UNIVERSITY OF ZAGREB SCHOOL OF MEDICINE. Plan of the course. Medical and Molecular Biology. Academic year 2017/2018. prof. dr. sc.

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1 UNIVERSITY OF ZGRE SCHOOL OF MEDICINE Plan of the course Medical and Molecular iology cademic year 2017/2018

2 I. COURSE IMS The course Medical and Molecular iology presents to students the basics of the contemporary knowledge about biological processes which is rapidly changing in accordance to the scientific progress in biomedical sciences. earing in mind their medical orientation and their future work in the medical practice, modern biological concepts are presented in an integrated manner using important medical examples. fter mastering this subject, students should be able to follow new trends in biomedical sciences important for full understanding of preclinical and clinical subjects and latest achievements in diagnostics and therapy. Study of the biological science in our medical school traditionally covers cell biology, molecular biology, developmental biology and genetics. Students are learning about the internal organisation of the prokaryotic and eukaryotic cell at its ultrastructural and molecular level and about cellular and molecular interactions in a multicellular organism. The principles and molecular basis of developmental processes in an embryo (growth, differentiation and morphogenesis) and in an adult multicellular organism are addressed as well as the consequences of their deregulation (malformations, cancer). Reproductive cloning and transgenic organisms are addressed. Developmental potential of embryonic cells and their nuclei, therapeutic cloning and reversal of differentiated cells to the pluripotency are put in the context of tissue engineering, cell and tissue replacement therapy for regenerative medicine. oth classical Mendelian and molecular genetics/epigenetics are studied in the context of the latest achievements in molecular biology. Importance of the DN technology and genomics, epigenomics, transcriptomics and proteomics research for the diagnostics and individualized therapy of human disorders is addressed. II. COURSE STRUCTURE Course hours: : 30 : 45 : 45 Total hours: 120 In lectures given by experienced teachers students can learn about the most important fundamental biological discoveries and concepts and their significance for human diseases and treatment. special accent is put on individual work of every student in laboratory exercises where various biological processes as well as modern research methods and diagnostic techniques are presented in order to develop practical skills. In seminars students are encouraged to actively present important topics alone or in teams, discuss and solve problems related to human diseases. III. PLN OF THE COURSE ND COURSE SCHEDULE LOCKS OF THE COURSE Number of blocks: 1 lock number Start End LOCKS OF THE COURSE Number of blocks: 1 lock number Start End

3 LOCKS OF THE COURSE SHEME lock 1 Date Time Group Course :00-10:30;, iology today, molecular biology of the cell 10:30-11:15;, iology today, molecular biology of the cell 13:00-15:15; Studying the cell (microscopy) :00-19:15; 09:00-10:30; 13:00-14:30; :00-09:45; 09:45-12:00; 09:45-11:15; 12:00-14:15; 12:00-13:30; :00-08:45; 08:45-11:00; 08:45-11:00; 12:00-14:15; 12:00-14:15; :00-10:15; Studying the cell (microscopy), C ell membrane Studying the cell (cytology, immunohistochemistry) Prokaryotic and eukaryotic cell Studying the cell (cytology, immunohistochemistry) Prokaryotic and eukaryotic cell, Internal organization of the cell Studying semipermeability Protein sorting, vesicular traffic Studying semipermeability Protein sorting, vesicular traffic, Organelles, energy conversion Erythrocytes, white ghosts The cytoskeleton Erythrocytes, white ghosts The cytoskeleton DN isolation, electrophoresis, blots (nucleic acids, proteins) Katušić ojanac, Katušić ojanac, Katušić ojanac, Paić Katušić ojanac, nja Kafka, mag. sc. na Katušić ojanac Paić nja Kafka, mag. sc. na Katušić ojanac, izv. Nikuševa-, izv. Nikuševa-, izv. prof. dr. sc.

4 Date Time Group Course :00-10:15; Kompjutorska učionica 10:15-12:30; 10:15-12:30; 14:30-15:15; Wickerhauser 08:30-09:30;, SVI Exam 1 EXM 08:30-09:30; SVI Exam 1 EXM 09:30-11:00; 11:00-13:15; 13:15-15:30; :00-10:30; 13:00-14:30; :00-10:30; Wickerhauser,, Transcription, reverse transcription, translation DN isolation, electrophoresis, blots (nucleic acids, proteins) Transcription, reverse transcription, translation From DN to proteins, the central dogma of molecular biology, DN replication The cell cycle and programmed cell death, regulation Phases of the cell cycle (interphase, mitosis Phases of the cell cycle (interphase, mitosis iology of the reproduction, Early embryonic development Meiosis, gametogenesis, fertilization iology of the reproduction Meiosis, gametogenesis, fertilization iology of the reproduction, Early development, morphogenesis, induction C leavage, embryo transfe Transgenic organisms C leavage, embryo transfe Paić, izv. prof. dr. sc., nja Kafka, mag. biol. exp., doc. dr. sc. na Katušić ojanac, izv. prof. dr. sc. Ljiljana Šerman, doc. dr. sc. Nino, izv. Nikuševa-, izv. Nikuševa-, izv. Nikuševa-, izv. Nikuševa- Katušić ojanac Katušić ojanac, Katušić ojanac,

