Kollidon SR: A polyvinyl acetate based excipient for DCsustained-release
|
|
- Herbert Baker
- 6 years ago
- Views:
Transcription
1 Kollidon SR: A polyvinyl acetate based excipient for DCsustained-release oral dosage forms by Dr. Bernhard Fussnegger BASF Aktiengesellschaft, Ludwigshafen Strategic Marketing Pharma Excipients Introduction Sustained-release oral dosage forms are in the focus of interest for several reasons. Customer compliance with the trend to simplicity and more comfort of use, the prolonged drug release with more reliable blood levels than those obtained with conventional dosage forms and life-cycle management of existing APIs directed the pharmaceutical development towards sustained release formulations [1, 2]. Due to the permanent cost pressure for newly developed pharmaceutical formulations the selection of the right excipient becomes a very crucial factor. No doubt that the production of a sustained release dosage form by direct compression offers several advantages such as rapid and easy formulation processes in combination with reduced manufacturing costs. Existing polymers for sustained-release formulations show some draw-backs and none of them can be used easily for direct compression technology. These reasons led BASF to develop a series of new excipients based on polyvinyl acetate for an easy and more reliable formulation of sustained-release oral dosage forms. The product for the DC-Technology is Kollidon SR Kollidon SR: Product Properties Kollidon SR is derived from a polyvinyl acetate-dispersion (Kollicoat SR 30D) and appears as a spray dried, non hygroscopic powder consisting of polyvinyl acetate (8 parts w/w) and polyvinyl pyrrolidone (2 parts w/w). As shown in table 1 the product proofs to have excellent flow properties. The angle of repose was determined to be far below 30 and the flow time of 150 ml powder passing a Pfrengle-funnel was fast and consistent. Table 1: Powder properties of Kollidon SR Angle of repose 21,0 Flow time 9,5 s Bulk density 0.37 [g/ml] Tap density 0.44 [g/ml] Hausner ratio 1.13 Medium particle size approx. 100 µm The powder properties such as bulk and tap density was determined using an Erweka SVM volumeter, the angle of repose and the flow time were measured with a Pfrengle funnel. The particle size was investigated by means of a Malvern Mastersizer.
2 These product characteristics allow Kollidon SR to be used in the manufacture of direct compressed, non-erodible tablets and when considering the bulk and tap densities, only small variations of the tablet weight are expected. Due to the extreme dry-binding capacity, matrix tablets can be achieved either with a high apparent density or they can be manufactured as very porous, floating systems with apparent densities below 1.0 [g/cm 3 ]. The latter dosage form is particularly suitable when a drug is intended to exert its actions locally in the stomach or is absorbed in the stomach or upper part of the small intestine. Floating systems prolong gastric and intestinal transit time and can thereby enhance bioavailability especially for drugs with an absorption window. Sustained-Release Tablets To demonstrate the potential of Kollidon SR sustained release matrix tablets were formulated using Kollidon SR (BASF); propranolol-hcl (Formulation A), caffeine (Formulation B) (Knoll); Mg-stearate (Bärlocher); Aerosil 200 (Degussa) in the quantities listed in table 2. To manufacture the tablets the ingredients were weighed, blended for 10 min in a turbula mixer and passed through a 800 µm sieve. The mixtures were compressed using an instrumented rotary press Korsch PH 106, rotation speed 30 rpm, with the compression forces 10, 18 and 25 kn, tablet diameter 10 and 12 mm, beveled edge. Table 2: Tablet compositions with Kollidon SR and the model drugs (amount per tablet [mg]) Formulation A Formulation B Kollidon SR Propranolol-HCl Caffeine Aerosil Mg-stearate tablet weight [mg] Table 3 shows the results. The tablets with an extremely high hardness, and a low friability showed a very acceptable content uniformity. According to the chemical composition and the adjusted particle size distribution, the marked dry binding capacity in combination with the good flow properties, are regarded as additional benefits when using Kollidon SR as sustained release excipient.
3 Table 3: tablet parameters of Kollidon SR tablets (compression force 18 kn) Formulation A Formulation B Hardness [N] Hardness stand. dev. [%] Friability [%] Disintegration time [min] > 120 > 120 Content uniformity [%] Even with the highly water soluble drug caffeine the test on the release characteristics revealed a sustained-release action over a period of more than 16 h. Moderate swelling of the tablets was observed, but the tablet shape remained intact due to the water insoluble polyvinyl acetate. The release mechanism can be assumed as diffusion controlled. Furthermore it is obvious that neither different ph-values, the variation of the ionic strength or the change of the paddle speed imitating different hydrodynamic conditions, influenced the release profile of caffeine tablets with Kollidon SR (Figure 1) 100 released drug [%] time [h] 0.08 N HCl ph 1 PBS ph 7.4 PBS ph % NaCl 0.08 N HCl (2h) + PBS ph 6.8 PBS rpm Figure 1 Influence of dissolution medium on the release profile of caffeine tablets with Kollidon SR (diameter 12 mm) When checked for the influence of the compaction force on the release profile of caffeine and propranolol-hcl tablets, overall no influence could be detected. Figure 2, show the situation for propranolol-hcl formulation with Kollidon SR.
