Pesticide Residues in Food

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1 DIE AKADEMIE FRESENIUS Where Experts Meet! 9 th International Fresenius Conference Pesticide Residues in Food 26 and 27 June 2017 in Mainz/Germany Highlights Regulatory issues Revision of the guidance document SANCO/825/00 Update: Regulation (EC) No 396/2005 Impact of residues and MRLs on global trade of agricultural commodities Harmonisation on a global level (WTO, Codex Alimentarius and OECD) Review of analytical methods QuEChERS and QuOil routine analysis of all pesticides without any trouble? Critical aspects during homogenisation Focus: high resolution mass spectrometry Comparison of workflows provided by different instrument types and manufacturers Most efficient workflows applicable for targeted and non-targeted analysis in LC-MS/HRMS Instrument performance and compliance with SANTE criteria Monitoring challenges Pesticide residue monitoring in the EU state of play Pesticide control from a manufacturer s perspective Challenges for residue analysis and monitoring programs in Latin-American countries The Experts Stuart Adams Fera Science Lutz Alder formerly German Federal Institute for Risk Assessment (BfR) Michelangelo Anastassiades EU Reference Laboratory for Pesticides Requiring Single Residue Methods (EURL-SRM), CVUA Stuttgart Cindy Bion Nestlé Research Centre Monika Bross BASF Caroline Harris Exponent Jochen Heidler German Federal Institute for Risk Assessment (BfR) Andreas Heinrich-Lenz Austrian Agency for Health and Food Safety (AGES) Karsten Hohgardt German Federal Office for Consumer Protection and Food Safety (BVL) Magnus Jezussek Bavarian Authority for Health and Food Safety (LGL) Ana Lozano EU Reference Laboratory for Fruits and Vegetables (EURL-FV), University of Almería Jens Lütjohann GALAB Laboratories Roberto Manos European Commission, DG Sante Hans Mol RIKILT - Wageningen University & Research Ionara Pizzutti Federal University of Santa Maria (UFSM) Łukasz Rajski EU Reference Laboratory for Fruits and Vegetables (EURL-FV), University of Almería Hermine Reich European Food Safety Authority (EFSA) Jos Scholten Netherlands Food and Consumer Product Safety Authority (NVWA) Carmen Tiu Dow AgroSciences

2 The Programme Get-together on Sunday, 25 June 2017 Will you arrive on Sunday? Come to the hotel bar at 8 p.m. and meet other participants and experts in a relaxed atmosphere. Monday, 26 June Registration and coffee 9.00 Welcome address by Akademie Fresenius and introduction by the Chair Monika Bross, BASF, Germany Regulatory issues 9.05 Status quo of residue analytical methods in the EU guidance document SANCO/825/00 rev. 8.1 General aspects of method validation Matrices: plant, animal, soil, water and air Current experiences by AGES with SANCO/825/00 rev. 8.1 Andreas Heinrich-Lenz, Agency for Health and Food Safety (AGES), Austria 9.35 The upcoming revision of the guidance document on residue analytical methods (SANCO/825/00) Reasons for the necessity of a revision Specific proposals for the revision of SANCO/825/00 Update and integration of guidance for pre-registration methods (SANCO/3029/99 rev.4) Jochen Heidler, Federal Institute for Risk Assessment (BfR), Germany Panel discussion Coffee break Impact of residues and MRLs on global trade of agricultural commodities MRLs how they turned from GAP enforcement to trade standards Potential solutions for avoiding unharmonised MRL issues Tools for harmonisation Carmen Tiu, Dow AgroSciences, United States of America Harmonisation on a global level (WTO, Codex Alimentarius and OECD) Impact of World Trade Organisation in food safety The Codex Alimentarius and its impact on food safety Contribution of OECD Karsten Hohgardt, Federal Office of Consumer Protection and Food Safety (BVL), Germany Regulation (EC) No 396/2005: implementation, recent developments and future improvement opportunities How the Regulation (EC) No 396/2005 is implemented (procedural steps, actors) Last developments in the framework of the actual legislation Roberto Manos, European Commission, DG SANTE, Belgium Panel discussion Lunch Analytical methods Chair Person: Lutz Alder formerly German Federal Institute for Risk Assessment (BfR), Germany Critical aspects during homogenisation Common ways of homogenisation Losses of pesticides during and after homogenisation Impact of homogenisation on homogeneity Michelangelo Anastassiades, EURL-SRM, CVUA Stuttgart, Germany QuEChERS and QuOil routine analysis of all pesticides without any trouble? Characteristics of QuEChERS and QuOil Limitation of the scope Magnus Jezussek, Bavarian Authority for Health and Food Safety (LGL), Germany Ion chromatography mass spectrometry for polar pesticide analysis: successes and pitfalls IC-MS in the routine analysis laboratory Specialised applications, not just a one analyte wonder Stuart Adams, Fera Science, United Kingdom Panel discussion Coffee break Focus: high resolution mass spectrometry Overview of the new workflows in measurements with Q-TOF and Q-Orbitrap which extras do we get? New options of HR-MS offered by the additional quadrupole and a collision cell A lot of new acronyms which measurements (workflows) are similar or identical? Similar workflows realized with Q-TOF and Q-Orbitrap are they equally effective? Lutz Alder, formerly Federal Institute for Risk Assessment (BfR), Germany

