TIME IT S PRIME. chemagic TM Prime TM instrument Streamlined Walk-away Automation. For all Human Sample Materials. Primary Sample Handling

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1 IT S PRIME TIME chemagic TM Prime TM instrument Streamlined Walk-away Automation. For all Human Sample Materials. Primary Sample Nucleic Acid Isolation Eluate Quantitation of Extracted Samples Assay Setup For research use only. Not for use in diagnostic procedures.

2 The new chemagic TM Prime TM instrument Dimensions: L 2.3 m, W 0.9 m, H 1.9 m (incl. table) Integrated Automation of Nucleic Acid Isolation Through Assay Setup NOW IT S PRIME TIME The new chemagic Prime instrument is a fully automated research solution for primary sample transfer, DNA and RNA isolation, optional normalization, and PCR setup applications, that offers streamlined, walk-away sample processing. It delivers contaminant-free, extracted DNA and RNA in high concentrations, offering researchers a validated, single supplier workflow. Nucleic acid isolation is a critical prerequisite for many downstream applications. The chemagic Prime instrument uses patented magnetic bead technology (M-PVA-Magnetic Beads) with fully automated liquid handling to provide high quality and high yield isolation of nucleic acids from a variety of sample types, suitable for NGS, MLPA, genotyping and PCR. Unlike other automated solutions, the chemagic Prime instrument uses magnetized rods instead of magnetic plates to separate nucleic acids from solutions. By transferring the beads instead of the process solutions, the contamination risk is minimized, and higher purity, more intact DNA and RNA can be isolated. Reagent kits are available for the isolation of DNA and RNA from various human samples including whole, saliva, plasma, tissues, FFPE samples, and feces. Workflow Primary Sample Nucleic Acid Isolation Eluate Quantitation of Extracted Samples Assay / PCR Setup / Library Prep. Visit the chemagic Prime website For research use only. Not for use in diagnostic procedures.

3 Make Your Lab Full Traceability Barcode reading of sample tubes Barcode reading of output tubes/plates racks Reagent lotnumber tracking Bidirectional LIMS communication Integrated Liquid of primary samples Dispensing of magnetic beads, elution buffer and required enzymes Final eluate transfer with integrated removal of magnetic bead traces Optional additon of internal controls Tracking of all liquid operations Safe travel path Double Sample Set Capacity Walkaway automation for 2 x 12, 2 x 24 and 2 x 96 samples Minimizes hands on time Gripper hardware and cradles/racks optimized for transports

4 a Prime Site! Integrated chemagic Dispenser Flexible reagent volumes Economic bulk reagents Fast processing times Superior chemagic Kit and Technology Performance Transfer of magnetic beads instead of liquids High yields, recoveries and purities Outstanding performance for human sample materials Simultaneous sample preparation Optional Add Ons PCR setup Library preparation Eluate aliquoting Normalization

5 Order Information Product chemagic Prime 4 (4 pipetting channels) chemagic Prime 8 (8 pipetting channels) Mandatory Accessories* chemagic Prime 12 Rod Head Set chemagic Prime 24 Rod Head Set chemagic Prime 96 Rod Head Set Optional Accessories chemagic Prime PCR setup basic chemagic Prime Normalization module Consumables JANUS TM 900 µl cond. Filter tips JANUS TM 20 µl cond. Filter tips CMG-403 CMG-404 CMG-386 CMG-387 CMG-388 CMG-407 CMG *At least one to be ordered with the chemagic Prime 4 or chemagic Prime 8 Supported Applications Genomic DNA and RNA isolation from, cells, saliva and tissue for biobanking Isolation of viral/bacterial nucleic acids from serum/plasma pools Processing human body fluids for research applications Extraction of high molecular weight DNA for long range sequencing Isolation of DNA from various samples for microbiome analysis Kits Information Target Molecule Viral/bacterial NA Viral/bacterial NA Viral/bacterial NA Genomic / viral / bacterial NA cfdna Total RNA Sample Volume Sample Type µl 2-4 ml 7-10 ml 600 µl 200 µl 200 µl 300 µl 2.4 ml 1 g 5 ml saliva buffy coat / body fluids serum / plasma plasma stool plasma CMG-1091 CMG-1074 CMG-704 CMG-1037 CMG-713 CMG-1049 CMG-1033 CMG-1001 CMG-1076 CMG ml CMG-1084 Visit the chemagic Kits website For research use only. Not for use in diagnostic procedures.

6 PerkinElmer chemagen Technologie GmbH Arnold-Sommerfeld-Ring Baesweiler, Germany Phone: (+49) Fax: (+49) support.chemagen@perkinelmer.com Visit the chemagen website Copyright 2017, PerkinElmer, Inc. All rights reserved. PerkinElmer is a registered trademark of PerkinElmer, Inc. All other trademarks are the property of their respective owners. CT8/10/ Printed in Germany