated in Sectin 21002.1(a) f the CEQA Statutes (Public Resurces Cde): The purpse f an envirnmental impact reprt is t identify the
More informationExtended Inventory Items
Extended Inventry Items Using the Item Number SmartFinder buttn Extended Inventry Items Extended Inventry Items is an enhanced replacement fr the Sage I/C Items screen. It prvides yu with mre functinality
More informationSummary of Nelson City Land Demand and Capacity June 2017
Summary f Nelsn City Land Demand and Capacity June 2017 NATIONAL POLICY STATEMENT ON URBAN DEVELOPMENT CAPACITY (NPS-UDC) The Natinal Plicy Statement n Urban Develpment Capacity requires cuncils t ensure
More informationUsing EMV Devices with Shift4 Payments
This dcument is intended fr merchants wh have EMV-capable payment devices that have already been cnfigured in the Universal Transactin Gateway (UTG ) TuneUp. The dcument utlines the steps needed t enable
More informationAcceptance criteria for process capability indexes generated from statistical tolerance intervals as per ISO
Acceptance criteria fr prcess capability indexes generated frm statistical tlerance intervals as per Backgrund Justificatin fr sampling plans and statistical analysis f results is a requirement fr prcess
More informationIESBA Meeting (November/December 2015) Long Association Proposed Changes to Section 290 (MARK-UP from ED)
IESBA Meeting (Nvember/December 2015) Agenda Item 5-B General Prvisins Lng Assciatin Prpsed Changes t Sectin 290 (MARK-UP frm ED) 290.148A Familiarity and self-interest threats, which may impact an individual
More informationCHOOSING THE RIGHT RECRUITMENT PARTNER
CHOOSING THE RIGHT RECRUITMENT PARTNER Chsing the right recruitment partner, wh has the ability t identify thse key individuals, can be critical t business success. Businesses need t generate psitive messages
More informationIESBA Meeting (March 2013) Agenda Item
Agenda Item 7-A Backgrund Lng Assciatin f Senir Persnnel (Including Partner Rtatin) with an Audit Client Matters fr Cnsideratin 1. Paragraph 290.150 f the IESBA Cde f Ethics fr Prfessinal Accuntants (the
More informationCAFS Core 1: COMPLETE Research Methodology Notes. HSC Community & Family Studies. Year 2016 Mark Pages 13 Published Feb 22, 2018
HSC Cmmunity & Family Studies Year 2016 Mark 95.00 Pages 13 Published Feb 22, 2018 CAFS Cre 1: COMPLETE Research Methdlgy Ntes By Katie (99.15 ATAR) Pwered by TCPDF (www.tcpdf.rg) Yur ntes authr, Katie.
More information5 th Grade Goal Sheet
5 th Grade Gal Sheet Week f December 3 rd, 2018 Frm Ms. Simmns: Upcming dates: 12/4 Prgress Reprts fr 2 nd Quarter 12/4 Math Benchmark Testing 12/11- Parent Partnership Meeting: ELA, the Cmmn Cre, and
More informationSelling and Purchasing Items
Selling and Purchasing Items Selling t custmers invlves the fllwing dcuments: Dcument Qute Invice Custmer Credit Ntes Definitin Qutes are ptinal. A qute is an ffer t sell ne r mre items t a custmer at
More informationSTAFF REPORT. Peter Zielsdorf
STAFF REPORT Applicatin: Cnstruct a new septic drainfield t replace the existing drainfield apprximately 64 feet frm Mink Lake (min. 75 ft required). Applicant: Agenda Item: 4(a) Peter Zielsdrf Backgrund
More informationWhat is the deadline to sign up for Rockwell Automation TechED EMEA? What is the cost to register for the Rockwell Automation TechED EMEA event?
Registratin Questins What is the deadline t sign up fr Rckwell Autmatin TechED EMEA? When sessin registratin pens in July 2017, yu may register t attend, select sessins and/r change yur sessin selectin
More informationVersion 4.0 LineDesign Engineering 11/1/04
Ple Lading Prgram (Transverse, Vertical, Guying & Buckling) User's Guide Versin 4.0 LineDesign Engineering 11/1/04 Cntents Intrductin 3 Descriptin f Tabs 4-7 Ple Data 7 Wire Data 8-9 Inputs, Drives & Flders.....
