Engineering the Medicines of Tomorrow
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1 January 15, 2018 Engineering the Medicines of Tomorrow Company Update
2 This presentation includes forward-looking statements. Actual results could differ materially from those included in the forward-looking statements due to various risk factors and uncertainties including changes in business, economic competitive conditions, regulatory reforms, foreign exchange rate fluctuations and the availability of financing. These and other risks and uncertainties are detailed in the Company s Annual Report. The compounds discussed in this slide presentation are investigational products being developed by MorphoSys and its partners and are not currently approved by the U.S. Food and Drug Administration (FDA), European Medicine Agency (EMA) or any other regulatory authority (except for guselkumab/tremfya ). 2
3 Investment Highlights Pipeline Leading antibody platform: over 100 active programs*, 28 in clinic Tremfya Potential blockbuster, offers lucrative royalty opportunity MOR208 Late-stage, proprietary candidate with promising data in DLBCL *Probability of success cannot be predicted 3
4 Business Model Building a Commercial, Product-Based Biopharmaceutical Company Value Partnered Discovery Maximizing utilization of technology Lucrative source of revenue from licence fees, milestones & royalties Proprietary Development Proprietary Development Focus on oncology/inflammation Retained rights translate into greater revenue potential Partnered Discovery Time 4
5 Our Clinical Pipeline 28 Product Candidates in Clinical Development, First Product Launched Program Partner Target Disease area Phase 1 Phase 2 Phase 3 Launched Tremfya (Guselkumab) Janssen IL-23p19 Psoriasis Gantenerumab Roche Amyloid-ß Alzheimer s disease MOR208 - CD19 DLBCL, CLL/SLL 2 Anetumab Ravtansine (BAY ) Bayer Mesothelin (ADC) Solid tumors BHQ880 Novartis DKK-1 Multiple myeloma Bimagrumab (BYM338) Novartis ActRIIB Musculoskeletal diseases BPS804 Mereo/Novartis Sclerostin Brittle bone syndrome CNTO6785 Janssen - Inflammation Elgemtumab (LJM716) Novartis HER3 Cancer MOR103/GSK * GSK GM-CSF Inflammation 12 MOR202 I-Mab Biopharma** CD38 Multiple myeloma Tesidolumab (LFG316) Novartis C5 Eye diseases Utomilumab (PF ) Pfizer 4-1BB Cancer VAY736 Novartis BAFF-R Inflammation Xentuzumab (BI ) BI IGF-1 Solid tumors BAY Bayer TFPI Hemophilia MOR106 Galapagos IL-17C Inflammation MOR107 (LP2-3) Lanthio Pharma AT2-R Not disclosed NOV 7 Novartis - Eye diseases NOV 8 Novartis - Inflammation NOV-9 Novartis - Diabetic eye diseases NOV-10 Novartis - Cancer 13 NOV-11 Novartis - Blood disorders NOV-12 Novartis - Prevention of thrombosis NOV-13 Novartis - Cancer NOV-14 Novartis - Asthma PRV-300 (CNTO3157) ProventionBio TLR-3 Inflammation Vantictumab (OMP-18R5) OncoMed Fzd 7 Solid tumors Partnered Discovery Programs Proprietary Development Programs *MOR103/GSK is fully outlicensed to GSK. ** For development in Greater Chinese Market (China, Hong Kong, Taiwan, Macao) 5
6 Diffuse Large B Cell Lymphoma: High Unmet Medical Need Most frequently-occurring malignant lymphoma worldwide Incidence of non-hodgkin s lymphoma (NHL) in : 87,830 85% of all NHL arise from B cells 30% of these belong to diffuse large B cell lymphoma (DLBCL) Very aggressive and resistant tumor 40% of all patients with DLBCL either fail to respond to or show a relapse to initial therapy Relapsed or refractory DLBCL (R/R DLBCL) Disease is difficult to treat Prognosis is dismal, especially for elderly and frail patients High unmet medical need 1 DRG 2016; DLBCL, diffuse large B cell lymphoma; NHL, non-hodgkin lymphoma 6
