Formulation and in-vitro evaluation of pregabalin mini tablets for sustained release
|
|
- Harvey Berry
- 6 years ago
- Views:
Transcription
1 Available online at Scholars Research Library Der Pharmacia Lettre, 2016, 8 (2): ( ISSN USA CODEN: DPLEB4 Formulation and in-vitro evaluation of pregabalin mini tablets for sustained release S. B. Thirumalesh Naik 1*, Kambham Venkateswarlu 1 and K. B. Chandrasekhar 2 1 Faculty of Pharmacy, Department of Pharmaceutics, Oil Technological and Pharmaceutical Research Institute, Jawaharlal Nehru Technological University Anantapur, Ananthapuramu, Andhra Pradesh, India 2 Oil Technological and Pharmaceutical Research Institute, Jawaharlal Nehru Technological University Anantapur, Ananthapuramu, Andhra Pradesh, India ABSTRACT The present research was aimed to develop sustained release mini tablets of Pregabalin by direct compression method. These were prepared by using chitosan, locust bean gum, microcrystalline cellulose (MCC), Xanthan gum, polyvinyl pyrrolidine K-30 (PVP K30). The precompression parameters like angle of repose, bulk density, true density, Carr s index, Hausner s ratio and post compression parameters like thickness, hardness test, friability and weight variation, drug content uniformity were evaluated and the results were lies within the limits. In-vitro dissolution study was performed by using 0.1 N HCl for first 2 h and it was replaced by ph 6.8 phosphate buffer for further study. It was found from the results that the formulation F6 showed sustained release of 12 h and followed zero order kinetics with non fickian mechanism. Key words: Pregabalin, Sustained release, Mini tablets. INTRODUCTION The best new therapeutic entity in the world is of little value without an appropriate delivery system [1]. Tablet delivery system can range from simple immediate release formulations to complex extended or modified release dosage forms [2]. The most important role of drug delivery system is to get the drug delivered to the site of action in sufficient amount and at the appropriate rate [3-4]. However, it should meet other important criteria such as physical and chemical stability, ability to be mass-produced in a manner that assures content uniformity [5]. Mini-tablets are flat or slightly curved tablets with a diameter ranging between mm. They are usually filled into a capsule, occasionally compressed into larger tablets [6]. Pregabalin is used in the treatment of epilepsy and neuropathic pain. It also uses in the treatment other diseases like diabetic neuropathy, surgical dental pain and pain syndromes. A considerable research has been done on the drug Pregabalin for sustained release property [7-8]. The present study was aimed to formulate the sustained release mini tablets of Pregabalin by direct compression method. MATERIALS AND METHODS Materials Pregabalin was obtained from Dr. Reddy s laboratories, India and PVP K-30 from Hetero Drugs, India. Remaining all ingredients was purchased from Vijlak Pharma Limited, India. 277
2 FTIR studies The pure drug and its physical mixtures were analysed by FTIR spectrophotometer for determining the chemical interactions between pure drug and its excipients. Samples were mixed thoroughly with 100 mg of potassium bromide IR powder and compacted under vacuum at a pressure of about 12 psi for 3 minutes. The resultant disc was mounted in a suitable holder in Perkin Elmer IR spectrophotometer and the IR spectrum was recorded from 4000cm -1 to 400cm -1. The resultant spectrum of pure drug was compared with the spectra of its physical mixtures. Preparation of mini (core) tablets All the ingredients were accurately weighed as per formula (Table 1) and were dispensed in clean polythene cover, mixed well and sieved through 60 mesh and subjected to compression. Direct compression of mini tablets was done in rotary compression tablet machine (Rimek mini press I) using 4 mm concave punch. Table 1. Formulation of Pregabalin mini tablets Ingredients (mg) F1 F2 F3 F4 F5 F6 F7 F8 F9 Pregabalin Chitosan Locust bean gum Xanthan gum PVP-k Magnesium stearate Talc MCC Total Weight Evaluation studies The powder blends were evaluated for precompression parameters like angle of repose, bulk density, true density, Carr s index, Hausner s ratio and prepared tablets for post compression parameters like thickness, hardness test, friability and weight variation according to standard procedures [9-10]. Drug Content estimation The content uniformity test is used to ensure that every tablet contains the amount of drug substance intended with little variation among tablets within a batch. Four mini tablets were weighed and crushed in the mortar. The powder equivalent to 1.25 mg of the drug was weighed and dissolved in 100 ml ph 6.8 phosphate buffer. The appropriate dilutions were done and the absorbance of the prepared solution was measured at 214 nm using UV-Visible spectrophotometer (Lab India, UV-3200). In-vitro dissolution studies 900 ml of 0.1N HCl was placed in vessel and the USP apparatus-ii (Paddle Method) was assembled (Electro lab TDT-06N USP dissolution test apparatus). The medium was allowed to equilibrate to the temperature of 37 C±0.5 C and set at the rotation of 50 rpm. Tablet was placed in the vessel and operated for 2 h. Then this medium was replaced with ph 6.8 phosphate buffer and operated for upto 12 h. At definite time intervals, 5 ml of the receptor s fluid was withdrawn, filtered and again 5 ml receptor fluid was replaced. Suitable dilutions were done