BRITISH BIOMEDICAL BULLETIN
|
|
- Barrie Payne
- 6 years ago
- Views:
Transcription
1 Journal Home Page BRITISH BIOMEDICAL BULLETIN Original Formulation and In vitro Evaluation of Metoprolol Succinate Extended Release Pellets Ch.Kalyani 1*, K. Veer Reddy 1, E.Anka Rao 2 and M Prashanta Kumari 3 1 VJ s College of Pharmacy, Affiliated to Andhra University, Rajahmundry, Andhra Pradesh, India. 2 Scientist, Hetero Drugs, Hyderabad, Andhra Pradesh, India. 3 KJR College of Pharmacy, Affiliated to Andhra University, Rajahmundry, Andhra Pradesh, India. A R T I C L E I N F O A B S T R A C T Received 26 Sept 2013 Received in revised form 04 Oct 2013 Accepted 06 Oct 2013 Keywords: Metoprolol succinate, Pellets, HPMC, Di ethyl phthalate, Plasticizer. Corresponding author: VJ S college of Pharmacy, Rajahmundry, Andhra Pradesh, India. address: kalyanich.ch@gmail.com The objective of the present study was for improving bioavailability and reducing the dosage frequency of Metoprolol succinate in the form of extended release pellets by pan coating technology. Initially drug solution coated on different cores i.e. water soluble, insoluble and swellable cores and layered by different combinations of extended release polymers as EC(ethyl cellulose) 10 cps + HPMC (Hydroxy propyl methyl cellulose), EC 10 cps + Di ethyl phthalate and EC 10 cps + HPMC+ Diethyl phthalate. Formulated pellets were evaluated for flow properties, surface morphology, size analysis and in vitro dissolution studies. Studies were done on the effect of core nature and coating composition and effect of plasticizer. In vitro dissolution studies revealed that higher release observed from water-soluble core compared to insoluble and swellable cores. Controlled drug release observed from coating composition containing combination of EC + diethyl phthalate. Moderate drug release observed from combination of HPMC + EC+ diethyl phthalate. The mechanism of drug release follows Higuchi diffusion model. In conclusion the resulting formulations F6 (Water soluble core and coat was EC 10 cps + HPMC+ Di ethyl phthalate) can reduce the dosing frequency of the Metoprolol succinate to once daily British Biomedical Bulletin. All rights reserved
2 Introduction Several approaches existed for administration of drugs to the patients. In all those approaches oral administration has been received more attention due to more flexibility in designing of dosage forms. From the years onwards tremendous work had done for designing of controlled delivery systems to reduce the fluctuations in plasma concentrations which is observed in conventional delivery. The main aim in designing of controlled delivery is to reduce fluctuations in plasma concentrations and increasing the patient compliance. Now a days in pharmaceutical market per oral multi unit controlled release dosage forms (pellets, granules, nano particles, micro particles, mini tablets) are more important than single unit dosage forms (tablets and capsules) due to low risk of dose dumping, increasing the bioavailability of drugs, flexibility to produce different release patterns and targeted drug delivery 1-4. Pelletization technology is an agglomeration process that converts fine powders or granules of bulk drugs and excipients into small free flowing spherical units, (0.5 to 1.5 mm) known as pellets. Pellets not only have technological advancements but also show better flow properties, uniform and reproducible fill weights of capsules and tablets, disperse freely in GI tract leads to maximum drug absorption and pack easily without significant difficulties. Coating of multiparticulates is used for modifying the drug release such as targeted or extended release 5, 6. Metoprolol succinate is cardio selective β1 blocker used for the treatment of angina pectoris, hypertension and heart failure. According to the Biopharmaceutical classification system (BCS) Metoprolol succinate comes under class I drug means that highly soluble and highly permeable. It is rapidly and completely absorbed but due to extensive first pass effect, it is bioavaiable only 50% after oral administration. Due to its short half life (3-7 hrs) drug should be administer 4 times daily. Whenever dose is missing leads to nocturnal attack. Therapeutic level of β1 (beta 1) blockage occurs when plasma concentration is nm. Immediate release dosage forms increase the plasma concentration above 300nM leads to more β2 (beta 2) blockage and little β1 blockade. For maintaining the therapeutic concentration and eliminating the fluctuation in plasma concentration Metoprolol succinate is suitable agent for controlled drug delivery 7, 8. It is a challenge to pharmaceutical technologist to design a sustained release dosage form for class I drugs having extensive hepatic metabolism like Metoprolol succinate. Poor formulation leads to high rate of drug release and produce toxic concentrations in the body. Polymeric film coatings used for achieving sustained release because coated dosage forms enable précised drug release with good reproducibility. Main objective of the present study is to prepare extended release pellets of Metoprolol succinate by using three different inert cores i.e water soluble, water insoluble and water swellable and to study the effect of coating composition and the effect of water insoluble plasticizer in drug release. In the present study Hydroxy propyl methyl cellulose (HPMC) confers more hydrophilic nature to the film and alters its structure by virtue of pores and channels through which the substance can diffuse more easily to control the release pattern. Ethyl cellulose (EC) 10 cps is used as water insoluble polymer and di ethyl phthalate is used as water in soluble plasticizer 9, 10.