7 MOR208: Proprietary Antibody in Hematological Cancers An Investigational Anti-CD19 Program for B Cell Malignancies The Drug Candidate IgG1 kappa antibody targeting CD19 In-licensed from Xencor Fc-engineered to enhance target cell-killing Mode of Action ADCC, phagocytosis, direct cytotoxicity Strong Preclinical Package Depletes B cells in in vitro and in vivo models Rationale for multiple combination therapies W Jurczak et al.; ASH 2016 ADCC: Antibody-Dependent Cell-Mediated Cytotoxicity ADCP: Antibody-Dependent Cell-Mediated Phagocytosis 7
8 MOR208: Development Plan Opportunity Across Spectrum of B Cell Malignancies Indication Trial / Phase Design Timeline DLBCL L-MIND Phase 2 Lenalidomide + MOR208 in relapsed or refractory DLBCL pts ineligible for HDCT and ASCT Under discussion with FDA (Q1 2018) B-MIND Phase 3 Bendamustine + MOR208 vs. bendamustine + rituximab in relapsed or refractory DLBCL pts ineligible for HDCT and ASCT Primary endpoint: Q CLL COSMOS Phase 2 MOR208 + idelalisib in relapsed or refractory CLL BTKi-failures Updates at medical conferences 2018 MOR208 + venetoclax in relapsed or refractory CLL BTKi-failures DLBCL Front line Under evaluation Indolent lymphomas Under evaluation 8
9 Existing and Upcoming Approaches in R/R DLBCL Comparison to Literature Data* Parameter L-MIND Salles et al., 2017** Dang et al., 2014 Sehn et al., 2017 Scholar-1 Crump et al., 2017 Juliet Schuster et al., 2017 Zuma-1 Neelapu et al., 2017 Compound(s) MOR208 + lenalidomide RTX + bendamustine Polatuzumab + RTX + bendamustine Salvage chemotherapies + radiation Tisagenlecleucel (CTL019) Axi-CEL (CD19 CAR-T) Phase II III II Retrospective study II I+II Evaluable patient population Objective response rate Complete response rate R/R DLBCL n=44 R/R DLBCL n=135 R/R DLBCL n=40 R/R DLBCL n=635 R/R DLBCL n=81 52% 49% 70% 26% 53%/37% Best/@6 mo 32% 18% 58% 8% 40%/30% Best/@6 mo DLBCL,FL, PMBCL n=108 (DLBCL n=77) 82%/42% Best/@6 mo 58%/ 40% Best/@6 mo Median PFS, months 11.3 (preliminary) n/a Median overall survival, months NR*** NR*** NR*** Please note limitations of of cross-trial comparisons. ** Data cut-off June 13th, 2017; *** NR, not reached. n/a, no information available. R/R, relapsed/refractory; DLBCL, Diffuse Large B-cell Lymphoma; RTX, rituximab; OBI, obinutuzumab; CR, complete response; ORR, objective response rate; PFS, progression-free survival 9
10 Comparison of Previous LEN-Approaches in R/R DLBCL Comparison to Literature Data* Number of patients L-MIND MOR208 + LEN Cut-off June 2017 LEN mono Witzig et al LEN mono Czuzcman et al RTX + LEN Wang et al OBI + LEN Morschhauser et al. ASH 2016 n=44 n=108 n=51 n=32 n=71 ORR 52% 28% 28% 28% 45% CR 32% 7% 10% 22% 16% median PFS, month 11.3 (preliminary) *Please note limitations of cross-trial comparisons. R/R= relapsed/refractory; DLBCL = Diffuse Large B cell Lymphoma, LEN, lenalidomide; RTX, rituximab; OBI, obinutuzumab; CR, complete response; ORR, objective response rate; PFS, progression-free survival 10
11 MOR202: Proprietary Anti-CD38 Antibody An Antibody for Multiple Myeloma & Potentially Other Cancers The Drug Candidate Developed to target a unique epitope on CD38 ADCC & ADCP cell-killing mechanisms Low NK cell depletion, which may translate into longer duration of response Clinical* Efficacy Responses ongoing in 65% of patients Patient with longest time on study with ongoing response: >22 months Infusion time of 2h, shorter time being explored Potentially opportunities in other oncology indications and auto-immune diseases ADCC ADCP *From ongoing phase 1/2a trial: Raab et al., Poster presentation at ASCO, June 5, 2017: Abstract #8024 ADCC: Antibody-Dependent Cell-Mediated Cytotoxicity ADCP: Antibody-Dependent Cell-Mediated Phagocytosis 11
