Biotech Sell Side Research: A Retrospective Analysis

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1 Biotech Sell Side Research: A Retrospective Analysis January 2013 Mark G. Edwards Managing Director

2 Biotech Sell Side Research: A Retrospective Analysis 250 Public Biotech Cos (2+ Reports per Co) 2,492 Sell Side Reports over 14 years - Initiation of Coverage (IOC) Reports only (10+ pages each report) - All reports between 1998 and 2011 Key Question: Which of These Biotech Initiation of Coverage Reports Reached Their Target Stock Price Within a Year?

3 Biotech Initiation of Coverage Reports by Year (N=2,492)

4 # of Initiation of Coverage Reports for Each Biotech Company (N=250 biotech cos.)

5 Top 12 Most Frequent Issuers of Biotech Initiation of Coverage Reports Rodman UBS Wells Fargo Credit Suisse ThinkEquity Jefferies Citibank JP Morgan Cowen Royal Bank of Canada Morgan Stanley Piper

6 Other Frequent Issuers of Biotech Initiation of Coverage Reports Roth Oppenheimer Brean Merriman Pacific Natexis Prudential Punk Hambrecht William Blair Merrill Lynch Wedbush Unterberg CIBC Deutsche Bank Canaccord

7 Most Prolific Authors of Biotech Initiation of Coverage Reports Aschoff, Jonathan Kantor, Jason Farmer, George Yang, Eun Augustine, Mark McMinn,Rachel Harr, Steven Sonnier, John To, Alex Reames, Aaron Jellinek, Derek Chovav, Meirav Geller, Matt Werber, Yaron Pantginis, Joseph King, Michael Tenthoff, Edward

8 Distribution of Stock Ratings by Period of Biotech Coverage Initiation Pre-2005 (N=826) Q08 (N=938) 4Q (N=728)

9 Distribution of Stock Ratings by Top 12 Most Frequent Issuers of Biotech Initiation of Coverage Reports Buy Neutral Sell Morgan Stanley Rodman UBS Wells Fargo Credit Suisse ThinkEquity Jefferies Citibank JP Morgan Cowen Royal Bank of Canada Piper

10 Distribution of Stock Ratings by Most Prolific Authors of Biotech Initiation of Coverage Reports Buy Neutral Sell Pantginis, Joseph King, Michael Tenthoff, Edward Aschoff, Jonathan Kantor, Jason Farmer, George Yang, Eun Augustine, Mark McMinn,Rachel Harr, Steven Sonnier, John To, Alex Reames, Aaron Jellinek, Derek Chovav, Meirav Geller, Matt Werber, Yaron

11 Predicted % Change in $/Share Over 12 Month Period Buy Rating (N=1,835)* Neutral Rating (N=537)** Sell Rating (N=120)*** * 99 w/o Target Price ** 128 w/o Target Price *** 12 w/o Target Price

12 What Percentage of Biotech Initiation of Coverage Reports Reached Their Target Stock Price Within a Year? Analyst Buy Recommendations (N=1,645)

13 Key Question: Which of These Initiation of Coverage Reports Reached Their Target Stock Price Within a Year? Analysis of Buy Recommendations that met their Target Stock Price within a Year by Investment Bank by Research Analyst Analysis of Buy Recommendations with a Target Stock Price at Least 40% Higher within a Year by Investment Bank by Research Analyst

14 How Often Did the Most Frequent Issuers Of Biotech IOC Reports Reach Their Buy Target Price? # of Reports Met Buy Target Morgan Stanley Rodman UBS Wells Fargo Credit Suisse ThinkEquity Jefferies Citibank JP Morgan Cowen Royal Bank of Canada IOC = Initiation of Coverage Piper

15 How Often Did Other Frequent Issuers of Biotech IOC Reports Reach Their Buy Target Price? # of Reports Met Buy Target Deutsche Bank Canaccord CIBC Roth Oppenheimer Brean Merriman Pacific Natexis Prudential Punk Hambrecht William Blair Merrill Lynch Wedbush Unterberg IOC = Initiation of Coverage