More informationEUROPEAN COMMISSION DIRECTORATE-GENERAL JOINT RESEARCH CENTRE Directorate B Growth and Innovation Circular Economy and Industrial Leadership
EUROPEAN COMMISSION DIRECTORATE-GENERAL JOINT RESEARCH CENTRE Directrate B Grwth and Innvatin Circular Ecnmy and Industrial Leadership Seville, 6 th April 2018 Level(s) testing phase Guidance and rules
More informationNotes and guidance: Paper 1 Section B Poetic voices
Ntes and guidance: Paper 1 Sectin B Petic vices This resurce explains hw the questin in the specimen assessment materials fr AS Paper 1, Sectin B, Petic vices, addresses the assessment bjectives, with
More informationCCE Application Guidelines
CCE Applicatin Guidelines - 2017 General This dcument cntains infrmatin n hw t cmplete and submit yur CCE applicatin. If yu have any questins, please cntact Susan McGuire at smcguire@acce.rg. Tips befre
More informationEID POLICY MANUAL. ADMIN Increases in Irrigation Acres, Criteria and Guidelines Revised Feb [supersedes Jan ]
Plicy Guidelines: The District has established criteria and guidelines t assist staff in evaluating and administering, and the directrs in apprving and/r rejecting, applicatins fr increases in irrigatin
More informationActivity=>Sales Order and Invoice=>Create Invoices
Create Invice Menu Path Functin Activity=>Sales Order and Invice=>Create Invices There are several different ways t create invices: 1. Custmers pick up the merchandise and create invice while the custmer
More informationCustomer best practices
Custmer dcument Custmer best practices Recmmendatins fr new Basware transactin services custmers Basware Crpratin Cpyright Basware Crpratin All rights reserved 1 (11) 1 Intrductin Our best advice This
More informationCCE Application Guidelines
CCE Applicatin Guidelines - 2018 General This dcument cntains infrmatin n hw t cmplete and submit yur CCE applicatin. If yu have any questins, please cntact Susan McGuire at smcguire@acce.rg. Tips befre
More informationHSC Biology. Year 2014 Mark Pages 21 Published Jan 12, Biology: Option Genetics: The Code Broken. By Leah (97.7 ATAR)
HSC Bilgy Year 2014 Mark 90.00 Pages 21 Published Jan 12, 2017 Bilgy: Optin Genetics: The Cde Brken. By Leah (97.7 ATAR) Pwered by TCPDF (www.tcpdf.rg) Yur ntes authr, Leah. Leah achieved an ATAR f 97.7
More informationGuidance notes for completing the International Start-up Form
Guidance ntes fr cmpleting the Internatinal Start-up Frm These guidance ntes are designed t supprt yu in cmpleting the Internatinal start-up frm. Yu will als need t refer t a) yur Stage 2 applicatin frm
More informationOracle Revenue Management and Billing. Version Release Notes. Revision 1.1
Oracle Revenue Management and Billing Versin 2.5.0.2.0 Release Ntes Revisin 1.1 E72808-01 April, 2016 Release Ntes Oracle Revenue Management and Billing Versin 2.5.0.2.0 Release Ntes E72808-01 Cpyright
More informationOpen House Fact Sheet
Open Huse Fact Sheet What is an Open Huse? An pen huse is an infrmal meeting prcess where participants begin by explring varius displays, r statins, related t the meeting purpse. Each statin has a knwledgeable
More informationCompleting an Introductory Review Using the Online Performance Appraisal System Standard Form
Cmpleting an Intrductry Review Using the Online Perfrmance Appraisal System Standard Frm Step One: Cmpleting Perfrmance Expectatins Standard Frm Yu will receive an email frm HR Manager alerting yu that
More informationFlaw indications in the reactor pressure vessels of Doel 3 and Tihange 2
Flaw indicatins in the reactr pressure vessels f Del 3 and Tihange 2 1. Cntext Technical infrmatin nte 2013.02.01 Del 3 and Tihange 2 are tw f the seven Belgian nuclear reactrs perated by Electrabel, a
More informationITIL FOUNDATION SUMMARY NOTES. Sessions
ITIL FOUNDATION SUMMARY NOTES Sessins 2 Service Management as a Practice 2 3 Service Lifecycle 3 4 Service Strategy 4 5 Service Design 5 6 Service Transitin 6 7 Service Operatin 7 8 Cntinual Service Imprvement
More informationThe purpose of IPRO 304 is to create a software package to assist A. Finkl & Sons in tracking of parts in heat treatment furnaces.