3 Materials and Methods Materials Metoprolol Succinate was a gift sample by Dr. Reddy s Laboratories, Hyderabad, India. Hydroxy propyl methyl cellulose (HPMC), ethyl cellulose 10 cps (PVP) were obtained from Dow chemical company, USA. Water swellable core, insoluble core and soluble cores are procured from Asahikasei Chemicals Corporation, Japan, Rhodi, UK and Nexus Drugs, Hyderabad, India respectively. Remaining all chemicals used were analytical grade. Formulation of Extended release pellets A) Coating of the core pellets with drug solution Inert cores (water soluble, water in soluble and swellable) were sieved through 80# and drug loaded pellets were prepared by layering the aqueous solution of Metoprolol succinate on inert cores using fluid bed processor (Wurster technique). Drug solution was prepared by heating the purified water up to 60 C and Metoprolol succinate was slowly added while heating with continuous stirring by pneumatic stirrer (Remi Motors Ltd. Mumbai) to get clear solution. Composition of drug loaded pellets and coating parameters for drug layering are shown in table 1 & 2 respectively. Sprayed the drug solution on the prewarmed the inert core beads by using Wurster technique. Continued the drugloading till desired weight gain occurs to yield the unit dose as per the formula. After coating pellets were dried with an inlet air temperature maintained at 40 ± 3 C for 1 hour. B) Extended release coating of drug pellets Ethyl cellulose was dissolved in required quantity of isopropyl alcohol with continuous stirring to prevent formation of lumps and foam. To this 5% methylene chloride solution was added to get clear solution. To this mixture varying proportions of HPMC and di ethyl phthalate were added according to the composition shown in table 3.This is to evaluate the effect of plasticizer and polymer on dissolution behavior. Characterization of Pellets Prepared Metoprolol succinate extended release pellets were evaluated for particle size, size distribution surface morphology, density, porosity, flow properties, friability drug content and in vitro dissolution studies. Surface Morphology Surface morphology of extended release coated pellets was observed before and after dissolution by Trinocular Microscope (with Dewinter pharmapro 4.0 software) which was attached with a camera (Nikon). Particle Size distribution Mechanical sieve shaker was used to evaluate the particle size distribution of pellets of each core. The particle size distribution for different batches is shown in the Table 5. Drug content Pellets of weight equivalent to unit dosage form were transferred in to 100ml volumetric flask. To this 10ml of methanol and 10 ml of 6.8 ph phosphate buffer was added and sonicated for 20 min for complete solubilization. Then make up the volume with phosphate buffer and dilutions were made to get the absorbance in linearity range and measured at 274 nm by using UV-Visible double beam spectrophotometer. In vitro Dissolution study & Kinetics Dissolution study of formulations F1- F9 was performed using USP 23 Dissolution
4 procedure over a 24-hour period (11), using an automated Electro lab paddle dissolution system tester coupled to an automated sample collector. Capsule containing pellets equivalent to 50 mg were taken and release study performed in 900ml of ph 6.8 phosphate buffer with USP Type-II apparatus at 100 rpm with temperature of 37 ± 0.5 C. At the predetermined sampling points (1, 2, 4, 8, 12 and 24 hours) 5 ml of aliquot sample was withdrawn and replaced with fresh dissolution medium. Pellets release of corresponding core was determined by UV- Visible Spectrophotometer at 274 nm. In vitro drug release data was fitted into various mathematical models, zero-order, first order, Higuchi for determination of rate and drug release mechanism Comparative dissolution profile of optimized formulation and marketed formulation In vitro dissolution profile of optimized formulation was compared with the similarity factor using marketed drug release profile (PROLOMET- XL) as a reference. Similarity factor 14, 15 (f2) is a logarithmic reciprocal square root transformation to the sum of squared errors. If f2 value in between two dissolution profiles considered to be similar. Stability studies Stability studies were performed according to ICH guidelines for the optimized formulation. Optimized formulation was kept at humidity chamber maintained at 40 o C and 75% relative humidity (RH) for 3 months. The sample was analyzed for the physical changes and percent drug content at interval of 7, 15, 30, 60 and 90 days. Results Surface Morphology Surface morphology of pellets was observed by Trinocular Microscope and the photographs of pellets before and after 24 hrs of dissolution presented were presented below Fig.1-4. Particle Size distribution and Drug content of the formulations The particle size distribution and drug content of the Metoprolol succinate pellets were given in the Table 4. In Vitro dissolution studies & kinetics Fig.5-7 showed the dissolution profiles of Metoprolol succinate pellets in 6.8 ph phosphate buffer. The dissolution data of batches were fitted to zero-order, first-order and Higuchi. The linearization parameters are shown in table 5. The average r2 of all batches was used to select best fit model. Comparative dissolution profile of optimized formulation and marketed formulation From the in vitro release data obtained by dissolution studies formulation F6 was selected optimized formulation. The dissolution profile of the optimized formulation of extended release pellets was compared with marketed MS formulation (PROLOMET-XL) and similarity factor (f2) was found to be Stability studies The stability studies of optimized formulation showed no significant changes in the physical parameters when stored at temperature and humidity conditions of 40±20C/75±5% RH. Discussion Metoprolol succinate is a ß1-selective adreno receptor blocking agent used for the treatment of hypertension and angina pectoris. Multi unit particulate systems are advantageous over single unit dosage forms to
5 reduce dose fluctuations and increase bioavailability of drugs. The present work was aimed to formulate Metoprolol succinate pellets on different cores i.e. water soluble, insoluble and swellable. After they are coated with different extended release coatings and release rate was observed. Effect of core nature on pellets In this study, the drug release was found to be higher from all the three ER coating formulations of water soluble core (F4, F5 & F6 releases 99%, 81% and 93.2% respectively) when compare to other two core formulations. The controlled release of drug from the water soluble core was seen only up to 8 h. After 8 hours, burst release of was observed (Fig 5b). However, other two formulations with water-insoluble core and water swellable yielded controlled release for approximately 24 hours (Fig 5a & 5c). Further, the drug release from water insoluble core and water swellable core has more or less similar rate. The higher release from water-soluble core is due to disrupted integrity of the film after contact with dissolution medium. As dissolution media penetrates in to the film and chance of rupturing, leading to higher release. Effect of type of extended release coating composition Among all ER coating compositions, higher drug release was observed in F1, F4 & F7 (63%, 99% & 67% respectively) containing EC 10 cps + HPMC. This is due to higher hydrophilic nature of film and rapid hydration rate of film during dissolution leads to increased dissolution rate. On the other hand, the drug release was found to be less in F3, F6 & F9 (52% 93.2% & 55% respectively) containing ER coating of EC 10 cps + Di ethyl phthalate and moderate release was observed in F2, F5 & F8 (59%, 81% & 63% respectively) containing HPMC+EC10 cps +Di ethyl phthalate. The morphological observation of these pellets before and after dissolution was seen in the Fig 1-4. Effect of water insoluble plasticizer on pellets Three ER coating formulations were prepared with each core and from these coatings, effect of hydrophilic agent (HPMC) and diethyl phthalate (plasticizer) has been studied. HPMC has a property to form channels in the film along with EC 10 cps, which enhances the permeability of the film for dissolution. Hydrophobic di ethyl phthalate gives the flexibility to the film and extends the drug release. The drug release in film with HPMC+EC 10 cps (F1, F4 & F7) was higher in the all three pellet formulations. This is due to absent of plasticizer in the formulation and leads to brittle in nature and rupture of the film during the dissolution. Additionally, HPMC channeling property further enhances the release. This release was found higher in the water-soluble core than water in-soluble core and water-swellable core. More controlled release effect was seen in the film with EC 10cps and Di ethyl phthalate (F3, F6 & F9) Moderate release was seen with the film having EC10 cps +HPMC+ Di ethyl phthalate (F2, F5 &F8). Drug Release Kinetics Based on the in vitro dissolution studies F6 was considered as the optimized formulation for extended delivery of drug as it controls the release up to 24 hrs. All of the formulations follow first order release kinetics. Higuchi plots were found to be linear in all the cases except in case of formulation F9. Linearity indicates that the drug release from coated beads might be of diffusion type as proposed by Higuchi (1961) from insoluble matrices. Accordingly, drug release from these coated beads involves penetration of dissolution fluid, dissolution of drug in the medium and leaching out of the drug through interstitial channels or pores.