3 16.50 Using high resolution mass spectrometry which are the most efficient workflows applicable for targeted and non-targeted analysis? Differences between target and non-target workflows pros and cons Typical examples of target and non-target workflows The most efficient workflows for target and non-target pesticide analysis Łukasz Rajski, EURL-FV, University of Almería, Spain Reliable identification of pesticides using high resolution mass spectrometry do we need ion ratios in HRMS to avoid false positives? Validation results of pesticides in lettuce and orange using Q-TOF MS Method acceptance criteria Results of pesticides in difficult matrices Jos Scholten, Food and Consumer Product Safety Authority (NVWA), The Netherlands Panel discussion End of the first conference day Departure time for the evening event After the first conference day, Akademie Fresenius would like to invite you to a leisurely evening at the restaurant Brentano-Haus, a historical building and very unique place of the German romantic period. You have the opportunity of better getting to know other participants you met during the day over a relaxed meal and wine from the Rheingau region. Tuesday, 27 June Welcome address by the Chair Lutz Alder 9.10 Saturation and mass drift in high resolution mass spectrometry at high analytic concentrations: proposals to overcome these problems Detector saturation, source saturation, mass drift Proposal for overcoming saturation and drift problems Ana Lozano, EURL-FV, University of Almería, Spain 9.40 Application of GC-EI-high resolution Orbitrap MS in pesticide residue analysis Resolving power, scan speed, acquisition modes Practical benefits and limitations Work flows for quantitative analysis and screening Instrument performance and compliance with SANTE criteria Hans Mol, RIKILT - Wageningen University & Research, The Netherlands Pros and cons of ion mobility (IMS) as an additional identification tool in pesticide residue analysis Cleanup of HR-MS spectra in complex commodities IMS separation of isobaric compounds via CCS as identification point Further elucidation of electrospray ionisation Jens Lütjohann, GALAB Laboratories, Germany Panel discussion Coffee break Monitoring challenges Chair Person: Caroline Harris, Exponent, United Kingdom EU pesticide monitoring data Overview on control activities Data warehouse on pesticide monitoring data Current and future uses of the monitoring results Hermine Reich, European Food Safety Authority (EFSA), Italy Pesticide control from a manufacturer s perspective Analytical strategy to analyse pesticides residues in food by LC- and GC-MS/MS Analytical challenges/issues encountered during method development Cindy Bion, Nestlé Research Centre, Switzerland Challenges for residue analysis and monitoring programmes in Latin-American countries: the role of pre-export control Brazilian network of monitoring laboratories Infrastructure of Latin-American laboratories Trends in analytical methods applied Typical monitoring results of residue control Ionara Pizzutti, Centre of Research and Analysis of Residues and Contaminants (CEPARC), Federal University of Santa Maria (UFSM), Brazil Panel discussion and closing remarks by the Chair Lunch buffet and end of the conference Information available online at:

The Experts Stuart Adams is a Senior Analytical Chemist at Fera working in the Food Quality and Safety Department.

Lutz Alder worked for the Federal Institute for Risk Assessment between 1991 and 2015.

After his retirement in 2015, he continued to work as convenor for the CEN and started to act as private consultant.

Since 2006, he is Head of the EU Reference Laboratory for Pesticide Residue Analysis using single residue methods.

Her work priority is the management of the pesticides harmonisation project to simplify and standardise the current pesticides methods.

Within BASF, she has been involved in all types of residue and metabolism studies, but also in dietary exposure assessment and the preparation of

Caroline Harris is the Centre Director for Chemical Regulation and Food Safety in Exponent International s UK office.

Jochen Heidler is a Scientific Officer at the German Federal Institute for Risk Assessment Unit for Residues and Analytical Methods.

Alimentarius electronic Working Group on Methods of Analysis). Andreas Heinrich-Lenz studied foodand biotechnology in Vienna.

evaluation for active substances and for national registration of plant protection products.

active substances. Since 2006 he is also Deputy Head of Department Plant Protection Products at BVL.

He started his career at the pesticide residue laboratory of the LGL in 2003. In 2006 he became Head of the laboratory.

Ana Lozano is a Researcher at the European Union Reference Laboratory for pesticide residue analysis in Fruits & Vegetables at the University of Almería,

Jens Lütjohann is a Food Chemist and is working for GALAB Laboratories in Hamburg. Since 2007, he is the Head of the R&D department.