with receptor fluid and analyzed by spectrophotometrically using UV-spectrophotometer. Application of Release Rate Kinetics to Dissolution Data Various models were tested for explaining the kinetics of drug release. To analyze the mechanism of the drug release and kinetics of the dosage form, the obtained data were fitted into zero order, first order, Higuchi and Korsmeyer- Peppas release models. Stability studies The formulation F6 was subjected to stability studies at room temperature (RT) at 30 0 C/60% RH and accelerated stability studies (ASS) at 40 0 C/75% RH for 1 month and evaluated for thickness, hardness, drug content and drug release studies. RESULTS AND DISCUSSION The present study was aimed to develop sustained release mini tablets of Pregabalin using various polymers. All the formulations were evaluated for physicochemical properties and in vitro drug release studies. Drug-excipient Compatibility studies FTIR techniques have been used to study the physical and chemical interaction between drug and excipients. From the infrared spectral analysis, it was clear that the characteristic absorption peaks of pure drug found in physical 278
3 mixture of drug and excipients, so it indicates that there was no reciprocal action between the drug and excipients (Table 2-5 & Figure 1-4). Figure 1. FTIR spectra of Pregabalin pure drug Table 2. Interpretation of FTIR Spectra of Pregabalin pure drug Groups General range (cm -1 ) Observed range (cm -1 ) C-H stretch Figure 2. FT-IR spectra of Pregabalin with chitosan Table 3. Interpretation of FTIR Spectra of Pregabalin with chitosan Groups General range Observed range (cm -1 ) (cm -1 ) C-H stretch
4 Figure 3. FTIR spectra of Pregabalin with Locustbean gum Table 4. Interpretation of FTIR spectra of Pregabalin with locust bean gum Groups General range (cm -1 ) Observed range (cm -1 ) C-H stretch Figure 4. FTIR spectra of Pregabalin with Xanthan gum Table 5. Interpretation 0f FTIR spectra 0f Pregabalin with Xanthan gum Groups General range (cm -1 ) Observed range (cm -1 ) C-H stretch Precompression studies Angle of repose was carried out and it was found to be to , the results were indicates that the Pregabalin blends had shown good flow properties. Bulk density of blend was carried out and it was found to be gm/cc and tapped density of blend was found to be mg/cc which indicates that powder was not bulky. Compressibility index was found to be %, the Hausner s ratio was found to be , indicates that the Pregabalin blends had shown good to fair flow properties for compression (Table 6). 280
5 Table 6. Evaluation of precompression parameters of powder blend Formulation Angle of repose (θ) Bulk density (gm/cc) Tapped density (gm/cc) Compressibility index (%) Hausner s ratio F ± ± ± ± ±0.04 F ± ± ± ± ±0.06 F ± ± ± ± ±0.05 F ± ± ± ± ±0.03 F ± ± ± ± ±0.01 F ± ± ± ± ±0.08 F ± ± ± ± ±0.07 F ± ± ± ± ±0.01 F ± ± ± ± ±0.02 Results were expressed in Avg ± SD (n=3) Post compression studies The hardness of the tablet formulations was found to be in the range of 3.44 to 3.86 kg/cm 2. The friability values were found to be in the range of 0.33 to 0.46 %. All the formulations showed less than 1% friability ensuring that the tablets were mechanically stable. All the prepared tablets of Pregabalin were evaluated for weight variation. The weight of all the tablets was found to be uniform with low values of standard deviation and lies within the prescribed IP limits of ±10%. The low values of standard deviation indicate uniform drug content within the tablets. The percent drug content of all the tablets was found to be in the range of to percent (which was within the acceptable limits of ±5 %) (Table 7). Table 7. Evaluation of post compression parameters of Pregabalin mini tablets Formulation Thickness Hardness Weight variation Friability Drug content (mm) (kg/cm 2 ) (mg) (%) (%) F1 1.66± ± ± ± ±0.45 F2 1.70± ± ± ± ±0.65 F3 1.66± ± ± ± ±0.43 F4 1.59± ± ± ± ±0.62 F5 1.60± ± ± ± ±0.42 F6 1.60± ± ± ± ±0.52 F7 1.61± ± ± ± ±0.44 F8 1.63± ± ± ± ±0.63 F9 1.65± ± ± ± ±0.43 Results were expressed in Avg±SD (n=6) In -vitro drug release studies From the dissolution data it was evident that the formulations prepared with Chitosan as polymer were unable to retard the drug release up to desired time period i.e., 12 hours. Whereas the formulations prepared with Locust bean gum retarded the drug release in the concentration of 90 mg (F6 Formulation) showed required release pattern i.e., retarded the drug release up to 12 h and showed maximum of 96.10% in 12 hours with good retardation. The formulations prepared with Xanthan gum showed more retardation even after 12 h, they were not shown total drug release. Hence, they were not considered for further study (Table 8 & Figure 5). Table 8. In-vitro drug release of all the Formulations Time (h) Cumulative Percent Drug Release F1 F2 F3 F4 F5 F6 F7 F8 F ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ±o ± ± ± ± ± ± ± ± ± ±0.09 Results were expressed in Avg±SD (n=3) 281