6 Stability studies Samples were withdrawn and retested for drug content after intervals of 7, 15, 30, 60 and 90 indicating that no significant reduction in the content of active drug was observed over a period of 3 months; the percent drug contained is found within a specified limit of USP. Therefore, there was no evidence of degradation of drug quantity. Comparative dissolution profile of optimized formulation and marketed formulation Similarity factor of optimized formulation (F6) and marketed formulation was f2 is greater than 50. Then two formulations are identical. Acknowledgements The authors are thankful to Dr. Reddy s Laboratories Hyderabad, Andhra Pradesh, for the generous gift sample of Metoprolol Succinate. Authors Statements (Competing Interests) The authors declare no conflict of interest. References 1. Ali Asghar L, Chandra S. Multi particulate formulation approach to colon specific drug delivery: current perspectives. Journal of Pharmacy and Pharmaceutical Sciences. 2002; 9(3): Chopra R, Podczeck F, Newton JM. The influence of pellet shape and film coating on the filling of pellets into hard shell capsules. European Journal of Pharmaceutics and Biopharmaceutics. 2002; 53(3): Lian-Dong H, Yang L, Xing T, Qian Z. Preparation and in vitro / in vivo evaluation of sustained release metformin hydrochloride pellets. Eur J Pharm Biopharm.2006; 64: Sousa J.J, Sousa A, Moura MJ, Newton JM. The influence of core materials and film coating on the drug release from coated pellets. Int J Pharm.2002; 233: Suryakusuma H, Jun HW. Encapsulated hydrophilic polymer beads containing indomethacin as controlled release drug delivery systems. J Pharm Pharmacol. 1984; 36: Pong paibul Y, Price JC, Withworth CW. Preparation and evaluation of controlled release Indomethacin microspheres. Drug Dev Ind Pharm. 1984; 10: Derle DV, Kasliwal NH, Development & comparative evaluation of xanthan gum & guar gum based sustained release matrix tablets of tizanidine HCL. Int Journal of Excipients.2006; Rahman N, Yuen KH, Khan NA, Wong JW. Drug polymer mixed coating: a new approach for controlling drug release rates in pellets. Pharm Dev Technol. 2006; 11: John w, Anderson B, Kendall MJ. Pharmacokinetic consideration of formulation of extended release Metoprolol succinate in the treatment of heart failure. Journal of cardiovascular Pharmacology. 2003; 41: Aulton ME, Abdul-Razzak MH, Hogan JE. The mechanical properties of hydroxy propyl methylcellulose film derived from aqueous systems. Part 1: the influence of plasticizers. Drug Dev Ind Pharm. 1981, 7, The United States Pharmacopeal, 30th ed. Convention Inc., Washington Rockville, MD; Costa P, Lobo JMS. Modeling and comparison of dissolution profiles. Eur J Pharm Sci. 2001;13: Chavda HV, Patel CN. Chitosan superporous hydrogel composite-based floating drugdelivery system: A newer formulation approach. J Pharm Bioall Sci. 2010; 2: Gohel MC, Panchal MK. Novel use of similarity factors f 2 and S d for the development of diltiazem HCl modifiedrelease tablets using a 32 factorial design. Drug Dev Ind Pharm.2002; 28: Banakar UV. Pharmaceutical dissolution testing. New York: Marcel Dekker; 1992.
7 Table 1. Composition of Drug loaded Pellets Ingredients Per Unit (mg) Core (Water Soluble or in Soluble core or Water 25 swellable) Metoprolol succinate 95 Purified water Q.s. Theoretical average unit 120 Table 2. Parameters used for the drug loading & ER coating Parameters For Drug loading For Extended release coating Blower speed (rpm) Inlet air temperature ( C) Exhaust temperature ( C) Product temperature ( C) Atomization air pressure (bar) Solution spray rate (rpm) Table 3. Coating composition for extended release coating of Metoprolol succinate pellets S.No Ingredients (gm) Water insoluble core Water soluble core Water swellable core F1 F2 F3 F4 F5 F6 F7 F8 F9 1. Drug Loaded Pellets Ethyl cellulose 10cps HPMC Diethyl phthalate Iso Propyl Alcohol Purified water Q.S Q.S Q.S Q.S Q.S Q.S Q.S Q.S Q.S Table 4. Particle size Distribution and Drug content of Metoprolol Succinate Pellets
8 F. Code Particle size Drug content Mesh size % w/w (%) F1 #30/# ±0.98 F2 #30/# F3 #30/# F4 #30/# F5 #30/# ±0.55 F6 #30/# F7 #30/# F8 #30/# F9 #30/# Table 5. Comparison of correlation coefficient the release rate constant for various mathematical models Formulations Zero order First order Higuchi Model Pellets r 2 Ko r 2 K, r 2 KhO F F F F F F F F F
9 Figure.1. Effect of Core nature on coated pellets before dissolution (Magnification with 100X) Figure.2. Effect of Core nature on coated pellets after 24 hrs dissolution (Magnification with 100X) Figure.3. Effect of plasticizer (Di ethyl phthalate) on coated pellets before dissolution (Magnification with 100X)
10 Figure.3. Effect of plasticizer (Di ethyl phthalate) on coated pellets after 24 hrs of dissolution (Magnification with 100X) Figure. 5. Showed In vitro dissolution profiles from water in soluble core (5a), in soluble core (5b) & water swellable cores (5c)
Research Article Pharmaceutical Sciences
Page185 Research Article Pharmaceutical Sciences ENHANCEMENT OF DISSOLUTION RATE OF EFAVIRENZ BY SOLID DISPERSION TECHNIQUE B. Venkateswara Reddy 1*, K.V. Ramana Murthy 2 1* Department of Pharmaceutics,
More informationInvestigation of a Venlafaxine HCl (37.5 mg) Extended Release Formulation Using Hypromellose (HPMC) Matrices
METHOCEL Application Data Partially Pregelatinized Maize Starch Investigation of a Venlafaxine HCl (37.5 mg) Extended Release Formulation Using Hypromellose (HPMC) Matrices ABSTRACT SUMMARY The aim of
More informationPreparation and Evaluation of Sustained Release Tablet of Cyproheptadine Hydrochloride Using Carbopol and HPMC
Received: 06-01-2013 Accepted: 26-02-2013 ISSN: 2277-7695 CODEN Code: PIHNBQ ZDB-Number: 2663038-2 IC Journal No: 7725 Vol. 2 No. 1 2013 Online Available at www.thepharmajournal.com THE PHARMA INNOVATION
More informationThe research work highlights the development and evaluation of. bioavailability of drugs. The buccal route can bypass the first-pass
212 9. Summary, conclusion and recommendation 9.1 Summary and conclusion The research work highlights the development and evaluation of novel transbuccal drug antagonist of Famotidine. route have a rapid
More informationEFFECT OF PLASTICIZER ON STABILITY OF BUDESONIDE (C.R) MUPS PREPARED BY AQUEOUS POLYMER LAYERING
IJPSR (2015), Vol. 6, Issue 4 (Research Article) Received on 06 August, 2014; received in revised form, 31 October, 2014; accepted, 30 December, 2014; published 01 April, 2015 EFFECT OF PLASTICIZER ON
More informationAmerican Journal of Advanced Drug Delivery.