4 100,0 90,0 released drug [%] 80,0 70,0 60,0 50,0 40,0 30,0 18kN 25kN 20,0 10,0 0, time [h] Figure 2 Influence of compression force on the release profile of Kollidon SR tablets with propranolol-hcl (diameter 12 mm) When a drug is intended to exert its actions locally in the stomach or is absorbed in the stomach or upper part of the small intestine floating systems are particularly suitable. These systems prolong gastric and intestinal transit time and can thereby enhance bioavailability especially for drugs with an "absorption window". Floating Sustained-Release Systems To date only few manufacturing techniques for floating systems are known, all of them very demanding. In contrast to HPMC based floating tablets, which are observed to sink in the dissolution test medium after a certain time [3], Kollidon SR floating tablets manufactured by direct compression at very low compression forces show uniform behaviour. A formulation with the model drug diltiazem consisting of diltiazem HCl, mg, Kollidon SR, mg, Aerosil 200, 3.2 mg and Mg stearate, 3.2 mg was used for the tests. The final tablet weight was mg.
5 Compression force [kn] Apparent density [g/mm_] Floating behaviour immediately immediately immediately after 45 min/immediately after 90 min to 48 hours Table 4 Influence of compression force on apparent density and floating behaviour of Dilitiazem tablets The density of the tablets correlates with the floating behaviour (Table 4): If their density after manufacture is below 1.0g/ml they immediately float on the surface and do not sink again even during an observation period of 48 hours. When increasing the compression force the volume of the tablets asymptotically approaches a value of 300 mm_ (Figure 3), hardness increases linearly over the entire measured range. In case of a diltiazem formulation compression forces of less than 4 kn result in stable tablets with a hardness exceeding 90 N, however with the ability to float. When the formulation is compressed with around 4,5 kn, the apparent density of the diltiazem tablets approximates the density of the dissolution medium, the tablets sink. volume [mm ] hardnes [N] compression force [kn] 0 Figure 3 Hardness and tablet volume of Diltiazem tablets as a function of compression force In the range investigated the compression force has hardly any influence on the dissolution of diltiazem HCl floating tablets (Figure 3). There is thus no risk that minor deviations in compression pressure within a tablet batch would result in pronounced changes in the dissolution period.
6 Summary Kollidon SR, an excipient for drug delivery matrices based on Polyvinyl acetate, possesses good controlled release properties. The release profiles of tablet formulations with Kollidon SR were not influenced by different dissolution media or compression forces. The excellent flow properties and the dry binding activity of Kollidon SR, provide easy handling and effective development and production of sustained release tablets. By applying low compression force floating tablets with a longer residence time in the stomach can be achieved. Floating times exceeding 24 h can be achieved easily. Furthermore it can be shown that even for low compression forces dissolution is independent of the pressure applied Literature [1] M. J. Vasquez; Drug Dev. Ind. Pharm., 18; 1355, (1992) [2] U. Gundert-Remy, Oral controlled release products, WVG, Stuttgart, (1990) [3] Baumgartner S., _mid-korbar J., Physical and technological parameters influencing floating properties of matrix tablets based on cellulose ethers, S.T.P. Pharma Science 8 (5), (1998).
Pharma Ingredients & Services. Ludiflash. Technical Information
Technical Information Ludiflash March 2012 Supersedes issue dated August 2011 03_070805e-03/Page 1 of 10 = Registered trademark of BASF group Excipient for fast-disintegrating oral dosage forms Direct
More informationMaximizing Roller Compaction Benefits with Proper Excipient Selection
A sponsored whitepaper. Maximizing Roller Compaction Benefits with Proper Excipient Selection By: Bernhard Fussnegger, Global Development and Technical Marketing, PVP/Coatings, Instant & Modified Release,
More informationPharma Ingredients & Services. Ludiflash. Technical Information
Technical Information Ludiflash April 2008 Supersedes issue dated September 2007 EMP 070805e-01/Page 1 of 12 = Registered trademark of BASF SE Excipient for fast-disintegrating oral dosage forms Direct
More informationDesign of Controlled Release Non-erodible Polymeric Matrix Tablet Using Microwave Oven-assisted Sintering Technique
Pharmaceutics Design of Controlled Release Non-erodible Polymeric Matrix Tablet Using Microwave Oven-assisted Sintering Technique Patel DM Patel BK Patel A Patel CN Department of Pharmaceutics and Pharmaceutical
More informationInternational Journal of Pharmacy and Industrial Research
329 Research Article Available Online at: International Journal of Pharmacy and Industrial Research ISSN Print 2231 3648 Online 2231 3656 FORMULATION AND EVALUATION OF OLMESARTAN MEDOXOMIL FLOATING TABLETS
More informationPharma Ingredients & Services. Kollidon SR. Technical Information
Technical Information Kollidon SR July 2011 Supersedes issue dated June 2008 03_030728e-08/Page 1 of 12 = Registered trademark of BASF group Polyvinyl acetate and povidone based matrix sustained release
More informationInvestigation of a Venlafaxine HCl (37.5 mg) Extended Release Formulation Using Hypromellose (HPMC) Matrices
METHOCEL Application Data Partially Pregelatinized Maize Starch Investigation of a Venlafaxine HCl (37.5 mg) Extended Release Formulation Using Hypromellose (HPMC) Matrices ABSTRACT SUMMARY The aim of
More informationKollicoat IR. The application of Kollicoat IR as a Zero Peroxide Binder for use in Solid Oral Dosage Forms. ExcipientFest.
