POFILE: EDUCATION & TRAINING: WORKING EXPERIENCE:

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1 Jing YANG, M.D. Project Scientist Department of Ophthalmology University of California, Irvine Sue and Bill Gross Hall-a CIRM Institute Stem Cell Research Center, 1st Fl., Room Health Sciences Road Irvine, CA POFILE: 8 years in retinal stem/progenitor cells and neural stem/progenitor cells research, develop retinal progenitor cell lines from cat, pig, rat, mouse, human. 6 years practice in Ophthalmology clinic EDUCATION & TRAINING: Doctoral Degree in Medicine: Ophthalmology, Peking University, China, 2005 Master s Degree in Medicine: Ophthalmology, Jilin University, China, 2000 Bachelor s Degree in Medicine: Medicine, Jilin University, China, 1998 WORKING EXPERIENCE: 2006 Sep-Present, Project Scientist, Department of Ophthalmology, University of California, Irvine, CA, USA , Research Fellow, Stem Cell Research, Department of International Health Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark 2000, Chief Resident in Ophthalmology, Department of Ophthalmology, Peking University Third Hospital, Peking University, Beijing, China , Ophthalmology Residency, Department of Ophthalmology, Peking University Third Hospital, Peking University, Beijing, China , Internship, Jilin University First Hospital, Changchun, China 1

2 PATENT: 1. Jing Yang, Henry J. Klassen. Compositions and methods for treating retinal diseases. US Application Serial No 61/487,419. PUBLICATIONS: 1. Jing Yang, Jinmei Wang, Ping Gu, X. Joann You, and Henry J. Klassen. Feline neural progenitor cells I: Long-term expansion of under defined culture conditions. Stem Cells International 2012, in press. 2. X. Joann You, *Jing Yang, Ping Gu, Chee Gee Liew, and Henry J. Klassen. Feline neural progenitor cells II: Use of novel plasmid vector and hybrid promoter to drive expression of Glial Cell Line-Derived Neurotrophic Factor transgene. Stem Cells International 2012, in press. *Co-first author. 3. Chee Gee Liew, Laughing Bear Torrez, Yukie Perez, Nicole Isolde zur Nieden, Jing Yang, Henry J. Klassen. Derivation of neural progenitors and retinal pigment epithelium from common marmoset and human pluripotent stem cells. Stem Cells International 2012, in press. 4. Jing Yang, Ping Gu, Henry Klassen. Quantitative changes in gene transcription during induction of differentiation in porcine neural progenitor cells include decreased KLF4 and elevated CXCR4. Molecular vision 2012; in press. 5. Wang J, Yang J, Gu P, Klassen H. Effects of glial cell line-derived neurotrophic factor on cultured murine retinal progenitor cells. Molecular Vision 2010 Dec 31; 16: X.Joann You, Ping Gu, Jinmei Wang, Tianran Song, Jing Yang, Chee Gee Liew, Henry Klassen. Efficient Transduction of Feline Neural Progenitor Cells for Delivery of Glial Cell Line-Derived Neurotrophic Factor Using a Feline Immunodeficiency Virus-Based Lentiviral Construct. Journal of Ophthalmology, 2011, pii: Cho SJ, Lee YS, Lee JI, Bang JI, Yang J, Klassen H, Kong IK. Confirmation of Germ-Line Transmission in the Red Fluorescence Protein (RFP) transgenic Cloned Male Cat. Cell Reprogram; 2010 Dec; 12 (6): Ping Gu, *Jing Yang, Jinmei Wang, Henry Klassen. Sequential changes in the gene expression profile of murine retinal progenitor cells during the induction of differentiation. Molecular Vision 2009 Oct 20; 15: *Co-first author. 2

3 9. Redenti S, Neeley WL, Rampani S, Saigal S, Yang J, Klassen H, Langer R, Young MJ. Engineering retinal progenitor cell and scrollable poly(glycerolsebacate) composites for expansion and subretinal transplantation. Biomaterials 2009; 30(20): *Jing Yang, Henry Klassen, Mette Pries, Wei Wang, Mogens Holst Nissen. Vitreous humor and albumin augment the proliferation of cultured retinal precursor cells. Journal of Neuroscience Research 2009; 87(2): *Corresponding author 11. Xiaoyong Chen, Jing Yang, Chun Zhang, Wei Wang. The randomly sampling survey of glaucoma awareness in general clinic. Chinese Ophthalmic Research 2009; 27(5): Stephen Redenti, Sarah Tao, Jing Yang, Ping Gu, Henry Klassen, Sunita Saigal, Tejal Desai and Michael J. Young. Retinal tissue engineering using mouse retinal progenitor cells and a novel biodegradable, thin-film poly(e-caprolactone) nanowire scaffold. Journal of Ocular Biology, Diseases, and Informatics 2008; 1: *Jing Yang, Henry Klassen, Mette Pries, Wei Wang, Mogens Holst Nissen. Aqueous humor enhances the proliferation of rat retinal precursor cells in culture and this effect is partially reproduced by ascorbic acid. Stem Cells 2006; 24: *Corresponding author 14. *Jing Yang, Mogens Holst Nissen, Wei Wang. Isolation, culture and identification of rat retinal progenitor cells in vitro. Zhonghua Yanke Zazhi 2006; 42 (2): *Corresponding author 15. Jing Yang, Chun Zhang, Wei Wang. The application of amniotic membrane in glaucoma surgery. Zhongguo Shiyongyanke 2003; 12: PUBLISHED ABSTRACTS (SELECTED): 1. J Yang, VR Sharma, J Wang, S Kamjoo, P Checa, I Molina-Martinez, MC Kenney, R Herrero-Vanrell, BD Kuppermann, H Klassen. GDNF-microspheres for Treatment of Atrophic AMD BIMR meeting. Abstract. 2. J Yang, J Wang, P Checa, I Molina-Martinez, R Herrero-Vanrell, H Klassen. Effects of Glial Cell Line-Derived Neurotrophic Factor (GDNF) Releasing Poly Lactic-co- Glycolic Acid (PLGA) Microparticles on Retinal Progenitor Cells (RPCs). ARVO S Kamjoo, VR Sharma, J Yang, P Checa, I Molina-Martinez, R Herrero-Vanrell, GA Limb, H Klassen, MC Kenney, BD Kuppermann. Glial Cell Line-Derived 3