Prject Plan Reprt: Heat Treat Subgrup 1.0 Objective The purpse f IPRO 304 is t create a sftware package t assist A. Finkl & Sns in tracking f parts in heat treatment furnaces. Objective fr Spring 2008:
More informationDATA ON THE 4PS. WCAI Research Opportunity 27 September
DATA ON THE 4PS FOR A MULTI-CHANNEL/MULTI-BRAND RETAILER WCAI Research Opprtunity 27 September 2012 1 http://wcai.whartn.upenn.edu @WhartnCAI WHY SHOULD YOU SUBMIT A PROPOSAL? Access t unique data Simple,
More informationFEI What does it Mean On-Farm?
FEI What des it Mean On-Farm? Kim Rbinsn AgFirst FEI What is it? The Fat Evaluatin Index has been develped by Fnterra t mnitr the likely effect f PKE feeding n the cmpsitin and manufacturing prperties
More informationBIOLOGY 101. CHAPTER 23: Evolution of Populations: Alleles Change
BIOLOGY 101 CHAPTER 23: Evlutin f Ppulatins: Evlutin f Ppulatins: CONCEPTS: 23.1 Genetic Variatin Makes Evlutin Pssible 23.3 Frces that can alter allele frequencies in a ppulatin 23.4 Natural selectin
More informationActivity Insight User Guide
Cntents: Overview Wh is Required t Reprt Accessing System Reasns fr Cllecting Data Entering Activity Infrmatin Manual Data Entry Selecting Activities fr Web Prfile Running Reprts Custmized Reprts Ad Hc
More informationACUSERA 24.7 LIVE ONLINE INTERACTIVE DEMO GUIDE
ACUSERA 24.7 LIVE ONLINE INTERACTIVE DEMO GUIDE INTERNAL TRAINING DOCUMENT. NOT FOR DISTRIBUTION Acusera 24.7 Live Online Interactive Dem Guide Overview Yur Acusera 24.7 Live Online dem accunt has been
More informationSUNBURST SKI & SNOWBOARD CLUB PROGRAM PARENT, CLUB MEMBER & ADVISOR INFORMATION
SUNBURST SKI & SNOWBOARD CLUB PROGRAM PARENT, CLUB MEMBER & ADVISOR INFORMATION Thank yu fr yur interest in Sunburst s Ski & Snwbard Club Prgram! The infrmatin belw summarizes ur Club prgram s purpse and
More information2018 CT3. All Rights Reserved
2018 CT3. All Rights Reserved. www.ct3educatin.cm 800.561.3073 1 D Nws and Exit Tickets Strategy Resurce Bklet DO NOWS AND EXIT TICKETS - INTRODUCTION D Nws and Exit Tickets: What are they? D Nws and Exit
More informationMaking the move from Sage Abra Suite (FoxPro) to Sage HRMS (SQL)
Making the mve frm Sage Abra Suite (FxPr) t Sage HRMS (SQL) 5272 S. LEWIS, SUITE 100 TULSA, OK 74105 918.496.1600 TOLL FREE: 877.496.1600 Making the mve frm Sage Abra Suite (FxPr) t Sage HRMS (SQL) As
More informationNZATD Education Trust Awards elearning Award Guidelines for Entrants
NZATD Educatin Trust Awards elearning Award Guidelines fr Entrants Fcus f Award NZATD intrduced this award t recgnise excellence in the design and implementatin f elearning initiatives within rganisatins.
More informationPort Manager. Microsoft Dynamics CRM for Ports
Prt Manager Micrsft Dynamics CRM fr Prts February 2015 Overview Celedn Partners Prt Manager encapsulates the functinality f many prt related prcesses int an easy t learn and easy t use tl. The slutin leverages
More informationFront end GUI automation ROI: a changing definition
Frnt end GUI autmatin ROI: a changing definitin Capgemini India Private Limited July 2013 Prepared by: Angshuman Dutta 1 Table f Cntents 1. Abstract...2 2. Autmatin ROI backgrund...2 2.1 Traditinal expectatins...
More informationInspiration. What is Inspiration? Visual mapping software that organises, plans and presents ideas.
