Histoacryl A revolution in mesh fixation

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Joseph Lindsey
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1 Histoacryl A revolution in mesh fixation Closure Technologies

Histoacryl A revolution in mesh fixation A new indication for a classic product Histoacryl has been used for more than 40 years in operating rooms around the world as an excellent skin closure

2 Histoacryl A revolution in mesh fixation A new indication for a classic product Histoacryl has been used for more than 40 years in operating rooms around the world as an excellent skin closure adhesive and as a standard technique to treat esophageal and fundus varices. More than publications demonstrate the usefulness of adhesives. Histoacryl is now also available to fix reinforcement materials on soft tissues. trends A new trend in a classical surgery Nowadays ensuring a healthy abdominal wall is a universal concept, which involves providing solutions for the reduction of recurrences, postoperative chronic pain and infection, among others. In the field of hernia repair, the importance of a strong, quick and efficient fixation method to reduce these complications is undisputed. According to literature the technique of mesh fixation with synthetic glues has been known since 1996 (1). Achieving haemostasis, promoting wound healing or fixing implants are some of the examples where synthetic adhesives are used, from cardiovascular to orthopaedic surgery, including general surgery (2). Histoacryl, a well-known synthetic glue among the medical community, offers these and other advantages. From its preparation to the patients comfort: it is strong, it is quick and it is efficient. 2

Non-invasive method reported to be better tolerated by the patient (3, 5, 6, 8) It is quick Fast and efficient polymerization in

3 Easy identification: drop of Histoacryl applied onto an Optilene Mesh strong quick It is strong Low recurrence rate (1, 3, 4, 8) Stand-alone fixation method in different hernia repair techniques, such as: mesh and plug (3), TAPP (4, 5) or Lichtenstein (6) Non-invasive method reported to be better tolerated by the patient (3, 5, 6, 8) It is quick Fast and efficient polymerization in contact with tissue (4), allowing mesh respositioning Ready-to-use product (9) Storage at room temperature (9) Decreases surgery time 3

efficient It is efficient Efficacy demonstrated in vitro and in vivo (4) It acts as a sterile occlusive system (1) Intrinsic bacteriostatic properties that help to reduce local septic complications

4 efficient It is efficient Efficacy demonstrated in vitro and in vivo (4) It acts as a sterile occlusive system (1) Intrinsic bacteriostatic properties that help to reduce local septic complications (1) Tissue closure is rapid and with minimized risk of injury (1) (1) Farouk R, Drew PJ, Qureshi A, Roberts AC, Duthie GS, Monson JR. Preliminary experience with butyl-2-cyanoacrylate adhesive in tension-free inguinal hernia repair. Br J Surg Aug;83(8):1100. (2) Peng HT, Shek PN. Novel wound sealants: biomaterials and applications. Expert Rev Med Devices Sep;7(5): (3) Testini M, Lissidini G, Poli E, Gurrado A, Lardo D, Piccinni G. A single-surgeon randomized trial comparing sutures, N-butyl-2-cyanoacrylate and human fibrin glue for mesh fixation during primary inguinal hernia repair. Can J Surg Jun;53(3): (4) Kukleta JF, Freytag C, Weber M. Efficiency and safety of mesh fixation in laparoscopic inguinal hernia repair using n-butyl cyanoacrylate: long-term biocompatibility in over mesh fixations. Hernia Oct 21; in print. (5) Agresta F, Baldazzi GA, Ciardo LF, Trentin G, Giuseppe S, Ferrante F, Bedin N. Lightweight partially absorbable monofilament mesh (polypropylene/poliglecaprone 25) for TAPP inguinal hernia repair: initial experience. Surg Laparosc Endosc Percutan Tech Apr;17(2):91-4. (6) Helbling C, Schlumpf R. Sutureless Lichtenstein: first results of a prospective randomised clinical trial. Hernia Jun;7(2):80-4. Fascia and skin can also be closed with the glue (8, 9) Low intra- and postoperative morbidity Potentially less harmful than traditional invasive methods (1, 5, 7) No human or animal components (9) (3, 5, 6) (7) Jourdan IC, Bailey ME. Initial experience with the use of N-butyl 2-cyanoacrylate glue for the fixation of polypropylene mesh in laparoscopic hernia repair. Surg Laparosc Endosc Aug;8(4): (8) Nowobilski W, Dobosz M, Wojciechowicz T, Mionskowska L. Lichtenstein inguinal hernioplasty using butyl-2-cyanoacrylate versus sutures. Preliminary experience of a prospective randomized trial. Eur Surg Res Nov- Dec;36(6): (9) Instruction for use Histoacryl. Histoacryl 4

5 Histoacryl A revolution in mesh fixation Ordering information Combine Histoacryl with our product range of meshes to achieve the best interaction: Description Article No. Contents Histoacryl Blue x 0.5 ml Histoacryl Blue x 0.5 ml Optilene Mesh 7.5 x 15 cm (60 g/m 2 ; pore size 1.5 mm) Optilene Mesh 10 x 15 cm (60 g/m 2 ; pore size 1.5 mm) Optilene Mesh 15 x 15 cm (60 g/m 2 ; pore size 1.5 mm) Optilene Mesh LP 7.5 x 15 cm (36 g/m 2 ; pore size 1 mm) Optilene Mesh LP 10 x 15 cm (36 g/m 2 ; pore size 1 mm) Optilene Mesh LP 15 x 15 cm (36 g/m 2 ; pore size 1 mm) Optilene Mesh Elastic 10 x 15 cm (48 g/m 2 ; pore size 2.4 x 3.6 mm) Premilene Mesh 7.5 x 15 cm (80 g/m 2 ; pore size 0.8 mm) Premilene Mesh 10 x 15 cm (80 g/m 2 ; pore size 0.8 mm) Premilene Mesh 15 x 15 cm (80 g/m 2 ; pore size 0.8 mm) Histoacryl 5

6 B. Braun Surgical SA Carretera de Terrassa, Rubí Spain Phone Fax Aesculap AG Am Aesculap-Platz Tuttlingen Germany Phone Fax Aesculap a B. Braun company Subject to technical changes. All rights reserved. This brochure may only be used for the exclusive purpose of obtaining information about our products. Reproduction in any form partial or otherwise is not permitted. Brochure No. B /1/3

Histoacryl Flexible Improved closure of surgical incisions

Histoacryl Flexible Improved closure of surgical incisions Improved closure of surgical incisions Closure Technologies Improved closure of surgical incisions New NEW! The new generation of Histoacryl glue has been designed to close and protect surgical wounds.