6 Figure 5. In-vitro drug release profiles of all the formulations Application of release rate kinetics to dissolution data Various models were tested for explaining the kinetics of drug release. To analyze the mechanism of the drug release and rate kinetics of the dosage form, the obtained data were fitted into zero-order, first order, Higuchi and Korsmeyer- Peppas release model (Table 9). Table 9. Release kinetics data for optimised formulation Formulation Zero order First order Higuchi Korsemeyer R 2 R 2 R 2 R 2 Type of release F Nonfickian F Nonfickian F Fickian F Nonfickian F Nonfickian F Nonfickian F Nonfickian F Nonfickian F Nonfickian Stability studies The formulation F6 was subjected to stability studies for 1 month at room temperature 30 0 C/60% RH and accelerated condition 40 0 C/75% RH shows that there is no significant change in the parameters like thickness, hardness, drug content and in-vitro drug release. Results of the dissolution studies for best formulation F6 values were compared with the results of the same formulation at room temperature and accelerated stability conditions after one month shows no significant change (Table 10-11). Table 10. Evaluation of formulated tablets F6 tablets in stability condition S. No. Parameters 30 0 C/60% RH 40 0 C/75% RH 1 Thickness (mm) Hardness (N) Drug content
7 Table 11. Cumulative % drug release of F6 formulation at stability conditions Time intervals F6 formulation at different conditions At RT At ASS F CONCLUSION The present investigation aimed to formulate Pregabalin Sustained release tablets by using Chitosan, locustbean gum, Xantham gum, PVP K30 for the better treatment of neurological diseases like neuroglia and seizures. Among all the formulations, F6 is considered to be the best formulation because of the drug release was retarded up to 12 h with 96.78% of release. Based on mathematical data revealed from release kinetic models, it was concluded that F6 formulation followed zero order kinetics with non- fickian mechanism. Stability studies were performed for one month for the best formulation in controlled room temperature 30 o C/60% RH and accelerated condition 40 C/75% RH and the results indicated that there is no significant change in evaluation parameters. REFERENCES [1] A. Srikanth, Y. Prasanna Raju, N. Devanna, K. Venkateswarlu. Int. J. Med. Pharm. Res., 2014, 2(3), [2] K. Venkateswarlu, J. Thirumaran. Int. J. Pharm. Sci. Rev. Res., 2013, 18(1), [3] S. B. Thirumalesh Naik, K. Venkateswarlu, K. B. Chandrasekhar. J. Chem. Pharm. Res., 2016, 8(1), [4] S. B. Thirumalesh Naik, K. Venkateswarlu, K. B. Chandrasekhar. Indo. Am. J. Pharm. Res., 2016, 6(01), [5] K. Venkateswarlu. Am. J. Phytomed. Ther., 2013, 1(6), [6] M. Leela Keerthi, R. Shireesh Kiran, V. Uma Maheshwar Rao, Aparna Sannapu, A. Geetha Dutt, K. Sai Krishna. Int. J. Pharm. Sci. Rev. Res., 2014, 28(1), [7] N. Tehseen, Vinay Rao, M. Abdul Hadi. Int. J. Pharm. Pharm. Sci., 2013, 5(1), [8] D. Pawar. Int. J. Pharm. Res. Develop., 2012, 4(2), [9] K. Venkateswarlu, A. Shanthi. IOSR J. Pharm. Biol. Sci., 2012, 2(5), [10] K. Vijayabhaskar, K. Venkateswarlu, S. B. Thirumalesh Naik, R. Kiran Jyothi, G. Nethra Vani and K. B. Chandrasekhar. Br. J. Pharm. Res., 2016, 10(2),
Research Article. Formulation and in-vitro evaluation of orodispersible tablets of olanzapine for the improvement of dissolution rate
Available online www.jocpr.com Journal of Chemical and Pharmaceutical Research, 2016, 8(1):177-181 Research Article ISSN : 0975-7384 CODEN(USA) : JCPRC5 Formulation and in-vitro evaluation of orodispersible
More informationInternational Journal of Pharmacy and Industrial Research
329 Research Article Available Online at: International Journal of Pharmacy and Industrial Research ISSN Print 2231 3648 Online 2231 3656 FORMULATION AND EVALUATION OF OLMESARTAN MEDOXOMIL FLOATING TABLETS
More informationFORMULATION AND EVALUATION OF ROPINIROLE SUSTAINED RELEASED TABLETS BY USING NATURAL AND SYNTHETIC POLYMERS
International Journal of Pharmacy Review & Research www.ijprr.com FORMULATION AND EVALUATION OF ROPINIROLE SUSTAINED RELEASED TABLETS BY USING NATURAL AND SYNTHETIC POLYMERS V.Naga Manoj kiran 1*, Arun
More informationAsian Journal of Research in Pharmaceutical Sciences and Biotechnology
Research Article ISSN: 2349 7114 Asian Journal of Research in Pharmaceutical Sciences and Biotechnology Journal home page: www.ajrpsb.com FORMULATION DEVELOPMENT AND EVALUATION OF PANTOPRAZOLE DELAYED
More informationFORMULATION DEVELOPMENT AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF VERAPAMIL HYDROCHLORIDE
IJPSR (2014), Vol. 5, Issue 5 (Research Article) Received on 09 December, 2013; received in revised form, 19 April, 2014; accepted, 29 April, 2014; published 01 May, 2014 FORMULATION DEVELOPMENT AND EVALUATION
More informationScholars Research Library. Formulation and evaluation of Tramadol Hydrochloride sustained matrix tablets
Available online at www.scholarsresearchlibrary.com Der Pharmacia Lettre, 2011, 3(3): 245-249 (http://scholarsresearchlibrary.com/archive.html) ISSN 0975-5071 USA CODEN: DPLEB4 Formulation and evaluation
More informationPreparation and evaluation of loratadine tablets by using novel polacrilin potassium
Available online at www.scholarsresearchlibrary.com Scholars Research Library Der Pharmacia Lettre, 215, 7 (5):2-24 (http://scholarsresearchlibrary.com/archive.html) ISSN 975-571 USA CODEN: DPLEB4 Preparation
More informationFormulation and in vitro evaluation of bosentan osmatic controlled release tablets
IJPAR Vol.4 Issue 4 Oct- Dec -2015 Journal Home page: ISSN: 2320-2831 Research article Open Access Formulation and in vitro evaluation of bosentan osmatic controlled release tablets Mohammed Asif Hussain,
More informationDESIGN AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF LEVOFLOXACIN EMPLOYING ALMOND GUM
Int. J. Chem. Sci.: 12(3), 14, 762-772 ISSN 0972-768X www.sadgurupublications.com DESIGN AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF LEVOFLOXACIN EMPLOYING ALMOND GUM K. V. R. N. S. RAMESH *,