Kollicoat IR The application of Kollicoat IR as a Zero Peroxide Binder for use in Solid Oral Dosage Forms ExcipientFest Nigel Langley Market Need Platforms Instant & Modified Release Solubilization Skin
More informationMethacrylic acid ethyl acrylate copolymer (1:1) dispersion 30 per cent (e.g. Kollicoat MAE 30 DP)
Investigating the effect of partial neutralisation of the polymer on the dissolution characteristics of poly(methacrylic acid-co-ethyl acrylate) based coats Carolina Corell 1,3 ; Florian Bang 1 ; Thorsten
More informationResearch Paper. Development of Prolonged Delivery of Tramadol and Dissolution Translation by Statistical Data Treatment
330 International Journal of Pharmaceutical Sciences and Nanotechnology Volume 4 Issue April-June 20 Research Paper International Journal of Pharmaceutical Sciences and Nanotechnology Volume 4 Issue April
More informationCHAPTER 8: SOLID DOSAGE FORM COATING TECHNOLOGY NOOR MUHAMMAD SYAHRIN BIN YAHYA INTRODUCTION
CHAPTER 8: SOLID DOSAGE FORM COATING TECHNOLOGY NOOR MUHAMMAD SYAHRIN BIN YAHYA INTRODUCTION INTRODUCTION Coating technology is used extensively in the pharmaceutical industry, e.g. for the application
More informationContent. Imprint. Dear Reader, Ludipress LCE A new direct compression excipient. Kollidon SR Sustained release formulations of different drugs.
No. 1, May 23 Dear Reader, Content Numerous drugs that are marketed as solid oral dosage forms are available in many different potencies. The easiest way of producing a range of these is to develop formulations
More informationAhmed et al., Received- 5 February 2009 Accepted for Publication- 1 March, 2009
The Effect of Manufacturing Methods and Different Shapes on the Release Pattern of Diclofenac Sodium Matrix Tablet Tajnin Ahmed 1, Muhammad Shahidul Islam 2*, Tasnuva Haque 1, Mohammad Abusyed 3 1 Department
More informationInvestigation of Aqueous Ethylcellulose Dispersion in Extended Release Metformin Inert Matrices
Surelease Application Data Aqueous Ethylcellulose Dispersion Investigation of Aqueous Ethylcellulose Dispersion in Extended Release Metformin Inert Matrices ABSTRACT SUMMARY: In the present study, Surelease,
More informationPreparation and Evaluation of Sustained Release Tablet of Cyproheptadine Hydrochloride Using Carbopol and HPMC
Received: 06-01-2013 Accepted: 26-02-2013 ISSN: 2277-7695 CODEN Code: PIHNBQ ZDB-Number: 2663038-2 IC Journal No: 7725 Vol. 2 No. 1 2013 Online Available at www.thepharmajournal.com THE PHARMA INNOVATION
More informationFormulation and Evaluation of Floating Capsules of 3 rd Generation Cephalosporin
International Journal of PharmTech Research CODEN (USA): IJPRIF ISSN : 0974-4304 Vol.4, No.3, pp 986-993, July-Sept 2012 Formulation and Evaluation of Floating Capsules of 3 rd Generation Cephalosporin
More informationFormulation and Evaluation of Gastro retentive Bilayer Tablets- Glimepiride as Sustained Release and Lisinopril as Immediate Release
Farhat A et al / Int. J. of Pharmacy and Analytical Research Vol-5(4) 216 [658-669] IJPAR Vol.5 Issue 4 Oct - Dec -216 Journal Home page: ISSN:232-2831 Research article Open Access Formulation and Evaluation
More informationSoluplus. Technical Information. October _090801e-01/Page 1 of 8. = Registered trademark of BASF group. Pharma Ingredients & Services
Technical Information Soluplus October 2009 03_090801e-01/Page 1 of 8 = Registered trademark of BASF group Pharma Ingredients & Services 03_090801e-01 October 2009 Page 2 of 8 Soluplus 1. Introduction
More informationRESEARCH ARTICLE e-issn:
Available online at www.ijtpls.com International Journal of Trends in Pharmacy and Life Sciences Vol. 2, Issue: 2, 2016: 801-812. FORMULATION AND EVALUATION OF FLOATING DRUG DELIVERY SYSTEM OF ENALAPRIL
More informationNISSO HPC for Pharmaceutical Applications
NISSO HPC for Pharmaceutical Applications Contents Introduction Features of NISSO HPC Major Application of NISSO HPC NISSO HPC Grades and Availability How to use based on Application and Features of NISSO
More informationRoller Compaction: New trends, challenges and solutions
Roller Compaction: New trends, challenges and solutions TODD STUTZMAN, PHARM.D. R.PH. DIRECTOR, PHARMACEUTICS SARAH PYSZCZYNSKI, PH.D. PRINCIPAL SCIENTIST 21FEB2017 2017 Catalent Pharma Solutions. All
More informationPharma Ingredients & Services. Kollicoat IR White. Technical Information
