a) JOURNAL OF BIOLOGICAL CHEMISTRY b) PNAS c) NATURE

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2 a) JOURNAL OF BIOLOGICAL CHEMISTRY b) c) d)

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5 JOURNAL OF BIOLOGICAL CHEMISTRY MOLECULAR PHARMACOLOGY TRENDS IN PHARMACOLOGICAL S AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY other 1 Brian Kobilka

6 Nature High-resolution crystal structure of an engineered human beta( 2)-adrenergic G protein-coupled receptor Crystal structure of the human beta( 2) adrenergic G- protein-coupled receptor GPCR engineering yields high-resolution structural insights into beta( 2)-adrenergic receptor function Science Nature Science Nature % 592 3% 598 4% % JOURNAL OF BIOLOGICAL CHEMISTRY TRENDS IN PHARMACOLOGICAL S 768 4% % % % MOLECULAR PHARMACOLOGY JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS Other

7 JOURNAL OF BIOLOGICAL CHEMISTRY Science JOURNAL OF BIOLOGICAL CHEMISTRY CIRCULATION RESEARCH MOLECULAR PHARMACOLOGY JOURNAL OF CLINICAL INVESTIGATION other 2 Robert Lefkowitz

8 JOURNAL OF BIOLOGICAL CHEMISTRY REVIEWS MOLECULAR CELL BIOLOGY ANNUAL REVIEW OF PHYSIOLOGY Seven-transmembrane receptors beta-arrestin-dependent formation of beta( 2) adrenergic receptor Src protein kinase complexes beta-arrestins and cell signaling BIOLOGICAL CHEMISTRY % 721 3% 783 3% 958 3% % % % % % JOURNAL OF BIOLOGICAL CHEMISTRY REVIEWS MOLECULAR CELL BIOLOGY CURRENT OPINION IN CELL BIOLOGY CELL ANNUAL REVIEW OF PHYSIOLOGY other

9 Nature METHODS Science METHODS ANGEWANDTE CHEMIE-INTERNATIONAL EDITION CELL CURRENT BIOLOGY other 3 Eric Betzig

10 METHODS METHODS Imaging intracellular fluorescent proteins at nanometer resolution Live-cell photoactivated localization microscopy of nanoscale adhesion dynamics High-density mapping of single-molecule trajectories with photoactivated localization microscopy 293 7% 155 3% % 3% 208 5% METHODS % % PLOS BIOLOGY CELL NEURON other METHODS

11 Nature Methods Biophysical Optic Express OPTICS LETTERS BIOPHYSICAL JOURNAL METHODS CHEMISTRY-A EUROPEAN JOURNAL NANO LETTERS NEW JOURNAL OF PHYSICS 3 2% other 4 Stefan Hell

12 Far-field optical nanoscopy Fluorescence microscopy with diffraction resolution barrier broken by stimulated emission Direct observation of the nanoscale dynamics of membrane lipids in a living cell Nature Methods Science METHODS BIOPHYSICAL JOURNAL OPTICS EXPRESS BIOTECHNOLOGY PHYSICAL REVIEW LETTERS NANO LETTERS other

13 IF BIOLOGICAL CHEMISTRY % 78 14% 55 10% 13 2% % 3% 20 3% 20 4% 25 4% 24 4% JOURNAL OF BIOLOGICAL CHEMISTRY OPTICS EXPRESS METHODS BIOCHEMICAL JOURNAL MOLECULAR PHARMACOLOGY CHEMISTRY-A EUROPEAN JOURNAL Other

14 % JOURNAL OF BIOLOGICAL CHEMISTRY % % % % % % % % METHODS TRENDS IN PHARMACOLOGICAL S REVIEWS MOLECULAR CELL BIOLOGY CELL BIOPHYSICAL JOURNAL Other Nature ANGEWANDT CHEMIE- INTERNATIONAL EDITION NEURON

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17 Nature CELL JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION PHYSICAL REVIEW LETTERS BIOTECHNOLOGY ANGEWANDT CHEMIE-INTERNATIONAL EDI METHODS ADVANCED MATERIALS NANO LETTERS REVIEWS MOLECULAR CELL BIOLOGY PHOTONICS CIRCULATION ACS NANO NEURON IMMUNITY PHYSICS COMMUNICATIONS MOLECULAR CELL REVIEWS NEURO REVIEWS DRUG DISCOVERY NEURO JOURNAL OF CLINICAL INVESTIGATION JOURNAL OF BIOLOGICAL CHEMISTRY CELL BIOLOGY JOURNAL OF NEURO CHEMICAL COMMUNICATIONS

Bi177 - Lecture 13 Microscopy Outside the Box. Fluorescence Nanoscopy TIRF 4-pi STED STORM/PALM

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