5 Date Time Group Course 13:00-14:30; Kompjutorska učionica :00-10:30; 13:00-15:15; :00-13:30; Transgenic organisms, Genetics of developmental processes :45-12:00; 09:45-12:45; 12:00-15:00; 15:00-15:45; :00-11:00; 13:00-16:00; 17:00-18:30; :00-08:45; Wednesday :30-09:30; 08:30-09:30; 12:00-13:30; Kompjutorska učionica Developmental stages, experimental in vitro models of development Inductive interactions, critical phases of the mammalian development Developmental stages, experimental in vitro models of development Inductive interactions, critical phases of the mammalian development Differentiation, differential gene activity Differentiation, differential gene activity, Genetics, Mendelian and Molecular Differentiated cells Phenotype, genotype, patterns of inheritance Phenotype, genotype, patterns of inheritance Differentiated cells, Independent assortment, X-linkage Monogenic and polygenic human disorder Monogenic and polygenic human disorder, Genomics (human and other genomes), recombinant DN technology, Genetics of prokaryotes, biotechnology SVI Exam 2 EXM SVI Exam 2 EXM Linkage and recombination, recombinant DN technology, nja Kafka, Katušić ojanac, nja Kafka, Katušić ojanac, nja Kafka,, nja Kafka,, prof. dr. sc. Nives,, doc. dr. sc. na Katušić ojanac, prof. dr. sc. Maja Vlahović,, nja Kafka, mag. biol. exp.

6 Date Time Group Course 14:30-15:15; laboratorij 16:15-17:00; laboratorij 16:15-17:45; Kompjutorska učionica Thursday :30-14:15; Nova vijećnica 14:30-16:45; Mikroskopirnica 2 16:45-19:00; Mikroskopirnica 2 Friday :30-11:00; 14:30-16:45; :30-16:00; 16:45-19:00; Human DN fingerprinting (results) Human DN fingerprinting (results) Linkage and recombination, recombinant DN technology, Mutations, molecular mechanisms acterial transformation acterial transformation, C ontrol of gene expression acterial transformation, results, chromosomes, cytogenetics Procaryotic and eukaryotic gene acterial transformation, results, chromosomes, cytogenetics 16:45-18:15; Procaryotic and eukaryotic gene 09:00-09:45;, Molecular biology of cancer 09:45-12:00; Experimental tumorigenesis, teratoma, teratocarcinoma 09:45-12:00; Molecular iology in Medicine 12:00-14:15; Molecular iology in Medicine 12:15-14:30; 08:30-10:45; 10:45-13:00; 10:45-12:15; 13:00-13:45; 14:00-15:30; Experimental tumorigenesis, teratoma, teratocarcinoma Primary culture, subcultivation Primary culture, subcultivation, Gene therapy Genetic and epigenetic mechanisms of tumorigenesis Genetic and epigenetic mechanisms of tumorigenesis Katušić ojanac, izv. prof. dr. sc. Paić, izv. prof. dr. sc. Tamara Nikuševa- nja Kafka, mag. sc. na Katušić ojanac nja Kafka, mag. biol. exp., izv. prof. dr. sc. Ljiljana Šerman Katušić ojanac, nja Kafka,, nja Kafka, nja Kafka, mag. sc. na Katušić ojanac nja Kafka, mag. sc. na Katušić ojanac

7 Date Time Group Course Wednesday Thursday Friday :00-09:45; 10:00-11:30; 10:00-11:30; Wickerhauser 09:00-11:15; (C) - Šercer 09:00-11:15; 13:00-14:30; 14:30-16:45; 14:30-16:45; 10:30-11:30; 10:30-11:30;, C loning C ell culture C ell culture, Regenerative medicine. Mapping of the human genome, structural and functional genomics Regenerative medicine. Mapping of the human genome, structural and functional genomics Molecular biology, genomics, proteomics and the future of medicine Mammalian cloning, ethical considerations Mammalian cloning, ethical considerations SVI Exam 3 EXM SVI Exam 3 EXM 09:00-10:00; Nova vijećnica SVI Exam EXM 09:00-10:00; SVI Exam EXM Nova vijećnica 09:00-10:00; :00-11:15; 09:00-10:00; :00-10:00; SVI Exam EXM SVI Exam EXM SVI Exam EXM SVI Exam EXM SVI Exam EXM SVI Exam EXM SVI Exam EXM SVI Exam EXM SVI Exam EXM Katušić ojanac Paić Katušić ojanac, izv. prof. dr. sc.,, nja Kafka,, prof. dr. sc. Maja Vlahović, prof. dr. sc. Floriana, doc. dr. sc. na Katušić ojanac prof. dr. sc. Maja Vlahović, doc. dr. sc. Nino, izv. Nikuševa-, doc. dr. sc. na Katušić ojanac

8 and seminars will take place in halls Šalata 3. Practicals will take place at the Department of iology. IV. EXMINTIONS. Examination: Written and oral Written exam is divided in three compulsory multiple-choice tests, taking place during the course (1, 2, and 3). fter the course, students may take exams (multiple-choice tests) which they failed and after passing must take the oral exam. Once passed, any part or whole written examination needs not to be taken again except when the student refuses the final grade at the oral examination..types of examination and examination dates 1) Obligatory partial multiple-choice tests or partial exams (1, 2, 3) during the course a) b) c) ) Multiple-choice and final oral exam Regular terms Date Winter Summer utumn V./I. LIST OF LECTURERS ND TECHING STFF 1. prof. dr. sc. Maja Vlahović Katušić ojanac 6. Paić nja Kafka,

9 9. V./II EXTERNL SSOCITES: V./III UNTENURED LECTURERS: VI. LITERTURE 01. G.M.Cooper, Hausman R.E.7th ed (2016): The Cell, a Molecular pproach, SM Press, Sinauer ssociates, Washington DC, Sunderland, Massachusetts. dditional 01.. lberts,. Johnson, J. Lewis, M. Raff, K. Roberts, P. Walter (2008) : Molecular iology of the Cell, Fourth Edition, Garland Publishing, Inc., New York & London 02. P. Turnpenny, S. Eliard (2012): Emery s Elements of Medical Genetics, 14th Edition, Churchill Livingstone, Edinburgh, London, New York, selected chapters NOTE: Consultations are held by all lecturers and assistants every for 1hr after the last session