12 MOR202: Efficacy Evaluation Comparison of Response Data Among Study Cohorts MOR202q1w + DEX cohorts MOR202q1w + LEN/DEX cohorts MOR202q1w + POM/DEX cohorts n=18 n=17 n= NE: 6% PD: 6% NE: 18% NE: 15% Best Overall Responses (%) SD: 50% MR: 11% PR: 17% VGPR: 11% ORR: 28% PD: 6% SD: 6% PR: 47% VGPR: 18% CR: 6% ORR: 71% PD: 8% SD: 8% MR: 23% PR: 23% VGPR: 8% CR: 15% ORR: 46% CR, complete response; NE, not evaluable; ORR, objective response rate; PD, progressive disease; PR, partial response; SD, stable disease; VGPR, very good partial response; MR, marginal response; modified from Raab et al, ASCO 2017; ITT population shown 12
13 MOR202: Safety Profile Incidence of Infusion-Related Reactions and Infusion Time Safety MOR202 appears to be well tolerated, with 6% infusion related reactions, mainly limited to the first infusion (grade 1 and 2) Convenience Infusion time of 2 hours at highest doses Shorter duration of infusion currently being explored Infusion related reactions (IRR) in % 45% 47% 50% 11% 6% 0% MOR202 q1w + Dex* MOR202 q1w + LEN/Dex* MOR202 q1w + POM/Dex* SIRIUS** POLLUX*** EQUULEUS**** No clinical data exist that directly compare these therapies, please note limitations of cross-trial comparisons. *Raab et al., Poster Presentation at ASCO, June 5, 2017: Abstract #8024 / ** Lonial et al., Lancet, 2016 / *** Dimopoulos et al., NEJM, 2016 / **** Chari et al., Blood,
14 MOR202: First Partnering Deal Agreement with I-MAB Biopharma for Greater Chinese Market Agreement signed November 30, 2017 I-MAB receives exclusive development and commercialization rights in China, Taiwan, Hong Kong and Macao Payments to MorphoSys $20 million upfront Up to $100 million milestones Tiered, double digit royalties I-MAB s head of R&D was formerly responsible for the clinical development of Daratumumab in China as Janssen China s head of development 14
15 MOR106: Phase 1 Study in Atopic Dermatitis First Signs of Clinical Activity The Drug Candidate Ylanthia antibody against IL-17C, 50/50 co-development with Galapagos Clinical Top line results published end of September 2017: No clinically relevant safety signals At the highest dose level, 5 out of 6 patients (83%) reached an improvement of at least 50% in atopic dermatitis symptoms (EASI-50) by week 4 Results support progression to Phase 2 study Single ascending dose Healthy males, 7 cohorts, i.v. infusion (n=42) Placebo (n=14) 7-week follow up Multiple ascending dose Patients*, 3 cohorts, weekly i.v. infusion for 4 weeks (n=18) Placebo (n=6) 11-week follow up *Patients with moderate-to-severe atopic dermatitis 15
16 Partnered Discovery Program: Tremfya (Guselkumab) Developed by Janssen in Inflammatory Indications The Drug First-in-class IL-23-specific HuCAL antibody Status Approved in U.S., EU, Canada for moderate-to-severe psoriasis First royalties will be reflected in FY 2017 results Differentiation Compelling clinical efficacy Convenience: 8-weekly s.c. dosing Phase 3 Trials Ongoing Head-to-head vs. Cosentyx in psoriasis: ongoing Psoriatic arthritis: 2 trials ongoing Crohn s disease: planned 16
17 Financial Guidance 2017* Updated November 30, 2017 In million Q1-Q Guidance 2017 (Issued March 9, 2017) Guidance 2017 (Updated Nov. 30, 2017) Group Revenues to to 66 Proprietary R&D Expenses (incl. Technology Development) to to 100 EBIT (53.8) (75) to (85) (66) to (71) Cash, cash equivalents & marketable securities as well as other short-term and long-term financial assets (end of reporting period) Total shares issued (as of December 31, 2017): 29,420,785 MorphoSys is listed on the Frankfurt Stock Exchange under the symbol MOR *Guidance for revenues and EBIT includes royalty income on Tremfya sales in Q Royalty income based on Tremfya sales in Q will be booked in Q
