Surface Plasmon Resonance Systems

Transcription

1 Innovative precision instruments for over a century Surface Plasmon Resonance Systems Label-free Molecular Interaction Analysis

2 ReichertSPR Answers: Is there an interaction? How fast? How strong? How long? How much? How specific? Modular, component-based system. Highly flexible. Excellent value. ReichertSPR Measures: Kinetics Affinity/Equilibrium Thermodynamics Concentration Adsorption rates ReichertSPR Flexibility: Combine Reichert SPR with: Electrochemistry Fluorescence Photochemistry Couple Reichert SPR with: Mass Spectrometry Liquid Chromatography Unlimited Possibilities for Breakthrough Work

3 Explore Critical Interactions with Reichert Surface Plasmon Resonance Technology Reichert Surface Plasmon Resonance (SPR) Systems provide robust, reliable precision instruments to investigate molecular interactions in real time without the need to label molecules. We are dedicated to serving the diverse interests of academia and industry by providing the most flexible SPR platform available in today s marketplace at an unbeatable price. Our systems allow for a wide range of applications and are easily modified to meet different experimental requirements. With more than a decade of experience in SPR technology, Reichert Life Sciences is happy to discuss your SPR applications, arrange for demonstrations, and configure systems to meet your research needs. Surfaces Polymers Proteins Antibody/Antigen Nucleic Acids Carbohydrates Lipids Small Molecules Drugs Bacteria Viruses BASELINE ASSOCIATION DISSOCIATION REGENERATION TIME TIME TIME TIME

4 Open architecture Flexible Flow Cell Design The Reichert SPR systems provide flexibility in experimental design with their exclusive collection of flow cell designs. The instruments can be configured with any of the flow cells to carry out SPR in combination with other measurements. And Reichert s sensor slides are available in pure gold or with a variety of surface chemistries. SPR Instruments Reichert s SPR instruments are powerful research tools offering a high level of flexibility, outstanding performance, and remarkable affordability. The SR7000 offers critical angle capability in a single channel instrument while the SR7000DC features simultaneous two-channel measurements, with user definable flow configurations. Both models provide: Virtually indestructible sapphire prism Excellent baseline stability Extremely low noise Temperature control from 100 C below ambient to 900 C Broad refractive index range (1.32 to 1.52) High speed scanning for fast kinetics Full access to reflectivity data in the lab Variety of sensor slides Reichert SPR Adapts to your research A new generation of sophisticated tools for cutting edge research and scientific discovery Diverter Valve Thanks to their modular/component-based design, Reichert SPR systems offer the most flexible platform to date. Researchers can target specific applications by configuring the most appropriate system. As a scientific research partner and teaching tool, Reichert SPR offers outstanding value with low maintenance at an affordable price. High flexibility Minimal maintenance Upgrade/Add components anytime Low operating costs Remarkable value This valve allows the flow to be switched between one channel only or to series, allowing automated immobilization/capture of ligand onto only one channel. Flexible Fluidics Platform Injecting the Samples Reichert offers several methods to manage sample injection. These include an autosampler and a semiautomatic injection valve. The systems are easily adapted to accommodate other injection methods. Other advantages include: Series or parallel flow Different flow cell modules for The Reichert Robotic Autosampler is designed to combining SPR with electrochemistry, photochemistry, and fluorescence Combine Reichert SPR with mass spectrometry and liquid chromotography Sapphire prism provides high thermal conductivity Stop flow capability SPR maximize the performance and throughput of the SPR instrument. Easy to operate and maintain, the autosampler automatically injects your samples while you do other work or leave the lab allowing for 24 hours of unattended analysis time. Automatic execution of experimental protocol Inject from two 384- or 96- well plates or two 48- vial trays Sample cooling to 40 C The Reichert Semi-Automatic Valve is electronically actuated and Programmable Syringe Pump computer-controlled through Reichert s Data Acquisition software, providing extremely uniform sample injections. The sample loop is manually filled, but the computer controls the injection time by automatically switching the injection valve. Easy to choose any loop size aspirate extremely small sample volumes into the flow cell A precision syringe pump is and can pump forward/reverse very quickly to mimic constant essential for optimum performance. flow conditions. This provides the capability to immobilize a The Reichert SR7500 syringe pump molecule of interest despite limited sample volumes. offers high precision flow with an Wide flow rate range (0.1 to 3000 μl/min) extremely wide flow rate range to Automated refills suit the application, e.g. slow flow Different sized syringes (0.5, 1, 5 ml) for equilibrium measurements or Forward/reverse push/pull fast flow for mass-transport limited Software control applications. The pump can also Real-time, High Quality, Publication-Ready Data The high sensitivity and low noise characteristics of Reichert SPR systems provide high quality kinetic and equilibrium data for interactions of interest. Easy-to-use data acquisition software makes it simple to set up instrument operating parameters, monitor/record experiment data in real time, and efficiently save/analyze data. The Reichert SPR system is designed to use low-cost, off-theshelf HPLC fittings and tubing, allowing for easy changeover. The system accommodates a wide range of sample compositions (from salt solution to cell lysates), varying viscosities, and particulate matter. The tubing is compatible with an array of solvents and easy to replace if damaged, blocked, or clogged. HPLC structure/setup Tubing from 64 to 500 μm inner diameter Variable loop size 10 to 5000 μl Parallel or series flow Compatible with a wide range of solvents and samples Computer and Software The Reichert SPR instrument has a single GUI interface that integrates all system components from operation through data collection. It has the ability to interface with popular data analysis programs such as Scrubber and Clamp.

