The Institute of Microbiology of the Czech Academy of Sciences is looking for. four POSTDOCTORAL FELLOW positions in the fields of:

Transcription

1 4 Postdoctoral Fellow positions in microbiology, molecular biology and ecology The Institute of Microbiology of the Czech Academy of Sciences, Prague, Czech Republic The Institute of Microbiology of the Czech Academy of Sciences is looking for four POSTDOCTORAL FELLOW positions in the fields of: Nr.1 Ecology of plant-microbe interactions Nr. 2 Post-transcriptional control of gene expression Nr. 3 Regulation of translational control in humans Nr. 4 Discovery and biosynthesis of natural products Qualifications and experience who can apply: PhD degree or its equivalent awarded no more than 7 years ago in relevant field. The said period may be extended for the maternity and paternity leave period, long-term sickness (more than 90 days), care for a family member (more than 90 days), pre-attestation preparation and military training. Be a researcher who has worked for at least 2 years over the period of the last 3 years in organisation/s outside the Czech Republic in the field of research, with working time at least 0.5 FTE or who was a Ph.D. student abroad. Both categories include Czech citizens. Be an author of at least two publications published in the last three years Excellence in English international certificate (min. level B2 or its equivalent) Motivation for independent scientific work and, in the same time, the support of projects of others in relevant field International experience, know-how, skills, laboratory techniques, experience with student mentoring Motivation to publish results in highly impacted journals Conditions we offer: 24 months / 12 months fellowship at The Institute of Microbiology of the Czech Academy of Sciences in Prague, Czech Republic Full time contract for the whole period of fellowship Gross salary: USD/month + consumables see details for each position Support of excellent mentors, international creative environment, access to interesting experiments Employee benefits: 30 days paid holiday per year, meal tickets

2 Start between April and July see details for each position The position is supported from the European Union Funds - Operational Programme Research, Development and Education Application: Select one of the research field mentioned above Send your professional Curriculum Vitae (including the list of your publications), a motivation letter, copies of relevant course/degree certificates, and contacts to at least two senior researchers, such as your previous supervisors or lead scientists, who can provide reference, to mobility@biomed.cas.cz before December 5 th, Subject of the postdoc1 postdoc4 according to your selected position. About the employer: The Institute of Microbiology of the Czech Academy of Sciences represents the leading and largest institution (over 500 employees) of basic research in microbiology in Central and Eastern Europe, with a track record of scientific excellence in research on microbial ecology, microbial secondary metabolism, microbial cell biology, photosynthetic microorganisms, immunology and molecular and cellular biology of microbe interactions with environment. Details about each position and mentors: Nr. 1 Ecology of plant-microbe interactions The Laboratory of Environmental Microbiology is looking for a motivated postdoctoral fellow to work in the field of ecology of plant-microbe interactions. The person will collaborate on the projects of the Laboratory and perform his/her own research. The research focus is the community ecology of microorganisms and their interactions with plants in natural and managed ecosystems. We offer the work in inspiring and friendly environment of an international team of the Laboratory of Environmental Microbiology (laboratory head: Petr Baldrian) of the Institute of Microbiology in Prague, Czech Republic (see e.g. and access to interesting experiments / datasets produced by the host institution and their collaborators. Gross salary: 3300 USD / month. The starting date is negotiable, but the position has to start before April 30, The position is offered for two years.

3 PhD degree or its equivalent in the field of ecology, microbiology, plant sciences or similar Experience in microbial or plant ecology, biostatistics or bioinformatics. Mastery of advanced statistical methods (including general linear models, multivariate analyses, structural equation modeling) and knowledge of the R statistical environment. First-authored papers in leading IF journals in the field of microbial ecology, plant ecology, plant-microbe interactions, biostatistics or bioinformatics For more information about the position Nr. 1, please contact mentor Petr Baldrian (baldrian@biomed.cas.cz). Nr. 2 Post-transcriptional control of gene expression The Laboratory of Post-transcriptional Control of Gene Expression is looking for a motivated postdoctoral fellow. Successful candidate will be engaged in one of the major projects running in the Laboratory focused on post-transcriptional control of gene expression mediated by noncoding srnas and RNA chaperone Hfq. Research group currently identifies factors required for successful infection and persistence of current clinical isolates of Bordetella pertussis, a strictly human pathogen causing whooping cough. In addition to transcriptomics, proteomics will be also applied for identification of biomarkers responsible for pathogenesis of whooping cough. We offer the work in an international team of the Laboratory of Post-transcriptional Control of Gene Expression (laboratory head: Branislav Vecerek) of the Institute of Microbiology in Prague, Czech Republic (see e.g. ) closely collaborating with several laboratories abroad (Vienna, Lille). Gross salary: 2900 USD / month. The starting date is negotiable, but the position has to start before April 30, The position is offered for two years. PhD degree or its equivalent in the field of molecular biology or microbiology Knowledge and expertise in microbiology and cell biology (methods of molecular microbiology, work with bacterial pathogens and tissue cultures, FACS) and RNA biology (Northern blot, 5 /3 RACE, EMSA, RT-qPCR). Experience with global transcriptomic analysis (RNA-seq) is welcome Solid record of peer-reviewed publications in this field For more information about the position Nr. 2, please contact mentor Branislav Vecerek (vecerek@biomed.cas.cz).