Technical Information Kollicoat IR White August 2008 Supersedes issue dated June 2008 EMP 040901e-10/Page 1 of 12 = Registered trademark of BASF SE Ready-to-use coating for instant-release dosage forms
More informationFormulation and Evaluation of Telmisartan with Hydrochlorothiazide Conventional Release Tablets
Human Journals Research Article July 2018 Vol.:12, Issue:4 All rights are reserved by S. Meena et al. Formulation and Evaluation of Telmisartan with Hydrochlorothiazide Conventional Release Tablets Keywords:
More informationInternational Journal of Research in Pharmaceutical and Nano Sciences Journal homepage:
Research Article CODEN: IJRPJK ISSN: 2319 9563 International Journal of Research in Pharmaceutical and Nano Sciences Journal homepage: www.ijrpns.com FORMULATION AND EVALUATION OF ESOMEPRAZOLE MAGNESIUM
More informationTypical excipients in a tablet formulation. Glidant SiO 2
Development of a lubricant coated binder Dr. Reinhard Vollmer Technical Competence Center JRS Pharma, HQ Holzmühle GERMANY Typical excipients in a tablet formulation Binder Lubricant Disintegrant MCC Na
More informationDESIGN AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF LEVOFLOXACIN EMPLOYING ALMOND GUM
Int. J. Chem. Sci.: 12(3), 14, 762-772 ISSN 0972-768X www.sadgurupublications.com DESIGN AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF LEVOFLOXACIN EMPLOYING ALMOND GUM K. V. R. N. S. RAMESH *,
More informationEffect of Various Sustained Release Polymers on Naproxen Sodium Release from Control Release Tablets
International Journal of Pharmacy Teaching & Practices 3, Vol.4, Issue, 636-643. Effect of Various Sustained Polymers on Sodium from Control Tablets Md. Shamim Akhter *, Md. Amir Hossain, Emran Hossain
More informationUniversity of Sulaimani College of Pharmacy Dept. of Pharmaceutics 5 th stage Second Semester
University of Sulaimani College of Pharmacy Dept. of Pharmaceutics 5 th stage Second Semester 2/26/2018 Industrial Pharmacy II, Dr. rer. nat. Rebaz Ali 1 Outlines Powder flow Introduction Factor affecting
More informationProviding insight into pharmaceutical formulations
Providing insight into pharmaceutical formulations Dr Steve Ward-Smith Pharmaceutical Industry The average cost of developing a drug is reported to be approx $500 million, but up to 70% of new chemical
More informationRaman mapping to identify dry and wet states of pharmaceutical components in a hydroxypropyl methylcellulose (HPMC) hydrophilic matrix tablet
Raman mapping to identify dry and wet states of pharmaceutical components in a hydroxypropyl methylcellulose (HPMC) hydrophilic matrix tablet By Yewande Oni Formulation Insights Group School of Pharmacy
More informationPHARMACEUTICAL TECHNOLOGY REPORT. Introduction. Experimental Methods
PHARMACEUTICAL TECHNOLOGY REPORT Consumer Specialties ashland.com PTR-079 Page 1 of 5 Advantages of Hot Melt Extrusion for the Controlled Release of High Doses of Highly Soluble Actives E. Pinto, H. Yang,
More informationThe Role of Polymer Excipients in Hot Melt Extrusion A Continuous Manufacturing Process
The Role of Polymer Excipients in Hot Melt Extrusion A Continuous Manufacturing Process Nigel Langley ExcipientFest May 1, 2018 Hot-Melt Extrusion A Continuous Manufacturing Process Principle of HME 2
More informationFORMULATION AND EVALUATION OF ROPINIROLE SUSTAINED RELEASED TABLETS BY USING NATURAL AND SYNTHETIC POLYMERS
International Journal of Pharmacy Review & Research www.ijprr.com FORMULATION AND EVALUATION OF ROPINIROLE SUSTAINED RELEASED TABLETS BY USING NATURAL AND SYNTHETIC POLYMERS V.Naga Manoj kiran 1*, Arun
More informationf a c t s T C C T B Tricalcium citrate as excipient for direct compression
f a c t s T C C T B Tricalcium citrate as excipient for direct compression Direct compression has gained enormous popularity in tablet manufacturing in recent times. It is seen as the most economic process
More informationQUALITY OF PROLONGED RELEASE ORAL SOLID DOSAGE FORMS
QUALITY OF PROLONGED RELEASE ORAL SOLID DOSAGE FORMS Guideline Title Quality of Prolonged Release Oral Solid Dosage Forms Legislative basis Directive 75/318/EEC as amended Date of first adoption October
More informationHydroxypropylcellulose Polymer Molecular Weight: Influence on Erodible Modified Release Matrix Systems By T. Dürig, W.W. Harcum, and R. A.