18 Proprietary Portfolio: Expected Newsflow 2018 Compound Indication Expected Newsflow MOR208 DLBCL L-MIND: Updated development plan following BTD interactions with FDA, Q CLL COSMOS: Phase 2 data mid 2019 MOR202 (I-MAB Biopharma*) Multiple myeloma Further partnering discussions ongoing Final data phase 1/2a study late 2018 MOR106 Atopic dermatitis Start of phase 2 trial Q MOR103/ GSK ** Rheumatoid arthritis Hand osteoarthritis Data from phase 2b trial Data from phase 2a trial * For development in Greater Chinese Market (China, Hong Kong, Taiwan, Macao) **MOR103/GSK is fully outlicensed to GSK. 18
19 Partnered Pipeline: Expected Primary Completion Dates Up to 19 Clinical Phase 2 and 3 Read-outs Potentially Due in 2018* Phase 2 Phase 3 BSP804 Type I, III or IV Osteogenesis Imperfecta (ASTEROID) Bimagrumab (BYM338) Muscular atrophy after hip fracture surgery BSP804 Type I, III or IV Osteogenesis Imperfecta (METEOROID) Bimagrumab (BYM338) Sarcopenia Gantenerumab Mild Alzheimer s disease (open label extension) Guselkumab Pustular or Erythrodermic Psoriasis Tesidolumab (LFG316) Geographic atrophy (+ CLG561) Tesidolumab (LFG316) Paroxysmal nocturnal hemoglobinuria VAY736 Primary Sjögren s syndrome Xentuzumab (BI ) Prostate cancer (+ enzalutamide) Tesidolumab (LFG316) Panuveitis VAY736 Rheumatoid arthritis VAY736 Pemphigus Vulgaris Xentuzumab (BI ) Breast cancer Guselkumab Moderate to severe plaque psoriasis Guselkumab Moderate to severe plaque psoriasis (ECLIPSE; Head-to-head with Cosentyx ) Guselkumab Moderate to severe plaque psoriasis (POLARIS; Comparison to Fumaric Acid Esters) Guselkumab Palmoplantar Pustulosis Guselkumab Severe plaque psoriasis *Anticipated primary completion dates, according to clinicaltrials.gov 19
20 Our Future Lucrative milestone & royalty streams from deep partnered pipeline Commercializing own products in selected geographies Innovative science and technology driving expansion of proprietary portfolio A fully-integrated biopharmaceutical company Attractive partner for big pharma and biotech 20
21 Appendix 21
22 Clinical Programs Ongoing Clinical Trials (1) Program Partner Target Indication Phase 1 Phase 2 Phase 3 Launched Guselkumab Janssen/J&J IL23p19 Plaque psoriasis (CNTO1959) Plaque psoriasis (VOYAGE 1) Plaque psoriasis (VOYAGE 2) Pustular/Erythrodermic psoriasis Plaque psoriasis Plaque psoriasis (POLARIS) Palmoplantar pustulosis Moderate to severe plaque psoriasis (efficacy & safety) Moderate to severe plaque psoriasis (ECLIPSE) Psoriatic arthritis (PsA) Gantenerumab Roche Amyloid-ß Mild Alzheimer's disease (Marguerite RoAD) Prodromal Alzheimer's disease Genetically predisposed for Alzheimer's disease (DIAN) Safety, tolerability and pharmacokinetics (sc) Pain, tolerability, safety and pharmacokinetics (sc) Bioavailability (sc) MOR208 - CD19 Diffuse large B cell lymphoma (DLBCL) (B-MIND) Chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) (COSMOS) Diffuse large B cell lymphoma (DLBCL) (L-MIND) Anetumab Ravtansine Bayer Mesothelin Mesothelioma (MPM) (BAY ) Cancer multi-indications BHQ880 Novartis DKK-1 Multiple myeloma (MM) (renal insufficiency) Smoldering multiple myeloma Bimagrumab Novartis ActRIIB Muscular atrophy hip fracture surgery (BYM338) Sarcopenia (dose-ranging) Sarcopenia (withdrawal extension study) Type 2 diabetes BPS804 Mereo/Novartis Sclerostin Osteoporosis Hypophosphatasia (HPP) Brittle bone disease Brittle bone disease (Type I, III, IV) (ASTEROID) Brittle bone disease (Type I, III, IV) (METEOROID) CNTO6785 Janssen/J&J Chronic obstructive pulmonary disease (COPD) Rheumatoid arthritis (RA) Partnered Discovery Programs Proprietary Development Programs 22