5 Open architecture Flexible Flow Cell Design The Reichert SPR systems provide flexibility in experimental design with their exclusive collection of flow cell designs. The instruments can be configured with any of the flow cells to carry out SPR in combination with other measurements. And Reichert s sensor slides are available in pure gold or with a variety of surface chemistries. SPR Instruments Reichert s SPR instruments are powerful research tools offering a high level of flexibility, outstanding performance, and remarkable affordability. The SR7000 offers critical angle capability in a single channel instrument while the SR7000DC features simultaneous two-channel measurements, with user definable flow configurations. Both models provide: Virtually indestructible sapphire prism Excellent baseline stability Extremely low noise Temperature control from 100 C below ambient to 900 C Broad refractive index range (1.32 to 1.52) High speed scanning for fast kinetics Full access to reflectivity data in the lab Variety of sensor slides Reichert SPR Adapts to your research A new generation of sophisticated tools for cutting edge research and scientific discovery Diverter Valve Thanks to their modular/component-based design, Reichert SPR systems offer the most flexible platform to date. Researchers can target specific applications by configuring the most appropriate system. As a scientific research partner and teaching tool, Reichert SPR offers outstanding value with low maintenance at an affordable price. High flexibility Minimal maintenance Upgrade/Add components anytime Low operating costs Remarkable value This valve allows the flow to be switched between one channel only or to series, allowing automated immobilization/capture of ligand onto only one channel. Flexible Fluidics Platform Injecting the Samples Reichert offers several methods to manage sample injection. These include an autosampler and a semiautomatic injection valve. The systems are easily adapted to accommodate other injection methods. Other advantages include: Series or parallel flow Different flow cell modules for The Reichert Robotic Autosampler is designed to combining SPR with electrochemistry, photochemistry, and fluorescence Combine Reichert SPR with mass spectrometry and liquid chromotography Sapphire prism provides high thermal conductivity Stop flow capability SPR maximize the performance and throughput of the SPR instrument. Easy to operate and maintain, the autosampler automatically injects your samples while you do other work or leave the lab allowing for 24 hours of unattended analysis time. Automatic execution of experimental protocol Inject from two 384- or 96- well plates or two 48- vial trays Sample cooling to 40 C The Reichert Semi-Automatic Valve is electronically actuated and Programmable Syringe Pump computer-controlled through Reichert s Data Acquisition software, providing extremely uniform sample injections. The sample loop is manually filled, but the computer controls the injection time by automatically switching the injection valve. Easy to choose any loop size aspirate extremely small sample volumes into the flow cell A precision syringe pump is and can pump forward/reverse very quickly to mimic constant essential for optimum performance. flow conditions. This provides the capability to immobilize a The Reichert SR7500 syringe pump molecule of interest despite limited sample volumes. offers high precision flow with an Wide flow rate range (0.1 to 3000 μl/min) extremely wide flow rate range to Automated refills suit the application, e.g. slow flow Different sized syringes (0.5, 1, 5 ml) for equilibrium measurements or Forward/reverse push/pull fast flow for mass-transport limited Software control applications. The pump can also Real-time, High Quality, Publication-Ready Data The high sensitivity and low noise characteristics of Reichert SPR systems provide high quality kinetic and equilibrium data for interactions of interest. Easy-to-use data acquisition software makes it simple to set up instrument operating parameters, monitor/record experiment data in real time, and efficiently save/analyze data. The Reichert SPR system is designed to use low-cost, off-theshelf HPLC fittings and tubing, allowing for easy changeover. The system accommodates a wide range of sample compositions (from salt solution to cell lysates), varying viscosities, and particulate matter. The tubing is compatible with an array of solvents and easy to replace if damaged, blocked, or clogged. HPLC structure/setup Tubing from 64 to 500 μm inner diameter Variable loop size 10 to 5000 μl Parallel or series flow Compatible with a wide range of solvents and samples Computer and Software The Reichert SPR instrument has a single GUI interface that integrates all system components from operation through data collection. It has the ability to interface with popular data analysis programs such as Scrubber and Clamp.