PHARMACEUTICAL TECHNOLOGY REPORT Consumer Specialties ashland.com PTR-032-1 (Supersedes PTR-032) Page 1 of 7 Hydroxypropylcellulose Polymer Molecular Weight: Influence on Erodible Modified Release Matrix
More informationCo-Processed Lactosebased excipients for Direct Compression. Ulrich Marcher Meggle GmbH & Co. KG, Germany
Co-Processed Lactosebased excipients for Direct Compression Ulrich Marcher Meggle GmbH & Co. KG, Germany Co-processed Excipients Definition: two or more by an appropriate process Aim: Formation of excipients
More informationThe Pharmaceutical and Chemical Journal, 2015, 2(1): Research Article
, 2015, 2(1):51-58 Available online www.tpcj.org Research Article ISSN: 2349-7092 CODEN(USA): PCJHBA Formulation and Evaluation of Gastroretentive Tablet of Ondansetron hydrochloride Using 3 2 Factorial
More informationPharma Ingredients & Services. Kollidon VA 64 Kollidon VA 64 Fine. Copovidone Ph.Eur., USP, Copolyvidone JPE. Technical Information
Technical Information June 2008 Supersedes issue dated October 2007 EMP 050602e-05/Page 1 of 16 Kollidon VA 64 Kollidon VA 64 Fine Copovidone Ph.Eur., USP, Copolyvidone JPE = Registered trademark of BASF
More informationInternational Journal of Pharmacy
International Journal of Pharmacy Journal Homepage: http://www.pharmascholars.com Research Article CODEN: IJPNL6 FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF RANOLAZINE M Vanaja kumari
More informationTaste Masked Orodispersible Formulation of Fexofenadine Hydrochloride Using Ion Exchange Resins
Research Paper Taste Masked Orodispersible Formulation of Fexofenadine Hydrochloride Using Ion Exchange Resins DIVYA SUARES* AND ARTI HIRAY Shobhaben Pratapbhai Patel School of Pharmacy and Technology
More informationTable 1. Particle size distributions and peroxide levels of various superdisintegrants. D50 (μm) D10 (μm)
PHARMACEUTICAL TECHNOLOGY REPORT Consumer Specialties ashland.com PTR-97 Page 1 of 5 Utility of Polyplasdone crospovidone as a Superdisintegrant Quyen Schwing, Marvin Davis, Divya Tewari, Thomas Dürig
More informationFormulation and Evaluation of Gastro Retentive Tablet of Ondansetron hydrochloride Using 3 2 Factorial Design
Received on 03/01/2012; Revised on 16/01/2012; Accepted on 09/02/2012. Formulation and Evaluation of Gastro Retentive Tablet of Ondansetron hydrochloride Using 3 2 Factorial Design Naruka P S*, Meena M
More informationFORMULATION AND EVALUATION OF RANITIDINE FLOATING TABLETS
INTERNATIONAL JOURNAL OF PHARMACEUTICAL, CHEMICAL AND BIOLOGICAL SCIENCES Available online at www.ijpcbs.com Research Article FORMULATION AND EVALUATION OF RANITIDINE FLOATING TABLETS K. Kavitha*, Narendra
More informationNew Developments in Spray-Dried Lactose
New Developments in Spray-Dried Lactose Gerad Bolhuis, Klaas Kussendrager, and John Langridge* Recent advances in spraydrying technology have led to the production of new directly compressible lactose
More informationThe research work highlights the development and evaluation of. bioavailability of drugs. The buccal route can bypass the first-pass
212 9. Summary, conclusion and recommendation 9.1 Summary and conclusion The research work highlights the development and evaluation of novel transbuccal drug antagonist of Famotidine. route have a rapid
More informationPHARMACEUTICAL TECHNOLOGY REPORT. Introduction. Experimental Methods
PHARMACEUTICAL TECHNOLOGY REPORT Consumer Specialties ashland.com PTR-81 Page 1 of 5 Hot Melt Extrusion with Klucel hydroxypropylcellulose HPC for the Controlled Release of High Doses of a Highly Soluble
More informationRajesh Kaza. et al /J. Pharm. Sci. & Res. Vol.1(4), 2009,
Design and Evaluation of Sustained release Floating tablets for the treatment of Gastric Ulcers Rajesh Kaza* 1, E. Usharani 2, R.Nagaraju 2, R.Haribabu 3 and P.V.Siva Reddy 4 1* Sree Vidyanikethan College
More informationFormulation and in vitro evaluation of captopril floating tablets by using natural polymers
2018; 7(8): 82-89 ISSN (E): 2277-7695 ISSN (P): 2349-8242 NAAS Rating: 5.03 TPI 2018; 7(8): 82-89 2018 TPI www.thepharmajournal.com Received: 11-06-2018 Accepted: 13-07-2018 Ayesha Salma Habeeb Department
More informationInternational Journal of Research in Pharmaceutical and Nano Sciences Journal homepage:
Research Article CODEN: IJRPJK ISSN: 2319 9563 International Journal of Research in Pharmaceutical and Nano Sciences Journal homepage: www.ijrpns.com FORMULATON AND EVALUATION OF RAMIPRIL IMMEDIATE RELEASE
More informationFORMULATION DEVELOPMENT AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF VERAPAMIL HYDROCHLORIDE
IJPSR (2014), Vol. 5, Issue 5 (Research Article) Received on 09 December, 2013; received in revised form, 19 April, 2014; accepted, 29 April, 2014; published 01 May, 2014 FORMULATION DEVELOPMENT AND EVALUATION
More informationKollidon The Original Setting new standards in stability, purity and patient safety.