Inspiratin What is Inspiratin? Visual mapping sftware that rganises, plans and presents ideas. This pwerful visual thinking tl inspires peple t develp their ideas, while planning and structuring wrkflw.
More informationMethod 1: Establish a rating scale for each criterion. Some options are:
Decisin Matrix Als called: Pugh matrix, decisin grid, selectin matrix r grid, prblem matrix, prblem selectin matrix, pprtunity analysis, slutin matrix, criteria rating frm, criteria-based matrix. Descriptin
More informationWeb Financial Office How to Setup a New HR User and Security Specialized Data Systems, Inc Revised Last:
Specialized Data Systems, Inc. Web Financial Office Specialized Data Systems, Inc. 2017 Revised Last: 2.22.2017 Table f Cntents... 3 Adding & Setting Up a New Emplyee...3 Input New Emplyee Basic Demgraphics...
More informationDesign Alternatives Sheet: The Objective Function in Capacity Market Clearing
Design Alternatives Sheet: The Objective Functin in Capacity Market Clearing 1.1 What is the bjective functin when ptimizing the auctin clearing? Maximizing Scial Surplus Typically, the market clearing
More informationStandard Operating Procedure Secchi Depth
Standard Operating Prcedure revised January 8, 2017 Secchi Depth Page 1 f 5 Standard Operating Prcedure Secchi Depth Table f Cntents 1 POINT OF CONTACT... 1 2 OBJECTIVE... 1 3 DEFINITIONS AND ABBREVIATIONS...
More informationCENTENARY PLAINS BMX SOCIAL MEDIA POLICY
CENTENARY PLAINS BMX SOCIAL MEDIA POLICY Plicy number 4170913 001 BP Versin 1 Drafted by Brendan Platt Apprved-Cmmittee 19/09/2013 Respnsible persn Media Manager Scheduled review date 19/09/2014 INTRODUCTION
More informationRelease Notes for SAP ERP Financial Accounting and Operations 2.0
Release Ntes fr SAP ERP Financial Accunting and Operatins 2.0 What's New? Release Ntes Cpyright 2013 SAP AG r an SAP affiliate cmpany. All rights reserved. N part f this publicatin may be reprduced r transmitted
More informationRelease Notes for SAP enhancement package 7 for SAP ERP 6.0, Support Package Stack 03. SD Sales and Distribution
Release Ntes fr SAP enhancement package 7 fr SAP ERP 6.0, Supprt Package Stack 03 SD Sales and Distributin Cpyright 2014 SAP AG r an SAP affiliate cmpany. All rights reserved. N part f this publicatin
More informationIPCC Emission Factor Database (EFDB)
IPCC Emissin Factr Database (EFDB) IPCC TFI Side-event at COP-24 Katwice, Pland 7 December 2019 Pavel Shermanau, IPCC TFI TSU What is EFDB? Emissin Factr Database (EFDB) is an electrnic library f greenhuse
More informationECNG Energy Group. Performance Review Plan
ECNG Energy Grup Perfrmance Review Plan Cntents Overview 3 Summary 3 Purpse 3 Key Phases and Timelines 4 1) Perfrmance Planning: Start f Q1 4 Setting Individual Objectives 5 2) Onging Caching and Mid-year
More informationEMISSION REDUCTIONS UNDER CAP-AND-TRADE PROPOSALS IN
EMISSION REDUCTIONS UNDER CAP-AND-TRADE PROPOSALS IN THE 111 TH CONGRESS Jhn Larsen and Rbert Heilmayr June 25, 2009 This analysis prvides an assessment f reductins in greenhuse gas (GHG) emissins relative
More informationConnect for SAP (Classic)
Cnnect fr SAP (Classic) Fact Sheet 1 Abut Cnnect fr SAP (Classic) Cnnect fr SAP is an bject-riented sftware library. It has been specially designed fr an access t SAP applicatin servers by using Embarcader
More informationof approximately 140 Catholic primary and secondary schools and colleges within the Archdiocese of Brisbane.
Privacy PURPOSE Brisbane Cathlic Educatin (BCE) is respnsible fr the administratin f apprximately 140 Cathlic primary and secndary schls and clleges within the Archdicese f Brisbane. This Privacy Plicy
More informationMIS Exam Revision Modules 1-11!