More informationBrahmaiah Bonthagarala *, Prasanna Kumar Desu, Sreekanth Nama, Donthiboina Sudarshan
e - ISSN XXXX-XXXX Print ISSN - XXXX-XXXX Singapore Journal of Pharmaceutical Research Journal homepage: www.mcmed.us/journal/sjpr FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF OZCARBAZEPINE
More informationFormulation and in vitro evaluation of ofloxacin as floating drug delivery system
Available online at www.scholarsresearchlibrary.com Scholars Research Library Der Pharmacia Lettre, 2013, 5 (5):82-92 (http://scholarsresearchlibrary.com/archive.html) ISSN 0975-5071 USA CODEN: DPLEB4
More informationFormulation and evaluation of cap-in-cap technology for biphasic drug delivery of glimepiride
Available online at www.scholarsresearchlibrary.com Scholars Research Library Der Pharmacia Lettre, 216, 8 (12):17-182 (http://scholarsresearchlibrary.com/archive.html) ISSN 975-571 USA CODEN: DPLEB4 Formulation
More informationInternational Journal of Research in Pharmaceutical and Nano Sciences Journal homepage:
Research Article CODEN: IJRPJK ISSN: 2319 9563 International Journal of Research in Pharmaceutical and Nano Sciences Journal homepage: www.ijrpns.com FORMULATION AND EVALUATION OF ESOMEPRAZOLE MAGNESIUM
More informationFORMULATION AND EVALUATION OF ACECLOFENAC MATRIX TABLETS USING ETHYL CELLULOSE AND CELLULOSE ACETATE PHTHALATE
M. Vijaya Laxmi et al. / JGTPS/ 5(3)-(2014) 1804-1810 ISSN: 2230-7346 (Research Article) Journal of Global Trends in Pharmaceutical Sciences Journal home page: www.jgtps.com FORMULATION AND EVALUATION
More informationFORMULATION AND EVALUATION OF ONCE-DAILY SUSTAINED RELEASE ACECLOFENAC PROSOPHIS JULIFLORA GUM MATRIX TABLETS
FORMULATION AND EVALUATION OF ONCE-DAILY SUSTAINED RELEASE ACECLOFENAC PROSOPHIS JULIFLORA GUM MATRIX TABLETS Hindustan Abdul Ahad *, Chitta Suresh Kumar 1, Pilli Yesupadam 2, Harika B 1, Deepika D 1,
More informationFormulation and Evaluation of Cefixime Trihydrate Matrix Tablets Using HPMC, Sodium CMC, Ethyl Cellulose
Research Paper Formulation and Evaluation of Cefixime Trihydrate Matrix Tablets Using HPMC, Sodium CMC, Ethyl Cellulose JANAKIDEVI SIRISOLLA* AND K. V. RAMANAMURTHY AU College of Pharmaceutical Sciences,
More informationDirect compression of cushion layered ethyl cellulose coated extended release pellets into rapidly disintegrating tablets
Research Article ISSN: 0974-6943 M.Yasmin Begum et al. / Journal of Pharmacy Research 2016,10(1), Available online through http://jprsolutions.info Direct compression of cushion layered ethyl cellulose
More informationFormulation and Evaluation of Orodispersible Tablets of Ambroxol Hydrochloride
DOI:10.21276/ijprhs.2017.06.24 Manichandrika et al CODEN (USA)-IJPRUR, e-issn: 2348-6465 International Journal of Pharma Research and Health Sciences Available online at www.pharmahealthsciences.net Original
More informationInternational Journal of Applied Pharmaceutical Sciences and Research
International Journal of Applied Pharmaceutical Sciences and Research 2016; 1(2):76-87 S. Ullas et al/international Journal of Applied Pharmaceutical Sciences and Research 2016; 1(2): 76-87 International
More informationPreparation and Evaluation of Sustained Release Tablet of Cyproheptadine Hydrochloride Using Carbopol and HPMC
Received: 06-01-2013 Accepted: 26-02-2013 ISSN: 2277-7695 CODEN Code: PIHNBQ ZDB-Number: 2663038-2 IC Journal No: 7725 Vol. 2 No. 1 2013 Online Available at www.thepharmajournal.com THE PHARMA INNOVATION
More informationRESEARCH ARTICLE e-issn:
Available online at www.ijtpls.com International Journal of Trends in Pharmacy and Life Sciences Vol. 2, Issue: 2, 2016: 801-812. FORMULATION AND EVALUATION OF FLOATING DRUG DELIVERY SYSTEM OF ENALAPRIL
More informationFORMULATION DEVELOPMENT AND EVALUATION OF FAMOTIDINE FLOATING TABLET
FORMULATION DEVELOPMENT AND EVALUATION OF FAMOTIDINE FLOATING TABLET Patel Amit* 1, Jha Sajal Kumar 1, Panchal Harishanker 2, Shukla Tarkeshwar 1, Shah Arpit 3 1 Dept. of Pharmaceutics, NIMS Institute
More informationHuman Journals Research Article October 2018 Vol.:13, Issue:3 All rights are reserved by Gourishyam Pasa et al.
Human Journals Research Article October 2018 Vol.:13, Issue:3 All rights are reserved by Gourishyam Pasa et al. Formulation Development and In-Vitro Evaluation of Sustained-Release Gastro Retentive Tablets
More informationDesign of Controlled Release Non-erodible Polymeric Matrix Tablet Using Microwave Oven-assisted Sintering Technique
Pharmaceutics Design of Controlled Release Non-erodible Polymeric Matrix Tablet Using Microwave Oven-assisted Sintering Technique Patel DM Patel BK Patel A Patel CN Department of Pharmaceutics and Pharmaceutical
More informationDevelopment and evaluation of sustained release matrix tablets of naproxen
Available online at www.scholarsresearchlibrary.com Scholars Research Library Der Pharmacia Lettre, 2015, 7 (2):270-279 (http://scholarsresearchlibrary.com/archive.html) ISSN 0975-5071 USA CODEN: DPLEB4
More informationTaste Masked Orodispersible Formulation of Fexofenadine Hydrochloride Using Ion Exchange Resins
Research Paper Taste Masked Orodispersible Formulation of Fexofenadine Hydrochloride Using Ion Exchange Resins DIVYA SUARES* AND ARTI HIRAY Shobhaben Pratapbhai Patel School of Pharmacy and Technology
More informationFormulation and in vitro evaluation of captopril floating tablets by using natural polymers
