CURRICULUM VITAE. Lecturer (Pharmaceutical Chemistry Department, Faculty of Pharmacy, Al- Azhar University, Cairo, Egypt)

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1 CURRICULUM VITAE Farag F. S. Selim, PhD CONTACT DETAILS Name: Farag Farouk Sherbiny Selim Nationality: Egyptian Position: Lecturer (Pharmaceutical Chemistry Department, Faculty of Pharmacy, Al- Azhar University, Cairo, Egypt) Phones: s: Address in Egypt: Pharmaceutical Chemistry Department, Faculty of Pharmacy, Al-Azhar University, Nasr City, 6th district, Cairo Egypt EDUCATION Ph.D. Thesis: PhD at the University of Bonn under supervision of Prof. Dr. Christa E. Müller, Pharmaceutical Institute, Pharmaceutical Chemistry I, University of Bonn and Fraunhofer Institut SCAI, Schloss Birlinghoven, Sankt Augustin, Germany, (2011) "The Human Adenosine A 2B Receptor: Homology Modeling, Virtual Screening, and Computer-aided Drug Design" 1

2 M.Sc. Thesis: Pharmaceutical Chemistry, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt, (2003) "Synthesis of new Heterocyclic of Pharmaceutical Interest" B.Sc. Pharmaceutical Sciences, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt, (1995) LANGUAGES: English, German GENERAL AREAS OF INTEREST AND EXPERTISE: HOMOLOGY MODELING AND DRUG DESIGN The following are hands-on experience and skills proven by track of publication, conference abstracts and teaching: 1. Experience in Computational Chemistry and Molecular Modeling applied to Structurebased and Ligand-based drug discovery 2. Experience in performing Molecular Docking (FlexX, AutoDock and Schrodinger) and MD Simulations (in Phospholipid Bilayers) (using Amber and Gromacs) 3. Experience in Homology Modeling (MOE, Sybyl), Pharmacophore Search and High Throughput Screening 4. Protein Structure and Sequence Analysis (ClustalW, BLAST) 5. Rational Design (QSAR, Molecular Dynamics, De Novo Design) 6. Structure manipulation programs (JalView, UCSF Chimera and Pymol) 7. Experience in UNIX/Linux-based platform 8. Organic Chemistry TEACHING ACTIVITIES Laboratory Demonstration and Tutoring Organic, Analytical and Pharmaceutical Chemistry for undergraduate pharmacy students in the College of Pharmacy, Al-Azhar University, Cairo, Egypt ( ) ACTIVITIES AS A SCIENCE REVIEWER European Journal of Medicinal Chemistry 2

3 PUBLICATIONS 1. A. A. El-Helby, M. A. Amin, M. M. El-Sawah, A. A. Bayomi, Adel S. El-Azab and Farag F. Sherbiny Synthesis and Microbiological Testing of Some new Derivatives of Compounds Containing Active Methylene Group J. Saudi Chem. Soc. 2006, 10, Farag F. Sherbiny, Anke C. Schiedel, Astrid Maaß, and Christa E. Müller Homology modelling of the human adenosine A 2B receptor based on X ray structures of bovine rhodopsin, the β 2 -adrenergic receptor and the human adenosine A 2A receptor J. Comput. Aided Mol. Des. 2009, 23, Anke C. Schiedel, Dominik Thimm, Sonja Hinz, Farag F. Sherbiny, Thomas Borrmann, Astrid Maaß, Christa E Müller Adenosine A( 2B ) receptors: Mutagenesis, modeling and new ligands to study drug-receptor interaction and activation. Third joint Italian-German Purine Club meeting: Purinergic receptors: new frontiers for novel therapies Purinergic signaling 2010, 6, Anke Schiedel, Dominik T. Thimm, Sonja Hinz, Farag Sherbiny, Thomas Borrmann, Astrid Maaß, Christa E. Müller Importance of selected amino acid residues of the human adenosine A 2B receptor for ligand binding and receptor activation. Purines 2010: Adenine Nucleosides and Nucleotides in Biomedicine. Purinergic Signal. 2010, 6, S36-S37 5. Mohamed-Kamal Ibrahim, Ashraf A. Abd-Elrahman, Rezk R. A. Ayyad, Khaled El-Adl, Farag F Sherbiny, Mahmoud Rashed Design and synthesis of some novel N-phthalimide derivatives with potential anticonvulsant activity Az. J. Pharm. Sci. 2010, 42, Anke C. Schiedel, Sonja Hinza, Dominik Thimm, Farag Sherbiny, Thomas Borrmann, Astrid Maaß and Christa E. Müller The four cysteine residues in the second extracellular loop of the human adenosine A 2B receptor: role in ligand binding and receptor function Biochem. Pharmacol. 2011, 82, Sonja Hinz, Anke C. Schiedel, Dominik Thimm, Farag Sherbiny, Thomas Borrmann, AstridMaaß, and Christa E. Müller One is all it takes: disulfide bonds and cysteine residues in the extracellular loop 2 of the adenosine A 2B receptor. Abstracts of the Fourth Joint German-Italian Purine Club Meeting 2011 Purinergic Signalling 2012, 8, Dominik Thimm, Anke C. Schiedel, Farag F. Sherbiny, Sonja Hinz, Katharina Hochheiser, Daniela C. G. Bertarelli, Astrid Maas, and Christa E. Muller. Ligand-specific binding and activation of the human adenosine A 2B receptor. Biochemistry, 2013 (accepted) 9. Benjamin F. Seibt, Anke C. Schiedel, Dominik Thimm, Sonja Hinz, Farag F. Sherbiny, Astrid Maas, and Christa E. Muller. The second extracellular loop of GPCRs determines subtype-selectivity and controls efficacy as evidenced by loop exchange studies at A2 adenosine receptors. Biochemical Journal (submitted) CONFERENCE ATTENDED AND POSTER PRESENTATIONS 3

