Brazilian Biosafety System

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2 Brazilian Biosafety System

3 Timeline 1995 USA - First GMO product (FlavrSavr tomato) Brazil - First Biosafety Law Brazil - First Commercial Approval (Soybean Round up Ready - RR) EU - GMO import approval Brazil - Law of Biosafety and CTNBio EU - GMO Harvest Approval (Potato, Corn). DNA recombinant technology 2011 Brazil - Bean GM Commercial Approval Brazil - Mosquito GM Commercial Approval Brazil - Eucalyptus GM Comercial Ap Brazil - CTNBio invasion Brazil - CTNBio invasion.

4 Biosafety Law Guidelines The scientific development in biosafety and biotechnology The protection of human, animal and plant life and health The compliance with the Precautionary Principal for environmental protection

5 Brazilian Biosafety Law Provides for safety norms and inspection mechanisms for activities with GMOs and their by-products. Law nº , dated March 24th, Comprehensive review of the 1995 Law. Establishes the National Biosafety System.

6 Brazilian Biosafety System MAPA Agriculture Anvisa Human Health National Biosafety Council National Biosafety Technical Commission Internal Biosafety Commissions Registration and Inspection Bodies Ibama Environmental CIBio CIBio CIBio CIBio CIBio CIBio CIBio CIBio CIBio CIBio CIBio CIBio CIBio CIBio CIBio CTNBio

7 Brazilian Biosafety System Biosafety Maintenance Risk Assessment CIBio Biosafety Internal Commission OERF MAPA ANVISA IBAMA CTNBio National Technical Commission CNBS National Biosafety Council Law /2005 Decree 5.591/2005 CTNBio Normatives Registration and inspection agencies specific areas National interest and socio economic factors

8 Institutions Institutions and with Companies Biosafety Authorized Quality to conduct research Certificate with (CQBs) GMOs in Brazil AM: 7 RO:1 MT:2 PA:2 PI:1 BA:9 CE:4 RN:2 PB:2 PE:5 AL:1 SE:1 MS: 5 GO: 4 DF: 9 MG:25 SP:142 PR: 28 SC:10 RS: 39 RJ:25 ES:3 List and address available at the CTNBio website CTNBio (

9 The National Biosafety Technical Commission (CTNBio) Linked to the Ministry of Science Technology and Inovation. Human health It has a President and is organized in 4 subcomissions: Animal health Plant health Environment An Executive Secretariat provides technical and administrative support to CTNBio members and facilitate the meetings.

10 The National Biosafety Technical Commission (CTNBio) Meetings at least once a month; The Technical Opinion of CTNBio is legally binding for the other Federal Agencies. All decisions and technical opinions are necessarily published in the Federal Journal (DOU).

11 The National Biosafety Technical Commission (CTNBio) CTNBio Secretariat Members 27 Brazilians Ph.D. (27 Holders + 27 Alternates) 12 Experts 9 Representatives 6 Experts Work health expert,(minister of Labour and Employment) Allotment farm expert (Minister for Land Development) Biotechnology expert (Ministry of Agri., L. and Food supply) Environment expert (Minister of Environment) Health expert (Minister of Health) Consumer rights (Minister of Justice) Ministry of Foreign Affairs Special Secretariat for Agriculture and Fisheries to the PR Ministry of Defense Ministry of Development, Industry and Foreign Trade Ministry for Land Development; Ministry of Enviromental Ministry oh Health Ministry of Agriculture, Livestock and Food supply Ministry Of Cience and Technology and Inovation Environmental Area Vegetal/Enviromental Palnt Area Animal Area Human/Animal Human Health

12 It competes to the CTNBio: 1) To establish norms for research with GMOs; 2) To issue the Quality Certificate of Biosafety (CQB); 3) To authorize research with GMOs; 4) To authorize importation of GMOs for research; 5) To give technical support to the Inspection Agencies; 6) To proceed the GMOs risk analysis, case by case 7) Among others

13 From the Lab to the Market Commercial Approval Field Test Contention

14 Executive Secretariat Confidentiality Public Consultation + Published in the Federal Journal (DOU) Sectoral Commission (Depending of the process) All Commission (Inepending of the process) Plenary (Favorable, Unfavorable, Diligence, Pub. Consultation) Plenary (Favorable, Unfavorable, Diligence, Pub. Consultation) National Biosafety Council (CNBS) Published in the Federal Journal (DOU) Published in the Federal Journal (DOU) Registration and Inspection Bodies (OERFs) Registration and Inspection Bodies (OERFs)