American Journal of Advanced Drug Delivery www.ajadd.co.uk Original Article Development and Study of an Erodible Matrix Drug Delivery Platform for Sustained Release of Non-Steroidal Anti-Inflammatory Drugs
More informationInternational Journal of Pharmacy and Industrial Research
329 Research Article Available Online at: International Journal of Pharmacy and Industrial Research ISSN Print 2231 3648 Online 2231 3656 FORMULATION AND EVALUATION OF OLMESARTAN MEDOXOMIL FLOATING TABLETS
More informationOptimization Of Propranolol Hydrochloride Controlled Release Matrix Tablet Using Factorial Design
Article ID: WMC00914 2046-1690 Optimization Of Propranolol Hydrochloride Controlled Release Matrix Tablet Using Factorial Design Corresponding Author: Dr. Ritesh Patel, Lecturer, Phrmaceutics and Pharmaceutical
More informationInternational Journal of Research in Pharmaceutical and Nano Sciences Journal homepage:
Research Article CODEX: IJRPJK ISSN: 2319 9563 International Journal of Research in Pharmaceutical and Nano Sciences Journal homepage: www.ijrpns.com DESIGN, PREPARATION AND CHARACTERIZATION OF ORAL DISINTEGRATING
More informationFormulation and in vitro evaluation of bosentan osmatic controlled release tablets
IJPAR Vol.4 Issue 4 Oct- Dec -2015 Journal Home page: ISSN: 2320-2831 Research article Open Access Formulation and in vitro evaluation of bosentan osmatic controlled release tablets Mohammed Asif Hussain,
More informationPreparation and Optimization of Glimepiride Multiparticulate System Using Novel Liquid Layering Technique
Original Article Preparation and Optimization of Glimepiride Multiparticulate System Using Novel Liquid Layering Technique Roopa Rani Balivada 1 *.,Vijayalakshmi P 2.,Venkateswara Rao J 3., Murthy T E
More informationEffect of Granulation Technique and Drug-Polymer Ratio on Release Kinetics of Gliclazide from Methocel K4M Matrix Tablet
Effect of Granulation Technique and Drug-Polymer Ratio on Release Kinetics of Gliclazide from Methocel K4M Matrix Tablet Tanbir Ahammed 1, Moynul Hasan 2, Md. Saiful Islam 3, Muhammad Rashedul Islam 3
More informationFormulation and Evaluation of Floating Capsules of 3 rd Generation Cephalosporin
International Journal of PharmTech Research CODEN (USA): IJPRIF ISSN : 0974-4304 Vol.4, No.3, pp 986-993, July-Sept 2012 Formulation and Evaluation of Floating Capsules of 3 rd Generation Cephalosporin
More informationIonotropic Gelation Technique For Microencapsulation Of Antihypertensive Drug
Article ID: WMC00922 ISSN 2046-1690 Ionotropic Gelation Technique For Microencapsulation Of Antihypertensive Drug Corresponding Author: Dr. Hitesh Patel, Lecturer, Phrmaceutics and Pharmaceutical Technology,
More informationIN VITRO CHARACTERZATIOAN AND EVALUATION OF TRANSDERMAL DRUG DELIVERY SYSTEM FOR METOPROLOL TARTARATE DR.B.ANILREDDY
JPRHC Research Article IN VITRO CHARACTERZATIOAN AND EVALUATION OF TRANSDERMAL DRUG DELIVERY SYSTEM FOR METOPROLOL TARTARATE DR.B.ANILREDDY For author affiliations, see end of text This paper is available
More informationFORMULATION DEVELOPMENT AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF VERAPAMIL HYDROCHLORIDE
IJPSR (2014), Vol. 5, Issue 5 (Research Article) Received on 09 December, 2013; received in revised form, 19 April, 2014; accepted, 29 April, 2014; published 01 May, 2014 FORMULATION DEVELOPMENT AND EVALUATION
More informationFormulation and in-vitro evaluation of pregabalin mini tablets for sustained release
Available online at www.scholarsresearchlibrary.com Scholars Research Library Der Pharmacia Lettre, 2016, 8 (2):277-283 (http://scholarsresearchlibrary.com/archive.html) ISSN 0975-5071 USA CODEN: DPLEB4
More informationFORMULATION AND EVALUATION OF CONTROLLED RELEASE DELIVERY OF TRAMADOL HYDROCHLORIDE USING FULL FACTORIAL DESIGN
International Journal of ChemTech Research CODEN( USA): IJCRGG ISSN : 0974-490 Vol., No.1, pp 669-675, Jan-Mar 010 FORMULATION AND EVALUATION OF CONTROLLED RELEASE DELIVERY OF TRAMADOL HYDROCHLORIDE USING
More informationPelagia Research Library
Available online at www.pelagiaresearchlibrary.com Der Pharmacia Sinica, 2010, 1 (2): 130-135 ISSN: 0976-8688 CODEN (USA): PSHIBD Formulation and Evaluation of Modified Release Trimetazidine Dihydrochloride
More informationReal-Time Prediction of Polymer-Coated Multiparticulate Dissolution using Process Analytical Technology
Real-Time Prediction of Polymer-Coated Multiparticulate Dissolution using Process Analytical Technology Authors: Piyush Patel A, Edward Godek B, Chris O Callaghan C, Dr. Ian Jones D A Colorcon, PA, USA
More informationPreparation and Characterization of Mebeverine Hydrochloride Microspheres
Int. J. Pharm. Sci. Rev. Res., 50(1), May - June 2018; Article No. 02, Pages: 9-13 Research Article Preparation and Characterization of Mebeverine Hydrochloride Microspheres A. Lakshmi Usha*, Radha Rani