2018; 7(8): 82-89 ISSN (E): 2277-7695 ISSN (P): 2349-8242 NAAS Rating: 5.03 TPI 2018; 7(8): 82-89 2018 TPI www.thepharmajournal.com Received: 11-06-2018 Accepted: 13-07-2018 Ayesha Salma Habeeb Department
More informationDesign and Evaluation of Sustained Release Tablets containing Solid dispersion of Ziprasidone hydrochloride
International Journal of PharmTech Research CODEN (USA): IJPRIF ISSN : 0974-4304 Vol.6, No.3, pp 959-968, July-Aug 2014 Design and Evaluation of Sustained Release Tablets containing Solid dispersion of
More informationInternational Journal of Pharma and Bio Sciences FORMULATION AND EVALUATION OF BILAYER TABLETS OF GLIMEPIRIDE AND CAPTOPRIL ABSTRACT
ResearchArticle Pharmaceutics International Journal of Pharma and Bio Sciences ISSN 0975-6299 FORMULATION AND EVALUATION OF BILAYER TABLETS OF GLIMEPIRIDE AND CAPTOPRIL J. AISHWARYA * AND N. SRINIVAS Department
More informationJournal of Pharmaceutical and Biological Research. Journal of Pharmaceutical and Biological Research
Naga Lasxmi et al, JPBR, 2015, 3(2): 261 266 ISSN: 2347-8330 Journal of Pharmaceutical and Biological Research Journal Home Page: www.pharmaresearchlibrary.com/jpbr Research Article Open Access Formulation
More informationTreatment of diabetes mellitus (DM) with conventional dosage forms is not effective as the drugs do not reach the site of
ISSN: 0975-766X CODEN: IJPTFI Available Online through Research Article www.ijptonline.com FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF GLIBENCLAMIDE Shree Ram Jayaswal 1, V. Felix
More informationFormulation and Evaluation of Gastro retentive Bilayer Tablets- Glimepiride as Sustained Release and Lisinopril as Immediate Release
Farhat A et al / Int. J. of Pharmacy and Analytical Research Vol-5(4) 216 [658-669] IJPAR Vol.5 Issue 4 Oct - Dec -216 Journal Home page: ISSN:232-2831 Research article Open Access Formulation and Evaluation
More informationInternational Journal of Innovative Pharmaceutical Sciences and Research
International Journal of Innovative Pharmaceutical Sciences and Research www.ijipsr.com FORMULATION AND EVALUATION OF TENOFOVIR DISOPROXIL FUMARATE IMMEDIATE RELEASE TABLETS 1 Farha Amna Shaik*, 2 Shubhrajit
More informationMohammed Muqtader. et al. / International Journal of Biopharmaceutics. 2012; 3(1): International Journal of Biopharmaceutics
17 e- ISSN 0976-1047 Print ISSN 2229-7499 International Journal of Biopharmaceutics Journal homepage: www.ijbonline.com IJB DEVELOPMENT OF FAMOTIDINE BUOYANT DRUG DELIVERY SYSTEM USING NATURAL POLYMERS
More informationFormulation and Evaluation of Stable Extended Release Tablets of Tapentadol Hydrochloride
Research Article S. S. S. Rakesh 1*, Dr. S. Anbazhagan 2, Prof. M.V. Basaveswara Rao 3, Joginapalli Sreekanth 4 1 MSN R&D Center, MSN Laboratories Pvt Ltd, Hyderabad, Telangana, India. 2 Principal and
More informationDevelopment, Characterisation and Invitro Evaluation of Buccoadhesive Bilayered Tablets for the Treatment of Hypertension
58 Research Article Development, Characterisation and Invitro Evaluation of Buccoadhesive Bilayered Tablets for the Treatment of Hypertension Kavitha Reddy Jupally*, A.Pavani, R. Raja Reddy, Habibuddin.
More informationFORMULATION AND EVALUATION OF POLYMER EFFECT ON in-vitro KINETICS OF SUSTAINED RELEASE MATRIX TABLETS OF CARVEDILOL USING MODEL DEPENDENT METHODS
FORMULATION AND EVALUATION OF POLYMER EFFECT ON in-vitro KINETICS OF SUSTAINED RELEASE MATRIX TABLETS OF CARVEDILOL USING MODEL DEPENDENT METHODS Umme Rahela, Md. Mizanur Rahman Moghal *, Syed Masudur
More informationFormulation and Evaluation of Floating Capsules of 3 rd Generation Cephalosporin
International Journal of PharmTech Research CODEN (USA): IJPRIF ISSN : 0974-4304 Vol.4, No.3, pp 986-993, July-Sept 2012 Formulation and Evaluation of Floating Capsules of 3 rd Generation Cephalosporin
More informationSustained release matrix tablets of indomethacin using Hibiscus rosa-sinensis as release retardant
Available online at www.scholarsresearchlibrary.com Scholars Research Library Der Pharmacia Lettre, 2012, 4 (1):227-233 (http://scholarsresearchlibrary.com/archive.html) ISSN 0975-5071 USA CODEN: DPLEB4
More informationFabrication of Extended Release Tablets of Pramipexole: In-vitro Studies
Pharm Methods, 2017; 8(2): 115-120 A multifaceted peer reviewed journal in the field of Pharm Analysis and Pharmaceutics www.phmethods.net www.journalonweb.com/phm Original Article Fabrication of Extended
More informationFORMULATION DEVELOPMENT AND OPTIMIZATION OF EXTENDED RELEASE MATRIX TABLETS OF AZILSARTAN USING NATURAL AND SYNTHETIC POLYMERS
ejpmr, 2016,3(4), 294-304 Iswariya et al. SJIF Impact Factor 3.628 EUROPEAN JOURNAL OF PHARMACEUTICAL ISSN 3294-3211 AND MEDICAL RESEARCH EJPMR www.ejpmr.com Research Article FORMULATION DEVELOPMENT AND
More informationKollidon SR: A polyvinyl acetate based excipient for DCsustained-release
Kollidon SR: A polyvinyl acetate based excipient for DCsustained-release oral dosage forms by Dr. Bernhard Fussnegger BASF Aktiengesellschaft, Ludwigshafen Strategic Marketing Pharma Excipients Introduction
More informationInternational Journal of Pharma and Bio Sciences V1(1)2010
International Journal of Pharma and Bio Sciences V1(1)010 Nagendra Kumar D 1*, Raju SA, Shirsand SB 1 S.V.E.T. s College of Pharmacy, Humnabad-55330, Dist: Bidar (Karnataka) Department of Pharmaceutical
More informationThe frictional forces in a loose powder or granules can be measured by the. A funnel was filled to the brim and the test sample was allowed to flow