MIS Exam Revisin Mdules 1-11 Mdules 1-4 Chapter 1: Why MIS? The Imprtance f MIS All based arund Mre s Law. The number f transistrs per square inch n an integrated chip dubles every 18 mnths. Speed f a
More informationEVAPOTRANSPIRATION IN FOREST STANDS OF THE SOUTHERN APPALACHIAN MOUNTAINS J. L. KOVNEE Southeastern Forest Experiment Station, Forest Service, USDA
EVAPOTRANSPIRATION IN FOREST STANDS OF THE SOUTHERN APPALACHIAN MOUNTAINS J. L. KOVNEE Sutheastern Frest Experiment Statin, Frest Service, USDA Experiments at the Cweeta Hydrlgic Labratry in the high rainfall
More informationLarge Building Energy and Water Reporting and Benchmarking. LEED Breakfast Meeting
MINISTRY OF ENERGY Large Building Energy and Water Reprting and Benchmarking LEED Breakfast Meeting April 2016 Prepared by: Cnservatin and Renewable Energy Divisin Recgnizing Great Wrk 2 Ontari Electricity
More informationOPTIMIZE 2009 TOC Optimize and its affiliates. All rights reserved. Page 1 of 10
Enterprise Architecture Prcess Nthing is permanent except change. Heraclitus (ca. 535 475 BC) Jean-Luc Caste, 24 August 2009 DcID: 092101005 The Issues Decisin makers arund the wrld have cme t understand
More informationReinhart Foodservice, L.L.C. Data Synchronization Initiative
Reinhart Fdservice, L.L.C. Data Synchrnizatin Initiative Frequently Asked Questins fr Suppliers Versin 1 June 2016 Cpyright 2016. All Rights Reserved. FAQs fr Reinhart Suppliers REVISION HISTORY Date Ver
More informationKNOWLEDGE CAPTURE INTERVIEW
Inter-American Develpment Bank KNOWLEDGE AND LEARNING SECTOR (KNL) TECHNICAL NOTES KNOWLEDGE CAPTURE INTERVIEW N. IDB-TN-424 June 2012 KNOWLEDGE CAPTURE INTERVIEW Inter-American Develpment Bank 2012 http://www.iadb.rg
More informationService Description Transfer of Material XML (C2B)
Service Descriptin Transfer f Material XML (C2B) 27.7.2017 Cntents 2 1 XML file message... 4 1.1 General... 4 2 Descriptin f messages... 4 2.1 Sending and retrieving messages... 4 2.1.1 Treatment f messages...
More informationLOOKING TO THE FUTURE: MEDIDATA RAVE. Laura Smith P1115 Training November 2015
LOOKING TO THE FUTURE: MEDIDATA RAVE Laura Smith P1115 Training Nvember 2015 AGENDA Backgrund System Features Data Cllectin Screens Transitin 2 WHAT IS A CTDMS? CTDMS = Clinical Trials Data Management
More informationHeating Rate Effects. > Tm. Extended Chains. o o ,000 Heating Rate ( K / min )
Heating Rate Effects Large sample size Tm > Tm 400 Extended Chains Dendrites 395 Single Crystals 1 10 100 1,000 Heating Rate ( K / min ) Single crystals melting pint increases as heating rate decreases
More informationYou can also click Jobs in the left hand navigation bar and then select Create Job toward the right hand corner.
T pst a jb n Handshake: 1. Start by clicking Pst a Jb frm yur hme dashbard: Yu can als click Jbs in the left hand navigatin bar and then select Create Jb tward the right hand crner. Yu will nw be asked
More informationMIS The Expert System Expert System Development
Expert System (ES) An Expert System (ES) is a knwledge based infrmatin system that uses its knwledge abut a specific, cmplex applicatin area t act as an expert cnsultant t end users. Expert system prvides
More informationBROCHURE # 50 DOES MY BUILDING DESIGN NEED ENGINEERING?