23 Clinical Programs Ongoing Clinical Trials (2) Program Partner Target Indication Phase 1 Phase 2 Phase 3 Launched Elgemtumab Novartis HER3 ESCC (combo with BYL719) (LJM716) HER2+ cancer (combo with BYL719 & trastuzumab) HER2+ cancer (combo with trastuzumab) MOR103/GSK * GSK GM-CSF Rheumatoid arthritis (RA) Rheumatoid arthritis (RA) (mechanistic study) Hand osteoarthritis Rheumatoid arthritis (RA) (combo with methotrexate) MOR202 I-Mab CD38 Multiple myeloma (MM) Biopharma** Tesidolumab Novartis C5 Age-related geographic atrophy (LFG316) Geographic atrophy (combo with CLG561) Panuveitis Paroxysmal nocturnal hemoglobinuria Renal disease patients awaiting kidney transplant Utomilumab Pfizer 4-1BB Solid tumors (JAVELIN medley) (combo with avelumab) (PF ) Advanced Malignancies (combo with avelumab and PF ) Solid tumors (combo with ISA101b Vaccination) Solid tumors, NHL (combo with rituximab) Solid tumors (combo with mogamulizumab) Solid tumors (combo with PF ) Diffuse large B cell lymphoma (DLBCL) (combo with avelumab) VAY736 Novartis BAFF-R Pemphigus vulgaris Primary Sjögren's syndrome Rheumatoid arthritis (RA) ADCC Mediated B Cell Depletion and BAFF-R Blockade (AMBER) Primary Sjögren's syndrome (efficacy & safety) Xentuzumab (BI ) BI IGF-1 Breast cancer Castration-resistant prostate cancer (CRPC)(combo with enzalutamide) Solid tumors (Japan) Solid tumors (combo with abemaciclib) EGFR mutant non-small cell lung cancer (NSCLC) Partnered Discovery Programs Proprietary Development Programs *MOR103/GSK is fully outlicensed to GSK. ** For development in Greater Chinese Market (China, Hong Kong, Taiwan, Macao) 23
24 Clinical Programs Ongoing Clinical Trials (3) Program Partner Target Indication Phase 1 Phase 2 Phase 3 Launched BAY Bayer TFPI Hemophilia MOR106 Galapagos IL-17C Atopic dermatitis MOR107 (LP2-3) Lanthio Pharma AT2-R Not disclosed NOV-7 Novartis n.d. Eye disease NOV-8 Novartis n.d. Inflammation NOV-9 Novartis n.d. Diabetic eye disease NOV-10 Novartis n.d. Cancer NOV-11 Novartis n.d. Blood disorders NOV-12 Novartis n.d. Prevention of thrombosis NOV-13 Novartis n.d. Cancer NOV-14 Novartis n.d. Asthma PRV-300 (CNTO3157) ProventionBio TLR-3 Colitis Vantictumab Oncomed/Bayer Fzd 7 Breast cancer (combo with paclitaxel) (OMP-18R5) Pancreatic cancer (combo with nap-paclitaxel & gemcitabine) Non-small-cell lung carcinoma (NSCLC) (combo with docetaxel) Partnered Discovery Programs Proprietary Development Programs 24
25 Covering Analysts Institution Berenberg Bryan Garnier Commerzbank Deutsche Bank Goldman Sachs HSBC Independent Research GmbH J.P. Morgan Cazenove Kempen & Co. Landesbank Baden-Württemberg Oddo BHF Contact Klara Fernandes Jamila El Bougrini Daniel Wendorff Gunnar Romer Keyur Parekh Julie Mead Bernhard Weininger James Gordon Anastasia Karpova Timo Kürschner Igor Kim 25
26 Thank You Anke Linnartz Head of Corporate Communications & IR Phone +49 (0)89 / Fax +49 (0)89 / investors@morphosys.com MOR208, MOR202, MOR106, MOR103, anetumab ravtansine, gantenerumab and all other product candidates mentioned here are investigational drugs and have not been approved by the FDA or other ex-us regulatory agencies. HuCAL, HuCAL GOLD, HuCAL PLATINUM, CysDisplay, RapMAT, aryla, Ylanthia, 100 billion high potentials, Slonomics, Lanthio Pharma and LanthioPep are registered trademarks of the MorphoSys Group. Tremfya is a trademark of Janssen Biotech, Inc.
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