Kollidon The Original Setting new standards in stability, purity and patient safety. Now with new PeroXeal packaging Bernhard Fussnegger, an enabler in excipients Pharma Ingredients & Services. Welcome
More informationStreamlined Manufacture of Modified Release Matrix Tablets via Direct Compression. Katie Hewlett, Dow Gus LaBella, Colorcon
Streamlined Manufacture of Modified Release Matrix Tablets via Direct Compression Katie Hewlett, Dow Gus LaBella, Colorcon Controlled Release Alliance Unique Together Leading polymer expertise Quality
More informationFormulation and in-vitro evaluation of pregabalin mini tablets for sustained release
Available online at www.scholarsresearchlibrary.com Scholars Research Library Der Pharmacia Lettre, 2016, 8 (2):277-283 (http://scholarsresearchlibrary.com/archive.html) ISSN 0975-5071 USA CODEN: DPLEB4
More informationEffect of Hydrophobic Polymers on the Gastro Retention Time and In vitro Release of Ciprofloxacin HCl from Co-matrix Tablets
Effect of Hydrophobic Polymers on the Gastro Retention Time and In vitro Release of Ciprofloxacin HCl from Co-matrix Tablets Muhammad Shahidul Islam 1, Kumar Bishwajit Sutradhar 2, Jakir Ahmed Chowdhury
More informationDeconvoluting Amorphous Solid Dispersion Dissolution
Deconvoluting Amorphous Solid Dispersion Dissolution Jonathan Booth Formulation Science Section AstraZeneca Macclesfield PhysChem Forum 11 Meeting Nottingham, September 21 st 2011 Whats the Problem? ~
More informationBrahmaiah Bonthagarala *, Prasanna Kumar Desu, Sreekanth Nama, Donthiboina Sudarshan
e - ISSN XXXX-XXXX Print ISSN - XXXX-XXXX Singapore Journal of Pharmaceutical Research Journal homepage: www.mcmed.us/journal/sjpr FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF OZCARBAZEPINE
More informationPharma & Food Solutions. ETHOCEL One of the Few Water-Insoluble Polymers Approved for Global Pharmaceutical Applications
Pharma & Food Solutions ETHOCEL One of the Few Water-Insoluble Polymers Approved for Global Pharmaceutical Applications ETHOCEL Premium Polymers are essentially tasteless, colorless, odorless, noncaloric
More informationPharma Ingredients & Services. Soluplus. Technical Information. = Registered trademark of BASF group. July 2010 Supersedes issue dated May 2010
Technical Information Soluplus July 21 Supersedes issue dated May 21 3_981e-4/Page 1 of 8 = Registered trademark of BASF group Pharma Ingredients & Services 3_981e-4 July 21 Page 2 of 8 Soluplus 1. Introduction
More informationFORMULATION AND EVALUATION OF CONTROLLED RELEASE DELIVERY OF TRAMADOL HYDROCHLORIDE USING FULL FACTORIAL DESIGN
International Journal of ChemTech Research CODEN( USA): IJCRGG ISSN : 0974-490 Vol., No.1, pp 669-675, Jan-Mar 010 FORMULATION AND EVALUATION OF CONTROLLED RELEASE DELIVERY OF TRAMADOL HYDROCHLORIDE USING
More informationIn the present investigation, suitability of a cost effective and convenient granulation technique that is, moisture activated
Original Article Application of a convenient and cost effective granulation technology for the formulation of tablets using conventional excipients Nidhi Prakash Sapkal, Vaishali A. Kilor, Minal Nandkumar
More informationInternational Journal of PharmTech Research CODEN (USA): IJPRIF, ISSN: Vol.7, No.1, pp ,
International Journal of PharmTech Research CODEN (USA): IJPRIF, ISSN: 0974-4304 Vol.7, No.1, pp 139-147, 2014-2015 Pharmaceutical Prospective Process Validation Of Chloroquiune Tablets Vilas S Jadhav*,
More informationHuman Journals Research Article October 2018 Vol.:13, Issue:3 All rights are reserved by Gourishyam Pasa et al.
Human Journals Research Article October 2018 Vol.:13, Issue:3 All rights are reserved by Gourishyam Pasa et al. Formulation Development and In-Vitro Evaluation of Sustained-Release Gastro Retentive Tablets
More informationFormulation and Evaluation of Captopril. Gastroretentive Floating Drug Delivery System
INTERNATIONAL JOURNAL OF ADVANCES IN PHARMACY, BIOLOGY AND CHEMISTRY Formulation and Evaluation of Captopril Research Article Gastroretentive Floating Drug Delivery System Swalin Parija* Institute of Pharmacy
More informationKollidon VA 64. Technical Information. Copovidone Ph.Eur.
