Viscoelastics in Ophthalmic Surgery
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1 Viscoelastics in Ophthalmic Surgery
2 Springer Berlin Heidelberg New York Barcelona Hong Kong London Milano Paris Singapore Tokyo
3 H. B. Dick o. Schwenn Viscoelastics in Ophthalmic Surgery With 147 Figures, some in Color, Springer
4 Priv.-Doz. Dr. med. H. Burkhard Dick Department of Ophthalmology Johannes Gutenberg-University Langenbeckstrasse I, D Mainz Germany Dr. med. Oliver Schwenn Department of Ophthalmology Johannes Gutenberg-University Langenbeckstrasse 1, D Mainz Germany ISBN-13: DOl: / e-isbn-13: Library of Congress Cataloging-in-Publication Data Dick, H. Burkhard: Viscoelastics in ophthalmic surgery I H.B. Dick; O. Schwenn. - Berlin; Heidelberg; New Yorki Barcelona; Hong Kong; Milano; Paris; Singapore; Tokyo: Springer, 2000 This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustration, recitation, broadcasting, reproduction on microfilm or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright law of September 9, 1965, in its current version, and permission for use mllst always be obtained from Springer-Verlag. Violations are liable for prosecution under the German Copyright Law. Springer-Verlag is a company in the BertelsmannSpringer publishing group Springer-Verlag Berlin Heidelberg 2000 The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Product Liability: The publishers cannot guarantee the accuracy of any information about dosage and application contained in this book. In every individual case the user must check such information by consulting the relevant literature. Cover design: design & production GmbH, Heidelberg Typesetting: Goldener Schnitt, Sinzheim Printed on acid-free paper - SPIN: /
5 Foreword It will be difficult to find an ophthalmic surgeon who will gladly do his work entirely without viscoelastics. Within just a few years this group of substances has enlarged the field of ophthalmic surgery enormously. Many procedures have become safer and simpler and other techniques could only be developed because of the availability of visco elastics. Especially cataract surgery and implantation of intraocular lenses have benefitted. Implantation of an intraocular lens can be performed much more reliably into the capsular bag without endangering the posterior capsule. Implantation of foldable lenses would be almost impossible without visco elastics. However, other surgical maneuvers also necessitate viscoelastics, especially when the anterior chamber must be maintained, the corneal endothelium must be protected and delicate tissues must be manipulated. A corneal transplant can be sutured safely into the recipient corneal ring using viscoelastics. Even in glaucoma surgery, visco elastics gain importance as they are being used in trabeculectomy or in deep sclerectomy with additional viscocanalostomy. But which substance is best for which purpose? Just as much as a basic pharmacological knowledge is necessary for a rational use of drugs, in-depth knowledge of physicochemical properties and objective investigations are prerequisites for a logical selection of visco elastics from an ever increasing number of available substances. H. Burkhard Dick and Oliver Schwenn, both ophthalmologists at the department of ophthalmology at Mainz university, have embarked on the enterprise to systematically investigate visco elastics and to collect the necessary knowledge. They present the basic principals and properties of substances and an up to date selection of the techniques that can be performed using visco elastics. This book is going to be a standard text and the reference for any viscoelastic which is available at present or will be available in the future. The book contains a precise presentation of the basics as well as a survey of practical and clinical information. Without any doubt it will find many thankful readers. Prof. Dr. med. Norbert Pfeiffer Chairman Department of Ophthalmology University of Mainz, Germany
6 Acknowledgements Our special appreciation goes to Prof. Dr. Tadeusz Pakula as well as to Mr. Thomas Hirschmann in the Max-Planck-Institute for Polymeric Research (Mainz) at the Department of Rheology for their constructive hints, everlasting willingness for discussions, and active support when investigating and calculating the properties of viscoelastic substances. A very special thanks is extended to our academic teacher and medical director of the eye clinic of the University Mainz Prof. Dr. med. Norbert Pfeiffer. Our gratitude goes to Mrs. Marlene Maser-Wahle and Mrs. Martina Pfeiffer for their supportive engagement with some illustrations. We extend our appreciation and thanks to Mrs. Dr. S. Petrou-Binder (Frankfurt/M.), Dr. M.U. Driisedau (PIau am See) for the helpful revision of our manuscript. We are indepted to the headphotographer Axel Welsch for the pleasing pictures and photographical art work. We extend our thanks to all the companies that