More informationInternational Journal of Research in Pharmaceutical and Nano Sciences Journal homepage:
Research Article CODEN: IJRPJK ISSN: 2319 9563 International Journal of Research in Pharmaceutical and Nano Sciences Journal homepage: www.ijrpns.com FORMULATION AND EVALUATION OF ESOMEPRAZOLE MAGNESIUM
More informationNovel Floating Pulsatile Approach for Chronotherapeutic Release of Indomethacin
Novel Floating Pulsatile Approach for Chronotherapeutic Release of Indomethacin Shaji Jessy and Patole Vishal Prin. K. M. Kundnani College of Pharmacy, 23, Jote Joy Bldg., Rambhau Salgaonkar Marg, Colaba,
More informationInternational Journal of Pharmaceutical Sciences and Drug Research 2017; 9(1): 10-16
Available online at www.ijpsdr.com International Journal of Pharmaceutical Sciences and Drug Research 2017; 9(1): 10-16 Research Article ISSN: 0975-248X CODEN (USA): IJPSPP Extended Release Micro-pellets
More informationDESIGN AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF LEVOFLOXACIN EMPLOYING ALMOND GUM
Int. J. Chem. Sci.: 12(3), 14, 762-772 ISSN 0972-768X www.sadgurupublications.com DESIGN AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF LEVOFLOXACIN EMPLOYING ALMOND GUM K. V. R. N. S. RAMESH *,
More informationInvestigation of Aqueous Ethylcellulose Dispersion in Extended Release Metformin Inert Matrices
Surelease Application Data Aqueous Ethylcellulose Dispersion Investigation of Aqueous Ethylcellulose Dispersion in Extended Release Metformin Inert Matrices ABSTRACT SUMMARY: In the present study, Surelease,
More informationDirect compression of cushion layered ethyl cellulose coated extended release pellets into rapidly disintegrating tablets
Research Article ISSN: 0974-6943 M.Yasmin Begum et al. / Journal of Pharmacy Research 2016,10(1), Available online through http://jprsolutions.info Direct compression of cushion layered ethyl cellulose
More informationScholars Research Library. Formulation and evaluation of Tramadol Hydrochloride sustained matrix tablets
Available online at www.scholarsresearchlibrary.com Der Pharmacia Lettre, 2011, 3(3): 245-249 (http://scholarsresearchlibrary.com/archive.html) ISSN 0975-5071 USA CODEN: DPLEB4 Formulation and evaluation
More informationThe purpose of this research work was to develop and evaluate transdermal therapeutic system containing
ISSN: 975-766X CODEN: IJPTFI Available Online through Research Article www.ijptonline.com FORMULATION AND IN-VITRO EVALUATION OF TRANSDERMAL PATCHES OF METHYL SALICYLATE Dhawal Dorwal* M. Pharm, Department
More informationFORMULATION AND EVALUATION OF ACYCLOVIR CR TABLETS: OPTIMIZATION BY 2 2 FACTORIALSTUDY
WORLD JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES Patil et al. SJIF Impact Factor 5.210 Volume 4, Issue 12, 992-1000 Research Article ISSN 2278 4357 FORMULATION AND EVALUATION OF ACYCLOVIR CR TABLETS:
More informationInternational Journal of Biomedical and Advance Research
International Journal of Biomedical and Advance Research ORAL CONTROLLED RELEASE METFORMIN HYDROCHLORIDE ION EXCHANGE RESINATE BEADS Ajit S. Raghuwanshi *1, Ajay S. Raghuwanshi 2 and U. K. Jain 2 1 Department
More informationInternational Journal of Pharmacy and Industrial Research
274 Research Article Available Online at: International Journal of Pharmacy and Industrial Research ISSN Print 2231 3648 Online 2231 3656 FORMULATION AND EVALUATION OF ELETRIPTAN HYDROBROMIDE PELLETS *
More informationVolume 6, Issue 2, January February 2011; Article-019
Research Article FORMULATION AND PROCESS OPTIMIZATION OF TRIMETAZIDINE HCL LOADED ETHYL CELLULOSE MICROSPHERES PREPARED BY AN EMULSION SOLVENT EVAPORATION METHOD Ganesh N S, Patel Mehul Pravinchandra*
More informationFull Length Original Research Paper
Copyright 2015 By IYPF All rights reserved Open Access Contents Int. J. Drug Dev. & Res. January - March 2015 Vol. 7 Issue 1 ISSN 0975-9344 Formulation and Evaluation of sustained release Pellets of www.ijddr.in
More informationExcipient Development at NCL
New Reverse Enteric Polymer for Oral Dosage Forms Excipient Development at omplete Solution for Taste Masking Moisture Barrier Sustained Release Immediate Release Polymorphism Inhibition National hemical
More informationScholars Research Library
Available online at www.scholarsresearchlibrary.com Scholars Research Library Der Pharmacia Lettre, 2010, 2(3): 286-296 (http://scholarsresearchlibrary.com/archive.html) ISSN 0975-5071 USA CODEN: DPLEB4
More informationFORMULATION AND EVALUATION OF ROPINIROLE SUSTAINED RELEASED TABLETS BY USING NATURAL AND SYNTHETIC POLYMERS
International Journal of Pharmacy Review & Research www.ijprr.com FORMULATION AND EVALUATION OF ROPINIROLE SUSTAINED RELEASED TABLETS BY USING NATURAL AND SYNTHETIC POLYMERS V.Naga Manoj kiran 1*, Arun
More informationHuman Journals Research Article October 2018 Vol.:13, Issue:3 All rights are reserved by Gourishyam Pasa et al.