Technical Information ME 080 e (939) March 2000 (MPM) Kollidon VA 64 Copovidone Ph.Eur. Register 2 = Registered trademark of BASF Aktiengesellschaft Kollidon VA 64 is a vinylpyrrolidone-vinyl acetate copolymer
More informationEffect of Granulation Technique and Drug-Polymer Ratio on Release Kinetics of Gliclazide from Methocel K4M Matrix Tablet
Effect of Granulation Technique and Drug-Polymer Ratio on Release Kinetics of Gliclazide from Methocel K4M Matrix Tablet Tanbir Ahammed 1, Moynul Hasan 2, Md. Saiful Islam 3, Muhammad Rashedul Islam 3
More informationFormulation and Evaluation of Floating Tablets Using Nimesulide as a Model Drug
International Research Journal of Engineering and Technology (IRJET) e-issn: 2395-56 Volume: 4 Issue: 9 Sep -217 www.irjet.net p-issn: 2395-72 Formulation and Evaluation of Floating Tablets Using Nimesulide
More informationFORMULATION AND EVALUATION OF ACECLOFENAC MATRIX TABLETS USING ETHYL CELLULOSE AND CELLULOSE ACETATE PHTHALATE
M. Vijaya Laxmi et al. / JGTPS/ 5(3)-(2014) 1804-1810 ISSN: 2230-7346 (Research Article) Journal of Global Trends in Pharmaceutical Sciences Journal home page: www.jgtps.com FORMULATION AND EVALUATION
More informationImpact factor: 3.958/ICV: 4.10 ISSN:
Impact factor: 3.958/ICV: 4.10 ISSN: 0976-7908 255 Pharma Science Monitor 8(1), Jan-Mar 2017 PHARMA SCIENCE MONITOR AN INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES Journal home page: http://www.pharmasm.com
More informationInnovations in Pharmaceuticals and Pharmacotherapy
Innovations in Pharmaceuticals and Pharmacotherapy eissn: 2321 323X pissn: 2395-0781 www.innpharmacotherapy.com Research article Design and evaluation of floating gastro retentive tablets of fixed dose
More informationInternational Journal of Biomedical and Advance Research
International Journal of Biomedical and Advance Research ORAL CONTROLLED RELEASE METFORMIN HYDROCHLORIDE ION EXCHANGE RESINATE BEADS Ajit S. Raghuwanshi *1, Ajay S. Raghuwanshi 2 and U. K. Jain 2 1 Department
More informationApplication as liquid carrier
Application as liquid carrier Calcium Silicate FLORITE 1 Features High liquid absorbency and great compressibility derived from specific pore structure Stable liquid uniformity in powder with simple method
More informationTablet formulation design spaces for direct compression and roller compaction. QbD in Pharmaceutical Development: processes
QbD in Pharmaceutical Development: Tablet formulation design spaces for direct compression and roller compaction processes Morten Allesø, PhD (MSc Pharm) Pharmaceutical scientist ISPE Nordic PAT CoP, June
More informationDirect compression of cushion layered ethyl cellulose coated extended release pellets into rapidly disintegrating tablets
Research Article ISSN: 0974-6943 M.Yasmin Begum et al. / Journal of Pharmacy Research 2016,10(1), Available online through http://jprsolutions.info Direct compression of cushion layered ethyl cellulose
More informationµm - 52 µm and 79 µm - 54 µm for formulation FDS1 and FPS1, respectively.
Irritable bowel syndrome (IBS) is a mild intestinal chronic disorder associated with abdominal pain, altered bowel motility resulting in either diarrhea or constipation, and increased visceral hypersensitivity
More informationPelagia Research Library
Available online at www.pelagiaresearchlibrary.com Der Pharmacia Sinica, 2012, 3 (5):598-603 ISSN: 0976-8688 CODEN (USA): PSHIBD Formulation and evaluation of solid matrix tablets of repaglinide Jitender
More informationTricalcium citrate as excipient for direct compression
f a c t s T C C T B Tricalcium citrate as excipient for direct compression Introduction Direct compression has gained enormous popularity in tablet manufacturing in recent times. It is seen as the most
More informationPelagia Research Library
Available online at www.pelagiaresearchlibrary.com Der Pharmacia Sinica, 2010, 1 (2): 130-135 ISSN: 0976-8688 CODEN (USA): PSHIBD Formulation and Evaluation of Modified Release Trimetazidine Dihydrochloride
More informationPelagia Research Library
Available online at www.pelagiaresearchlibrary.com Der Pharmacia Sinica, 2014, 5(5):106-111 ISSN: 0976-8688 CODEN (USA): PSHIBD Formulation, characterization and in-vitro evaluation of Cefixime floating
More informationADVANTAGES OF MULTIPARTICULATES (PELLETS):
INTRODUCTION: Multiparticulate Drug Delivery Systems (MDDS): The concept of multiple unit dosage form was initially introduced in the early 1950 s.these forms play a major role in the design of solid dosage
More informationFormulation and Evaluation of Orodispersible Tablet with an Extended Release Profile
Formulation and Evaluation of Orodispersible Tablet with an Extended Release Profile Chavan Ritesh A.* and Mayee Rahul Shri Jagdish Prasad Jhabarmal Tibrewala University, Jhunjhunu, Rajasthan 333001 ABSTRACT
More informationFORMULATION AND EVALUATION OF VENLAFAXINE HYDROCHLORIDE TABLETS AS CONTROLLED RELEASE MODULES
INTERNATIONAL JOURNAL OF RESEARCH IN PHARMACY AND CHEMISTRY Available online at www.ijrpc.com Research Article FORMULATION AND EVALUATION OF VENLAFAXINE HYDROCHLORIDE TABLETS AS CONTROLLED RELEASE MODULES
More informationApplication Studies using the GTP at an Excipient Manufacturer s Laboratory
Application Studies using the GTP at an Excipient Manufacturer s Laboratory Dr. Andreas Sauer andreas.sauer@se-pfmd.com Gamlen User Meeting 22.02.2017 Outline Shin-Etsu excipients and application laboratory
More informationTABLETABILITY, COMPACTABILITY, AND COMPRESSIBILTY: WHAT S THE DIFFERENCE?