supplied us with sufficient material of their viscoelastic products for our research (mostly without charging us). We thank the following companies for supplying us with illustrations: Pharmacia & Upjohn; Alcon Pharma. Our appreciation is extended to the publishing company Springer-Verlag, we are especially indepted to Mrs. Yvonne Bertram and Mr. Rainer Kusche for their outstanding cooperation and fast completion of this project. I extend my sincerest appreciation to my teachers for ophtalmic surgery Prof. Dr. med. Dr. h.c. Franz Grehn (medical director of the eye clinic of the University Wiirzburg) and Dr. med. Bernd Weber (head physician of the eye clinic of the "Biirgerhospital" Frankfurt); sincerely Dr. med. o. Schwenn. A very special thanks to my partner in life Dr. jur. Astrid Meckel (judge at the Landgericht) for her supportive input for the chapter "Medical device or drug" and her patience and consideration during the preparation of this textbook, thankfully Priv.-Doz. Dr. med. H.B. Dick. Finally I thank my teacher for ophtalmic surgery and head physician Dr. med. Oliver Schwenn. H. Burkhard Dick Oliver Schwenn
7 Preface Nowadays viscoelastics are applied in almost every cataract operation and in many other ophthalmic surgeries. It is hard to think of related fields and surgical steps whithout viscoelastic substances. Everyday we are confronted with a increasing number of new viscoelastic products and accordingly with new surgical techniques. Last but not least recent research results present a number of new facts which are not always easy to correlate to the actions in the clinical field. Qualified handling of viscoelastics however is impossible without the foundation of knowledge and without relation to practical matters clinical research will not be successful. The main purpose of this book was to give a critical overview about all aspects of the possible application of viscoelastics. It imparts updated basic knowledge as well as practical information and experiences concerning clinical matters. We tried to emphasize on combining updated basic knowledge and comparative studies with easy to understand information of practical relevance. Important fresh impetus was added to this project due to the interdisciplinary research cooperation with the Max-Planck-Institute for Polymeric research, department of rheology, in Mainz, Germany. This book adresses beginning as well as experienced ophthalmic surgeons. Mainz, April 2000 H. Burkhard Dick Oliver Schwenn
8 Table of Contents 1 Overview.... Introduction.... Historical Development Current Breakdown of Viscoelastic Substances Analysis of Current Application Modes Basics Physicochemical Properties of Ophthalmic Viscosurgical Devices... 7 Flow Characteristics Viscosity... 8 Influence of the Shear Rate on Viscosity Elasticity Viscoelasticity Pseudoplasticity Coatability Rigidity Cohesiveness Optical Properties of Viscoelastic Substances Chemical Properties of Viscoelastic Substances, Biocompatibility and Safety Requirements ph-value Colloid Osmotic Pressure Osmolality Structural Formulas and Chemical Composition Complications Through Visco elastics The Owl Monkey Eye Test International Organization for Standardization Viscoelastic Substances Hyaluronate Hydroxypropylmethylcellulose... 28
9 XII Table of Contents Chondroitin Sulfate 30 Polyacrylamide Collagen Cellugel Product Specifications Manufacturers' Information About Their Viscoelastics Our Own Comparative Trials Zero Shear Viscosity Pseudoplasticity Relaxation Time Intersection G'/G" (Elasticity Modulus/Viscosity Modulus) ph-value General Applications of Visco elastics Maintenance of the Anterior Chamber Injection Techniques Into a Deep Anterior Chamber Injection Techniques Into a Collapsed Anterior Chamber Tissue Manipulations Visco mydriasis Facilitating Lens Implantation Coatability Corneal Endothelial Protection Hemostasis Management of Complications Complications Through the Use of Visco elastics Therapy for Raised lop Following Phacoemulsification Special Uses of Visco elastics Cataract Surgery Routine Complications and Difficult Situations "Soft-Shell" Technique "Best of Both Worlds" Technique Implantation of Foldable lols " Perforating and Lamellar Keratoplasty Glaucoma Surgery Trauma Surgery Posterior Segment Surgery Surgery of Eye Muscles Lacrimal Dysfunction (Coating Medium)... 86
10 Table of Contents XIII 8 Removal of Viscoelastic Substances 89 The "Rock and Roll" Technique Retention of the Viscoelastic Substance Healon 5: A New Viscoadaptive Formulation Aseptic Production vs. Terminal Sterilization Viscoelastics: Medical Device or Drug Summary Appendix 105 Product Overview... " 107 Hyaluronic Acid Products HPMC-Products Measured Values for Certain Products Gained by Individual Investigations Visco elastics Containing Hyaluronic Acid Viscoelastics from Hydroxypropylmethylcellulose References Subject Index
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