Human Journals Research Article October 2018 Vol.:13, Issue:3 All rights are reserved by Gourishyam Pasa et al. Formulation Development and In-Vitro Evaluation of Sustained-Release Gastro Retentive Tablets
More information4.4 MICROBIOLOGICAL METHOD FOR THE ESTIMATION OF. The microbiological assay was performed by using the test
109 4.4 MICROBIOLOGICAL METHOD FOR THE ESTIMATION OF AMOXICILLIN The microbiological assay was performed by using the test organism Staphylococcus aureus. The strain was isolated from soil and allowed
More information4. PREPARATION OF GELATIN MICROSPHERES. Intra-articular delivery of drug loaded microspheres has been developed by
64 4. PREPARATION OF GELATIN MICROSPHERES Intra-articular delivery of drug loaded microspheres has been developed by many authors (Ratcliffe et al., 1987; Pavanetto et al., 1994; Tuncay et al., 2000a;
More informationTHE DISSOLUTION PROCEDURE: DEVELOPMENT AND VALIDATION
THE DISSOLUTION PROCEDURE: DEVELOPMENT AND VALIDATION Pharmacopeial Forum Vol. 31(5)(Sept.-Oct. 2005) By : Mr. Seubpong Kumpusiri Mrs. Patima Maneesatid 26 May 2006 THE DISSOLUTION PROCEDURE: DEVELOPMENT
More informationInternational Journal of Innovative Pharmaceutical Sciences and Research
International Journal of Innovative Pharmaceutical Sciences and Research www.ijipsr.com FORMULATION AND EVALUATION OF NICARDIPINE HYDROCHLORIDE SUSTAINED RELEASE PELLETS 1 T.Nagendra Babu*, 2 K.Umasankar,
More informationOptimization Of Propranolol Hydrochloride Controlled Release Matrix Tablet Using Factorial Design
Article ID: WMC00914 2046-1690 Optimization Of Propranolol Hydrochloride Controlled Release Matrix Tablet Using Factorial Design Corresponding Author: Dr. Ritesh Patel, Lecturer, Phrmaceutics and Pharmaceutical
More informationResearch Paper Formulation Evaluation and Optimization of Stomach Specific In situ Gel of Ranitidine Hydrochloride
International Journal of Pharmaceutical Sciences and Nanotechnology Volume 3 Issue 1 April June 2010 Research Paper Formulation Evaluation and Optimization of Stomach Specific In situ Gel of Ranitidine
More informationInternational Journal of Pharmacy
International Journal of Pharmacy Journal Homepage: http://www.pharmascholars.com Research Article CODEN: IJPNL6 FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF RANOLAZINE M Vanaja kumari
More informationFormulation and Evaluation of Telmisartan with Hydrochlorothiazide Conventional Release Tablets
Human Journals Research Article July 2018 Vol.:12, Issue:4 All rights are reserved by S. Meena et al. Formulation and Evaluation of Telmisartan with Hydrochlorothiazide Conventional Release Tablets Keywords:
More informationPreparation and Evaluation of Extended Release Pellets of Chiral Molecules of s-metoprolol Succinate by Different Technology
ORIGINAL ARTICLE Preparation and Evaluation of Extended Release Pellets of Chiral Molecules of s-metoprolol Succinate by Different Technology Dipesh V. Patel 1, Bhupendra G. Prajapati 2 1 Department of
More informationDesign of Controlled Release Non-erodible Polymeric Matrix Tablet Using Microwave Oven-assisted Sintering Technique
Pharmaceutics Design of Controlled Release Non-erodible Polymeric Matrix Tablet Using Microwave Oven-assisted Sintering Technique Patel DM Patel BK Patel A Patel CN Department of Pharmaceutics and Pharmaceutical
More informationThe Pharmaceutical and Chemical Journal, 2015, 2(3): Research Article
, 215, 2(3):54-61 Available online www.tpcj.org Research Article ISSN: 2349-792 CODEN(USA): PCJHBA Formulation, Development and Evaluation of Metformin Hydrochloride Extended Release Tablets Kapil Tak
More informationPreparation and Evaluation of Ethyl Cellulose Coated Microcapsules of Gliclazide for Controlled Release
Asian Journal of Chemistry Vol. 20, No. 8 (2008), 5908-5914 Preparation and Evaluation of Ethyl Cellulose Coated Microcapsules of Gliclazide for Controlled Release K.P.R. CHOWDARY*, SRINIVAS PANGULURI
More informationFormulation and Development of Capsule in Capsule Drug Delivery System for Biphasic Delivery of Etoricoxib
Human Journals Research Article July 2016 Vol.:6, Issue:4 All rights are reserved by S. M. Thorat et al. Formulation and Development of Capsule in Capsule Drug Delivery System for Biphasic Delivery of
More informationApplication of Quality by Design (QbD) in product development. James E. Polli September 16, 2015
Application of Quality by Design (QbD) in product development James E. Polli jpolli@rx.umaryland.edu September 16, 2015 Pharmaceutical Equivalence Same active ingredient(s) Same dosage form Same route
More informationInternational Journal of Research in Pharmaceutical and Nano Sciences Journal homepage:
Review Article CODEN: IJRPJK ISSN: 2319 9563 International Journal of Research in Pharmaceutical and Nano Sciences Journal homepage: www.ijrpns.com REVIEW ARTICLE ON INPROCESS PROBLEMS AND EVALUATION TESTS
More informationFORMULATION AND DEVELOPMENT OF SUSTAINED RELEASE MATRIX TABLET OF NICORANDIL
FORMULATION AND DEVELOPMENT OF SUSTAINED RELEASE MATRIX TABLET OF NICORANDIL Mr. Ashish Pahade*, Dr. V. M. Jadhav, Dr. V. J. Kadam Quality assurance dept, Bharati Vidyapeeth s College of Pharmacy, CBD
More informationAsian Journal of Research in Pharmaceutical Sciences and Biotechnology
Research Article ISSN: 2349 7114 Asian Journal of Research in Pharmaceutical Sciences and Biotechnology Journal home page: www.ajrpsb.com FORMULATION DEVELOPMENT AND EVALUATION OF PANTOPRAZOLE DELAYED
More informationKollidon SR: A polyvinyl acetate based excipient for DCsustained-release
Kollidon SR: A polyvinyl acetate based excipient for DCsustained-release oral dosage forms by Dr. Bernhard Fussnegger BASF Aktiengesellschaft, Ludwigshafen Strategic Marketing Pharma Excipients Introduction
More informationAnanda Kumar CH. et al. / International Journal of Biological & Pharmaceutical Research. 2012; 3(7):
904 e- ISSN 0976-3651 Print ISSN 2229-7480 International Journal of Biological & Pharmaceutical Research Journal homepage: www.ijbpr.com IJBPR DEVELOPMENT OF ITRACONAZOLE IMMEDIATE RELEASE PELLETS BY USING
More informationFormulation and Evaluation of Captopril. Gastroretentive Floating Drug Delivery System
INTERNATIONAL JOURNAL OF ADVANCES IN PHARMACY, BIOLOGY AND CHEMISTRY Formulation and Evaluation of Captopril Research Article Gastroretentive Floating Drug Delivery System Swalin Parija* Institute of Pharmacy
More informationDesign and Evaluation of Sustained Release Tablets containing Solid dispersion of Ziprasidone hydrochloride
International Journal of PharmTech Research CODEN (USA): IJPRIF ISSN : 0974-4304 Vol.6, No.3, pp 959-968, July-Aug 2014 Design and Evaluation of Sustained Release Tablets containing Solid dispersion of
More informationMalleswari et.al Indian Journal of Research in Pharmacy and Biotechnology ISSN: (Print) ISSN: (Online)
Comparative in-vitro dissolution study of five brands of Diclofenac sodium delayed release tablets in QbD environment V Malleswari Bai* 1, M Prasada Rao 1, M Chandana 1, K Naga Harini 1, B Naga Deepthi
More informationADVANTAGES OF MULTIPARTICULATES (PELLETS):
INTRODUCTION: Multiparticulate Drug Delivery Systems (MDDS): The concept of multiple unit dosage form was initially introduced in the early 1950 s.these forms play a major role in the design of solid dosage
More informationFORMULATION AND EVALUATION OF ACECLOFENAC MATRIX TABLETS USING ETHYL CELLULOSE AND CELLULOSE ACETATE PHTHALATE
M. Vijaya Laxmi et al. / JGTPS/ 5(3)-(2014) 1804-1810 ISSN: 2230-7346 (Research Article) Journal of Global Trends in Pharmaceutical Sciences Journal home page: www.jgtps.com FORMULATION AND EVALUATION
More informationBCS, Biowaivers and Dissolution Test Methodologies
BCS, Biowaivers and Dissolution Test Methodologies Vinod P. Shah, Ph.D., FAAPS, FFIP Pharmaceutical Consultant, (Formerly with US FDA) North Potomac, MD., USA Disso Europe 2016 Romania Advances and Applications
More informationINTERNATIONAL JOURNAL OF INSTITUTIONAL PHARMACY AND LIFE SCIENCES
International Journal of Institutional Pharmacy and Life Sciences 7(6): November-December 2017 INTERNATIONAL JOURNAL OF INSTITUTIONAL PHARMACY AND LIFE SCIENCES Pharmaceutical Sciences Research Article!!!