WHITEPAPER TABLETABILITY, COMPACTABILITY, AND COMPRESSIBILTY: WHAT S THE DIFFERENCE? { To patients and consumers, tablets are a simple and convenient dosage form. But the science behind compressing a block
More informationPreparation of Antipyretic Analgesic by Direct Compression and Its Evaluation
1542 Chem. Pharm. Bull. 50(12) 1542 1549 (2002) Vol. 50, No. 12 Preparation of Antipyretic Analgesic by Direct Compression and Its Evaluation Keijiro TERASHITA* and Keisuke IMAMURA Osaka Prefecture University,
More informationFORMULATION DEVELOPMENT AND EVALUATION OF FAMOTIDINE FLOATING TABLET
FORMULATION DEVELOPMENT AND EVALUATION OF FAMOTIDINE FLOATING TABLET Patel Amit* 1, Jha Sajal Kumar 1, Panchal Harishanker 2, Shukla Tarkeshwar 1, Shah Arpit 3 1 Dept. of Pharmaceutics, NIMS Institute
More informationTreatment of diabetes mellitus (DM) with conventional dosage forms is not effective as the drugs do not reach the site of
ISSN: 0975-766X CODEN: IJPTFI Available Online through Research Article www.ijptonline.com FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF GLIBENCLAMIDE Shree Ram Jayaswal 1, V. Felix
More informationPreparation and evaluation of loratadine tablets by using novel polacrilin potassium
Available online at www.scholarsresearchlibrary.com Scholars Research Library Der Pharmacia Lettre, 215, 7 (5):2-24 (http://scholarsresearchlibrary.com/archive.html) ISSN 975-571 USA CODEN: DPLEB4 Preparation
More informationOptimization of Perindopril Erbumine Controlled Release Floating Tablet Using 3 2 Central Composite Design
Balkrushna K. Patel et al /J. Pharm. Sci. & Res. Vol.5(), 013, 36-41 Optimization of Perindopril Erbumine Controlled Release Floating Tablet Using 3 Central Composite Design Balkrushna K. Patel 1*, Paresh
More informationApplied Process Understanding in Drug Product Development
Applied Process Understanding in Drug Product Development A combined pharmaceutical science, materials science and chemical process engineering approach 17 October, Heidelberg, Germany ir Sander van den
More informationResearch Article Pharmaceutical Sciences
Page185 Research Article Pharmaceutical Sciences ENHANCEMENT OF DISSOLUTION RATE OF EFAVIRENZ BY SOLID DISPERSION TECHNIQUE B. Venkateswara Reddy 1*, K.V. Ramana Murthy 2 1* Department of Pharmaceutics,
More informationAnanda Kumar CH. et al. / International Journal of Biological & Pharmaceutical Research. 2012; 3(7):
904 e- ISSN 0976-3651 Print ISSN 2229-7480 International Journal of Biological & Pharmaceutical Research Journal homepage: www.ijbpr.com IJBPR DEVELOPMENT OF ITRACONAZOLE IMMEDIATE RELEASE PELLETS BY USING
More informationThe frictional forces in a loose powder or granules can be measured by the. A funnel was filled to the brim and the test sample was allowed to flow
3.1.5 Preformulation study: I) Pre-compression evaluation parameters: a) Angleof repose. b) Bulk density. c) Tapped density. d) Hausner sratio. e) Compressibility index(%). II) Drug polymer interaction
More informationFORMULATION AND OPTIMIZATION OF ACECLOFENAC MONOLITHIC OSMOTIC PUMP
Volume 6, Issue 2, January February 11; Article- ISSN 976 44X Research Article FORMULATION AND OPTIMIZATION OF ACECLOFENAC MONOLITHIC OSMOTIC PUMP Kh.Hussan Reza*,1,Sancheti Vikram N 1, Kumaravelrajan
More informationFormulation and Evaluation of Fast Dissolving Tablets of Ondansetron Hydrochloride
ISSN 2395-3411 Available online at www.ijpacr.com 736 Research Article Formulation and Evaluation of Fast Dissolving Tablets of Ondansetron Hydrochloride Rajeshree Panigrahi* and Iswori Prasad Padhy Royal
More informationPharma Silica Insights
high low permeability Pharma Silica Insights A newsletter for silica excipients for pharmaceutical formulations Issue 1 2012 What about silica? AEROSIL colloidal silicon dioxide is a well known excipient
More informationAsian Journal of Research in Pharmaceutical Sciences and Biotechnology
Research Article ISSN: 2349 7114 Asian Journal of Research in Pharmaceutical Sciences and Biotechnology Journal home page: www.ajrpsb.com FORMULATION DEVELOPMENT AND EVALUATION OF PANTOPRAZOLE DELAYED
More informationChemical Modifications and their effects on Binding/Disintegrating properties of Plectranthus esculentus starch in Chloroquine Phosphate tablets.
RESEARCH ARTICLE Am. J. PharmTech Res. 2013; 3(3) ISSN: 2249-3387 Chemical Modifications and their effects on Binding/Disintegrating properties of Plectranthus esculentus in Chloroquine Phosphate tablets.
More informationInternational Journal of Pharma and Bio Sciences V1(1)2010
International Journal of Pharma and Bio Sciences V1(1)010 Nagendra Kumar D 1*, Raju SA, Shirsand SB 1 S.V.E.T. s College of Pharmacy, Humnabad-55330, Dist: Bidar (Karnataka) Department of Pharmaceutical
More informationFormulation and in vitro evaluation of bosentan osmatic controlled release tablets
IJPAR Vol.4 Issue 4 Oct- Dec -2015 Journal Home page: ISSN: 2320-2831 Research article Open Access Formulation and in vitro evaluation of bosentan osmatic controlled release tablets Mohammed Asif Hussain,
More information