15 Pipeline of GM Crops

16 Grain Production in Brazil CTNBio Fonte / Source: IBGE, MAPA e Mídia

17 Adoption of GM Crops in Brazil 2014 (Million hectares) Crop Conventional GM Total Soybean 2,45 27,41 29,86 93,2% Corn 2,82 12,45 15,27 82,6% Cotton 0,39 0,71 1,10 66,5% Celeres Informativo em Biotecnologia

18 Adoption of GM Crops in Brazil Cotton Corn, total Corn, Summer Corn, Winter Soybean Convetional Soybean Winter Summer Corn Cotton Celeres Informativo em Biotecnologia

19 Million hectares Adoption of GM Crops in Brazil by tolerance/resistance Herbicide tolerance Insect resistance Combined Total Celeres Informativo em Biotecnologia

20 Field Tests SORGO Sorghum CITRUS Citrus CANA Sugar DE cane AÇÚCAR ALGODÃO Cotton EUCALIPTO Eucalyptus MILHO Corn SOJA Soybean CTNBio

21 Field Tests SOJA Soybean MILHO Corn #REF! ALGODÃO Cotton #REF! Eucalyptus Insect RESISTENTE resistance A INSETOS Herbicide TOLERANTE tolerance A HERBICIDAS RESISTENTE Insect resistance A INSETOS + E TOLERANTES A Herbicide tolerance HERBIDAS CTNBio

22 Commercial Approvals Plant Human vaccine Animal vaccine Mosquito Enzimes Microorganisms CTNBio

23 Commercial Plants Approvals in Brazil Corn - 29 T25 Liberty Link MON YieldGard Bt11 NK Roundup Ready 2 GA21 TC Herculex MIR162 - Viptera MON 810 x NK603 YieldGard/RR2 Bt11 x GA21 MON YieldGard VT Pro TC1507 x NK603 MON x NK 603 YieldGard VT Pro Bt 11 x MIR 162 x GA21 MON YieldGard VT Rootworm/RR2 MON x TC 1507 x NK 603 TC 1507 x MON 810 x NK 603 TC 1507 x MON 810 MON x MON TC1507 x DAS Bt11xMIR162XMIR604XGA21 MIR604 DAS NK603 x T25 TC15Ø7 x MON81Ø x MIR162 x NK6Ø3 TC1507xMIR162xNK603 TC1507xMIR162 MIR162xNK603 MON810xMIR162 TC1507 x MON810 x MIR162 Cotton - 12 MON Bolgard I LLCOTTON25 Liberty Link MON 1445 Roundup Ready / Widestrike MON Bolgard II MON 531 x MON 1445 GHB 614 GlyTol GHB 119 x T TwinLink MON GlyTol x TwinLink GlyTol x LibertyLink MON X MON Soybean - 6 GTS Roundup Ready BSP-CV Cultivance A Liberty Link A Liberty Link MON x MON Intacta RR2 PROTM DAS Bean - 1 EMBRAPA 5.1 Eucalyptus - 1 H421 CTNBio

24 Other Commercial Products Approved in Brazil Animal vaccines - 20 Recombitek Cães Vaxxitek MD/IBD Suvaxyn PCV2 Ingelvac Poulvac Aves/E. coli Fort Dodge Vectormune FPMG Vectormune FPMG+AE Vectormune HVTIBD Vectormune FPLT Vectormune FPLT-AE Vectormune HVTNDV PouvacSt INNOVAX Intervet InnovaxND ProteqFlu TE ProteqFlu Provac B058 Bovella Yeasts - 6 RN1016 Prototheca Y5056 Y1979 Bioprodutos Prothotheca S. Cerevisiae - Celere2L Mosquito - 1 Suppression of populations of Aedes CTNBio

25 Commercial Process in analysis SOJA Soybean MILHO Corn ALGODÃO Cotton Insect RESISTENTE resistance A INSETOS TOLERANTE Herbicide A HERBICIDAS tolerance RESISTENTE Insect r. A INSETOS + E TOLERANTES Herbicide t. A HERBIDAS Produção Seeds de Sementes production

26 Embrapa

27 Brazilian Agricultural Research Corporation Establishment: Linked to the Ministry of Agriculture, Livestock and Food Supply (MAPA). Provide solutions for research, development and innovation for sustainability of agriculture for the benefit of Brazilian society.

28 Embrapa

29 International Presence Scientific Cooperation, Technical Cooperation Technological Business and Global Policies

30

31 THANK YOU and

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