BROCHURE # 50 DOES MY BUILDING DESIGN NEED ENGINEERING? Overview Building cnstructin has becme increasingly cmplex during the last tw decades. Buildings are larger and use new materials and cnstructin
More informationRE: BRES Criteria - Support of Existing and Planned Commercial Areas in Bolton
January 24, 2016 Karen Bennett, MCIP, RPP, Assciate Glen Schnarr & Assciates Inc. 10 Kingsbridge Garden Circle, Ste.700 Mississauga, ON, L5R 3K6 Dear Ms Bennett: RE: BRES Criteria - Supprt f Existing and
More informationStudent Exploration: Plants and Snails
Name: Date: Student Explratin: Plants and Snails Vcabulary: brmthyml blue (BTB), carbn dixide-xygen cycle, indicatr, interdependence Prir Knwledge Questins (D these BEFORE using the Gizm.) 1. What imprtant
More informationTo download the documentation mentioned above, log into your Ariba SN account and navigate to Help link from the top of the page.
Intrductin This dcument cntains Cummins specificatins and requirements fr supplier invice file transactins. The infrmatin in this dcument is specific t Cummins internal requirements, nt necessarily the
More informationLecture # 8 -- Subsidies/Consumer Behavior: An Introduction to the Concept of Utility
Lecture # 8 -- Subsidies/Cnsumer Behavir: An Intrductin t the Cncept f Utility I. Subsidies In the case f a subsidy, we shift the demand r supply ut by the amunt f the subsidy The example belw shifts demand
More informationChapter 14 Mendel and the Gene Idea
Chater 14 Mendel and the Gene Idea Histrical Views f Heredity Histrically, what gene6c rinciles accunt fr the assing f traits frm arents t ffsring? Acquired traits Traits gained by arents in their lives
More informationRecruiting Companies for HealthLinks:
Recruiting Cmpanies fr HealthLinks: Tips fr Getting Started Create a pitch Get t knw HealthLinks (including prgrams, materials, recmmendatins, surveys, etc.) as well as yu can befre yu reach ut t any cmpanies.
More informationTimeClock Plus Department HR Reports
TimeClck Plus Department HR Reprts Reprt Categries Scheduler nly useful if using emplyee schedules Payrll time and apprved leave Prject time with bi-weekly prject infrmatin Accruals leave balances Miscellaneus
More informationhello Interim Partnership Marketing Manager January 2018
hell Interim Partnership Marketing Manager January 2018 0 Smart Metering Cmmunicatins Bdy Limited (trading as Smart Energy GB) is a cmpany registered in England and Wales. Cmpany number 8455995. Registered
More informationMentoring: Giving and Receiving
Mentring: Giving and Receiving Gwen Lmbard, PhD, RN Department f Neursurgery Rebecca Pauly, M.D., FACP Assciate Vice President fr Health Affairs, Equity and Diversity Casey White, PhD. Department f Anesthesilgy
More informationDefinition of General Concepts
Service desk cnfiguratin guide Definitin f General Cncepts The Slutin Manager Service Desk is based n CRM 5.0. The IMG activities t cnfigure the Service Desk, service prvider, system huse and sftware partner
More informationHead of Consumer PR October 2018
Head f Cnsumer PR Octber 2018 0 Smart Metering Cmmunicatins Bdy Limited (trading as Smart Energy GB) is a cmpany registered in England and Wales. Cmpany number 8455995. Registered ffice: 1 Alfred Mews,
More informationSeattle Public Schools The Office of Internal Audit
Seattle Public Schls The Office f Internal Audit Internal Audit Reprt September 1, 2013 thrugh August 31, 2016 Issue Date: June 13, 2017 Backgrund Infrmatin Executive Summary The District emplys apprximately
More informationPerformance Marketing Manager February 2019
Perfrmance Marketing Manager February 2019 0 1 2 3 The rle Jb title: Perfrmance Marketing Manager Jb salary: Cmpetitive Jb lcatin: Tttenham Curt Rad, Lndn W1 Deadline: 22 nd February 2019 Reprts t: Head
More informationExercise - INSTRUCTIONS
Learning mdule: Create a Simple App Exercise - INSTRUCTIONS Analysis Gal: Create an app designed t evaluate sales in different cuntries, cnsider sales trends ver time, and discver and fcus upn prduct categries
More informationDESIGN STEPS USING ADAPT FLOOR-PRO 1
Technical Nte Structural Cncrete Sftware System TN230_PT_design_prcedure_FP_12 053007 DESIGN STEPS USING ADAPT FLOOR-PRO 1 Bijan O Aalami 2 This Technical Nte utlines the steps that yu have t fllw in designing
More informationLEARNING OBJECTIVES Boot Campers will learn:
LOOSE LIPS CAN SINK AN ENTIRE CONGREGATION The destructive effects f gssip, gab, and the grapevine can undermine perfrmance and damage wrking relatinships. When txic talk infects an entire rganizatin,
More informationMultiple Traits & Microarrays
Multiple Traits & Micrarrays 1. why study multiple traits tgether? 2-13 diabetes case study central dgma via micrarrays 2. design issues fr expensive phentypes 14-21 selective phentyping 3. why are traits
More informationRMH SECURITY GUIDE. Retail Management Hero (RMH) Copyright 2016, Retail Management Hero. All Rights Reserved.
