High Profile Publishing in Molecular Biology. Hélène Hodak, Marina Ostankovitch,
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1 High Profile Publishing in Molecular Biology Hélène Hodak, Marina Ostankovitch,
2 The field of Molecular Biology, inception to current trends Preparing a high profile article in Molecular Biology Behind the scenes or the role of the editor
3 Reference journals in Molecular Biology
4 Establishment of the field of Molecular Biology ~1930: First mention of molecular biology Biological problems approached using various disciplines (chemistry, physics) Problem of specificity of structure and action ~1960: Creation of the field molecular biology Creation by scientists at leading institutions in USA (Caltech Institute, CA) and Europe (Medical Research Council laboratory, UK; Pasteur Institute, France; Max-Plank, Germany; Israel; Italy; Switzerland; ) Founding disciplines Structural biology (X-ray crystallographers) Perutz, Kendrew, Crick, Watson Microbiology and Genetics as microbial (molecular) genetics Monod, Jacob, Brenner Biochemistry, as enzymology or protein chemistry (Sanger, Monod) Biophysics Embryology
5 First multidisciplinary Life Science journal focused on Molecular Biology Journal of Molecular Biology: 1959 founded by Sir John Kendrew, Medical Research Council laboratory (Cambridge, UK), Nobel Prize winning biochemist and crystallographer
6 The field of Molecular Biology is managerial, problem oriented, and multidisciplinary New fundamental research enterprise, closely related to physics, relying on expensive instrumentation Funds administered by centralized agencies rather than universities (National public and private Science, Technologies and Research agencies and institutions) Caltech Rockefeller Foundation National Science Foundation National Institutes of Health Pasteur Institute Medical Research Council Laboratory European Molecular Biology Organization
7 The field of Molecular Biology is managerial, problem oriented, and multidisciplinary Relevance to medicine and capable of eventually bringing medical benefits a given number of problems which are among the most important in pathology seem to come directly under the jurisdiction of molecular biology... above all, the problem of cancer is obviously a molecular biology problem (Strasser BJ, 2002) Integration of multiple disciplines to approach fundamental problems of life Function and cellular significance of molecular interactions Structure function relationship
8 Disciplines in Molecular Biology Since inception Microbiology Molecular genetics Later included Molecular Cell biology Genetics and Epigenetics Structural Biology Biochemistry, enzymology, protein chemistry Biophysics Embryology Developmental biology (Regenerative medicine, Stem Cell biology, Aging ) Engineering Computational Biology Synthetic Biology
9 Multi-disciplinary to inter-disciplinary research Multidisciplinary research uses multiple disciplines to address a problem from each of their perspectives. The research is collaborative but a separation between the disciplines remains. Interdisciplinary research integrates multiple disciplines to create new instruments, models, approaches. New understanding is achieved by creating a new way of raising new questions.
10 Current approaches in Molecular Biology Diversification of biological samples (from test tube to cells, organs, whole organisms, cohorts) allows basic to translational science studies Smaller samples (miniaturization) Improvement of biological models and higher relevance to biology and medicine (in-vitro, in-silico, in-situ, ex-vivo, in-vivo, human health and disease samples..) Higher relevance of cellular environment of in vitro models (3D culture, microfluidics techniques, engineering of matrices and cellular media) More powerful and quantitative technologies (better resolution, more efficient) single cell, single molecule, time-resolved crystallography, microcrystals, deep-sequencing (detecting fewer number of copies), super-resolution imaging
11 Current approaches in Molecular Biology Structural biology: Nuclear Magnetic Resonance, Time-Resolved Crystallography, crystallography in microplates, cryo-electron microscopy Computational biology, bioinformatics, statistics: predictive, modelling, reconstruction studies of molecular interactions in biological systems using larger scale datasets. Automation, high-throughput and systematic studies allow large scale analyzes of systems and networks (proteomics, genomics, transcriptomics, metabolomics, ) Imaging, kinetics and computational studies address spatiotemporal and dynamic aspects of biological questions Single molecule analysis: optical/magnetic tweezers, atomic force microscopy, fluorescence spectroscopy, Förster resonance energy transfer High order genomic structure, Chromosome Conformation Capture and variants
12 Current trends in Molecular Biology The Molecular and Cellular Mechanisms of Amyloidosis Molecular Effects of Naturally Occurring Genetic Differences Allosteric Interactions and Biological Regulation Regulation of DNA Replication and Genomic Instability Non-coding RNAs in Systems Antiviral Innate Immunity
13 Current trends in Molecular Biology Emerging concepts in epigenetic signaling Functional and mechanistic aspects of ion channels Molecular mechanisms of microbiota Functional relevance and dynamics of nuclear organization
14 The field of Molecular Biology, inception to current trends Preparing a high profile article in Molecular Biology Behind the scenes or the role of the editor
15 Preparing a high profile article in Molecular Biology Before you start writing Conception of your research project Novelty Biologically significance Reproducibility Combine and integrate approaches to make new discoveries Choosing the right journal and the format of your paper Who is the journal s audience? How fast does the journal make a decision and publish your paper? What is the appropriate format of your paper? : Research article, Communication, Brevia, Method Notes, Database.
16 Preparing a high profile article in Molecular Biology Writing your manuscript Title: appealing, stating the main finding Figures and legends: self-explanatory, in logical order Highlights: 4-5 key sentences (background, results, conclusion) Abstract: includes background, highlights main findings and relevance Pre-submission Clarity, objectivity and accuracy (direct and short sentences, avoid multiple statements) Avoid over-interpretation Cite fairly all reference articles Cover letter explains additional research rational and specific circumstances Recommend Reviewers
17 The field of Molecular Biology, inception to current trends Preparing a high profile article in Molecular Biology? Behind the scenes or the role of the editor
18 Editorial Process Authors Scientific Editors Triage Oversee and smoothen review process Invitation of referees Provide guidance during decision making JMB office Scientific editors Academic Editors Expert evaluation Invitation of referees Make decision Editor in chief Editorial Board & Guest Editors Associate Editors Referees
19 Peer-review process at JMB Initial screening by the Editors Editorial rejection Peer review 1 >75% Reject Revise Accept 50% 2% Major revision Minor revision Peer review 2 Reject Accept
20 Manuscripts turnaround Turnaround time from submission to acceptance: 75 days Editorial Rejection: 3 days From submission to 1 st decision: 4 weeks Revision: Minor: 1 month Major: 2 months From re-submission to final decision: 2 weeks
21 Summary Role of the scientific editors Shape the content of the journal Work with the Editor-in-chief and academic editors Selection of articles suitable to the journal Commission of special content Work with Editorial Board Members during entire review process Oversee and smoothen entire review process Provide guidance to and ensure communication with authors, academic editors, and other stakeholders during the publishing process Promote content Featured articles & commentaries Editorials
22 Thank you Amy Keating, Associate Professor of Biology, MIT, Editorial Board Member Elizabeth Gaskell, Scientific Editor at Molecular Cell Daniel Day, co-chair of committee Academics, Research, & Careers, Graduate Student Council at MIT Ryan Bailey, Research Focus, Elsevier Peter Wright, Professor, Department of Integrative Structural and Computational Biology, The Scripps Research Institute, Editor-in-Chief of JMB Editorial Board Members at JMB Bart Wacek, Publishing Director, Elsevier Lucia Franco, Executive Publisher, Elsevier
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