3.1.5 Preformulation study: I) Pre-compression evaluation parameters: a) Angleof repose. b) Bulk density. c) Tapped density. d) Hausner sratio. e) Compressibility index(%). II) Drug polymer interaction
More informationRamadevi K*, Mahalakshmi Y, Susheela V, Santhosh Kumar T, Chandra Sekhara Rao G,
International Journal of Pharmaceutical Development & Technology e ISSN - 2248-910X www.ijpdt.com Print ISSN - 2248-9096 FORMULATION AND EVALUATION OF OLANZAPINE FAST DISINTEGRATING TABLETS USING COPROCESSED
More informationVolume 1 Issue 1 Page 82
DESIGN AND IN VITRO EVALUTION OF SUSTAINED RELEASE FILM COATED TABLETS OF VERAPAMIL HYDROCHLORIDE BS Venkateswarlu*, B Jaykar, Pasupathi A, R Margret Chandira, Palanisamy P Vinayaka mission s college of
More informationFormulation and Evaluation of Telmisartan with Hydrochlorothiazide Conventional Release Tablets
Human Journals Research Article July 2018 Vol.:12, Issue:4 All rights are reserved by S. Meena et al. Formulation and Evaluation of Telmisartan with Hydrochlorothiazide Conventional Release Tablets Keywords:
More informationIndian Journal of Pharmaceutical and Biological Research (IJPBR)
Indian J.Pharm.Biol.Res. 2013; 1(4):64-70 Original Research Article Development and evaluation of nifidipine loaded tablet formulation for colon drug delivery Renu Dinkar 1, Govind Mohan 2, Kumud Upadhyaya
More informationSingh et al Asian Journal of Pharmaceutical Research and Development. 2018; 6(5): 81-86
Asian Journal of Pharmaceutical Research and Development (An International Peer-Reviewed Journal of Pharmaceutical Research and Development) 2013-18, publisher and licensee AJPRD, This is an Open Access
More informationThe Pharmaceutical and Chemical Journal, 2016, 3(2): Research Article
, 2016, 3(2):207-220 Available online www.tpcj.org Research Article ISSN: 2349-7092 CODEN(USA): PCJHBA Formulation of Colon Specific Didanosine Enteric Coated Matrix Tablets Using ph Sensitive Polymer
More informationInternational Journal of Research in Pharmaceutical and Nano Sciences Journal homepage:
Research Article CODEN: IJRPJK ISSN: 2319 9563 International Journal of Research in Pharmaceutical and Nano Sciences Journal homepage: www.ijrpns.com FORMULATON AND EVALUATION OF RAMIPRIL IMMEDIATE RELEASE
More informationResearch Paper. Development of Prolonged Delivery of Tramadol and Dissolution Translation by Statistical Data Treatment
330 International Journal of Pharmaceutical Sciences and Nanotechnology Volume 4 Issue April-June 20 Research Paper International Journal of Pharmaceutical Sciences and Nanotechnology Volume 4 Issue April
More informationOptimization of Perindopril Erbumine Controlled Release Floating Tablet Using 3 2 Central Composite Design
Balkrushna K. Patel et al /J. Pharm. Sci. & Res. Vol.5(), 013, 36-41 Optimization of Perindopril Erbumine Controlled Release Floating Tablet Using 3 Central Composite Design Balkrushna K. Patel 1*, Paresh
More informationFormulation and Evaluation of Fast Dissolving Tablets of Ondansetron Hydrochloride
ISSN 2395-3411 Available online at www.ijpacr.com 736 Research Article Formulation and Evaluation of Fast Dissolving Tablets of Ondansetron Hydrochloride Rajeshree Panigrahi* and Iswori Prasad Padhy Royal
More informationFORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF BACLOFEN
IJPSR (218), Volume 9, Issue 1 (Research Article) Received on 1 February, 218; received in revised form, 27 August, 218; accepted, 2 September, 218; published 1 October, 218 FORMULATION AND EVALUATION
More informationThe research work highlights the development and evaluation of. bioavailability of drugs. The buccal route can bypass the first-pass
212 9. Summary, conclusion and recommendation 9.1 Summary and conclusion The research work highlights the development and evaluation of novel transbuccal drug antagonist of Famotidine. route have a rapid
More informationMiss. Monika B. Patil 1, Dr.Sunila T. Patil 2, Dr.Sunil P. Pawar 3,Dr. Bhushan R. Rane 4
Sustained Release Tablet using combination of Hydrophilic and Hydrophobic Polymers Miss. Monika B. Patil 1, Dr.Sunila T. Patil 2, Dr.Sunil P. Pawar 3,Dr. Bhushan R. Rane 4 PG Scholar, Department of Quality
More informationPelagia Research Library. Design fabrication and characterization of controlled released tablets of Trimetazidine di hydrochloride
Available online at www.pelagiaresearchlibrary.com Der Pharmacia Sinica, 2011, 2 (6):59-66 ISSN: 0976-8688 CODEN (USA): PSHIBD Design fabrication and characterization of controlled released tablets of
More informationScholars Research Library
Available online at www.scholarsresearchlibrary.com Scholars Research Library Der Pharmacia Lettre, 2010, 2(6): 212-216 (http://scholarsresearchlibrary.com/archive.html) ISSN 0975-5071 USA CODEN: DPLEB4
More informationFORMULATION AND EVALUATION OF RANITIDINE FLOATING TABLETS
INTERNATIONAL JOURNAL OF PHARMACEUTICAL, CHEMICAL AND BIOLOGICAL SCIENCES Available online at www.ijpcbs.com Research Article FORMULATION AND EVALUATION OF RANITIDINE FLOATING TABLETS K. Kavitha*, Narendra
More informationFormulation and Evaluation of Oro-Dispersible Tablets Containing Meclizine Hydrochloride
Int. J. Pharm. Sci. Rev. Res., 42(2), January - February 17; Article No. 10, Pages: 47-52 Research Article Formulation and Evaluation of Oro-Dispersible Tablets Containing Meclizine Hydrochloride Rakhee
More informationPelagia Research Library
Available online at www.pelagiaresearchlibrary.com Der Pharmacia Sinica, 2012, 3 (5):598-603 ISSN: 0976-8688 CODEN (USA): PSHIBD Formulation and evaluation of solid matrix tablets of repaglinide Jitender