More informationINTRODUCTION MATERIALS AND METHODS
Formulation development and investigation of ibuprofen controlled release tablets with hydrophilic polymers and the effect of coexcipients on drug release patterns Syed Umer Jan 1*, Gul Majid Khan 2 and
More informationINTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND BIO-SCIENCE FORMULATION AND EVALUATION OF AMBROXOL HYDROCHLORIDE SUSTAINED RELEASE TABLETT
RESEARCH ARTICLE INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND BIO-SCIENCE A Path for Horizing Your Innovative Work FORMULATION AND EVALUATION OF AMBROXOL HYDROCHLORIDE SUSTAINED RELEASE TABLETT
More informationNarendra Chary T et al. / Int. Res J Pharm. App Sci., 2012; 2(4):
International Research Journal of Pharmaceutical and Applied Sciences Available online at www.irjpas.com Int. Res J Pharm. App Sci., 2012; 2(4):97-103 Research Article Studies on formulation development
More informationFormulation and Evaluation of Gastro retentive Bilayer Tablets- Glimepiride as Sustained Release and Lisinopril as Immediate Release
Farhat A et al / Int. J. of Pharmacy and Analytical Research Vol-5(4) 216 [658-669] IJPAR Vol.5 Issue 4 Oct - Dec -216 Journal Home page: ISSN:232-2831 Research article Open Access Formulation and Evaluation
More informationResearch Article. *Corresponding author M. Tejakrishna
Scholars Academic Journal of Pharmacy (SAJP) ISSN 232-426 Sch. Acad. J. Pharm., 213; 2(3):199-28 Scholars Academic and Scientific Publisher (An International Publisher for Academic and Scientific Resources)
More informationTHE CHRONOTOPIC TECHNOLOGY
THE CHRONOTOPIC TECHNOLOGY The Chronotopic technology relates to an oral delivery system designed for timebased pulsatile release, which is generally referred to as the liberation of drugs after a predetermined
More informationResearch Article. Formulation and in-vitro evaluation of orodispersible tablets of olanzapine for the improvement of dissolution rate
Available online www.jocpr.com Journal of Chemical and Pharmaceutical Research, 2016, 8(1):177-181 Research Article ISSN : 0975-7384 CODEN(USA) : JCPRC5 Formulation and in-vitro evaluation of orodispersible
More informationChapter 1. Introduction
Chapter 1 Introduction Controlled drug delivery systems, which are intended to deliver drugs at predetermined rates for predefined periods of time, have been used to overcome the shortcomings of conventional
More informationResearch Paper. Development of Prolonged Delivery of Tramadol and Dissolution Translation by Statistical Data Treatment
330 International Journal of Pharmaceutical Sciences and Nanotechnology Volume 4 Issue April-June 20 Research Paper International Journal of Pharmaceutical Sciences and Nanotechnology Volume 4 Issue April
More informationFORMULATION AND EVALUATION OF POLYMER EFFECT ON in-vitro KINETICS OF SUSTAINED RELEASE MATRIX TABLETS OF CARVEDILOL USING MODEL DEPENDENT METHODS
FORMULATION AND EVALUATION OF POLYMER EFFECT ON in-vitro KINETICS OF SUSTAINED RELEASE MATRIX TABLETS OF CARVEDILOL USING MODEL DEPENDENT METHODS Umme Rahela, Md. Mizanur Rahman Moghal *, Syed Masudur
More informationTable Formula of Levodopa + Benserazide HCl capsule (batch no. 004 to 008)
Introduction After using pearlitol SD (200) along with avicel ph 112 the flow of the blend was improved but still not up to the mark. Weight variation was observed around (11.47%) which was not acceptable.