RMH SECURITY GUIDE Retail Management Her (RMH) rmhsupprt@rrdisti.cm www.rmhps.cm Cpyright 2016, Retail Management Her. All Rights Reserved. Revisin Versin Date Draft 3.1 12/01/2016 Disclaimer Infrmatin
More informationBest Practices for Safety Action Review Boards
Best Practices fr Safety Actin Review Bards By Brian Hughes, Vice President f Slgic A versin f this article appeared in the May 2011 issue f Prfessinal Safety magazine. Many safety departments I wrk with
More informationSUPERVISOR-SUPPORTED ASSESSMENT TOOL FOR THE AUSTRALIAN COMMUNITY WORK PRACTICE GUIDELINES
SUPERVISOR-SUPPORTED ASSESSMENT TOOL FOR THE AUSTRALIAN COMMUNITY WORK PRACTICE GUIDELINES Hw t use the assessment tl This assessment tl has been designed fr a practitiner and supervisr t wrk thrugh tgether.
More informationBirmingham Airport Response REDACTED (for external use)
The aim f the questins belw is t allw us t understand hw yu cnducted the recent pen tender prcesses. The questins frm a brad guide t ur areas f interest. We request that as well as either written r ral
More informationAn example of a Decision Support Framework for ecosystem-based fisheries management (MareFrame project)
An example f a Decisin Supprt Framewrk fr ecsystem-based fisheries management (MareFrame prject) Senir Scientist Petter Olsen, Nfima PrimeFish Stakehlder Wrkshp Vilanva i la Geltrú, Spain, April 6 th 2017
More informationHuman Resource Management
ALT 4 - WORKSHOP: Human Resurce Management Perfrmance Develpment Review Frm [Example Only] Perfrmance Develpment Review Frm (Example) Name: Review Perid: Jb Title: T&D Cnsultant Ntes n hw the frm is used:
More informationSolution: Unix and Linux are examples of multi-user operating systems used to handle voluminous data and complex reporting requirements.
1. State the fur basic requirements f a database applicatins. Slutin: The fur basic requirements f database applicatins are Frnt-end interface Back-end database Data prcessing Reprting System 2. Name the
More informationUNISHIPPERS GUIDE TO ACCURATE FREIGHT QUOTES. Do you know any business owner who wants to spend more money than necessary
UNISHIPPERS GUIDE TO ACCURATE FREIGHT QUOTES D yu knw any business wner wh wants t spend mre mney than necessary n a shipment? We didn t think s! Since even small missins r mistakes when quting shipments
More informationWITH EXAMPLES FROM THE WINDWARD ISLANDS. Andrew Bartlett. Keynote Presentation. 1st National Workshop on Development Communications.
PRINCIPLES OF EFFECTIVE DEVELOPMENT COMMUNICATION: WITH EXAMPLES FROM THE WINDWARD ISLANDS Andrew Bartlett Keynte Presentatin 1st Natinal Wrkshp n Develpment Cmmunicatins March 1986 Federal Agricultural
More informationepro FAQ Clearing the Browser Cache
Clearing the Brwser Cache epr FAQ Blank Screen (N Menu Present) Errr Adding an Item t the Cart (Item Unavailable) Accunting Date is Nt Open Missing Requisitins in Manage Requisitins Requisitin Statuses
More informationCochrane Statistical Methods Training Course. Minutes and actions from the session: Statistical contribution to CRGs
Cchrane Statistical Methds Training Curse 4 5 th March 2010, Cardiff, UK Minutes and actins frm the sessin: Statistical cntributin t CRGs Facilitatr: Steff Lewis Minutes: J McKenzie This sessin began with
More information