4 Nr. 3 Regulation of translational control in humans The Laboratory of Regulation of Gene Expression at the Institute of Microbiology CAS in Prague ( led by Dr. Leoš S. Valášek is seeking to fill a Postdoctoral fellow position in the area of regulation of Translational control in humans. One of the main goals of the Valášek laboratory s research program is to understand the role of several eukaryotic initiation factors in the process of regulation of translation initiation and termination in humans in both general, as well as gene-specific manner. The successful applicant will develop a new research project aiming to describe novel mechanisms of translational control in human cells and their deregulation in cancer cells using state-of-the art molecular studies. We offer the work in dynamic and multidisciplinary environment of the closely cooperating international team of the Laboratory of Regulation of Gene Expression (laboratory head: Dr. Leoš Shivaya Valášek) of the Institute of Microbiology in Prague, Czech Republic. The laboratory is supported by the Wellcome Trust, as well as by the Centre of Excellence Grant awarded by the Czech Grant Agency. Gross salary: 2900 USD / month, 30 days paid holiday per year. The starting date is negotiable, but the position has to start before April 30, The position is offered for two years. PhD degree or its equivalent in the field of molecular biology or microbiology at least 5-years long experience working in the field of regulation of gene expression and a broad knowledge of the principles of molecular biology (qpcr, cloning, immunoprecipitation, western blotting), genetics and biochemistry, as well as modern methodological approaches in higher eukaryotes. expertise in ribosomal profiling/footprinting, high throughput sequencing like RNA seq and its data analysis using various bioinformatic and biostatistical approaches would be very valuable. a proven ability to lead students and younger colleague-researches. a commitment to drive scientific projects, motivation for high impact, high quality research, ability to work closely with an interdisciplinary research team. a solid record of peer-reviewed publications

5 For more information about the position Nr. 3, please contact mentor Dr. Leoš Shivaya Valášek Nr. 4 Discovery and biosynthesis of natural products The Laboratory of Biology of Secondary Metabolism in Prague is seeking a postdoctoral fellow who will be involved in the research dealing with the biosynthetic pathways of natural products. The main task will be to participate in elucidation of individual biosynthetic steps of lincosamide antibiotics and anticancer pyrrolobenzodiazepines. The acquired knowledge will subsequently be exploited to prepare more efficient hybrid bioactive compounds with potential application in the pharmaceutical industry. The specific approach will be based on chemical analysis using liquid chromatography coupled with mass spectrometry. We offer the work in friendly and multidisciplinary team of the Laboratory of Biology of Secondary Metabolism (laboratory head: Jiri Janata) of the Institute of Microbiology in Prague, Czech Republic (see e.g. ). The main research interest of the group is elucidation of biosynthetic pathways of microbial metabolites. Specifically, we focus on lincosamide antibiotics, anticancer pyrrolobenzodiazepines and other metabolites, which contain unusual alkylproline derivatives in their molecules. We are also interested in the mechanism of action of bioactive compounds, bacterial resistance to antibiotics and environmental as well as oral microbiome. Gross salary: 2900 USD / month, 30 days paid holiday per year. The starting date is negotiable, but the position should start before July 31, 2018, unless otherwise specified. The position is offered for one year. PhD degree or its equivalent in the field of molecular biology or microbiology Previous experience with mass spectrometry and research in the field of natural products has to be documented using the record of published papers. Previous experience with preparation and purification of recombinant proteins would be very valuable, and so would be the proven ability to lead younger colleague-researches and students a commitment to drive scientific projects, motivation for high impact, high quality research, ability to work closely with an interdisciplinary research team. a solid record of peer-reviewed publications For more information about the position Nr. 4, please contact mentor Dr. Jiri Janata (janata@biomed.cas.cz).

6