More informationFORMULATION AND EVALUATION OF FLOATING MICROSPHERES OF CEPHALEXIN
Research Article FORMULATION AND EVALUATION OF FLOATING MICROSPHERES OF CEPHALEXIN Kamini Vasava, Rajesh KS, Lalit Lata Jha * Department of Pharmaceutics, Parul Institute of Pharmacy, Waghodia, Vadodara,
More informationFormulation and Evaluation of Transdermal Patches of Curcumin
Available online at www.ijntps.org ISSN: 2277 2782 INTERNATIONAL JOURNAL OF NOVEL TRENDS IN PHARMACEUTICAL SCIENCES Formulation and Evaluation of Transdermal Patches of Curcumin RESEARCH ARTICLE L Karpagavalli
More informationA Study of Dissolution Enhancement and Invitro Evaluation of Roxithromycin Matrix Tablets of Solid Dispersions
International Journal of Chemical and Pharmaceutical Sciences 2011, June., Vol.2 (2) ISSN: 0976-9390 A Study of Dissolution Enhancement and Invitro Evaluation of Roxithromycin Matrix Tablets of Solid Dispersions
More informationMEDICINES CONTROL COUNCIL
MEDICINES CONTROL COUNCIL DISSOLUTION This guideline is intended to provide recommendations to applicants wishing to submit applications for the registration of medicines. It represents the Medicines Control
More informationFormulation and Evaluation of Floating Tablets Using Nimesulide as a Model Drug
International Research Journal of Engineering and Technology (IRJET) e-issn: 2395-56 Volume: 4 Issue: 9 Sep -217 www.irjet.net p-issn: 2395-72 Formulation and Evaluation of Floating Tablets Using Nimesulide
More informationJournal of Pharmaceutical Research
Journal of Pharmaceutical Research ISSN - 097-700 online- ISSN-454-8405 www.journalofpharmaceuticalresearch.org Invited Article OPTIMIZATION OF PHARMACEUTICAL PRODUCT FORMULA-TION BY FACTORIAL DESIGNS:
More informationA Simple and Economical Approach/Concept to Evaluate Quality of Pharmaceutical Products Based on an Improved Dissolution Testing Methodology
The Open Drug Delivery Journal, 2008, 2, 33-37 33 Open Access A Simple and Economical Approach/Concept to Evaluate Quality of Pharmaceutical Products Based on an Improved Dissolution Testing Methodology
More informationInternational Journal of Research in Pharmaceutical and Nano Sciences Journal homepage:
Research Article CODEN: IJRPJK ISSN: 2319 9563 International Journal of Research in Pharmaceutical and Nano Sciences Journal homepage: www.ijrpns.com IN-VITRO DRUG RELEASE STUDIES OF DILTIAZEM SUSTAIN
More informationPelagia Research Library
Available online at www.pelagiaresearchlibrary.com Der Pharmacia Sinica, 2012, 3 (5):598-603 ISSN: 0976-8688 CODEN (USA): PSHIBD Formulation and evaluation of solid matrix tablets of repaglinide Jitender
More information7th Training School on Microencapsulation Strasbourg. Februar 2015 Textmasterformat in Mastervorlage eingeben
7th Training School on Microencapsulation Strasbourg Februar 2015 1 Dr. Anne Ettner, Glatt Pharmaceutical Services 2 Overview 1. Introduction 2. Fluid bed equipment 3. Basics of fluid bed Wurster technology
More informationImpact factor: 3.958/ICV: 4.10 ISSN:
Impact factor: 3.958/ICV: 4.10 ISSN: 0976-7908 255 Pharma Science Monitor 8(1), Jan-Mar 2017 PHARMA SCIENCE MONITOR AN INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES Journal home page: http://www.pharmasm.com
More informationTHE PHARMA INNOVATION - JOURNAL Formulation and Development of Floating and Mucoadhesive Microspheres of Clarithromycin
Received: 07-05-2013 Accepted: 09-06-2013 ISSN: 2277-7695 CODEN Code: PIHNBQ ZDB-Number: 2663038-2 IC Journal No: 7725 Vol. 2 No. 5 2013 Online Available at www.thepharmajournal.com THE PHARMA INNOVATION
More informationBrahmaiah Bonthagarala *, Prasanna Kumar Desu, Sreekanth Nama, Donthiboina Sudarshan
e - ISSN XXXX-XXXX Print ISSN - XXXX-XXXX Singapore Journal of Pharmaceutical Research Journal homepage: www.mcmed.us/journal/sjpr FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF OZCARBAZEPINE
More informationThis PDF is available for free download from a site hosted by Medknow Publications
Research Paper www.ijpsonline.com Statistical Evaluation of Influence of Viscosity of Polymer and Types of Filler on Dipyridamole Release from Floating Matrix Tablets V. F. PATEL* AND N. M. PATEL Shri
More informationDeveloping new drug products is very expensive, especially
As appeared in March 2018 Tablets & Capsules www.tabletscapsules.com formulation Developing fixed-dose combinations Amar Patel, Bruhalkumar Shah, Deep Patel, Satish Shetty, and Anthony Qu Halo Pharmaceuticals
More informationResearch and Reviews: Journal of Pharmacy and Pharmaceutical Sciences
Research and Reviews: Journal of Pharmacy and Pharmaceutical Sciences Optimization and Biopharmaceutical Evaluation of a Formulated Patch of Ondansetron for Transdermal Delivery. Anjan De 1 *, Subrata
More informationThe objective of this study was to develop modified release dosage forms of tramadol hydrochloride using wax matrix
ORIGINAL ARTICLE Development and evaluation of modified release wax matrix tablet dosage form for tramadol hydrochloride Paresh Ramesh Mahaparale, Bhanudas Shankarrao Kuchekar 1 Department of Pharmaceutics,
More informationModified-release multiple unit dosage form (MRMUD) of desloratadine and pseudoephedrine hydrochloride with
RESEARCH ARTICLE Development and evaluation of a novel modified release pellet-based system for the delivery of desloratadine and pseudoephedrine hydrochloride Sachin U Kushare, Atul A Phatak, Praveen
More informationExtended-release Venlafaxine Pellets: Scaling Up the Coating Process Stuart C. Porter, Bradley Beissner and Jeffrey Williamson
PHARMACEUTICAL TECHNOLOGY REPORT Consumer Specialties ashland.com PTR-104 Page 1 of 6 Extended-release Venlafaxine Pellets: Scaling Up the Coating Process Stuart C. Porter, Bradley Beissner and Jeffrey
More informationTejaswi M. et al. / International Journal of Biopharmaceutics. 2013; 4(1): International Journal of Biopharmaceutics
27 e- ISSN 0976-1047 Print ISSN 2229-7499 International Journal of Biopharmaceutics Journal homepage: www.ijbonline.com IJB DESIGN AND EVALUATION OF FELODIPINE EXTENDED RELEASE TABLETS EMPLOYING A NEW
More informationPelagia Research Library. Design fabrication and characterization of controlled released tablets of Trimetazidine di hydrochloride
Available online at www.pelagiaresearchlibrary.com Der Pharmacia Sinica, 2011, 2 (6):59-66 ISSN: 0976-8688 CODEN (USA): PSHIBD Design fabrication and characterization of controlled released tablets of
More informationFORMULATION DEVELOPMENT AND EVALUATION OF FAMOTIDINE FLOATING TABLET
FORMULATION DEVELOPMENT AND EVALUATION OF FAMOTIDINE FLOATING TABLET Patel Amit* 1, Jha Sajal Kumar 1, Panchal Harishanker 2, Shukla Tarkeshwar 1, Shah Arpit 3 1 Dept. of Pharmaceutics, NIMS Institute
More informationFormulation and invitro evaluation of albendazole nanosuspensions
IJPAR Vol.7 Issue 2 Apr - Jun -2018 Journal Home page: ISSN:2320-2831 Research article Open Access Formulation and invitro evaluation of albendazole nanosuspensions Mothkuri Sathish Kumar Manager, Novartis
More informationFormulation and In-Vitro Evaluation of Mucoadhesive Floating Microspheres of Repaglinide Using Solvent Evaporation Method
ISSN 2395-3411 Available online at www.ijpacr.com 141 Research Article Formulation and In-Vitro Evaluation of Mucoadhesive Floating Microspheres of Repaglinide Using Solvent Evaporation Method K. Harinada
More informationPerformance Testing of Novel Dosage Forms
RQA Ireland Regional Forum - Athlone, May 2016 Quality Considerations Pharma and Biopharma Performance Testing of Novel Dosage Forms Terry Way BPharm MAPS Dissolution Science Consultant Glasside Technologies
More information