Roberto Manos graduated in Veterinary Medicine in Parma University in 1992. Since 2001, he works in the European Commission, in the Direction General SANTE.

396/2005. Hans Mol is Senior Scientist at RIKILT- Wageningen University & Research.

He is an active member in EU working groups on analytical quality control in the fields of pesticides and mycotoxins.

4 The Experts Stuart Adams is a Senior Analytical Chemist at Fera working in the Food Quality and Safety Department. He has 14 years experience of developing and validating chemical residue methods in food focusing on the overall method performance. Lutz Alder worked for the Federal Institute for Risk Assessment between 1991 and In this period, he coordinated the development of official German analytical methods for pesticides. After his retirement in 2015, he continued to work as convenor for the CEN and started to act as private consultant. Michelangelo Anastassiades gained his PhD in pesticide residue analysis. From 2000 to 2002 he worked as visiting scientist at the USDA. Since 2006, he is Head of the EU Reference Laboratory for Pesticide Residue Analysis using single residue methods. Cindy Bion holds the position of Group Leader for Pesticides at the Nestlé Research Centre. Her work priority is the management of the pesticides harmonisation project to simplify and standardise the current pesticides methods. Monika Bross has been working at BASF Agricultural Center in Limburgerhof for more than 20 years. Within BASF, she has been involved in all types of residue and metabolism studies, but also in dietary exposure assessment and the preparation of submission documents to authorities (EU, US, JMPR). Caroline Harris is the Centre Director for Chemical Regulation and Food Safety in Exponent International s UK office. After many years as a regulator at CRD, she continues to be involved with MRLs, import tolerances and pesticide residues in international trade. Jochen Heidler is a Scientific Officer at the German Federal Institute for Risk Assessment Unit for Residues and Analytical Methods. He is also a member in national and international working groups (National Expert Group for Pesticide Residue Analytical Methods (EPRA) and Codex Alimentarius electronic Working Group on Methods of Analysis). Andreas Heinrich-Lenz studied foodand biotechnology in Vienna. Since 2004, he has been working at AGES on risk assessment for residue behaviour and additionally since 2014 for analytical methods in course of EU evaluation for active substances and for national registration of plant protection products. Karsten Hohgardt is Head of a unit responsible for risk management in the field of toxicology and residue behaviour of plant protection products and their active substances. Since 2006 he is also Deputy Head of Department Plant Protection Products at BVL. His main experience lies in MRL setting and residue behaviour. Magnus Jezussek received his PhD grade in the field of flavour research. He started his career at the pesticide residue laboratory of the LGL in In 2006 he became Head of the laboratory. He is member of several national and international working groups, e.g. CEN and of the EU PT & AQC Advisory Board. Ana Lozano is a Researcher at the European Union Reference Laboratory for pesticide residue analysis in Fruits & Vegetables at the University of Almería, Spain. Her research areas are framed in the field of pesticides analysis in fruits and vegetables. Jens Lütjohann is a Food Chemist and is working for GALAB Laboratories in Hamburg. Since 2007, he is the Head of the R&D department. He is also responsible for the setup and implementation of internal and external QC measures according to DAKKs and SANTE guidelines. Roberto Manos graduated in Veterinary Medicine in Parma University in Since 2001, he works in the European Commission, in the Direction General SANTE. In 2011, he joined the Pesticides and Biocides Unit, in the team Pesticides Residues, where he deals with the implementation of the Regulation (EU) No 396/2005. Hans Mol is Senior Scientist at RIKILT- Wageningen University & Research. He heads the National Reference Laboratory for Mycotoxins and the National Reference Laboratory for Pesticides in products of animal origin. He is an active member in EU working groups on analytical quality control in the fields of pesticides and mycotoxins. Ionara Pizzutti has been permanent Professor at the Chemistry Department of the Federal University of Santa Maria, Brazil, since With experience in analytical chemistry with emphasis on chromatography, she is mainly active in GC-MS/MS, LC-MS/MS, pesticides analysis in fruits, vegetables, cereals. Łukasz Rajski is a PhD student of advanced chemistry at the European Union Reference Laboratory for Pesticide Residues in Fruit & Vegetables at the University of Almería. Hermine Reich is working for EFSA since 2006, being in charge of the implementation of the provisions of the MRL Regulation (EC) 396/2005. Her background is in food chemistry, food technology and biotechnology. Jos Scholten is working in pesticides analysis for about 10 years, especially with LC-MS equipment ((MS/ MS (ESI-TQ)) and the last 1,5 years with LC-Q-TOF. Before that, he was working in the field of mycotoxins for about 20 years, using LC with UV-, fluorescence- and MS-detection. Carmen Tiu holds a Master of Science in Organic Chemistry and is Global Residue and Risk Leader at Dow AgroSciences. She has worked in R&D for 18 years, with expertise in residues, MRL s and food safety, risk assessment, regulatory and public affairs, and formulations development.