More informationFORMULATION AND EVALUATION OF ACYCLOVIR CR TABLETS: OPTIMIZATION BY 2 2 FACTORIALSTUDY
WORLD JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES Patil et al. SJIF Impact Factor 5.210 Volume 4, Issue 12, 992-1000 Research Article ISSN 2278 4357 FORMULATION AND EVALUATION OF ACYCLOVIR CR TABLETS:
More informationAsian Journal of Pharmaceutical and Clinical Research Vol. 3, Issue 4, 2010 ISSN
Asian Journal of Pharmaceutical and Clinical Research Vol. 3, Issue 4, 2010 ISSN - 0974-2441 Research Article A STUDY ON THE EFFECT OF DIFFERENT CELLULOSE POLYMERS ON RELEASE RATE FROM TRAMADOL LOADED
More informationInternational Journal of PharmTech Research CODEN (USA): IJPRIF, ISSN: Vol.7, No.1, pp ,
International Journal of PharmTech Research CODEN (USA): IJPRIF, ISSN: 0974-4304 Vol.7, No.1, pp 139-147, 2014-2015 Pharmaceutical Prospective Process Validation Of Chloroquiune Tablets Vilas S Jadhav*,
More informationFormulation and Development of Capsule in Capsule Drug Delivery System for Biphasic Delivery of Etoricoxib
Human Journals Research Article July 2016 Vol.:6, Issue:4 All rights are reserved by S. M. Thorat et al. Formulation and Development of Capsule in Capsule Drug Delivery System for Biphasic Delivery of
More informationScholars Research Library
Available online at www.scholarsresearchlibrary.com Scholars Research Library Der Pharmacia Lettre, 2010, 2(3): 286-296 (http://scholarsresearchlibrary.com/archive.html) ISSN 0975-5071 USA CODEN: DPLEB4
More informationFORMULATION AND EVALUATION OF ACECLOFENAC MATRIX TABLETS FOR COLON DRUG DELIVERY
ISSN:2230-7346 Research Article Available online http://www.jgtps.com Journal of Global Trends in Pharmaceutical Sciences Vol.1, Issue 1, pp 53-60, Oct Dec 2010 FORMULATION AND EVALUATION OF ACECLOFENAC
More informationScholars Research Library. Sustained release drug delivery systems of Cefuroxime Axetil
Available online at www.scholarsresearchlibrary.com Der Pharmacia Lettre, 2011, 3(3): 325-332 (http://scholarsresearchlibrary.com/archive.html) ISSN 0975-5071 USA CODEN: DPLEB4 Sustained release drug delivery
More informationFORMULATION AND EVALUATION OF ENTERIC COATED SUSTAIN RELEASE TABLETS OF LANSOPRAZOLE IN A β- CYCLODEXTRIN COMPLEX TO IMPROVE THE PHOTOSTABILITY
FORMULATION AND EVALUATION OF ENTERIC COATED SUSTAIN RELEASE TABLETS OF LANSOPRAZOLE IN A β- CYCLODEXTRIN COMPLEX TO IMPROVE THE PHOTOSTABILITY MADHUSUDAN BOKKA * 1, NARESH NOMULA 2 1 M Pharmacy, Department
More informationDrug exhibiting absorption from only a. Design and Clinical Evaluation of Floating Mini Matrix Tablets of Pyridoxine Hydrochloride ORIGINAL ARTICLE
ORIGINAL ARTICLE Design and Clinical Evaluation of Floating Mini Matrix Tablets of Pyridoxine Hydrochloride Kiran Kumar 1, P. Srikanth 1, M. Ajitha 2, Y. Madhusudan Rao 1 1 Department of Pharmaceutics,
More informationInternational Journal of Chemistry and Pharmaceutical Sciences. International Journal of Chemistry and Pharmaceutical Sciences
B. Venkateswara Reddy, IJCPS, 2015, 3(2): 1537 1543 ISSN: 2321-3132 International Journal of Chemistry and Pharmaceutical Sciences Journal Home Page: www.pharmaresearchlibrary.com/ijcps Research Article
More informationVigna Mungo Mucilage - A Natural Polymer in the Design of Matrix Based SR Tablet of Aceclofenac
Research Article Basappa Veerabhadraiah Basavaraj* 1, Naramsetty Saritha 1, Srinivasan Bharath 1, Rajamanickam Deveswaran 1, Varadharajan Madhavan 2 * 1 Department of pharmaceutics, 2 Department of pharmacognosy,
More informationScholars Research Library
Available online at www.scholarsresearchlibrary.com Scholars Research Library Der Pharmacia Lettre, 2011, 3(2): 304-315 (http://scholarsresearchlibrary.com/archive.html) ISSN 0975-5071 USA CODEN: DPLEB4
More informationInternational Journal of Research in Pharmaceutical and Nano Sciences Journal homepage:
Research Article CODEN: IJRPJK ISSN: 2319 9563 International Journal of Research in Pharmaceutical and Nano Sciences Journal homepage: www.ijrpns.com FORMULATION AND EVALUATION OF ZOLMITRIPTAN POROUS TABLET
More informationFormulation and Evaluation of Immediate Release Tablets of Fexofenadine Hydrochloride
Research Article ISSN: 0974-6943 Sachin Gholve et al. / Journal of Pharmacy Research 2016,10(2), Available online through http://jprsolutions.info Formulation and Evaluation of Immediate Release Tablets
More informationThe Pharmaceutical and Chemical Journal, 2015, 2(3): Research Article
, 215, 2(3):54-61 Available online www.tpcj.org Research Article ISSN: 2349-792 CODEN(USA): PCJHBA Formulation, Development and Evaluation of Metformin Hydrochloride Extended Release Tablets Kapil Tak
More informationINTERNATIONAL JOURNAL OF INSTITUTIONAL PHARMACY AND LIFE SCIENCES
International Journal of Institutional Pharmacy and Life Sciences 5(1): January-February 2015 INTERNATIONAL JOURNAL OF INSTITUTIONAL PHARMACY AND LIFE SCIENCES Pharmaceutical Sciences Research Article!!!
More informationFormulation and development of mucoadhesive tablets of rebamipide by using design of experiment
Available online at www.scholarsresearchlibrary.com Scholars Research Library Der Pharmacia Lettre, 2016, 8 (6):87-101 (http://scholarsresearchlibrary.com/archive.html) ISSN 0975-5071 USA CODEN: DPLEB4
More informationFigure 4 DSC Thermogram of Paracetamol
Preformulation studies DRUG IDENTIFICATION TESTS Determination of melting point(s) Differential scanning colorimetry (DSC) was performed to determine the melting point of the dicyclomine and paracetamol.