4 1- A. A. El-Helby, M. A. Amin, M. M. El-Sawah, A. A. Bayomi, and Farag F. Sherbiny. Synthesis of new Heterocyclic of Pharmaceutical Interest. Al-Azhar 2nd International Conference for Pharmaceutical and Biological Sciences 2003, Cairo, Egypt 2- Farag F. Sherbiny, Anke C. Schiedel, Astrid Maaß, and Christa E. Müller. Homology modelling of the human adenosine A 2B receptor based on bovine rhodopsin and the β 2 -adrenergic receptor: comparison of the binding modes and conformational effects of agonists and antagonists. DPhG symposium, 2008, University of Bonn, Germany 3- Dominik T. Thimm, Anke C. Schiedel, Sonja Hinz, Farag Sherbiny, Astrid Maaß, Thomas Borrmann and Christa E. Müller. Role of selected amino acid residues in ligand binding and activation of the human adenosine A 2B receptor. DPhG symposium, 2008, University of Bonn, Germany 4- Farag F. Sherbiny, Anke C. Schiedel, Astrid Maaß, and Christa E. Müller. Homology modelling of the human adenosine A 2B receptor based on X-ray structures of bovine rhodopsin, the 2 -adrenergic receptor and the human adenosine A 2A receptor. Purinergic Receptors: New Frontiers for Novel Therapies, Third Joint Italian-German Purine Club Meeting July 17-20, 2009, Camerino, Italy 5- Anke C. Schiedel, Dominik Thimm, Sonja Hinz, Farag Sherbiny, Thomas Borrmann, Astrid Maaß and Christa E. Müller. Adenosine A 2B receptors: mutagenesis, modeling and new ligands to study drug-receptor interaction and activation. Purinergic Receptors: New Frontiers for Novel Therapies, Third Joint Italian-German Purine Club Meeting July 17-20, 2009, Camerino, Italy 6- Farag F. Sherbiny, Anke C. Schiedel, Astrid Maaß, and Christa E. Müller. Homology modelling of the human adenosine A 2B receptor based on X-ray structures of bovine rhodopsin, the 2 -adrenergic receptor and the human adenosine A 2A receptor. Molecular Graphics and Modelling Society ( MGMS ) International Meeting and Modelling Workshop, September 6-11, 2009, Erlangen, Germany 7- Dominik T. Thimm, Anke C. Schiedel, Katharina Hochheiser, Sonja Hinz, Farag F. Sherbiny, Astrid Maaß and Christa E. Müller. From models to mutants to drugs new insights in ligand binding and activation of the human adenosine A 2B receptor. September, 2009, Stockholm 8- Anke C. Schiedel, Dominik Thimm, Sonja Hinz, Farag Sherbiny, Astrid Maaß and Christa E. Müller. Drug-receptor interaction and activation of the human adenosine A 2B receptor and selected mutants. The EMBO Meeting, 2009, Amsterdam 9- Anke C. Schiedel, Dominik T. Thimm, Sonja Hinz, Farag Sherbiny, Thomas Borrmann, Astrid Maaß and Christa E. Müller. Importance of selected amino acid residues of the human adenosine A2B receptor for lligand binding and receptor actiivatiion. International meeting Purines 2010: adenosine nucleosides and nucleotides in biomedicine. 30 May Jun 2010, Tarragona, Spain 4

5 10- Thimm, D. T. Schiedel, A. C. Hochheiser, K. Hinz, S. Sherbiny, F. F. Maaß, A. Müller, C. E. How 2B bound new insights into ligand recognition by the human adenosine A 2B receptor. 2010, Braunschweig, Germany 11- Sonja Hinz, Anke C. Schiedel, Dominik Thimm, Farag Sherbiny, Thomas Borrmann, Astrid Maaß, and Christa E. Müller. One is all it takes: disulfide bonds and cysteine residues in the extracellular loop 2 of the adenosine A 2B receptor. International Conference on Purinergic Drugs and Targets 4th Joint German-Italian Purine Club Meeting, July 22-25, 2011, Bonn, Germany AWARDS 2006 Egyptian Government PhD scholarship 2009 Poster present, Camerino, Italy COMPUTER KNOWLEDGE ICDL Certificte SPECIAL INTERESTS REFERENCES Reading, Bing Bong, Football and Computer. Prof. Dr. Christa E. Müller University of Bonn, Pharmaceutical Institute, Pharmaceutical Chemistry I An der Immenburg 4, D Bonn (Endenich), Germany Phone: +49-(0) Fax: +49-(0) christa.mueller@uni-bonn.de Prof. Dr. Michael Gütschow University of Bonn, Pharmaceutical Institute, Pharmaceutical Chemistry I An der Immenburg 4, D Bonn (Endenich), Germany Phone: Fax: guetschow@uni-bonn.de 5