4 Neurotrophic Factor (GDNF) Enriched Poly Lactic-co-Glycolic Acid (PLGA) Microspheres Suppress Apoptosis In Vitro. ARVO Jing Yang, Ping Gu, Henry Klassen. Molecular Characterization of Human Retinal Progenitor Cells During Long Term Culture. ARVO 2010 annual meeting. Abstract. 5. K Narfstrom, J Yang, GP Lewis, R Bragadottir, G Luna, SK Fisher, R Whiting, IK Kong, H Klassen. Development of Muller-Like Cells after Subretinal Transplantation of Feline Red Fluorescent Retinal Progenitors in Abyssinian Cat Hereditary Retinal Degeneration. ARVO J Wang, J. Yang, H. Klassen. GDNF Augments Proliferation and Reduces Apoptosis of Murine Retinal Progenitro Cells. ARVO 2010 annual meeting. Abstract. 7. J. Yang, P. Gu, H. Klassen. CNTF Induces Rapid Expression of Neuronal and Glial Transcripts in Cultured Porcine Retinal Progenitor Cells. ARVO Ping Gu, Jing Yang, Young S. Lee, Kristina Narfstrom, Il Keun Kong, Henry Klassen. Isolation, Proliferation, and Characterization of Retinal Progenitor Cells from Domestic and RFP-transgenic Cats. ARVO J Wang, J. Yang, H. Klassen. The Proliferation of Murine Retinal Progenitor Cells is Fundamentally Dependent on EGF Yet Relatively Independent of GDNF. ARVO Yang, J., Gu, P., Tao, S., Desai, T., Klassen, H. (2008) Quantitative changes in the gene expression of porcine CNS progenitor cells cultured on nanowire scaffolds. XVIII International Congress of Eye Research. 11. Gu, P., Yang, J., Young, M., Klassen, H. (2008) Quantitative changes in the gene expression profile of murine retinal progenitor cells during early differentiation. XVIII International Congress of Eye Research. 12. Jing Yang, Ping Gu, Sarah Tao, Tejal Desai, Henry Klassen. Sequential quantitative profiling of porcine CNS progenitor cells on biodegradable nanowire scaffolds. ARVO Ping Gu, Jing Yang, Michael J Young, Henry Klassen. Sequential changes in the gene expression profile of retinal progenitor cells during the induction of differentiation. ARVO S.M. Retendi, Sarah Tao, S. Saigal, Ping Gu, Jing Yang, Henry Klassen, Tejal Desai, M.J. Young. Tissue engineering using mouse retinal progenitor cells and a 4

5 novel biodegradable poly(e-caprolactone) nanofiber scaffold. ARVO Jing Yang, Henry Klassen, Mette Pries, Wei Wang, Mogens Holst Nissen. Vitreous humor enhances the proliferation of retinal precursor cells. ARVO Jing Yang, Henry Klassen, Mette Pries, Wei Wang, Mogens Holst Nissen. The role of aqueous humor in the proliferation of retinal progenitor cells. ARVO Jing Yang, Mogens Holst Nissen, Wei Wang. Isolation, culture and identification of rat retinal progenitor cells in vitro. The 10 th Chinese ophthalmic annual conference Abstract. 18. Jing Yang, Chun Zhang, Wei Wang. Amniotic membrane implantation in trabeculectomy and non-penetrating deep sclerectomy. The First SERI ARVO Meeting on Research in Vision and Ophthalmology Abstract. EDITORIAL SERVICE: Clinical Rehabilitative Tissue Engineering Research: Executive Reviewer since 2007 International Journal of Biomedical Science: Reviewer since 2009 Journal of Neuroscience Research: Reviewer since 2009 MEMBERSHIP OF SOCIETIES/ ORGANIZATIONS: The Association for Research in Vision and Ophthalmology (ARVO): 2005-Present Chinese Medical Doctor Association: Ophthalmologist/Physician, AWARDS: 2006: The Association for Research in Vision and Ophthalmology, International Award 2006: The China Association for Science and Technology, Excellent Paper Award 5