More informationEVALUATION OF MORINGA OLEIFERA GUM AS A SUSTAINED RELEASE POLYMER IN DICLOFENAC SODIUM TABLET FORMULATION
IJRPC 214, 4(3), 687-693 Ravi Varma et al. ISSN: 2231 2781 INTERNATIONAL JOURNAL OF RESEARCH IN PHARMACY AND CHEMISTRY Available online at www.ijrpc.com Research Article EVALUATION OF MORINGA OLEIFERA
More informationPelagia Research Library
Available online at www.pelagiaresearchlibrary.com Der Pharmacia Sinica, 2010, 1 (2): 130-135 ISSN: 0976-8688 CODEN (USA): PSHIBD Formulation and Evaluation of Modified Release Trimetazidine Dihydrochloride
More informationFormulation and Evaluation of Floating Tablets of RHCL Using Natural and Synthetic Polymers
International Journal of PharmTech Research CODEN (USA): IJPRIF ISSN : 0974-4304 Vol.2, No.2, pp 1513-1519, April-June 2010 Formulation and Evaluation of Floating Tablets of RHCL Using Natural and Synthetic
More informationDesign and evaluation of entacapone controlled release trilayer matrix tablets in the management of parkinson s disease
IJPAR Vol.5 Issue 1 Jan- Mar -2016 Journal Home page: ISSN:2320-2831 Research Article Open Access Design and evaluation of entacapone controlled release trilayer matrix tablets in the management of parkinson
More informationFORMULATION AND EVALUATION OF VENLAFAXINE HYDROCHLORIDE TABLETS AS CONTROLLED RELEASE MODULES
INTERNATIONAL JOURNAL OF RESEARCH IN PHARMACY AND CHEMISTRY Available online at www.ijrpc.com Research Article FORMULATION AND EVALUATION OF VENLAFAXINE HYDROCHLORIDE TABLETS AS CONTROLLED RELEASE MODULES
More informationResearch Article Pharmaceutical Sciences
Page185 Research Article Pharmaceutical Sciences ENHANCEMENT OF DISSOLUTION RATE OF EFAVIRENZ BY SOLID DISPERSION TECHNIQUE B. Venkateswara Reddy 1*, K.V. Ramana Murthy 2 1* Department of Pharmaceutics,
More informationInternational Journal of Pharmacy
International Journal of Pharmacy Journal Homepage: http://www.pharmascholars.com Research Article CODEN: IJPNL6 FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF RANOLAZINE M Vanaja kumari
More informationInvestigation of Aqueous Ethylcellulose Dispersion in Extended Release Metformin Inert Matrices
Surelease Application Data Aqueous Ethylcellulose Dispersion Investigation of Aqueous Ethylcellulose Dispersion in Extended Release Metformin Inert Matrices ABSTRACT SUMMARY: In the present study, Surelease,
More informationFORMULATION AND EVALUATION OF CONTROLLED RELEASE DELIVERY OF TRAMADOL HYDROCHLORIDE USING FULL FACTORIAL DESIGN
International Journal of ChemTech Research CODEN( USA): IJCRGG ISSN : 0974-490 Vol., No.1, pp 669-675, Jan-Mar 010 FORMULATION AND EVALUATION OF CONTROLLED RELEASE DELIVERY OF TRAMADOL HYDROCHLORIDE USING
More informationGanga Jyothi P. et al. / International Journal of Biopharmaceutics. 2014; 5(4): International Journal of Biopharmaceutics
245 e- ISSN 0976-1047 Print ISSN 2229-7499 International Journal of Biopharmaceutics Journal homepage: www.ijbonline.com IJB DEVELOPMENT AND CHARACTERIZATION OF MATRIX MINI- TABLETS OF BOSENTAN FOR CONTROLLED
More informationFormulation design and development of Orodispersible tablets of Levetiracetam
Research Article ISSN: 0974-6943 Available online through http://jprsolutions.info Formulation design and development of Orodispersible tablets of Levetiracetam Dr. Y. Ganesh Kumar 1 *, P. Goverdhan Reddy,
More informationPelagia Research Library
Available online at www.pelagiaresearchlibrary.com Der Pharmacia Sinica, 2014, 5(5):36-41 ISSN: 0976-8688 CODEN (USA): PSHIBD Development of chronomodulated drug delivery system of Pravastatin sodium for
More informationCHAPTER-4 FORMULATION AND EVALUATION OF RIZATRIPTAN SUBLINGUAL TABLETS
118 CHAPTER-4 FORMULATION AND EVALUATION OF RIZATRIPTAN SUBLINGUAL TABLETS 4.1 EXPERIMENTAL METHODS 4.1.1 Preparation of standard graph of rizatriptan in water at 282nm 16.3mg of rizatriptan benzoate was
More informationSTUDIES ON DEVELOPMENT OF SUSTAINED RELEASE DILTIAZEM HYDROCHLORIDE MATRICES THROUGH JACKFRUIT MUCILAGE
Innovare Academic Sciences International Journal of Pharmacy and Pharmaceutical Sciences ISSN- 0975-1491 Vol 6, Issue 7, 2014 Original Article STUDIES ON DEVELOPMENT OF SUSTAINED RELEASE DILTIAZEM HYDROCHLORIDE
More informationFORMULATION AND IN-VITRO EVALUATION OF CONVENTIONAL TABLETS OF EZETIMIBE BY USING SOLID DISPERSION
Academic Sciences International Journal of Pharmacy and Pharmaceutical Sciences ISSN- 0975-1491 Vol 5, Suppl 2, 2013 Research Article FORMULATION AND IN-VITRO EVALUATION OF CONVENTIONAL TABLETS OF EZETIMIBE
More informationIndian Journal of Novel Drug delivery 5(3), Jul-Sep, 2013, Indian Journal of Novel Drug Delivery
Indian Journal of Novel Drug delivery 5(3), Jul-Sep, 2013, 130-141 Indian Journal of Novel Drug Delivery IJNDD An Official Publication of Karnataka Education and Scientific Society Research Article Formulation
More informationInternational Journal of Pharmaceuticals and Health care Research
118 Research Article Available Online at: International Journal of Pharmaceuticals and Health care Research ISSN: - 2306 6091 FORMULATION AND EVALUATION OF MODIFIED RELEASE MATRIX TABLETS OF TOLTERODINE
More informationµm - 52 µm and 79 µm - 54 µm for formulation FDS1 and FPS1, respectively.
Irritable bowel syndrome (IBS) is a mild intestinal chronic disorder associated with abdominal pain, altered bowel motility resulting in either diarrhea or constipation, and increased visceral hypersensitivity
More informationJournal of Global Trends in Pharmaceutical Sciences
An Elsevier Indexed Journal ISSN-2230-7346 Journal of Global Trends in Pharmaceutical Sciences DEVELOPMENT AND IN-VITRO EVALUATION OF CARVEDILOL LOADED MUCOADHESIVE BUCCAL TABLET Venkatalakshmi Ranganathan*
More informationComparative analysis of eight brands of sulfadoxinepyrimethamine
Tropical Journal of Pharmaceutical Research, June 2003; 2 (1): 161-167 Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria. All rights reserved. Available online at http://www.tjpr.freehosting.net
More information