development Raw material management Sectors that should take part: Agrochemical industry Food and drink industry Regulatory authorities Food inspection offices Research institutes Scientific

5 About Who do you meet? Professionals working in the fields of: Residue analysis Food chemistry Monitoring Quality assurance and control Product safety Food safety Legal and regulatory affairs Registration Research and development Raw material management Sectors that should take part: Agrochemical industry Food and drink industry Regulatory authorities Food inspection offices Research institutes Scientific consultants Professional associations Trade Exhibition Our conference provides you with the opportunity of presenting your company in a trade display. Present your products and services and reach out to your specific target groups. We would be happy to provide you with information on all the various options available from displaying product information to an exhibition stand with no further obligation on your part. Use the attached fax reply sheet to request our information material. Or simply call us. We would be more than pleased to assist you personally. Rebecca Keuters phone: rkeuters@akademie-fresenius.de The Organiser For over 20 years, Akademie Fresenius has been your partner for practice-orientated training on all the latest topics surrounding the safety and quality of food, consumer goods and chemical products along the whole production chain. Our portfolio not only includes international conferences but also offers national trade meetings, intensive practical seminars and training in small work groups. Our events are designed to promote an active exchange amongst our participants and offer the perfect platform for bringing the industry, the scientific sector, the authorities and the consulting field together. Excellent service, all-inclusive. Our wide-ranging advanced training opportunities contribute to giving our customers the competitive edge in all quality assurance, risk assessment, legal, production and technical questions. Akademie Fresenius is a joint venture between Cognos, one of the largest private and independent education groups in Germany, and SGS Institut Fresenius, one of the leading German providers of chemical laboratory analysis. You can find details on upcoming and new events at Do you have any questions? Programme and conceptual design Sarah Kehasse phone: skehasse@akademie-fresenius.de Organisation and participant management Monika Stratmann phone: mstratmann@akademie-fresenius.de

6 Registration By web By By fax Hotline Die Akademie Fresenius GmbH Alter Hellweg 46, Dortmund Participation I would like to take part in the 9 th International Fresenius Conference "Pesticide Residues in Food", 26 and 27 June 2017 in Mainz/Germany. Fee: 1, plus VAT. I am a representative of an authority or a public university and therefore eligible for a reduced fee of plus VAT (please provide evidence). The reduced fee cannot be combined with other rebates. I would like to take part in the evening event on 26 June 2017 (included in the above price). Event Documentation Unfortunately, I am unable to attend. Please send me the complete documentation for plus VAT. Trade Exhibition Please send me information on available options for trade exhibition and presenting information. Your Account Number (if available) Title / First name / Name Position Department Phone / Fax Company (complete company name including legal form) Street / Number or P.O. Box / Building ZIP-code / City / Country Your order number / Cost unit (if required) Your VAT ID No. (for registrations from EU countries except Germany) Date Signature Terms of Participation and Purchase The registration fee includes the event participation, event documentation, lunch, coffee breaks, beverages as well as the evening event. You will receive written confirmation of your registration. Upon receiving our invoice, please transfer the amount due without further deductions before the event begins. The price of the event documentation includes a hard copy of the documentation as weii as an access code to the secure Akademie Fresenius download area. Both the documents and the secure access code will be dispatched around two weeks after the event and as soon as advance payment has been received. Group Reductions For joint bookings received from one company we grant a 15% discount from the third participant onwards. Terms of Cancellation Written cancellations or transfers will be accepted free of charge up to four weeks prior to the start of the event. After this date and up to a week prior to the start of the event we will reimburse 50% of the registration fee. We cannot, unfortunately, provide refunds for later cancellations. Please note that you can name a substitute free of charge at any time. General Terms and Conditions By registering, you agree to our General Terms and Conditions as well as to our Privacy Policy. You can find our GTC on the internet (www. akademie-fresenius.com/general-terms) or receive them on request. Personal Data The Akademie Fresenius will keep your data for the purpose of organising this event. We will under no circumstances use your data for commercial trade purposes. In signing this form you consent to our occasionally contacting you by mail, , fax or phone (please strike through if unwanted) in order to provide you with further information from our company. You can, of course, withdraw your consent whenever you wish. Occasionally we go around taking photos at our events. These are then published anonymously on our website. Further information can be found at: Picture credit pressmaster - Fotolia.com, tupungato Billing Address (only if different from the above address) Venue Atrium Hotel Mainz Flugplatzstr. 44, Mainz/Germany Phone: info@atrium-mainz.de, We have reserved a limited number of rooms for our participants at reduced rates at the hotel. These rooms can be booked up to 4 weeks prior to the start of the event. Please book early and directly through the hotel quoting Fresenius as reference.

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