Imaging Biomarkers: Paradigm Change Towards Personalized Medicine

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Conrad Wilkerson
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1 Biomedical Imaging Research Group (GIBI 2 30 ) Imaging Biomarkers: Paradigm Change Towards Personalized Medicine Ana Penadés Blasco Marseille, 28 th march 2015

2 GIBI2 30 -Clinical Area of Medical Imaging Scientific-Technical Direction Bank of Images Euro-BioImaging Clinical Trials XNAT Databases & Monitorization Director Radiation Dose Technological Evaluation GIBI-2 30 & Experimental Radiology QUIBIM (Imaging Biomarkers) Economic-Financial Direction

3 GIBI 2 30 : Who we are? Biomedical Imaging Research Group (Grupo de Investigación Biomédica en Imagen), multidisciplinary research group associated to the Clinical Area of Medical Imaging of La Fe University and Polytechnics Hospital. PI: Dr. Luis Martí-Bonmatí Members: radiologists, nuclear medicine specialists, biologists, physicists, biomedical engineers. N=20. Certified as emerging group by the Carlos III Health Institute Ministry of Health on 15 th October 2012.

4 GIBI 2 30 : What we do? Conceptualization, development and validation of imaging biomarkers. Integration of uni- and multi-variate information in structured reports. Generation of imaging based reference knowledge repositories. Stem-cell tracking by nanoparticles labeling and functional imaging. New imaging-based techniques and procedures for functional and molecular characterization. Development of percutaneous techniques and generation of new diagnostic systems and local treatment strategies. Development of new contrast media by using new visualization techniques like multi-spectral CT and MRI. Extraction and exploitation of the information associated to DICOM headers in order to evaluate and measure the quality and efficiency of medical imaging procedures and processes. Control of the security aspects of ionizing radiation.

5 GIBI 2 30 : Summary research projects in preparation phase H2020: PHC 30 (N= 3) EINFRA 9 FIS (N= 3) CDTI MINECO PROJECTS IN PREPARATION PHASE EU NATIONAL EU: 4 NATIONAL: 3 PRIVATE: 6 BBVA LA CAIXA & SABADELL FOUNDATION KOPLOWITZ FOUNDATION MAPFRE LILLY FOUNDATION PRIVATE PROJECTS & PRIZES REGIONAL REGIONAL(N= 6) CÁMARA VALENCIA

6 GIBI 2 30 : Experimental Radiology and Imaging Biomarkers Platform Designed for carry on experimental projects either in animal or human models. Aim: Arrange interventionism training courses and MRI Acquisition

7 GIBI 2 30 : Experimental Radiology and Imaging Biomarkers Platform Acquisition and quality assurance Methodology Design Definition and proposal writing Processing and Optimization Projects Management Analysis and modeling Biases and validation Idea and proof of concept Statistics and comparisons Publications and follow-up

8 GIBI 2 30 : Collaborators: Companies Public organizations

9 Imaging Biomarker - Definition It is a parameter obtained objectively from medical images which represents and quantifies a tissue property (structural, functional or biological) extracted after applying computational models to images and specific signal processing. A map or a parametric volume represents its spatial distribution in the tissue analysed, with the pixel /voxel signal proportional to the magnitude of biomarker.

10 Imaging Biomarkers Stepwise development of a new biomarker IDEA Proof of concept Proof of mechanism Image Acquisition Images Preparation Images Processing Measurement Proof of Principle Structured report Proof of Efficacy and Effectiveness Knowledge Value Martí-Bonmatí L, et al. Imaging biomarkers, quantitative imaging, and bioengineering. Radiologia. 2012;54:

Innovation QUIBIM stands for QUantitative Imaging Biomarkers In Medicine and, as an innovative company is specially dedicated to medical image

11 Innovation QUIBIM stands for QUantitative Imaging Biomarkers In Medicine and, as an innovative company is specially dedicated to medical image processing and extraction of imaging biomarkers for the medical imaging workflows. Spin-Off of La Fe Health Research Institute, since September 2014.

12 Added Value PATIENTS HOW CAN WE HELP YOU IN YOUR CLINICAL DISORDERS? Predictive Participative Preventive Personalized CLINICIANS IMAGING EXAM RADIOLOGY REPORT CAN WE PROVIDE YOU A SENSITIVE AN SPECIFIC DIAGNOSIS? NEED TO APPLY POST- PROCESSING AND EXTRACT IMAGING BIOMARKERS? DO YOU WANT TO HAVE THIS INFORMATION STRUCTURED IN YOUR PACS?

13 Solutions Developed Oncology MSK Central Nervous System Cardiovascular & Thorax Abdomen

14 Solutions Developed Services Offered: Trabecular bone analysis Cartilage degeneration evaluation (P)* Pharmacokinetics modelling Diffusion IVIM analysis Lung emphysema characterization (P)* Brain morphometry and volumetry + cortical thickness fmri analysis Tractography analysis Liver deposits quantification T1 mapping, T2 mapping (P)* = patents we have applied for register

15 Innovation Prostate gland 3D Mapping depicting the suspicious regions to guide biopsy Currently biopsy is a blind technique: performing injections to extract tumour samples

16 Innovation Full Workflow Images Morphology Mechanical Resistance Results Report

17 THANK YOU FOR YOUR ATTENTION MERCI POUR VOTRE ATTENTION Innovation in Personalized Medicine Contact:

QUIBIM PRECISION Powering AI and Imaging Biomarkers

Quantitative Imaging Biomarkers in Medicine www.quibim.com QUIBIM PRECISION Powering AI and Imaging Biomarkers @Quibimbiomarker 1896. William Morton First radiology report: Abdomen X-Ray there is no stone