16 How Often Did the Most Prolific Authors Of Biotech IOC Reports Reach Their Buy Target Price? # of Reports Met Buy Target Pantginis, Joseph King, Michael Tenthoff, Edward Aschoff, Jonathan Kantor, Jason Farmer, George Yang, Eun Augustine, Mark McMinn,Rachel Harr, Steven Sonnier, John To, Alex Reames, Aaron Jellinek, Derek Chovav, Meirav Geller, Matt Werber, Yaron IOC = Initiation of Coverage

17 The Best Sell Side Biotech Stock Pickers Over the Past Decade Are Among the Most Frequent Issuers of Coverage, Piper and ThinkEquity each met their Buy Target Price in 38% of their Biotech IOC Reports Among the Other Frequent Issuers of Coverage, Wedbush, Hambrecht and Canaccord met their Buy Target Price in at Least 40% of their Biotech IOC Reports Among the Most Prolific Authors of Coverage, Alex To (of Natexis, previously at Credit Suisse) met his Buy Target Price in 50% of his IOC Reports

18 What Percentage of Biotech Initiation of Coverage Reports Reached Their 40+% Gain Target Stock Price Within a Year? Analyst 40+% Gain Buy Recommendations (N=987)

19 How Often Did the Most Frequent Issuers Of Biotech IOC Reports Reach a Target Price of 40%+ Gain? %+ Gain <40% Gain Other Reports Piper Morgan Stanley Rodman UBS Wells Fargo Credit Suisse ThinkEquity Jefferies Citibank JP Morgan Cowen Royal Bank of Canada IOC = Initiation of Coverage

20 How Often Did the Other Frequent Issuers Of Biotech IOC Reports Reach a Target Price of 40%+ Gain? %+ Gain <40% Gain Other Reports Deutsche Bank Canaccord CIBC Roth Oppenheimer Brean Merriman Pacific Natexis Prudential Punk Hambrecht William Blair Merrill Lynch Wedbush Unterberg IOC = Initiation of Coverage

21 How Often Did the Most Frequent Authors Of Biotech IOC Reports Reach a Target Price of 40%+ Gain? %+ Gain < 40% Gain Other Reports Pantginis, Joseph King, Michael Tenthoff, Edward Aschoff, Jonathan Kantor, Jason Farmer, George Yang, Eun Augustine, Mark McMinn,Rachel Harr, Steven Sonnier, John To, Alex Reames, Aaron Jellinek, Derek Chovav, Meirav Geller, Matt Werber, Yaron IOC = Initiation of Coverage

22 And When Swinging for the Fences, Best Sell Side Biotech Stock Pickers Over the Past Decade Are Among the Most Frequent Issuers of Coverage, Rodman Predicted and Got a 40+% Gain in 22% of their Biotech IOC Reports Among the Other Frequent Issuers of Coverage, Wedbush & Canaccord Predicted and Got a 40+% Gain in 39% and 30% of their Reports, Respectively Among the Most Prolific Authors of Coverage, Joseph Pantginis (of Roth, previously at Merriman and Canaccord) Predicted and Got a 40+% Gain in in 36% of his Biotech IOC Reports

23 Next Question: What is the Sweet Spot for Biotech Analysts to Meet their Target Stock Price Within a Year? Analysis of All Biotech IOC Recommendations by Biotech Stage of Development by Biotech Therapeutic Area Analysis of 40+% Buy Recommendations by Biotech Stage of Development by Biotech Therapeutic Area

24 Until a Biotech Product is on the Market, the Odds Are Against an Analyst Hitting their Stock Recommendation Phase II Phase III NDA Filed Market Target Price Reached Target Price Not Reached

25 Infection is the Therapeutic Area Where Analysts are Most Likely to Hit their Stock Recommendation Infection CNS Cardiovascular Oncology Target Price Reached Target Price Not Reached

26 For Buy Recommendations of 40+% Price Gain, Even Products on the Market Make for a One in Three Bet Phase II Phase III NDA Filed Market Target Price Reached Target Price Not Reached

27 For Buy Recommendations of 40+% Price Gain, Infection is Still the Best Therapeutic Area Bet Infection CNS Cardiovascular Oncology Target Price Reached Target Price Not Reached

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