6 Open architecture Flexible Flow Cell Design The Reichert SPR systems provide flexibility in experimental design with their exclusive collection of flow cell designs. The instruments can be configured with any of the flow cells to carry out SPR in combination with other measurements. And Reichert s sensor slides are available in pure gold or with a variety of surface chemistries. SPR Instruments Reichert s SPR instruments are powerful research tools offering a high level of flexibility, outstanding performance, and remarkable affordability. The SR7000 offers critical angle capability in a single channel instrument while the SR7000DC features simultaneous two-channel measurements, with user definable flow configurations. Both models provide: Virtually indestructible sapphire prism Excellent baseline stability Extremely low noise Temperature control from 100 C below ambient to 900 C Broad refractive index range (1.32 to 1.52) High speed scanning for fast kinetics Full access to reflectivity data in the lab Variety of sensor slides Reichert SPR Adapts to your research A new generation of sophisticated tools for cutting edge research and scientific discovery Diverter Valve Thanks to their modular/component-based design, Reichert SPR systems offer the most flexible platform to date. Researchers can target specific applications by configuring the most appropriate system. As a scientific research partner and teaching tool, Reichert SPR offers outstanding value with low maintenance at an affordable price. High flexibility Minimal maintenance Upgrade/Add components anytime Low operating costs Remarkable value This valve allows the flow to be switched between one channel only or to series, allowing automated immobilization/capture of ligand onto only one channel. Flexible Fluidics Platform Injecting the Samples Reichert offers several methods to manage sample injection. These include an autosampler and a semiautomatic injection valve. The systems are easily adapted to accommodate other injection methods. Other advantages include: Series or parallel flow Different flow cell modules for The Reichert Robotic Autosampler is designed to combining SPR with electrochemistry, photochemistry, and fluorescence Combine Reichert SPR with mass spectrometry and liquid chromotography Sapphire prism provides high thermal conductivity Stop flow capability SPR maximize the performance and throughput of the SPR instrument. Easy to operate and maintain, the autosampler automatically injects your samples while you do other work or leave the lab allowing for 24 hours of unattended analysis time. Automatic execution of experimental protocol Inject from two 384- or 96- well plates or two 48- vial trays Sample cooling to 40 C The Reichert Semi-Automatic Valve is electronically actuated and Programmable Syringe Pump computer-controlled through Reichert s Data Acquisition software, providing extremely uniform sample injections. The sample loop is manually filled, but the computer controls the injection time by automatically switching the injection valve. Easy to choose any loop size aspirate extremely small sample volumes into the flow cell A precision syringe pump is and can pump forward/reverse very quickly to mimic constant essential for optimum performance. flow conditions. This provides the capability to immobilize a The Reichert SR7500 syringe pump molecule of interest despite limited sample volumes. offers high precision flow with an Wide flow rate range (0.1 to 3000 μl/min) extremely wide flow rate range to Automated refills suit the application, e.g. slow flow Different sized syringes (0.5, 1, 5 ml) for equilibrium measurements or Forward/reverse push/pull fast flow for mass-transport limited Software control applications. The pump can also Real-time, High Quality, Publication-Ready Data The high sensitivity and low noise characteristics of Reichert SPR systems provide high quality kinetic and equilibrium data for interactions of interest. Easy-to-use data acquisition software makes it simple to set up instrument operating parameters, monitor/record experiment data in real time, and efficiently save/analyze data. The Reichert SPR system is designed to use low-cost, off-theshelf HPLC fittings and tubing, allowing for easy changeover. The system accommodates a wide range of sample compositions (from salt solution to cell lysates), varying viscosities, and particulate matter. The tubing is compatible with an array of solvents and easy to replace if damaged, blocked, or clogged. HPLC structure/setup Tubing from 64 to 500 μm inner diameter Variable loop size 10 to 5000 μl Parallel or series flow Compatible with a wide range of solvents and samples Computer and Software The Reichert SPR instrument has a single GUI interface that integrates all system components from operation through data collection. It has the ability to interface with popular data analysis programs such as Scrubber and Clamp.

7 Innovative precision instruments for over a century Corporate Headquarters Reichert, Inc Walden Avenue Buffalo, New York USA Tel: Fax: Toll Free USA: European Headquarters Reichert Instruments GmbH Hubertusstrasse 2 D Seefeld Germany Tel: Fax: lifesciences@reichert.com