Sustainable Succinic Acid

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1 Sustainable Succinic Acid Will van den Tweel General Manager Reverdia October 7 th, 2010

2 Key Messages Commercializing a leading, sustainable technology Bio-based succinic acid will drive a portfolio of renewable and more sustainable products 5 Keys to Success to overcome commercialization challenges for bio-based chemicals and materials collaboration DSM-Roquette well positioned Demo-plant production and market development progressing very well DSM and Roquette will operate under 50:50 JV* for the commercialization of Biosuccinium TM * Subject to regulatory approvals and notifications.

3 A New Company in the Industrial Biotech Sector Addressing the Megatrends Decreasing oil dependency Environmental concern Sustainability, renewability Green Building blocks for green materials

4 Reverdia TM : Powered by DSM + Roquette Global Leaders Combine Expertise to Produce Bio-based Succinic Acid Experience large scale biorefineries and logistics Starch based chemistry pioneer & Leader in Starch based products Worldwide biorefinery operations Extensive purifications capabilities Strong scale-up experience Shared Vision on Sustainability and Complimentary Competencies Global biotech leader (chemicals, food, enzymes) Developing technologies for next generation feedstocks Leader in metabolic engineering Broad understanding of materials Strong fermentation & scale-up experience

5 Bio-based Succinic Acid Will Lead to a Portfolio of Products and Applications Pharmaceuticals Biopolymers - PBS Pyrrolidones Solvents Coatings and resins 1,4 BDO/THF Polyurethanes Food Plasticizers Freezing point depression agents

6 Succinic Acid Market - Today Global Market Polymers 7% Food 9% Pharma 12% Metal industry 14% Current 2010 (total ~35 kton) Photo 6% Agriculture 1% coating, pigments, dyes, inks 31% Miscellaneous 20% Coatings / resins 7% Biopolymers / plasticizers 16% Addressable 2020 (total ~2000 kton) Miscellaneous / metal ind. / pharma / food Solvents 4% 4% Polyurethanes 38% 1,4-Butanediol / Pyrrolidones 31% Drivers Energy security: reducing dependency on oil Climate change: increasing environmental concerns Public interests in sustainability: growing sustainable and renewable developments

7 Quality Will Be of Utmost Importance in Polymer Applications Bio-based thermoplastics Novel, bio-based polymer Biobased Succinic Acid + 1,4 BDO Biobased Succinic Acid 1,4 BDO Biobased Succinic Acid 1,4 BDO Poly-butylene Succinate

8 Favorable Bio-SA Economics Will Enable Bio-1,4 BDO leading to 100% renewable PBS Bio-based thermoplastics Novel, bio-based polymer + Biobased Succinic Acid 1,4 BDO Biobased Succinic Acid 1,4 BDO Biobased Succinic Acid 1,4 BDO Poly-butylene Succinate 100% Renewable Solution

9 5 Keys to Success for Biobased Chemicals INNOVATION IN PRODUCT RECOVERY Importance customer specification STRENGTHS IN STRAIN DEVELOPMENT & FERMENTATION Many groups have already worked many years on Succinic acid FEED STOCK KNOWLEDGE AND GLOBAL REACH Feedstock is major cost component MARKET KNOWLEDGE AND EXPERTISE New markets will need to be developed SCALE-UP EXPERTISE and TECHNOLOGY IMPLEMENTATION Requires a good demo and can be capital intensive Sustainable Solutions Powered by DSM + Roquette

10 Renewable Feedstocks Have Experienced Lower Price Volatility Crude Oil, Raw Cane Sugar and Corn Price Index Indexed at January 1984 = 100 Standard Deviation of Price Index : Indexed at January 1984 = : Indexed at January 1993 = Crude Oil (NYMEX) Raw Cane Sugar (NY#11) Corn (CBOT)

11 Technology Breakthrough for Sustainable Production Better Technology and Product Multiple host organisms, gene pathways and recovery methods were explored and tested Using e.g. yeast as the manufacturing organism allows the process to operate at low ph Less salt waste generated in the environment Better economics, not all fermentation processes are the same Yeast-based fermentation provides high quality starting point for DSP with less by-products Novel proprietary technology (more than15 patents filed)

12 S. cerevisiae Engineering Strategy Combination Reductive & Oxidative TCA Net CO 2 input DHAP PEP Glycerol Phosphoenolpyruvate carboxykinase CO 2 Pyr ATP Ethanol DCA transporter Succinic acid Secretion ATP/Pi Malate dehydrogenase Fumarase Mal OAA AcCoA Glyx Cit Malate synthase ICit Isocitrate lyase Fumarate reductase Fum Succ akg

13 Value Proposition to Customers FAVORABLE LIFE CYCLE ASSESSMENT Renewable but also a more favorable LCA and carbon footprint than alternatives which is becoming increasingly important to downstream customers MORE STABLE PRICING Integrated biorefinery will achieve the best economics and more stable pricing is expected in both the short and longer-term HIGHEST PRODUCT QUALITY/PURITY Tested and Validated Essential for applications where color and other criteria are important PROPRIETARY TECHNOLOGY Robust Patent Portfolio Non-gypsum process Able to achieve performance and value, opening up new markets faster overtime

14 Life Cycle Assessment & Carbon footprint Technology, Feedstock and Location Dependent The unique and proprietary low ph process has superior performance Potential for further substantial improvements 0,6 This Cradle-to-Gate study was executed by expert firm CE Consult (NL) The results were independently confirmed by Patel and Roes of the Copernicus Institute of Utrecht University (NL) kg CO2-eq/kg SA 0,4 0,2 0-0,2-0,4 Mature petrochemical Reverdia Low ph Reverdia potential

15 So Where are We with Commercialization? Product from demo plant available now in ton quantities On track to take a decision on large scale manufacturing end of 2010 Actively working with prospects in many new segments (for qualification /launch purposes)

16 Summary Bio-based succinic acid will drive a portfolio of renewable and more sustainable products 5 Keys to Success The industry, including ourselves, will continue to improve in all areas Reverdia, aspires to be an industry leader Powered by DSM + Roquette Enabled by a differentiated technology and product Assurance of improved sustainability

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