RNA does not adopt the classic B-DNA helix conformation when it forms a self-complementary double helix
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1 Reason: RNA has ribose sugar ring, with a hydroxyl group (OH) If RNA in B-from conformation there would be unfavorable steric contact between the hydroxyl group, base, and phosphate backbone. RNA structure (Uracil replaces thymine) RNA does not adopt the classic B-DNA helix conformation when it forms a self-complementary double helix
2 At least 50% double stranded in solution of any random RNA molecule incl.. mrna (~55-60% in trna) Most bases are stacked short-range pairings >hairpins, loops, bulges, junctions Compacted globular fold long-range pairing >intramolecular structural roles stabilizing 3D folding
3 Secondary structural elements
4 RNA tertiary structure Mainly based on transfer RNA structures Yeast phenylalanine transfer RNA (trna Phe ) -Findings universal. L -shape (solution -elongation experiments) Two segments of double Helix (A-DNA like) 10 base pairs in length Non helical regions participate in unusual hydrogen bonding interactions
5
6 THREE commonly found RNA-binding domains Ribonucleoprotein (RNP) domain Double stranded RNA binding domain (dsrsb) K homology (KH) domain ALL shown to have / domain similar to ribosomal proteins Specific RNA-protein interactions play crucial roles in gene regulation through transcription control, RNA processing, transport and translational control.
7 Ribonucleoprotein (RNP) domain Very common Contains two short conserved sequences within a weakly conserved motif aa RNP1 (RNP octamer) RNP2 (RNP hexamer) 4 anti-parallel stands flanked by 2 helices topology RNP1 and RNP2 located on central strands (crucial role in RNA binding)
8 Aromatic aa exposed on -sheet sheet provides a large surface area
9
10 Double stranded RNA binding domain Short motif 65 aa topology 3 anti-parallel stands flanked by 2 helices Conserved positive charged residues hydrogen donor/acceptors in loops 2 and 4 dsrbd and N-terminal domain of ribosomal protein s5 share sequence and structure similarities Fold specific
11 The KH domain Short conserved sequence found in heterogeneous nuclear RNP (hnrnp) K, associated with mrna precursors. Domain topology 3 anti-parallel stands and 3 helices
12 Aminoacyl-tRNA synthetases complexed with cognate trnas Transfer RNA (trna) is the 'adaptor' molecule that enables the Genetic Code contained in the nucleotide sequence of a messenger RNA (mrna) molecule to be translated into the amino acid sequence of a polypeptide chain. The key to this process lies in the specific recognition of the correct trna molecule by an aminoacyl-trna synthetase enzyme which attaches the correct amino acid for the trna to the acceptor stem at the 3' end of the molecule.
13 Aminoacyl-tRNA synthetases from all organisms belong to one of two classes depending on the amino acid they are responsible for. Class I enzymes are generally (though not always) monomeric, and attach the carboxyl of their target amino acid to the 2' OH of adenosine 76 in the trna molecule. Class II enzymes are generally dimeric or tetrameric, and attach their amino acid to the 3' OH of their trna, except for phenylalaninyl-trna synthetase which uses the 2' OH.
14 Two distinct domains (connected by hinge module) 20% of trna surface is buried (2500 Å) When function as dimers each bind one trna Acceptor stem Hinge region Anticodon reccognition Structure of Glutaminyl-tRNA synthetase
15 C-terminal domain ( ) 6 anti-parallel -strands enclosed by loops and -helices Interact with acceptor stem of trna and perform catalysis ATP binding site The structure also contains a classic 'Rossman Fold' nucleotide binding domain
16 Hinge connection ( ) Consists of 4 short -helices Interact with ribose and phosphate groups
17 N-terminal domain (1-206) Recognition of anticodon (Specific interaction) Consist of 5 stranded -barrel Lies on the side of the major groove Strands S1, S4, S5, S3, S2, (S1) anti-parallel except between S5 and S3 -helix between S3 and S4
18 Protein-RNA and RNA-RNA interactions Glutaminyl-tRNA synthetase Acceptor Stem D loop T C loop Interactions Specific conformational Non-specific Anticodon Stem
19 MS2 bacteriophage ssrna genome 5 anti-parallel -strands flanked with -helices
20 MS2 capsid protein binds to sequence specific RNA stem-loop structure (controls assembly of virus) RNA bases A4,C5, U6, and A10 (A10 shown to flip out from unbound state)
21 RNA- binding proteins RNA seems to bind to surface of -sheet RNA bases in ss loop regions seem to be able to conformationally move to base stack with adjacent bases or aromatic side chains Not possible in dsdna unless helix distorted (bent) as seen in TATA box-binding protein ssdna proteins may function the same way as RNA binding proteins
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